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Algebraic Comparison of Partial Lists in Bioinformatics

arXiv.org Machine Learning

The outcome of a functional genomics pipeline is usually a partial list of genomic features, ranked by their relevance in modelling biological phenotype in terms of a classification or regression model. Due to resampling protocols or just within a meta-analysis comparison, instead of one list it is often the case that sets of alternative feature lists (possibly of different lengths) are obtained. Here we introduce a method, based on the algebraic theory of symmetric groups, for studying the variability between lists ("list stability") in the case of lists of unequal length. We provide algorithms evaluating stability for lists embedded in the full feature set or just limited to the features occurring in the partial lists. The method is demonstrated first on synthetic data in a gene filtering task and then for finding gene profiles on a recent prostate cancer dataset.


Privacy Classification Systems: Recall and Precision Optimization as Enabler of Trusted Information Sharing

AAAI Conferences

Information is shared more extensively when a user can confidently classify all his information according to its desired degree of disclosure prior to transmission. While high quality classification is relatively straightforward for structured data (e.g., credit card numbers, cookies, "confidential" reports), most consumer and business information is unstructured (e.g., Facebook posts, corporate email). All current technological approaches to classifying unstructured information seek to identify only that information having the desired characteristics (i.e., to maximize the percentage of filtered content that requires privacy protection). Such focus on boosting classifier Precision (P) causes technology solutions to miss sensitive information [i.e., Recall (R) is compromised for the sake of P improvement]. Such privacy protection will fall short of user expectations no matter how "intelligent" the technology may be in extending beyond keywords to user meaning. Systems must simultaneously optimize both P and R in order to protect privacy sufficiently to encourage the free flow of personal and corporate information. This requires a socio-technical methodology wherein the user is intimately involved in iterative privacy improvement. The approach is a general one in which the classifier can be modified as necessary at any time when sampling measures of P and R deem it appropriate. Matching the ever-evolving user privacy model to the technology solution (e.g., active machine learning) affords a technique for building and maintaining user trust.


Whoโ€™s Calling? Demographics of Mobile Phone Use in Rwanda

AAAI Conferences

But whereas in the general Rwandan populace males tend Despite the increasing ubiquity of mobile phones in the developing to be much better educated (76.3% of males are literate, but world, remarkably little is known about the structure only 64.7% of females), among mobile phone users it is the and demographics of the mobile phone market. While a women who achieve higher levels of education: the median few qualitative studies have detailed social norms of phone woman completes secondary school, while the median man use in specific communities (Donner 2007; Burrell 2009), does not (t 4.79). Table 1 shows a few statistics on asset and a handful of quantitative researchers have begun to analyze ownership, with associated sampling error.


Case for Automated Detection of Diabetic Retinopathy

AAAI Conferences

Diabetic retinopathy, an eye disorder caused by diabetes, is the primary cause of blindness in America and over 99% of cases in India. India and China currently account for over 90 million diabetic patients and are on the verge of an explosion of diabetic populations. This may result in an unprecedented number of persons becoming blind unless diabetic retinopathy can be detected early. Aravind Eye Hospitals is the largest eye care facility in the world, handling over 2 million patients per year. The hospital is on a massive drive throughout southern India to detect diabetic retinopathy at an early stage. To that end, a group of 10-15 physicians are responsible for manually diagnosing over 2 million retinal images per year to detect diabetic retinopathy. While the task is extremely laborious, a large fraction of cases turn out to be normal indicating that much of this time is spent diagnosing completely normal cases. This paper describes our early experiences working with Aravind Eye Hospitals to develop an automated system to detect diabetic retinopathy from retinal images. The automated diabetic retinopathy problem is a hard computer vision problem whose goal is to detect features of retinopathy, such as hemorrhages and exudates, in retinal color fundus images. We describe our initial efforts towards building such a system using a range of computer vision techniques and discuss the potential impact on early detection of diabetic retinopathy.


