Non-invasive prostate cancer detection from MRI has the potential to revolutionize patient care by providing early detection of clinically-significant disease (ISUP grade group >= 2), but has thus far shown limited positive predictive value. To address this, we present an MRI-based deep learning method for predicting clinically significant prostate cancer applicable to a patient population with subsequent ground truth biopsy results ranging from benign pathology to ISUP grade group~5. Specifically, we demonstrate that mixed supervision via diverse histopathological ground truth improves classification performance despite the cost of reduced concordance with image-based segmentation. That is, where prior approaches have utilized pathology results as ground truth derived from targeted biopsies and whole-mount prostatectomy to strongly supervise the localization of clinically significant cancer, our approach also utilizes weak supervision signals extracted from nontargeted systematic biopsies with regional localization to improve overall performance. Our key innovation is performing regression by distribution rather than simply by value, enabling use of additional pathology findings traditionally ignored by deep learning strategies. We evaluated our model on a dataset of 973 (testing n=160) multi-parametric prostate MRI exams collected at UCSF from 2015-2018 followed by MRI/ultrasound fusion (targeted) biopsy and systematic (nontargeted) biopsy of the prostate gland, demonstrating that deep networks trained with mixed supervision of histopathology can significantly exceed the performance of the Prostate Imaging-Reporting and Data System (PI-RADS) clinical standard for prostate MRI interpretation.

Despite a surge of recent advances in promoting machine Learning (ML) fairness, the existing mainstream approaches mostly require retraining or finetuning the entire weights of the neural network to meet the fairness criteria. However, this is often infeasible in practice for those large-scale trained models due to large computational and storage costs, low data efficiency, and model privacy issues. In this paper, we propose a new generic fairness learning paradigm, called FairReprogram, which incorporates the model reprogramming technique. Specifically, FairReprogram considers the case where models can not be changed and appends to the input a set of perturbations, called the fairness trigger, which is tuned towards the fairness criteria under a min-max formulation. We further introduce an information-theoretic framework that explains why and under what conditions fairness goals can be achieved using the fairness trigger. We show both theoretically and empirically that the fairness trigger can effectively obscure demographic biases in the output prediction of fixed ML models by providing false demographic information that hinders the model from utilizing the correct demographic information to make the prediction. Extensive experiments on both NLP and CV datasets demonstrate that our method can achieve better fairness improvements than retraining-based methods with far less data dependency under two widely-used fairness criteria. Codes are available at https://github.com/UCSB-NLP-Chang/Fairness-Reprogramming.git.

Intensive Care in-hospital mortality prediction has various clinical applications. Neural prediction models, especially when capitalising on clinical notes, have been put forward as improvement on currently existing models. However, to be acceptable these models should be performant and transparent. This work studies different attention mechanisms for clinical neural prediction models in terms of their discrimination and calibration. Specifically, we investigate sparse attention as an alternative to dense attention weights in the task of in-hospital mortality prediction from clinical notes. We evaluate the attention mechanisms based on: i) local self-attention over words in a sentence, and ii) global self-attention with a transformer architecture across sentences. We demonstrate that the sparse mechanism approach outperforms the dense one for the local self-attention in terms of predictive performance with a publicly available dataset, and puts higher attention to prespecified relevant directive words. The performance at the sentence level, however, deteriorates as sentences including the influential directive words tend to be dropped all together.

We propose a framework in which multiple entities collaborate to build a machine learning model while preserving privacy of their data. The approach utilizes feature embeddings from shared/per-entity feature extractors transforming data into a feature space for cooperation between entities. We propose two specific methods and compare them with a baseline method. In Shared Feature Extractor (SFE) Learning, the entities use a shared feature extractor to compute feature embeddings of samples. In Locally Trained Feature Extractor (LTFE) Learning, each entity uses a separate feature extractor and models are trained using concatenated features from all entities. As a baseline, in Cooperatively Trained Feature Extractor (CTFE) Learning, the entities train models by sharing raw data. Secure multi-party algorithms are utilized to train models without revealing data or features in plain text. We investigate the trade-offs among SFE, LTFE, and CTFE in regard to performance, privacy leakage (using an off-the-shelf membership inference attack), and computational cost. LTFE provides the most privacy, followed by SFE, and then CTFE. Computational cost is lowest for SFE and the relative speed of CTFE and LTFE depends on network architecture. CTFE and LTFE provide the best accuracy. We use MNIST, a synthetic dataset, and a credit card fraud detection dataset for evaluations.

