Most current methods for prediction of protein secondary structure use a small window of the protein sequence to predict the structure of the central amino acid. We describe a new method for prediction of the non-local structure called,8-sheet, which consists of two or more,8-strands that are connected by hydrogen bonds. Since,8-strands are often widely separated in the protein chain, a network with two windows is introduced. After training on a set of proteins the network predicts the sheets well, but there are many false positives. By using a global energy function the,8-sheet prediction is combined with a local prediction of the three secondary structures a-helix,,8-strand and coil.

Most current methods for prediction of protein secondary structure use a small window of the protein sequence to predict the structure of the central amino acid. We describe a new method for prediction of the non-local structure called,8-sheet, which consists of two or more,8-strands that are connected by hydrogen bonds. Since,8-strands are often widely separated in the protein chain, a network with two windows is introduced. After training on a set of proteins the network predicts the sheets well, but there are many false positives. Byusing a global energy function the,8-sheet prediction is combined with a local prediction of the three secondary structures a-helix,,8-strand and coil.

Department of Electrical and Computer Engineering University of Queensland St. Lucia Qld 4072 Australia Abstract We define a Gamma multi-layer perceptron (MLP) as an MLP with the usual synaptic weights replaced by gamma filters (as proposed byde Vries and Principe (de Vries and Principe, 1992)) and associated gain terms throughout all layers. We derive gradient descent update equations and apply the model to the recognition of speech phonemes. We find that both the inclusion of gamma filters in all layers, and the inclusion of synaptic gains, improves the performance of the Gamma MLP. We compare the Gamma MLP with TDNN, Back-Tsoi FIR MLP, and Back-Tsoi I1R MLP architectures, and a local approximation scheme. We find that the Gamma MLP results in an substantial reduction in error rates. 1 INTRODUCTION 1.1 THE GAMMA FILTER Infinite Impulse Response (I1R) filters have a significant advantage over Finite Impulse Response(FIR) filters in signal processing: the length of the impulse response is uncoupled from the number of filter parameters.

We present a neural network-based face detection system. A retinally connected neural network examines small windows of an image, and decides whether each window contains a face. The system arbitrates between multiple networks to improve performance over a single network. We use a bootstrap algorithm for training, which adds false detections into the training set as training progresses. This eliminates the difficult task of manually selecting non-face training examples, which must be chosen to span the entire space of non-face images.

This paper presents new experimental evidence against the utility of Occam's razor. A~systematic procedure is presented for post-processing decision trees produced by C4.5. This procedure was derived by rejecting Occam's razor and instead attending to the assumption that similar objects are likely to belong to the same class. It increases a decision tree's complexity without altering the performance of that tree on the training data from which it is inferred. The resulting more complex decision trees are demonstrated to have, on average, for a variety of common learning tasks, higher predictive accuracy than the less complex original decision trees. This result raises considerable doubt about the utility of Occam's razor as it is commonly applied in modern machine learning.

A reported weakness of C4.5 in domains with continuous attributes is addressed by modifying the formation and evaluation of tests on continuous attributes. An MDL-inspired penalty is applied to such tests, eliminating some of them from consideration and altering the relative desirability of all tests. Empirical trials show that the modifications lead to smaller decision trees with higher predictive accuracies. Results also confirm that a new version of C4.5 incorporating these changes is superior to recent approaches that use global discretization and that construct small trees with multi-interval splits.

MLP networks provided slightly better risk prediction than conventional logistic regression when used to predict the risk of death, stroke, and renal failure on 1257 patients who underwent coronary artery bypass operations. Bootstrap sampling was required to compare approaches and regularization provided by early stopping was an important component of improved performance. A simplified approach to generating confidence intervals for MLP risk predictions using an auxiliary "confidence MLP" was also developed. The confidence MLP is trained to reproduce the confidence bounds that were generated during training by 50 MLP networks trained using bootstrap samples. Current research is validating these results using larger data sets, exploring approaches to detect outlier patients who are so different from any training patient that accurate risk prediction is suspect, developing approaches to explaining which input features are important for an individual patient, and determining why MLP networks provide improved performance.

An analogue VLSI neural network has been designed and tested to perform cardiac morphology classification tasks. Analogue techniques were chosen to meet the strict power and area requirements of an Implantable Cardioverter Defibrillator (ICD) system. The robustness of the neural network architecture reduces the impact of noise, drift and offsets inherent in analogue approaches. The network is a 10:6:3 multi-layer percept ron with on chip digital weight storage, a bucket brigade input to feed the Intracardiac Electrogram (ICEG) to the network and has a winner take all circuit at the output. The network was trained in loop and included a commercial ICD in the signal processing path. The system has successfully distinguished arrhythmia for different patients with better than 90% true positive and true negative detections for dangerous rhythms which cannot be detected by present ICDs. The chip was implemented in 1.2um CMOS and consumes less than 200n W maximum average power in an area of 2.2 x 2.2mm2.

The efficiency of image search can be greatly improved by using a coarse-to-fine search strategy with a multi-resolution image representation. However, if the resolution is so low that the objects have few distinguishing features, search becomes difficult. We show that the performance of search at such low resolutions can be improved by using context information, i.e., objects visible at low-resolution which are not the objects of interest but are associated with them. The networks can be given explicit context information as inputs, or they can learn to detect the context objects, in which case the user does not have to be aware of their existence. We also use Integrated Feature Pyramids, which represent high-frequency information at low resolutions. The use of multiresolution search techniques allows us to combine information about the appearance of the objects on many scales in an efficient way. A natural fOlm of exemplar selection also arises from these techniques. We illustrate these ideas by training hierarchical systems of neural networks to find clusters of buildings in aerial photographs of farmland.

MLP networks provided slightly better risk prediction than conventional logistic regression when used to predict the risk of death, stroke, and renal failure on 1257 patients who underwent coronary artery bypass operations. Bootstrap sampling was required to compare approaches and regularization provided by early stopping was an important component of improved performance. A simplified approach to generating confidence intervals for MLP risk predictions using an auxiliary "confidence MLP" was also developed. The confidence MLP is trained to reproduce the confidence bounds that were generated during training by 50 MLP networks trained using bootstrap samples. Current research is validating these results using larger data sets, exploring approaches to detect outlier patients who are so different from any training patient that accurate risk prediction is suspect, developing approaches to explaining which input features are important for an individual patient, and determining why MLP networks provide improved performance.