Magnetic resonance (MR) imaging offers a wide variety of imaging techniques. A large amount of data is created per examination which needs to be checked for sufficient quality in order to derive a meaningful diagnosis. This is a manual process and therefore time- and cost-intensive. Any imaging artifacts originating from scanner hardware, signal processing or induced by the patient may reduce the image quality and complicate the diagnosis or any image post-processing. Therefore, the assessment or the ensurance of sufficient image quality in an automated manner is of high interest. Usually no reference image is available or difficult to define. Therefore, classical reference-based approaches are not applicable. Model observers mimicking the human observers (HO) can assist in this task. Thus, we propose a new machine-learning-based reference-free MR image quality assessment framework which is trained on HO-derived labels to assess MR image quality immediately after each acquisition. We include the concept of active learning and present an efficient blinded reading platform to reduce the effort in the HO labeling procedure. Derived image features and the applied classifiers (support-vector-machine, deep neural network) are investigated for a cohort of 250 patients. The MR image quality assessment framework can achieve a high test accuracy of 93.7$\%$ for estimating quality classes on a 5-point Likert-scale. The proposed MR image quality assessment framework is able to provide an accurate and efficient quality estimation which can be used as a prospective quality assurance including automatic acquisition adaptation or guided MR scanner operation, and/or as a retrospective quality assessment including support of diagnostic decisions or quality control in cohort studies.

Given independent samples generated from the joint distribution $p(\mathbf{x},\mathbf{y},\mathbf{z})$, we study the problem of Conditional Independence (CI-Testing), i.e., whether the joint equals the CI distribution $p^{CI}(\mathbf{x},\mathbf{y},\mathbf{z})= p(\mathbf{z}) p(\mathbf{y}|\mathbf{z})p(\mathbf{x}|\mathbf{z})$ or not. We cast this problem under the purview of the proposed, provable meta-algorithm, "Mimic and Classify", which is realized in two-steps: (a) Mimic the CI distribution close enough to recover the support, and (b) Classify to distinguish the joint and the CI distribution. Thus, as long as we have a good generative model and a good classifier, we potentially have a sound CI Tester. With this modular paradigm, CI Testing becomes amiable to be handled by state-of-the-art, both generative and classification methods from the modern advances in Deep Learning, which in general can handle issues related to curse of dimensionality and operation in small sample regime. We show intensive numerical experiments on synthetic and real datasets where new mimic methods such conditional GANs, Regression with Neural Nets, outperform the current best CI Testing performance in the literature. Our theoretical results provide analysis on the estimation of null distribution as well as allow for general measures, i.e., when either some of the random variables are discrete and some are continuous or when one or more of them are discrete-continuous mixtures.

With the rapid commoditization of wearable sensors, detecting human movements from sensor datasets has become increasingly common over a wide range of applications. To detect activities, data scientists iteratively experiment with different classifiers before deciding which model to deploy. Effective reasoning about and comparison of alternative classifiers are crucial in successful model development. This is, however, inherently difficult in developing classifiers for sensor data, where the intricacy of long temporal sequences, high prediction frequency, and imprecise labeling make standard evaluation methods relatively ineffective and even misleading. We introduce Track Xplorer, an interactive visualization system to query, analyze, and compare the predictions of sensor-data classifiers. Track Xplorer enables users to interactively explore and compare the results of different classifiers, and assess their accuracy with respect to the ground-truth labels and video. Through integration with a version control system, Track Xplorer supports tracking of models and their parameters without additional workload on model developers. Track Xplorer also contributes an extensible algebra over track representations to filter, compose, and compare classification outputs, enabling users to reason effectively about classifier performance. We apply Track Xplorer in a collaborative project to develop classifiers to detect movements from multisensor data gathered from Parkinson's disease patients. We demonstrate how Track Xplorer helps identify early on possible systemic data errors, effectively track and compare the results of different classifiers, and reason about and pinpoint the causes of misclassifications.

Machine learning is revolutionizing the way we interact with the world. Popular websites use algorithms to analyze user data and recommend videos, customize social media feeds, and optimize advertisements. Unsurprisingly, machine learning is taking a large role in making decisions about human beings, ranging from credit to parole decisions, and is likely to be more and more widely used in the future. It is not hard to imagine that, even in cases where the final decisions are made by people, they will be doing so with advice from algorithms that make inferences from patterns in petabytes of data. Some proponents of machine learning have suggested that not only are these algorithms able to leverage the increasing amount of data we have access to, but also that they might be able to make these decisions more fairly, as they seem to not be subject to human biases. There is some truth to these claims.

