In this paper, we study the problem of fair sparse regression on a biased dataset where bias depends upon a hidden binary attribute. The presence of a hidden attribute adds an extra layer of complexity to the problem by combining sparse regression and clustering with unknown binary labels. The corresponding optimization problem is combinatorial, but we propose a novel relaxation of it as an \emph{invex} optimization problem. To the best of our knowledge, this is the first invex relaxation for a combinatorial problem. We show that the inclusion of the debiasing/fairness constraint in our model has no adverse effect on the performance. Rather, it enables the recovery of the hidden attribute. The support of our recovered regression parameter vector matches exactly with the true parameter vector. Moreover, we simultaneously solve the clustering problem by recovering the exact value of the hidden attribute for each sample. Our method uses carefully constructed primal dual witnesses to provide theoretical guarantees for the combinatorial problem. To that end, we show that the sample complexity of our method is logarithmic in terms of the dimension of the regression parameter vector.

Coronary heart disease (CHD) is the leading cause of adult death in the United States and worldwide, and for which the coronary angiography procedure is the primary gateway for diagnosis and clinical management decisions. The standard-of-care for interpretation of coronary angiograms depends upon ad-hoc visual assessment by the physician operator. However, ad-hoc visual interpretation of angiograms is poorly reproducible, highly variable and bias prone. Here we show for the first time that fully-automated angiogram interpretation to estimate coronary artery stenosis is possible using a sequence of deep neural network algorithms. The algorithmic pipeline we developed--called CathAI--achieves state-of-the art performance across the sequence of tasks required to accomplish automated interpretation of unselected, real-world angiograms. CathAI (Algorithms 1-2) demonstrated positive predictive value, sensitivity and F1 score of >=90% to identify the projection angle overall and >=93% for left or right coronary artery angiogram detection, the primary anatomic structures of interest. To predict obstructive coronary artery stenosis (>=70% stenosis), CathAI (Algorithm 4) exhibited an area under the receiver operating characteristic curve (AUC) of 0.862 (95% CI: 0.843-0.880). When externally validated in a healthcare system in another country, CathAI AUC was 0.869 (95% CI: 0.830-0.907) to predict obstructive coronary artery stenosis. Our results demonstrate that multiple purpose-built neural networks can function in sequence to accomplish the complex series of tasks required for automated analysis of real-world angiograms. Deployment of CathAI may serve to increase standardization and reproducibility in coronary stenosis assessment, while providing a robust foundation to accomplish future tasks for algorithmic angiographic interpretation.

Machine learning (ML) model explainability has received growing attention, especially in the area related to model risk and regulations. In this paper, we reviewed and compared some popular ML model explainability methodologies, especially those related to Natural Language Processing (NLP) models. We then applied one of the NLP explainability methods Layer-wise Relevance Propagation (LRP) to a NLP classification model. We used the LRP method to derive a relevance score for each word in an instance, which is a local explainability. The relevance scores are then aggregated together to achieve global variable importance of the model. Through the case study, we also demonstrated how to apply the local explainability method to false positive and false negative instances to discover the weakness of a NLP model. These analysis can help us to understand NLP models better and reduce the risk due to the black-box nature of NLP models. We also identified some common issues due to the special natures of NLP models and discussed how explainability analysis can act as a control to detect these issues after the model has been trained. Machine Learning (ML) model explainability has become a vital concern in the application of ML to different fields, such as finance, medical, marketing and recommendation systems etc. When an interpretable model is available, it's preferred than a non-interpretable one when their performances are comparable due to its transparency (Ribeiro et al., 2016). However, ML models are usually not transparent and model explainability analysis can help people to understand the ML models better and trust them more.

Automated machine learning techniques benefited from tremendous research progress in recently. These developments and the continuous-growing demand for machine learning experts led to the development of numerous AutoML tools. However, these tools assume that the entire training dataset is available upfront and that the underlying distribution does not change over time. These assumptions do not hold in a data stream mining setting where an unbounded stream of data cannot be stored and is likely to manifest concept drift. Industry applications of machine learning on streaming data become more popular due to the increasing adoption of real-time streaming patterns in IoT, microservices architectures, web analytics, and other fields. The research summarized in this paper surveys the state-of-the-art open-source AutoML tools, applies them to data collected from streams, and measures how their performance changes over time. For comparative purposes, batch, batch incremental and instance incremental estimators are applied and compared. Moreover, a meta-learning technique for online algorithm selection based on meta-feature extraction is proposed and compared while model replacement and continual AutoML techniques are discussed. The results show that off-the-shelf AutoML tools can provide satisfactory results but in the presence of concept drift, detection or adaptation techniques have to be applied to maintain the predictive accuracy over time.

