This paper deals with multivariate regression chain graphs (MVR CGs), which were introduced by Cox and Wermuth [3,4] to represent linear causal models with correlated errors. We consider the PC-like algorithm for structure learning of MVR CGs, which is a constraint-based method proposed by Sonntag and Pe\~{n}a in [18]. We show that the PC-like algorithm is order-dependent, in the sense that the output can depend on the order in which the variables are given. This order-dependence is a minor issue in low-dimensional settings. However, it can be very pronounced in high-dimensional settings, where it can lead to highly variable results. We propose two modifications of the PC-like algorithm that remove part or all of this order-dependence. Simulations under a variety of settings demonstrate the competitive performance of our algorithms in comparison with the original PC-like algorithm in low-dimensional settings and improved performance in high-dimensional settings.

Deep neural network (DNN) has demonstrated its success in multiple domains. However, DNN models are inherently vulnerable to adversarial examples, which are generated by adding adversarial perturbations to benign inputs to fool the DNN model to misclassify. In this paper, we present a cross-layer strategic ensemble framework and a suite of robust defense algorithms, which are attack-independent, and capable of auto-repairing and auto-verifying the target model being attacked. Our strategic ensemble approach makes three original contributions. First, we employ input-transformation diversity to design the input-layer strategic transformation ensemble algorithms. Second, we utilize model-disagreement diversity to develop the output-layer strategic model ensemble algorithms. Finally, we create an input-output cross-layer strategic ensemble defense that strengthens the defensibility by combining diverse input transformation based model ensembles with diverse output verification model ensembles. Evaluated over 10 attacks on ImageNet dataset, we show that our strategic ensemble defense algorithms can achieve high defense success rates and are more robust with high attack prevention success rates and low benign false negative rates, compared to existing representative defense methods.

Increasingly large electronic health records (EHRs) provide an opportunity to algorithmically learn medical knowledge. In one prominent example, a causal health knowledge graph could learn relationships between diseases and symptoms and then serve as a diagnostic tool to be refined with additional clinical input. Prior research has demonstrated the ability to construct such a graph from over 270,000 emergency department patient visits. In this work, we describe methods to evaluate a health knowledge graph for robustness. Moving beyond precision and recall, we analyze for which diseases and for which patients the graph is most accurate. We identify sample size and unmeasured confounders as major sources of error in the health knowledge graph. We introduce a method to leverage non-linear functions in building the causal graph to better understand existing model assumptions. Finally, to assess model generalizability, we extend to a larger set of complete patient visits within a hospital system. We conclude with a discussion on how to robustly extract medical knowledge from EHRs.

Cardiotoxicity related to cancer therapies has become a serious issue, diminishing cancer treatment outcomes and quality of life. Early detection of cancer patients at risk for cardiotoxicity before cardiotoxic treatments and providing preventive measures are potential solutions to improve cancer patients's quality of life. This study focuses on predicting the development of heart failure in cancer patients after cancer diagnoses using historical electronic health record (EHR) data. We examined four machine learning algorithms using 143,199 cancer patients from the University of Florida Health (UF Health) Integrated Data Repository (IDR). We identified a total number of 1,958 qualified cases and matched them to 15,488 controls by gender, age, race, and major cancer type. Two feature encoding strategies were compared to encode variables as machine learning features. The gradient boosting (GB) based model achieved the best AUC score of 0.9077 (with a sensitivity of 0.8520 and a specificity of 0.8138), outperforming other machine learning methods. We also looked into the subgroup of cancer patients with exposure to chemotherapy drugs and observed a lower specificity score (0.7089). The experimental results show that machine learning methods are able to capture clinical factors that are known to be associated with heart failure and that it is feasible to use machine learning methods to identify cancer patients at risk for cancer therapy-related heart failure.

Nowadays processing of Big Security Data, such as log messages, is commonly used for intrusion detection purposed. Its heterogeneous nature, as well as combination of numerical and categorical attributes does not allow to apply the existing data mining methods directly on the data without feature preprocessing. Therefore, a rather computationally expensive conversion of categorical attributes into vector space should be utilised for analysis of such data. However, a well-known k-modes algorithm allows to cluster the categorical data directly and avoid conversion into the vector space. The existing implementations of k-modes for Big Data processing are ensemble-based and utilise two-step clustering, where data subsets are first clustered independently, whereas the resulting cluster modes are clustered again in order to calculate metamodes valid for all data subsets. In this paper, the novel frequency-based distance function is proposed for the second step of ensemble-based k-modes clustering. Besides this, the existing feature discretisation method from the previous work is utilised in order to adapt k-modes for processing of mixed data sets. The resulting k-metamodes algorithm was tested on two public security data sets and reached higher effectiveness in comparison with the previous work.