In this second part of the article, I will explain how to train a logistic model and how to evaluate it. Here you will find the corresponding Colab Notebook with all the code shown here and used for the images. The dataset used in this tutorial is obtained from Warnat-Herresthal et al. They collected and re-analyzed many datasets from leukemia. The dataset and microarray techniques are presented in detail in the previous tutorial.

Supervised machine learning algorithms try to model the relationship between features (independent variables) and a label (target variable) given a set of observations. The two main types of supervised learning tasks are classification and regression. Classification is a supervised learning technique in which the target variable is discrete (or categorical). Consider a bank collecting a dataset that contains several features about their customers such as the number of products, transactions within the last month, expected monthly income, and so on. The bank is trying to predict whether a customer will churn based on this dataset.

This document describes strategies for using Artificial Intelligence (AI) to predict some journal article scores in future research assessment exercises. Five strategies have been assessed. These are summarised here for completeness, but we recommend that AI predictions are not used to help make scoring decisions yet but are further explored through pilot testing in the next REF or REF replacement. The pilot testing should assess whether using AI predictions and prediction probabilities alongside, or instead of, bibliometric data would be helpful for any UoAs. For example, depending on UoA, AI predictions may be used to help mop up difficult scoring decisions near the end of the assessment period, to gain interdisciplinary input, as a tiebreaker in the way that bibliometrics are currently sometimes used, or to cross check the final scores.

The increasing number of sophisticated malware poses a major cybersecurity threat. Portable executable (PE) files are a common vector for such malware. In this work we review and evaluate machine learning-based PE malware detection techniques. Using a large benchmark dataset, we evaluate features of PE files using the most common machine learning techniques to detect malware.

Although machine learning based algorithms have been extensively used for detecting phishing websites, there has been relatively little work on how adversaries may attack such "phishing detectors" (PDs for short). In this paper, we propose a set of Gray-Box attacks on PDs that an adversary may use which vary depending on the knowledge that he has about the PD. We show that these attacks severely degrade the effectiveness of several existing PDs. We then propose the concept of operation chains that iteratively map an original set of features to a new set of features and develop the "Protective Operation Chain" (POC for short) algorithm. POC leverages the combination of random feature selection and feature mappings in order to increase the attacker's uncertainty about the target PD. Using 3 existing publicly available datasets plus a fourth that we have created and will release upon the publication of this paper, we show that POC is more robust to these attacks than past competing work, while preserving predictive performance when no adversarial attacks are present. Moreover, POC is robust to attacks on 13 different classifiers, not just one. These results are shown to be statistically significant at the p < 0.001 level.

Electroencephalography (EEG) analysis extracts critical information from brain signals, which has provided fundamental support for various applications, including brain-disease diagnosis and brain-computer interface. However, the real-time processing of large-scale EEG signals at high energy efficiency has placed great challenges for electronic processors on edge computing devices. Here, we propose the EEG opto-processor based on diffractive photonic computing units (DPUs) to effectively process the extracranial and intracranial EEG signals and perform epileptic seizure detection. The signals of EEG channels within a second-time window are optically encoded as inputs to the constructed diffractive neural networks for classification, which monitors the brain state to determine whether it's the symptom of an epileptic seizure or not. We developed both the free-space and integrated DPUs as edge computing systems and demonstrated their applications for real-time epileptic seizure detection with the benchmark datasets, i.e., the CHB-MIT extracranial EEG dataset and Epilepsy-iEEG-Multicenter intracranial EEG dataset, at high computing performance. Along with the channel selection mechanism, both the numerical evaluations and experimental results validated the sufficient high classification accuracies of the proposed opto-processors for supervising the clinical diagnosis. Our work opens up a new research direction of utilizing photonic computing techniques for processing large-scale EEG signals in promoting its broader applications.