We consider conducting inference on the output of the Classification and Regression Tree (CART) [Breiman et al., 1984] algorithm. A naive approach to inference that does not account for the fact that the tree was estimated from the data will not achieve standard guarantees, such as Type 1 error rate control and nominal coverage. Thus, we propose a selective inference framework for conducting inference on a fitted CART tree. In a nutshell, we condition on the fact that the tree was estimated from the data. We propose a test for the difference in the mean response between a pair of terminal nodes that controls the selective Type 1 error rate, and a confidence interval for the mean response within a single terminal node that attains the nominal selective coverage. Efficient algorithms for computing the necessary conditioning sets are provided. We apply these methods in simulation and to a dataset involving the association between portion control interventions and caloric intake.

Identification methods for dynamic networks typically require prior knowledge of the network and disturbance topology, and often rely on solving poorly scalable non-convex optimization problems. While methods for estimating network topology are available in the literature, less attention has been paid to estimating the disturbance topology, i.e., the (spatial) noise correlation structure and the noise rank. In this work we present an identification method for dynamic networks, in which an estimation of the disturbance topology precedes the identification of the full dynamic network with known network topology. To this end we extend the multi-step Sequential Linear Regression and Weighted Null Space Fitting methods to deal with reduced rank noise, and use these methods to estimate the disturbance topology and the network dynamics. As a result, we provide a multi-step least squares algorithm with parallel computation capabilities and that rely only on explicit analytical solutions, thereby avoiding the usual non-convex optimizations involved. Consequently we consistently estimate dynamic networks of Box Jenkins model structure, while keeping the computational burden low. We provide a consistency proof that includes path-based data informativity conditions for allocation of excitation signals in the experimental design. Numerical simulations performed on a dynamic network with reduced rank noise clearly illustrate the potential of this method.

Classification algorithms face difficulties when one or more classes have limited training data. We are particularly interested in classification trees, due to their interpretability and flexibility. When data are limited in one or more of the classes, the estimated decision boundaries are often irregularly shaped due to the limited sample size, leading to poor generalization error. We propose a novel approach that penalizes the Surface-to-Volume Ratio (SVR) of the decision set, obtaining a new class of SVR-Tree algorithms. We develop a simple and computationally efficient implementation while proving estimation consistency for SVR-Tree and rate of convergence for an idealized empirical risk minimizer of SVR-Tree. SVR-Tree is compared with multiple algorithms that are designed to deal with imbalance through real data applications.

Scoring systems are highly interpretable and widely used to evaluate time-to-event outcomes in healthcare research. However, existing time-to-event scores are predominantly created ad-hoc using a few manually selected variables based on clinician's knowledge, suggesting an unmet need for a robust and efficient generic score-generating method. AutoScore was previously developed as an interpretable machine learning score generator, integrated both machine learning and point-based scores in the strong discriminability and accessibility. We have further extended it to time-to-event data and developed AutoScore-Survival, for automatically generating time-to-event scores with right-censored survival data. Random survival forest provides an efficient solution for selecting variables, and Cox regression was used for score weighting. We illustrated our method in a real-life study of 90-day mortality of patients in intensive care units and compared its performance with survival models (i.e., Cox) and the random survival forest. The AutoScore-Survival-derived scoring model was more parsimonious than survival models built using traditional variable selection methods (e.g., penalized likelihood approach and stepwise variable selection), and its performance was comparable to survival models using the same set of variables. Although AutoScore-Survival achieved a comparable integrated area under the curve of 0.782 (95% CI: 0.767-0.794), the integer-valued time-to-event scores generated are favorable in clinical applications because they are easier to compute and interpret. Our proposed AutoScore-Survival provides an automated, robust and easy-to-use machine learning-based clinical score generator to studies of time-to-event outcomes. It provides a systematic guideline to facilitate the future development of time-to-event scores for clinical applications.

This paper presents our research on leveraging social media Big Data and AI to support hurricane disaster emergency response. The current practice of hurricane emergency response for rescue highly relies on emergency call centres. The more recent Hurricane Harvey event reveals the limitations of the current systems. We use Hurricane Harvey and the associated Houston flooding as the motivating scenario to conduct research and develop a prototype as a proof-of-concept of using an intelligent agent as a complementary role to support emergency centres in hurricane emergency response. This intelligent agent is used to collect real-time streaming tweets during a natural disaster event, to identify tweets requesting rescue, to extract key information such as address and associated geocode, and to visualize the extracted information in an interactive map in decision supports. Our experiment shows promising outcomes and the potential application of the research in support of hurricane emergency response.

Recently pre-trained multimodal models, such as CLIP, have received a surge of attention for their exceptional capabilities towards connecting images and natural language. The textual representations in English can be desirably transferred to multilingualism and support promising downstream multimodal tasks for different languages. Nevertheless, previous fairness discourse in vision-and-language learning mainly focuses on monolingual representational biases, and rarely scrutinizes the principles of multilingual fairness in this multimodal setting, where one language is equated to a group of individuals and images provide the universal grounding for bridging different languages. In this paper, we provide a nuanced understanding of individual fairness and group fairness by viewing language as the recipient of fairness notions. We define new fairness notions within multilingual context and analytically articulate that, pre-trained vision-and-language representations are individually fair across languages but not guaranteed to group fairness. Furthermore, we conduct extensive experiments to explore the prevalent group disparity across languages and protected groups including race, gender and age.