Despite the great promise that machine learning has offered in many fields of medicine, it has also raised concerns about potential biases and poor generalization across genders, age distributions, races and ethnicities, hospitals, and data acquisition equipment and protocols. In the current study, and in the context of three brain diseases, we provide evidence which suggests that when properly trained, machine learning models can generalize well across diverse conditions and do not necessarily suffer from bias. Specifically, by using multi-study magnetic resonance imaging consortia for diagnosing Alzheimer's disease, schizophrenia, and autism spectrum disorder, we find that well-trained models have a high area-under-the-curve (AUC) on subjects across different subgroups pertaining to attributes such as gender, age, racial groups, and different clinical studies and are unbiased under multiple fairness metrics such as demographic parity difference, equalized odds difference, equal opportunity difference etc. We find that models that incorporate multi-source data from demographic, clinical, genetic factors and cognitive scores are also unbiased. These models have better predictive AUC across subgroups than those trained only with imaging features but there are also situations when these additional features do not help.

While it is tempting to believe that data distillation preserves privacy, distilled data's empirical robustness against known attacks does not imply a provable privacy guarantee. Here, we develop a provably privacy-preserving data distillation algorithm, called differentially private kernel inducing points (DP-KIP). DP-KIP is an instantiation of DP-SGD on kernel ridge regression (KRR). Following a recent work, we use neural tangent kernels and minimize the KRR loss to estimate the distilled datapoints (i.e., kernel inducing points). We provide a computationally efficient JAX implementation of DP-KIP, which we test on several popular image and tabular datasets to show its efficacy in data distillation with differential privacy guarantees.

As a prevalent problem in online advertising, CTR prediction has attracted plentiful attention from both academia and industry. Recent studies have been reported to establish CTR prediction models in the graph neural networks (GNNs) framework. However, most of GNNs-based models handle feature interactions in a complete graph, while ignoring causal relationships among features, which results in a huge drop in the performance on out-of-distribution data. This paper is dedicated to developing a causality-based CTR prediction model in the GNNs framework (Causal-GNN) integrating representations of feature graph, user graph and ad graph in the context of online advertising. In our model, a structured representation learning method (GraphFwFM) is designed to capture high-order representations on feature graph based on causal discovery among field features in gated graph neural networks (GGNNs), and GraphSAGE is employed to obtain graph representations of users and ads. Experiments conducted on three public datasets demonstrate the superiority of Causal-GNN in AUC and Logloss and the effectiveness of GraphFwFM in capturing high-order representations on causal feature graph.

In safety-critical decision-making scenarios being able to identify worst-case outcomes, or dead-ends is crucial in order to develop safe and reliable policies in practice. These situations are typically rife with uncertainty due to unknown or stochastic characteristics of the environment as well as limited offline training data. As a result, the value of a decision at any time point should be based on the distribution of its anticipated effects. We propose a framework to identify worst-case decision points, by explicitly estimating distributions of the expected return of a decision. These estimates enable earlier indication of dead-ends in a manner that is tunable based on the risk tolerance of the designed task. We demonstrate the utility of Distributional Dead-end Discovery (DistDeD) in a toy domain as well as when assessing the risk of severely ill patients in the intensive care unit reaching a point where death is unavoidable. We find that DistDeD significantly improves over prior discovery approaches, providing indications of the risk 10 hours earlier on average as well as increasing detection by 20%.

Adversarial defenses are naturally evaluated on their ability to tolerate adversarial attacks. To test defenses, diverse adversarial attacks are crafted, that are usually described in terms of their evading capability and the L0, L1, L2, and Linf norms. We question if the evading capability and L-norms are the most effective information to claim that defenses have been tested against a representative attack set. To this extent, we select image quality metrics from the state of the art and search correlations between image perturbation and detectability. We observe that computing L-norms alone is rarely the preferable solution. We observe a strong correlation between the identified metrics computed on an adversarial image and the output of a detector on such an image, to the extent that they can predict the response of a detector with approximately 0.94 accuracy. Further, we observe that metrics can classify attacks based on similar perturbations and similar detectability. This suggests a possible review of the approach to evaluate detectors, where additional metrics are included to assure that a representative attack dataset is selected.