Using Linked Data to Build Open, Collaborative Recommender Systems

AAAI Conferences

While recommender systems can greatly enhance the user experience, the entry barriers in terms of data acquisition are very high, making it hard for new service providers to compete with existing recommendation services. This paper proposes to build open recommender systems which can utilise Linked Data to mitigate the new-user, new-item and sparsity problems of collaborative recommender systems. We describe how to aggregate data about object centred sociality from different sources and how to process it for collaborative recommendation. To demonstrate the validity of our approach, we augment the data from a closed collaborative music recommender system with Linked Data, and significantly improve its precision and recall.


The Web as a Privacy Lab

AAAI Conferences

The privacy dangers of data proliferation on the Web are well-known. Information on the Web has facilitated the deanonymization of anonymous bloggers, the de-sanitization of government records and the identification of individuals based on search engine queries. What has received less attention is Web-mining in support of privacy. In this position paper we argue that the very ability ofWeb data to breach privacy demonstrates its value as a laboratory for the detection of privacy breaches before they happen. In addition, we argue that privacy-invasive services may become privacy-respecting by mining publicly available Web data, with little decrease in performance and efficiency.


Document Classification for Focused Topics

AAAI Conferences

Feature extraction is one of the fundamental challenges in improving the accuracy of document classification. While there has been a large body of research literature on document classification, most existing approaches either do not have a high classification accuracy or require massive training sets. In this paper, we propose a simple feature extraction algorithm that can achieve high document classification accuracy in the context of development-centric topics. Our feature extraction algorithm exploits two distinct aspects in development-centric topics: most of these topics tend to be very focused (unlike semantically hard classification topics such as chemistry or banks) due to local language and cultural underpinnings in these topics, the authentic pages tend to use several region specific features. Our algorithm uses a combination of popularity and rarity as two separate metrics to extract features that describe a topic. Given a topic, our output feature set comprises of: (i) a list of popular keywords closely related to the topic; (ii) a list of rare keywords closely related to the topic. We show that a simple joint classifier based on these two feature sets can achieve high classification accuracy while each feature sub-set in itself is insufficient. We have tested our algorithm across a wide range of development-centric topics.


Mining Road Traffic Accident Data to Improve Safety: Role of Road-Related Factors on Accident Severity in Ethiopia

AAAI Conferences

Road traffic accidents (RTAs) are a major public health concern, resulting in an estimated 1.2 million deaths and 50 million injuries worldwide each year. In the developing world, RTAs are among the leading cause of death and injury; Ethiopia in particular experiences the highest rate of such accidents. Thus, methods to reduce accident severity are of great interest to traffic agencies and the public at large. In this work, we applied data mining technologies to link recorded road characteristics to accident severity in Ethiopia, and developed a set of rules that could be used by the Ethiopian Traffic Agency to improve safety.


libtissue - implementing innate immunity

arXiv.org Artificial Intelligence

In a previous paper the authors argued the case for incorporating ideas from innate immunity into articficial immune systems (AISs) and presented an outline for a conceptual framework for such systems. A number of key general properties observed in the biological innate and adaptive immune systems were hughlighted, and how such properties might be instantiated in artificial systems was discussed in detail. The next logical step is to take these ideas and build a software system with which AISs with these properties can be implemented and experimentally evaluated. This paper reports on the results of that step - the libtissue system.


Information Fusion in the Immune System

arXiv.org Artificial Intelligence

Biologically-inspired methods such as evolutionary algorithms and neural networks are proving useful in the field of information fusion. Artificial Immune Systems (AISs) are a biologically-inspired approach which take inspiration from the biological immune system. Interestingly, recent research has show how AISs which use multi-level information sources as input data can be used to build effective algorithms for real time computer intrusion detection. This research is based on biological information fusion mechanisms used by the human immune system and as such might be of interest to the information fusion community. The aim of this paper is to present a summary of some of the biological information fusion mechanisms seen in the human immune system, and of how these mechanisms have been implemented as AISs