A universal fault-tolerant quantum computer that can solve efficiently problems such as integer factorization and unstructured database search requires millions of qubits with low error rates and long coherence times. While the experimental advancement towards realizing such devices will potentially take decades of research, noisy intermediate-scale quantum (NISQ) computers already exist. These computers are composed of hundreds of noisy qubits, i.e. qubits that are not error-corrected, and therefore perform imperfect operations in a limited coherence time. In the search for quantum advantage with these devices, algorithms have been proposed for applications in various disciplines spanning physics, machine learning, quantum chemistry and combinatorial optimization. The goal of such algorithms is to leverage the limited available resources to perform classically challenging tasks. In this review, we provide a thorough summary of NISQ computational paradigms and algorithms. We discuss the key structure of these algorithms, their limitations, and advantages. We additionally provide a comprehensive overview of various benchmarking and software tools useful for programming and testing NISQ devices.

In general-purpose particle detectors, the particle flow algorithm may be used to reconstruct a coherent particle-level view of the event by combining information from the calorimeters and the trackers, significantly improving the detector resolution for jets and the missing transverse momentum. In view of the planned high-luminosity upgrade of the CERN Large Hadron Collider, it is necessary to revisit existing reconstruction algorithms and ensure that both the physics and computational performance are sufficient in a high-pileup environment. Recent developments in machine learning may offer a prospect for efficient event reconstruction based on parametric models. We introduce MLPF, an end-to-end trainable machine-learned particle flow algorithm for reconstructing particle flow candidates based on parallelizable, computationally efficient, scalable graph neural networks and a multi-task objective. We report the physics and computational performance of the MLPF algorithm on on a synthetic dataset of ttbar events in HL-LHC running conditions, including the simulation of multiple interaction effects, and discuss potential next steps and considerations towards ML-based reconstruction in a general purpose particle detector.

An Orthogonal Least Squares (OLS) based feature selection method is proposed for both binomial and multinomial classification. The novel Squared Orthogonal Correlation Coefficient (SOCC) is defined based on Error Reduction Ratio (ERR) in OLS and used as the feature ranking criterion. The equivalence between the canonical correlation coefficient, Fisher's criterion, and the sum of the SOCCs is revealed, which unveils the statistical implication of ERR in OLS for the first time. It is also shown that the OLS based feature selection method has speed advantages when applied for greedy search. The proposed method is comprehensively compared with the mutual information based feature selection methods in 2 synthetic and 7 real world datasets. The results show that the proposed method is always in the top 5 among the 10 candidate methods. Besides, the proposed method can be directly applied to continuous features without discretisation, which is another significant advantage over mutual information based methods.

Objective: Machine learning algorithms are now widely used in predicting acute events for clinical applications. While most of such prediction applications are developed to predict the risk of a particular acute event at one hospital, few efforts have been made in extending the developed solutions to other events or to different hospitals. We provide a scalable solution to extend the process of clinical risk prediction model development of multiple diseases and their deployment in different Electronic Health Records (EHR) systems. Materials and Methods: We defined a generic process for clinical risk prediction model development. A calibration tool has been created to automate the model generation process. We applied the model calibration process at four hospitals, and generated risk prediction models for delirium, sepsis and acute kidney injury (AKI) respectively at each of these hospitals. Results: The delirium risk prediction models achieved area under the receiver-operating characteristic curve (AUROC) ranging from 0.82 to 0.95 over different stages of a hospital stay on the test datasets of the four hospitals. The sepsis models achieved AUROC ranging from 0.88 to 0.95, and the AKI models achieved AUROC ranging from 0.85 to 0.92. Discussion: The scalability discussed in this paper is based on building common data representations (syntactic interoperability) between EHRs stored in different hospitals. Semantic interoperability, a more challenging requirement that different EHRs share the same meaning of data, e.g. a same lab coding system, is not mandated with our approach. Conclusions: Our study describes a method to develop and deploy clinical risk prediction models in a scalable way. We demonstrate its feasibility by developing risk prediction models for three diseases across four hospitals.

Explicitly alerting users is not always an optimal intervention, especially when they are not motivated to obey. For example, in video-based learning, learners who are distracted from the video would not follow an alert asking them to pay attention. Inspired by the concept of Mindless Computing, we propose a novel intervention approach, Mindless Attractor, that leverages the nature of human speech communication to help learners refocus their attention without relying on their motivation. Specifically, it perturbs the voice in the video to direct their attention without consuming their conscious awareness. Our experiments not only confirmed the validity of the proposed approach but also emphasized its advantages in combination with a machine learning-based sensing module. Namely, it would not frustrate users even though the intervention is activated by false-positive detection of their attentive state. Our intervention approach can be a reliable way to induce behavioral change in human-AI symbiosis.

