Cardiac imaging known as echocardiography is a non-invasive tool utilized to produce data including images and videos, which cardiologists use to diagnose cardiac abnormalities in general and myocardial infarction (MI) in particular. Echocardiography machines can deliver abundant amounts of data that need to be quickly analyzed by cardiologists to help them make a diagnosis and treat cardiac conditions. However, the acquired data quality varies depending on the acquisition conditions and the patient's responsiveness to the setup instructions. These constraints are challenging to doctors especially when patients are facing MI and their lives are at stake. In this paper, we propose an innovative real-time end-to-end fully automated model based on convolutional neural networks (CNN) to detect MI depending on regional wall motion abnormalities (RWMA) of the left ventricle (LV) from videos produced by echocardiography. Our model is implemented as a pipeline consisting of a 2D CNN that performs data preprocessing by segmenting the LV chamber from the apical four-chamber (A4C) view, followed by a 3D CNN that performs a binary classification to detect if the segmented echocardiography shows signs of MI. We trained both CNNs on a dataset composed of 165 echocardiography videos each acquired from a distinct patient. The 2D CNN achieved an accuracy of 97.18% on data segmentation while the 3D CNN achieved 90.9% of accuracy, 100% of precision and 95% of recall on MI detection. Our results demonstrate that creating a fully automated system for MI detection is feasible and propitious.

The presented first-of-its-kind study effectively identifies and visualizes the second-by-second pattern differences in the physiological arousal of preschool-age children who do stutter (CWS) and who do not stutter (CWNS) while speaking perceptually fluently in two challenging conditions i.e speaking in stressful situations and narration. The first condition may affect children's speech due to high arousal; the latter introduces linguistic, cognitive, and communicative demands on speakers. We collected physiological parameters data from 70 children in the two target conditions. First, we adopt a novel modality-wise multiple-instance-learning (MI-MIL) approach to classify CWS vs. CWNS in different conditions effectively. The evaluation of this classifier addresses four critical research questions that align with state-of-the-art speech science studies' interests. Later, we leverage SHAP classifier interpretations to visualize the salient, fine-grain, and temporal physiological parameters unique to CWS at the population/group-level and personalized-level. While group-level identification of distinct patterns would enhance our understanding of stuttering etiology and development, the personalized-level identification would enable remote, continuous, and real-time assessment of stuttering children's physiological arousal, which may lead to personalized, just-in-time interventions, resulting in an improvement in speech fluency. The presented MI-MIL approach is novel, generalizable to different domains, and real-time executable. Finally, comprehensive evaluations are done on multiple datasets, presented framework, and several baselines that identified notable insights on CWSs' physiological arousal during speech production.

Area under the ROC curve, a.k.a. AUC, is a measure of choice for assessing the performance of a classifier for imbalanced data. AUC maximization refers to a learning paradigm that learns a predictive model by directly maximizing its AUC score. It has been studied for more than two decades dating back to late 90s and a huge amount of work has been devoted to AUC maximization since then. Recently, stochastic AUC maximization for big data and deep AUC maximization for deep learning have received increasing attention and yielded dramatic impact for solving real-world problems. However, to the best our knowledge there is no comprehensive survey of related works for AUC maximization. This paper aims to address the gap by reviewing the literature in the past two decades. We not only give a holistic view of the literature but also present detailed explanations and comparisons of different papers from formulations to algorithms and theoretical guarantees. We also identify and discuss remaining and emerging issues for deep AUC maximization, and provide suggestions on topics for future work.

Machine learning based malware detection techniques rely on grayscale images of malware and tends to classify malware based on the distribution of textures in graycale images. Albeit the advancement and promising results shown by machine learning techniques, attackers can exploit the vulnerabilities by generating adversarial samples. Adversarial samples are generated by intelligently crafting and adding perturbations to the input samples. There exists majority of the software based adversarial attacks and defenses. To defend against the adversaries, the existing malware detection based on machine learning and grayscale images needs a preprocessing for the adversarial data. This can cause an additional overhead and can prolong the real-time malware detection. So, as an alternative to this, we explore RRAM (Resistive Random Access Memory) based defense against adversaries. Therefore, the aim of this thesis is to address the above mentioned critical system security issues. The above mentioned challenges are addressed by demonstrating proposed techniques to design a secure and robust cognitive system. First, a novel technique to detect stealthy malware is proposed. The technique uses malware binary images and then extract different features from the same and then employ different ML-classifiers on the dataset thus obtained. Results demonstrate that this technique is successful in differentiating classes of malware based on the features extracted. Secondly, I demonstrate the effects of adversarial attacks on a reconfigurable RRAM-neuromorphic architecture with different learning algorithms and device characteristics. I also propose an integrated solution for mitigating the effects of the adversarial attack using the reconfigurable RRAM architecture.

