Early diagnosis, playing an important role in preventing progress and treating the Alzheimer's disease (AD), is based on classification of features extracted from brain images. The features have to accurately capture main AD-related variations of anatomical brain structures, such as, e.g., ventricles size, hippocampus shape, cortical thickness, and brain volume. This paper proposes to predict the AD with a deep 3D convolutional neural network (3D-CNN), which can learn generic features capturing AD biomarkers and adapt to different domain datasets. The 3D-CNN is built upon a 3D convolutional autoencoder, which is pre-trained to capture anatomical shape variations in structural brain MRI scans. Fully connected upper layers of the 3D-CNN are then fine-tuned for each task-specific AD classification. Experiments on the \emph{ADNI} MRI dataset with no skull-stripping preprocessing have shown our 3D-CNN outperforms several conventional classifiers by accuracy and robustness. Abilities of the 3D-CNN to generalize the features learnt and adapt to other domains have been validated on the \emph{CADDementia} dataset.

We derive a new discrepancy statistic for measuring differences between two probability distributions based on combining Stein's identity with the reproducing kernel Hilbert space theory. We apply our result to test how well a probabilistic model fits a set of observations, and derive a new class of powerful goodness-of-fit tests that are widely applicable for complex and high dimensional distributions, even for those with computationally intractable normalization constants. Both theoretical and empirical properties of our methods are studied thoroughly.

Brain networks in fMRI are typically identified using spatial independent component analysis (ICA), yet mathematical constraints such as sparse coding and positivity both provide alternate biologically-plausible frameworks for generating brain networks. Non-negative Matrix Factorization (NMF) would suppress negative BOLD signal by enforcing positivity. Spatial sparse coding algorithms ($L1$ Regularized Learning and K-SVD) would impose local specialization and a discouragement of multitasking, where the total observed activity in a single voxel originates from a restricted number of possible brain networks. The assumptions of independence, positivity, and sparsity to encode task-related brain networks are compared; the resulting brain networks for different constraints are used as basis functions to encode the observed functional activity at a given time point. These encodings are decoded using machine learning to compare both the algorithms and their assumptions, using the time series weights to predict whether a subject is viewing a video, listening to an audio cue, or at rest, in 304 fMRI scans from 51 subjects. For classifying cognitive activity, the sparse coding algorithm of $L1$ Regularized Learning consistently outperformed 4 variations of ICA across different numbers of networks and noise levels (p$<$0.001). The NMF algorithms, which suppressed negative BOLD signal, had the poorest accuracy. Within each algorithm, encodings using sparser spatial networks (containing more zero-valued voxels) had higher classification accuracy (p$<$0.001). The success of sparse coding algorithms may suggest that algorithms which enforce sparse coding, discourage multitasking, and promote local specialization may capture better the underlying source processes than those which allow inexhaustible local processes such as ICA.

In relation to Bayesian statistics, the sensitivity and specificity are the conditional probabilities, the prevalence is the prior, and the positive/negative predicted values are the posterior probabilities.

Manufacturers often have to deal with up to 800 hours of downtime annually. On average an automotive manufacturer's TDC is 22,000 per minute; that is 1.3M per month! With the advance of predictive analytics, TDC can easily be reduced however only 14% of the manufacturing industry is taking advantage of its big data, according to a recent survey from MESA. Predictive maintenance is realized through the application of sophisticated machine learning techniques to equipment condition data collected in real-time or near real-time. It is now the new standard for reducing cost, risk and lost production in manufacturing facilities.

This paper presents a simple but effective density-based outlier detection approach with the local kernel density estimation (KDE). A Relative Density-based Outlier Score (RDOS) is introduced to measure the local outlierness of objects, in which the density distribution at the location of an object is estimated with a local KDE method based on extended nearest neighbors of the object. Instead of using only $k$ nearest neighbors, we further consider reverse nearest neighbors and shared nearest neighbors of an object for density distribution estimation. Some theoretical properties of the proposed RDOS including its expected value and false alarm probability are derived. A comprehensive experimental study on both synthetic and real-life data sets demonstrates that our approach is more effective than state-of-the-art outlier detection methods.

This paper proposes a novel dynamic Hierarchical Dirichlet Process topic model that considers the dependence between successive observations. Conventional posterior inference algorithms for this kind of models require processing of the whole data through several passes. It is computationally intractable for massive or sequential data. We design the batch and online inference algorithms, based on the Gibbs sampling, for the proposed model. It allows to process sequential data, incrementally updating the model by a new observation. The model is applied to abnormal behaviour detection in video sequences. A new abnormality measure is proposed for decision making. The proposed method is compared with the method based on the non- dynamic Hierarchical Dirichlet Process, for which we also derive the online Gibbs sampler and the abnormality measure. The results with synthetic and real data show that the consideration of the dynamics in a topic model improves the classification performance for abnormal behaviour detection.

A novel dynamic Bayesian nonparametric topic model for anomaly detection in video is proposed in this paper. Batch and online Gibbs samplers are developed for inference. The paper introduces a new abnormality measure for decision making. The proposed method is evaluated on both synthetic and real data. The comparison with a non-dynamic model shows the superiority of the proposed dynamic one in terms of the classification performance for anomaly detection.

High-dimensional linear classifiers, such as the support vector machine (SVM) and distance weighted discrimination (DWD), are commonly used in biomedical research to distinguish groups of subjects based on a large number of features. However, their use is limited to applications where a single vector of features is measured for each subject. In practice data are often multi-way, or measured over multiple dimensions. For example, metabolite abundance may be measured over multiple regions or tissues, or gene expression may be measured over multiple time points, for the same subjects. We propose a framework for linear classification of high-dimensional multi-way data, in which coefficients can be factorized into weights that are specific to each dimension. More generally, the coefficients for each measurement in a multi-way dataset are assumed to have low-rank structure. This framework extends existing classification techniques, and we have implemented multi-way versions of SVM and DWD. We describe informative simulation results, and apply multi-way DWD to data for two very different clinical research studies. The first study uses metabolite magnetic resonance spectroscopy data over multiple brain regions to compare patients with and without spinocerebellar ataxia, the second uses publicly available gene expression time-course data to compare treatment responses for patients with multiple sclerosis. Our method improves performance and simplifies interpretation over naive applications of full rank linear classification to multi-way data. An R package is available at https://github.com/lockEF/MultiwayClassification .

With the rise of social media, people can now form relationships and communities easily regardless of location, race, ethnicity, or gender. However, the power of social media simultaneously enables harmful online behavior such as harassment and bullying. Cyberbullying is a serious social problem, making it an important topic in social network analysis. Machine learning methods can potentially help provide better understanding of this phenomenon, but they must address several key challenges: the rapidly changing vocabulary involved in cyber- bullying, the role of social network structure, and the scale of the data. In this study, we propose a model that simultaneously discovers instigators and victims of bullying as well as new bullying vocabulary by starting with a corpus of social interactions and a seed dictionary of bullying indicators. We formulate an objective function based on participant-vocabulary consistency. We evaluate this approach on Twitter and Ask.fm data sets and show that the proposed method can detect new bullying vocabulary as well as victims and bullies.