In 2015, a worried father asked Rhema Vaithianathan a question that still weighs on her mind. A small crowd had gathered in a basement room in Pittsburgh, Pennsylvania, to hear her explain how software might tackle child abuse. Each day, the area's hotline receives dozens of calls from people who suspect that a child is in danger; some of these are then flagged by call-centre staff for investigation. But the system does not catch all cases of abuse. Vaithianathan and her colleagues had just won a half-million-dollar contract to build an algorithm to help. Vaithianathan, a health economist who co-directs the Centre for Social Data Analytics at the Auckland University of Technology in New Zealand, told the crowd how the algorithm might work. For example, a tool trained on reams of data -- including family backgrounds and criminal records -- could generate risk scores when calls come in. That could help call screeners to flag which families to investigate.

There is a growing body of literature showing that deep neural networks are vulnerable to adversarial input modification. Recently this work has been extended from image classification to malware classification over boolean features. In this paper we present several new methods for training restricted networks in this specific domain that are highly effective at preventing adversarial perturbations. We start with a fully adversarially resistant neural network that has hard non-negative weight restrictions and is equivalent to learning a monotonic boolean function and then attempt to relax the constraints to improve classifier accuracy.

The task of drug-target interaction prediction holds significant importance in pharmacology and therapeutic drug design. In this paper, we present FRnet-DTI, an auto encoder and a convolutional classifier for feature manipulation and drug target interaction prediction. Two convolutional neural neworks are proposed where one model is used for feature manipulation and the other one for classification. Using the first method FRnet-1, we generate 4096 features for each of the instances in each of the datasets and use the second method, FRnet-2, to identify interaction probability employing those features. We have tested our method on four gold standard datasets exhaustively used by other researchers. Experimental results shows that our method significantly improves over the state-of-the-art method on three of the four drug-target interaction gold standard datasets on both area under curve for Receiver Operating Characteristic(auROC) and area under Precision Recall curve(auPR) metric. We also introduce twenty new potential drug-target pairs for interaction based on high prediction scores. Codes Available: https: // github. com/ farshidrayhanuiu/ FRnet-DTI/ Web Implementation: http: // farshidrayhan. pythonanywhere. com/ FRnet-DTI/

In ECOC framework, the ternary coding strategy is widely deployed in coding process. It relabels classes with {"-1,0,1" }, where -1/1 means to assign the corresponding classes to the negative/positive group, and label 0 leads to ignore the corresponding classes in the training process. However, the application of hard labels may lose some information about the tendency of class distributions. Instead, we propose a Centroid distance-based Soft coding scheme to indicate such tendency, named as CSECOC. In our algorithm, Sequential Forward Floating Selection (SFFS) is applied to search an optimal class assignment by minimizing the ratio of intra-group and inter-group distance. In this way, a hard coding matrix is generated initially. Then we propose a measure, named as coverage, to describe the probability of a sample in a class falling to a correct group. The coverage of a class a group replace the corresponding hard element, so as to form a soft coding matrix. Compared with the hard ones, such soft elements can reflect the tendency of a class belonging to positive or negative group. Instead of classifiers, regressors are used as base learners in this algorithm. To the best of our knowledge, it is the first time that soft coding scheme has been proposed. The results on five UCI datasets show that compared with some state-of-art ECOC algorithms, our algorithm can produce comparable or better classification accuracy with small scale ensembles.

We present an approach for building an active agent that learns to segment its visual observations into individual objects by interacting with its environment in a completely self-supervised manner. The agent uses its current segmentation model to infer pixels that constitute objects and refines the segmentation model by interacting with these pixels. The model learned from over 50K interactions generalizes to novel objects and backgrounds. To deal with noisy training signal for segmenting objects obtained by self-supervised interactions, we propose robust set loss. A dataset of robot's interactions along-with a few human labeled examples is provided as a benchmark for future research. We test the utility of the learned segmentation model by providing results on a downstream vision-based control task of rearranging multiple objects into target configurations from visual inputs alone. Videos, code, and robotic interaction dataset are available at https://pathak22.

We propose Quootstrap, a method for extracting quotations, as well as the names of the speakers who uttered them, from large news corpora. Whereas prior work has addressed this problem primarily with supervised machine learning, our approach follows a fully unsupervised bootstrapping paradigm. It leverages the redundancy present in large news corpora, more precisely, the fact that the same quotation often appears across multiple news articles in slightly different contexts. Starting from a few seed patterns, such as ["Q", said S.], our method extracts a set of quotation-speaker pairs (Q, S), which are in turn used for discovering new patterns expressing the same quotations; the process is then repeated with the larger pattern set. Our algorithm is highly scalable, which we demonstrate by running it on the large ICWSM 2011 Spinn3r corpus. Validating our results against a crowdsourced ground truth, we obtain 90% precision at 40% recall using a single seed pattern, with significantly higher recall values for more frequently reported (and thus likely more interesting) quotations. Finally, we showcase the usefulness of our algorithm's output for computational social science by analyzing the sentiment expressed in our extracted quotations.