Network classification aims to group networks (or graphs) into distinct categories based on their structure. We study the connection between classification of a network and of its constituent nodes, and whether nodes from networks in different groups are distinguishable based on structural node characteristics such as centrality and clustering coefficient. We demonstrate, using various network datasets and random network models, that a classifier can be trained to accurately predict the network category of a given node (without seeing the whole network), implying that complex networks display distinct structural patterns even at the node level. Finally, we discuss two applications of node-level network classification: (i) whole-network classification from small samples of nodes, and (ii) network bootstrapping.

Applications of machine learning in healthcare often require working with time-to-event prediction tasks including prognostication of an adverse event, re-hospitalization or death. Such outcomes are typically subject to censoring due to loss of follow up. Standard machine learning methods cannot be applied in a straightforward manner to datasets with censored outcomes. In this paper, we present auton-survival, an open-source repository of tools to streamline working with censored time-to-event or survival data. auton-survival includes tools for survival regression, adjustment in the presence of domain shift, counterfactual estimation, phenotyping for risk stratification, evaluation, as well as estimation of treatment effects. Through real world case studies employing a large subset of the SEER oncology incidence data, we demonstrate the ability of auton-survival to rapidly support data scientists in answering complex health and epidemiological questions.

With the rapid growth of software scale and complexity, a large number of bug reports are submitted to the bug tracking system. In order to speed up defect repair, these reports need to be accurately classified so that they can be sent to the appropriate developers. However, the existing classification methods only use the text information of the bug report, which leads to their low performance. To solve the above problems, this paper proposes a new automatic classification method for bug reports. The innovation is that when categorizing bug reports, in addition to using the text information of the report, the intention of the report (i.e. suggestion or explanation) is also considered, thereby improving the performance of the classification. First, we collect bug reports from four ecosystems (Apache, Eclipse, Gentoo, Mozilla) and manually annotate them to construct an experimental data set. Then, we use Natural Language Processing technology to preprocess the data. On this basis, BERT and TF-IDF are used to extract the features of the intention and the multiple text information. Finally, the features are used to train the classifiers. The experimental result on five classifiers (including K-Nearest Neighbor, Naive Bayes, Logistic Regression, Support Vector Machine, and Random Forest) show that our proposed method achieves better performance and its F-Measure achieves from 87.3% to 95.5%.

Causal relationships are commonly examined in manufacturing processes to support faults investigations, perform interventions, and make strategic decisions. Industry 4.0 has made available an increasing amount of data that enable data-driven Causal Discovery (CD). Considering the growing number of recently proposed CD methods, it is necessary to introduce strict benchmarking procedures on publicly available datasets since they represent the foundation for a fair comparison and validation of different methods. This work introduces two novel public datasets for CD in continuous manufacturing processes. The first dataset employs the well-known Tennessee Eastman simulator for fault detection and process control. The second dataset is extracted from an ultra-processed food manufacturing plant, and it includes a description of the plant, as well as multiple ground truths. These datasets are used to propose a benchmarking procedure based on different metrics and evaluated on a wide selection of CD algorithms. This work allows testing CD methods in realistic conditions enabling the selection of the most suitable method for specific target applications. The datasets are available at the following link: https://github.com/giovanniMen

The automatic segmentation of blood vessels in fundus images can help analyze the condition of retinal vasculature, which is crucial for identifying various systemic diseases like hypertension, diabetes, etc. Despite the success of Deep Learning-based models in this segmentation task, most of them are heavily parametrized and thus have limited use in practical applications. This paper proposes IterMiUnet, a new lightweight convolution-based segmentation model that requires significantly fewer parameters and yet delivers performance similar to existing models. The model makes use of the excellent segmentation capabilities of Iternet architecture but overcomes its heavily parametrized nature by incorporating the encoder-decoder structure of MiUnet model within it. Thus, the new model reduces parameters without any compromise with the network's depth, which is necessary to learn abstract hierarchical concepts in deep models. This lightweight segmentation model speeds up training and inference time and is potentially helpful in the medical domain where data is scarce and, therefore, heavily parametrized models tend to overfit. The proposed model was evaluated on three publicly available datasets: DRIVE, STARE, and CHASE-DB1. Further cross-training and inter-rater variability evaluations have also been performed. The proposed model has a lot of potential to be utilized as a tool for the early diagnosis of many diseases.

To create a large amount of training labels for machine learning models effectively and efficiently, researchers have turned to Weak Supervision (WS), which uses programmatic labeling sources rather than manual annotation. Existing works of WS for binary classification typically assume the presence of labeling sources that are able to assign both positive and negative labels to data in roughly balanced proportions. However, for many tasks of interest where there is a minority positive class, negative examples could be too diverse for developers to generate indicative labeling sources. Thus, in this work, we study the application of WS on binary classification tasks with positive labeling sources only. We propose WEAPO, a simple yet competitive WS method for producing training labels without negative labeling sources. On 10 benchmark datasets, we show WEAPO achieves the highest averaged performance in terms of both the quality of synthesized labels and the performance of the final classifier supervised with these labels. We incorporated the implementation of \method into WRENCH, an existing benchmarking platform.