IceCube, a cubic-kilometer array of optical sensors built to detect atmospheric and astrophysical neutrinos between 1 GeV and 1 PeV, is deployed 1.45 km to 2.45 km below the surface of the ice sheet at the South Pole. The classification and reconstruction of events from the in-ice detectors play a central role in the analysis of data from IceCube. Reconstructing and classifying events is a challenge due to the irregular detector geometry, inhomogeneous scattering and absorption of light in the ice and, below 100 GeV, the relatively low number of signal photons produced per event. To address this challenge, it is possible to represent IceCube events as point cloud graphs and use a Graph Neural Network (GNN) as the classification and reconstruction method. The GNN is capable of distinguishing neutrino events from cosmic-ray backgrounds, classifying different neutrino event types, and reconstructing the deposited energy, direction and interaction vertex. Based on simulation, we provide a comparison in the 1-100 GeV energy range to the current state-of-the-art maximum likelihood techniques used in current IceCube analyses, including the effects of known systematic uncertainties. For neutrino event classification, the GNN increases the signal efficiency by 18% at a fixed false positive rate (FPR), compared to current IceCube methods. Alternatively, the GNN offers a reduction of the FPR by over a factor 8 (to below half a percent) at a fixed signal efficiency. For the reconstruction of energy, direction, and interaction vertex, the resolution improves by an average of 13%-20% compared to current maximum likelihood techniques in the energy range of 1-30 GeV. The GNN, when run on a GPU, is capable of processing IceCube events at a rate nearly double of the median IceCube trigger rate of 2.7 kHz, which opens the possibility of using low energy neutrinos in online searches for transient events.

Efforts by foreign actors to influence public opinion have gained considerable attention because of their potential to impact democratic elections. Thus, the ability to identify and counter sources of disinformation is increasingly becoming a top priority for government entities in order to protect the integrity of democratic processes. This study presents a method of identifying Russian disinformation bots on Twitter using centering resonance analysis and Clauset-Newman-Moore community detection. The data reflect a significant degree of discursive dissimilarity between known Russian disinformation bots and a control set of Twitter users during the timeframe of the 2016 U.S. Presidential Election. The data also demonstrate statistically significant classification capabilities (MCC = 0.9070) based on community clustering. The prediction algorithm is very effective at identifying true positives (bots), but is not able to resolve true negatives (non-bots) because of the lack of discursive similarity between control users. This leads to a highly sensitive means of identifying propagators of disinformation with a high degree of discursive similarity on Twitter, with implications for limiting the spread of disinformation that could impact democratic processes.

In this paper we examine the use of semantically-aligned speech representations for end-to-end spoken language understanding (SLU). We employ the recently-introduced SAMU-XLSR model, which is designed to generate a single embedding that captures the semantics at the utterance level, semantically aligned across different languages. This model combines the acoustic frame-level speech representation learning model (XLS-R) with the Language Agnostic BERT Sentence Embedding (LaBSE) model. We show that the use of the SAMU-XLSR model instead of the initial XLS-R model improves significantly the performance in the framework of end-to-end SLU. Finally, we present the benefits of using this model towards language portability in SLU.

Ovarian cancer is one of the most serious cancers that threaten women around the world. Epithelial ovarian cancer (EOC), as the most commonly seen subtype of ovarian cancer, has rather high mortality rate and poor prognosis among various gynecological cancers. Survival analysis outcome is able to provide treatment advices to doctors. In recent years, with the development of medical imaging technology, survival prediction approaches based on pathological images have been proposed. In this study, we designed a deep framework named EOCSA which analyzes the prognosis of EOC patients based on pathological whole slide images (WSIs). Specifically, we first randomly extracted patches from WSIs and grouped them into multiple clusters. Next, we developed a survival prediction model, named DeepConvAttentionSurv (DCAS), which was able to extract patch-level features, removed less discriminative clusters and predicted the EOC survival precisely. Particularly, channel attention, spatial attention, and neuron attention mechanisms were used to improve the performance of feature extraction. Then patient-level features were generated from our weight calculation method and the survival time was finally estimated using LASSO-Cox model. The proposed EOCSA is efficient and effective in predicting prognosis of EOC and the DCAS ensures more informative and discriminative features can be extracted. As far as we know, our work is the first to analyze the survival of EOC based on WSIs and deep neural network technologies. The experimental results demonstrate that our proposed framework has achieved state-of-the-art performance of 0.980 C-index. The implementation of the approach can be found at https://github.com/RanSuLab/EOCprognosis.

Drug recommendation assists doctors in prescribing personalized medications to patients based on their health conditions. Existing drug recommendation solutions adopt the supervised multi-label classification setup and only work with existing drugs with sufficient prescription data from many patients. However, newly approved drugs do not have much historical prescription data and cannot leverage existing drug recommendation methods. To address this, we formulate the new drug recommendation as a few-shot learning problem. Yet, directly applying existing few-shot learning algorithms faces two challenges: (1) complex relations among diseases and drugs and (2) numerous false-negative patients who were eligible but did not yet use the new drugs. To tackle these challenges, we propose EDGE, which can quickly adapt to the recommendation for a new drug with limited prescription data from a few support patients. EDGE maintains a drug-dependent multi-phenotype few-shot learner to bridge the gap between existing and new drugs. Specifically, EDGE leverages the drug ontology to link new drugs to existing drugs with similar treatment effects and learns ontology-based drug representations. Such drug representations are used to customize the metric space of the phenotype-driven patient representations, which are composed of a set of phenotypes capturing complex patient health status. Lastly, EDGE eliminates the false-negative supervision signal using an external drug-disease knowledge base. We evaluate EDGE on two real-world datasets: the public EHR data (MIMIC-IV) and private industrial claims data. Results show that EDGE achieves 7.3% improvement on the ROC-AUC score over the best baseline.