The popularity and relative openness of Android means it is a popular target for malware. Over the years, various studies have found that machine learning models can effectively discriminate malware from benign applications. However, as the operating system evolves, so does malware, bringing into question the findings of these previous studies, many of which used small, outdated, and often imbalanced datasets. In this paper, we reimplement 16 representative past works and evaluate them on a balanced, relevant and up-to-date dataset comprising 124,000 Android applications. We also carry out new experiments designed to fill holes in existing knowledge, and use our findings to identify the most effective features and models to use for Android malware detection within a contemporary environment. Our results suggest that accuracies of up to 96.8% can be achieved using static features alone, with a further 1% achievable using more expensive dynamic analysis approaches. We find the best models to be random forests built from API call usage and TCP network traffic features.

To mitigate gender bias in contextualized language models, different intrinsic mitigation strategies have been proposed, alongside many bias metrics. Considering that the end use of these language models is for downstream tasks like text classification, it is important to understand how these intrinsic bias mitigation strategies actually translate to fairness in downstream tasks and the extent of this. In this work, we design a probe to investigate the effects that some of the major intrinsic gender bias mitigation strategies have on downstream text classification tasks. We discover that instead of resolving gender bias, intrinsic mitigation techniques and metrics are able to hide it in such a way that significant gender information is retained in the embeddings. Furthermore, we show that each mitigation technique is able to hide the bias from some of the intrinsic bias measures but not all, and each intrinsic bias measure can be fooled by some mitigation techniques, but not all. We confirm experimentally, that none of the intrinsic mitigation techniques used without any other fairness intervention is able to consistently impact extrinsic bias. We recommend that intrinsic bias mitigation techniques should be combined with other fairness interventions for downstream tasks.

High dimensional data for classification does create many difficulties for machine learning algorithms. The generalization can be done using ensemble learning methods such as bagging based supervised non-parametric random forest algorithm. In this paper we solve the problem of binary classification for high dimensional data using random forest for polycystic ovary syndrome dataset. We have performed the implementation and provided a detailed visualization of the data for general inference. The training accuracy that we have achieved is 95.6% and validation accuracy over 91.74% respectively.

The goal of the Search for Extraterrestrial Intelligence (SETI) is to quantify the prevalence of technological life beyond Earth via their "technosignatures". One theorized technosignature is narrowband Doppler drifting radio signals. The principal challenge in conducting SETI in the radio domain is developing a generalized technique to reject human radio frequency interference (RFI). Here, we present the most comprehensive deep-learning based technosignature search to date, returning 8 promising ETI signals of interest for re-observation as part of the Breakthrough Listen initiative. The search comprises 820 unique targets observed with the Robert C. Byrd Green Bank Telescope, totaling over 480, hr of on-sky data. We implement a novel beta-Convolutional Variational Autoencoder to identify technosignature candidates in a semi-unsupervised manner while keeping the false positive rate manageably low. This new approach presents itself as a leading solution in accelerating SETI and other transient research into the age of data-driven astronomy.

Abstract: MRI connectomics is an emerging approach to study the brain as a network of interconnected brain regions. Understanding and mapping the development of the MRI connectome may offer new insights into the development of brain connectivity and plasticity, ultimately leading to improved understanding of normal development and to more effective diagnosis and treatment of developmental disorders. In this review, we describe the attempts made to date to map the whole-brain structural MRI connectome in the developing brain and pay a special attention to the challenges associated with the rapid changes that the brain is undergoing during maturation. The two main steps in constructing a structural brain network are (i) choosing connectivity measures that will serve as the network "edges" and (ii) finding an appropriate way to divide the brain into regions that will serve as the network "nodes". We will discuss how these two steps are usually performed in developmental studies and the rationale behind different strategies.