People tend to make snap judgments on each other in a single look and now an algorithm claims to have the same ability to determine trustworthiness for obtaining a loan in just two minutes. Tokyo-based DeepScore unveiled its facial and voice recognition app last week at the Consumer Electronics Show that is touted as a'next-generation scoring engine' for loan lenders, insurance companies and other financial institutions. While a customer answers 10 question, the AI analyzes their face and voice to calculate a'True Score' that can be help companies with the decision to deny or approve. DeepScore says its AI can determine lies with 70 percent accuracy and a 30 percent false negative rate, and will alert companies that fees need to be increased if dishonesty is detected. However, scientists raise concerns about bias saying the app is likely to discriminate against people with tics or anxiety, resulting in these individuals not receiving necessary funds or coverage, Motherboard reports.

Traffic accidents have been a severe issue in metropolises with the development of traffic flow. This paper explores the theory and application of a recently developed machine learning technique, namely Import Vector Machines (IVMs), in real-time crash risk analysis, which is a hot topic to reduce traffic accidents. Historical crash data and corresponding traffic data from Shanghai Urban Expressway System were employed and matched. Traffic conditions are labelled as dangerous (i.e. probably leading to a crash) and safe (i.e. a normal traffic condition) based on 5-minute measurements of average speed, volume and occupancy. The IVM algorithm is trained to build the classifier and its performance is compared to the popular and successfully applied technique of Support Vector Machines (SVMs). The main findings indicate that IVMs could successfully be employed in real-time identification of dangerous pro-active traffic conditions. Furthermore, similar to the "support points" of the SVM, the IVM model uses only a fraction of the training data to index kernel basis functions, typically a much smaller fraction than the SVM, and its classification rates are similar to those of SVMs. This gives the IVM a computational advantage over the SVM, especially when the size of the training data set is large.

The information describing the conditions of a system or a person is constantly evolving and may become obsolete and contradict other information. A database, therefore, must be consistently updated upon the acquisition of new valid observations that contradict obsolete ones contained in the database. In this paper, we propose a novel approach for dealing with the information obsolescence problem. Our approach aims to detect, in real-time, contradictions between observations and then identify the obsolete ones, given a representation model. Since we work within an uncertain environment characterized by the lack of information, we choose to use a Bayesian network as our representation model and propose a new approximate concept, $\epsilon$-Contradiction. The new concept is parameterised by a confidence level of having a contradiction in a set of observations. We propose a polynomial-time algorithm for detecting obsolete information. We show that the resulting obsolete information is better represented by an AND-OR tree than a simple set of observations. Finally, we demonstrate the effectiveness of our approach on a real elderly fall-prevention database and showcase how this tree can be used to give reliable recommendations to doctors. Our experiments give systematically and substantially very good results.

The digitization of medical records ushered in a new era of big data to clinical science, and with it the possibility that data could be shared, to multiply insights beyond what investigators could abstract from paper records. The need to share individual-level medical data to accelerate innovation in precision medicine continues to grow, and has never been more urgent, as scientists grapple with the COVID-19 pandemic. However, enthusiasm for the use of big data has been tempered by a fully appropriate concern for patient autonomy and privacy. That is, the ability to extract private or confidential information about an individual, in practice, renders it difficult to share data, since significant infrastructure and data governance must be established before data can be shared. Although HIPAA provided de-identification as an approved mechanism for data sharing, linkage attacks were identified as a major vulnerability. A variety of mechanisms have been established to avoid leaking private information, such as field suppression or abstraction, strictly limiting the amount of information that can be shared, or employing mathematical techniques such as differential privacy. Another approach, which we focus on here, is creating synthetic data that mimics the underlying data. For synthetic data to be a useful mechanism in support of medical innovation and a proxy for real-world evidence, one must demonstrate two properties of the synthetic dataset: (1) any analysis on the real data must be matched by analysis of the synthetic data (statistical fidelity) and (2) the synthetic data must preserve privacy, with minimal risk of re-identification (privacy guarantee). In this paper we propose a framework for quantifying the statistical fidelity and privacy preservation properties of synthetic datasets and demonstrate these metrics for synthetic data generated by Syntegra technology.

Machine Learning or Artificial Intelligence algorithms have gained considerable scrutiny in recent times owing to their propensity towards imitating and amplifying existing prejudices in society. This has led to a niche but growing body of work that identifies and attempts to fix these biases. A first step towards making these algorithms more fair is designing metrics that measure unfairness. Most existing work in this field deals with either a binary view of fairness (protected vs. unprotected groups) or politically defined categories (race or gender). Such categorization misses the important nuance of intersectionality - biases can often be amplified in subgroups that combine membership from different categories, especially if such a subgroup is particularly underrepresented in historical platforms of opportunity. In this paper, we discuss why fairness metrics need to be looked at under the lens of intersectionality, identify existing work in intersectional fairness, suggest a simple worst case comparison method to expand the definitions of existing group fairness metrics to incorporate intersectionality, and finally conclude with the social, legal and political framework to handle intersectional fairness in the modern context.