We consider the problem of automatically generating textual paraphrases with modified attributes or properties, focusing on the setting without parallel data (Hu et al., 2017; Shen et al., 2017). This setting poses challenges for evaluation. We show that the metric of post-transfer classification accuracy is insufficient on its own, and propose additional metrics based on semantic preservation and fluency as well as a way to combine them into a single overall score. We contribute new loss functions and training strategies to address the different metrics. Semantic preservation is addressed by adding a cyclic consistency loss and a loss based on paraphrase pairs, while fluency is improved by integrating losses based on style-specific language models. We experiment with a Yelp sentiment dataset and a new literature dataset that we propose, using multiple models that extend prior work (Shen et al., 2017). We demonstrate that our metrics correlate well with human judgments, at both the sentence-level and system-level. Automatic and manual evaluation also show large improvements over the baseline method of Shen et al. (2017). We hope that our proposed metrics can speed up system development for new textual transfer tasks while also encouraging the community to address our three complementary aspects of transfer quality.

Conventional inclusion criteria used in osteoarthritis clinical trials are not very effective in selecting patients who would benefit the most from a therapy under test. Typically these criteria select majority of patients who show no or limited disease progression during a short evaluation window of the study. As a consequence, less insight on the relative effect of the treatment can be gained from the collected data, and the efforts and resources invested in running the study are not paying off. This could be avoided, if selection criteria were more predictive of the future disease progression. In this article, we formulated the patient selection problem as a multi-class classification task, with classes based on clinically relevant measures of progression (over a time scale typical for clinical trials). Using data from two long-term knee osteoarthritis studies OAI and CHECK, we tested multiple algorithms and learning process configurations (including multi-classifier approaches, cost-sensitive learning, and feature selection), to identify the best performing machine learning models. We examined the behaviour of the best models, with respect to prediction errors and the impact of used features, to confirm their clinical relevance. We found that the model-based selection outperforms the conventional inclusion criteria, reducing by 20-25% the number of patients who show no progression and making the representation of the patient categories more even. This result indicates that our machine learning approach could lead to efficiency improvements in clinical trial design.

We present the first application of adaptive machine learning to the identification of anomalies in a data set of non-periodic astronomical light curves. The method follows an active learning strategy where highly informative objects are selected to be labelled. This new information is subsequently used to improve the machine learning model, allowing its accuracy to evolve with the addition of every new classification. For the case of anomaly detection, the algorithm aims to maximize the number of real anomalies presented to the expert by slightly modifying the decision boundary of a traditional isolation forest in each iteration. As a proof of concept, we apply the Active Anomaly Discovery (AAD) algorithm to light curves from the Open Supernova Catalog and compare its results to those of a static Isolation Forest (IF). For both methods, we visually inspected objects within 2% highest anomaly scores. We show that AAD was able to identify 80% more true anomalies than IF. This result is the first evidence that AAD algorithms can play a central role in the search for new physics in the era of large scale sky surveys.

We develop a framework for learning sparse nonparametric directed acyclic graphs (DAGs) from data. Our approach is based on a recent algebraic characterization of DAGs that led to the first fully continuous optimization for score-based learning of DAG models parametrized by a linear structural equation model (SEM). We extend this algebraic characterization to nonparametric SEM by leveraging nonparametric sparsity based on partial derivatives, resulting in a continuous optimization problem that can be applied to a variety of nonparametric and semiparametric models including GLMs, additive noise models, and index models as special cases. We also explore the use of neural networks and orthogonal basis expansions to model nonlinearities for general nonparametric models. Extensive empirical study confirms the necessity of nonlinear dependency and the advantage of continuous optimization for score-based learning.

We present Generative Adversarial rePresentations (GAP) as a data-driven framework for learning censored and/or fair representations. GAP leverages recent advancements in adversarial learning to allow a data holder to learn universal representations that decouple a set of sensitive attributes from the rest of the dataset. Under GAP, finding the optimal mechanism? {decorrelating encoder/decorrelator} is formulated as a constrained minimax game between a data encoder and an adversary. We show that for appropriately chosen adversarial loss functions, GAP provides {censoring} guarantees against strong information-theoretic adversaries and enforces demographic parity. We also evaluate the performance of GAP on multi-dimensional Gaussian mixture models and real datasets, and show how a designer can certify that representations learned under an adversary with a fixed architecture perform well against more complex adversaries.