Originally published on Towards AI the World's Leading AI and Technology News and Media Company. If you are building an AI-related product or service, we invite you to consider becoming an AI sponsor. At Towards AI, we help scale AI and technology startups. Let us help you unleash your technology to the masses. The F-1 score is a popular binary classification metric representing a balance between precision and recall. It is the Harmonic mean of precision and recall.

Treatments targeting complex diseases, such as cancer, frequently lead to acquired drug resistance, due to patient-specific variability. For instance, drugs targeting only one key component of growth or proliferation pathways, may lead to selective pressure and activation of a compensatory mechanism [1], thus making this treatment suboptimal. However, during multi-target inhibition with reduced stringency, drug resistance is less likely. Therefore, the implementation of combination therapy might improve patient treatment as different drugs may target distinct pathways or genes, likely leading to decreased cancer cell survival. In addition to the increased efficacy, combination therapy often reduces toxicity and decreases the likelihood of treatment resistance compared to monotherapy (i.e., single drug) treatments [2]. Due to advancements in high-throughput screening (HTS), the number of drug screening datasets has been growing in recent years. Some examples include the NCI-ALMANAC dataset [3] which contains 103 FDA-approved drugs tested in 60 different cell lines (NCI-60) [4] or the large oncology dataset produced by Merck&Co [5] which is composed of 38 drugs tested in 39 different cell lines from 6 different tissue types.

Three key properties that are desired of trustworthy machine learning models deployed in high-stakes environments are fairness, explainability, and an ability to account for various kinds of "drift". While drifts in model accuracy, for example due to covariate shift, have been widely investigated, drifts in fairness metrics over time remain largely unexplored. In this paper, we propose FEAMOE, a novel "mixture-of-experts" inspired framework aimed at learning fairer, more explainable/interpretable models that can also rapidly adjust to drifts in both the accuracy and the fairness of a classifier. We illustrate our framework for three popular fairness measures and demonstrate how drift can be handled with respect to these fairness constraints. Experiments on multiple datasets show that our framework as applied to a mixture of linear experts is able to perform comparably to neural networks in terms of accuracy while producing fairer models. We then use the large-scale HMDA dataset and show that while various models trained on HMDA demonstrate drift with respect to both accuracy and fairness, FEAMOE can ably handle these drifts with respect to all the considered fairness measures and maintain model accuracy as well. We also prove that the proposed framework allows for producing fast Shapley value explanations, which makes computationally efficient feature attribution based explanations of model decisions readily available via FEAMOE.

The ubiquity of Machine Learning (ML) models, and more specifically deep neural network (NN) models, in all sorts of applications has become undeniable in recent years. From classifying images [1, 2, 3], detecting objects [4, 1] and performing semantic segmentation [5, 4] to translating from one human language to another [6] and doing sentiment analysis [7], the advances in different subfields of ML can be attributed mostly to the explosion of computing power and their ability to speed up the training process of artificial NNs. Most famously, AlexNet [8] allowed for an impressive jump in performance in the challenging ILSVRC2012 image classification dataset [1], also known as ImageNet, permanently cementing deep convolutional NN (CNN) architectures in the field of computer vision. Since then, architectures have gotten more refined [9, 10], training procedures have gotten increasingly more complex [11], and their performance and robustness have greatly improved as a consequence. Namely, the success of these deep CNN models is related to their ability to treat high-dimensional and complex data such as images or natural language. The impressive performance of NNs for machine learning tasks can be explained by the ability of their flexible architecture to capture meaningful information on various kinds of complex data and the fact that they are potentially composed of millions of parameters. However, this poses a major challenge: deciphering the reasoning behind the model's predictions. For instance, typical NN architectures for classification or regression problems incrementally transform the representation of the input data in the so-called latent space (or feature space) and then use this transformed representation to make their predictions, as summarized in Figure 1. Each step of this incremental data processing pipeline (or feature extraction chain) is carried out by a so-called layer, which is mathematically a non-linear function (blue rectangle in Figure 1).

Mental health research through data-driven methods has been hindered by a lack of standard typology and scarcity of adequate data. In this study, we leverage the clinical articulation of depression to build a typology for social media texts for detecting the severity of depression. It emulates the standard clinical assessment procedure Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and Patient Health Questionnaire (PHQ-9) to encompass subtle indications of depressive disorders from tweets. Along with the typology, we present a new dataset of 40191 tweets labeled by expert annotators. Each tweet is labeled as 'non-depressed' or 'depressed'. Moreover, three severity levels are considered for 'depressed' tweets: (1) mild, (2) moderate, and (3) severe. An associated confidence score is provided with each label to validate the quality of annotation. We examine the quality of the dataset via representing summary statistics while setting strong baseline results using attention-based models like BERT and DistilBERT. Finally, we extensively address the limitations of the study to provide directions for further research.