Learning with multiple modalities is crucial for automated brain tumor segmentation from magnetic resonance imaging data. Explicitly optimizing the common information shared among all modalities (e.g., by maximizing the total correlation) has been shown to achieve better feature representations and thus enhance the segmentation performance. However, existing approaches are oblivious to partial common information shared by subsets of the modalities. In this paper, we show that identifying such partial common information can significantly boost the discriminative power of image segmentation models. In particular, we introduce a novel concept of partial common information mask (PCI-mask) to provide a fine-grained characterization of what partial common information is shared by which subsets of the modalities. By solving a masked correlation maximization and simultaneously learning an optimal PCI-mask, we identify the latent microstructure of partial common information and leverage it in a self-attention module to selectively weight different feature representations in multi-modal data. We implement our proposed framework on the standard U-Net. Our experimental results on the Multi-modal Brain Tumor Segmentation Challenge (BraTS) datasets outperform those of state-of-the-art segmentation baselines, with validation Dice similarity coefficients of 0.920, 0.897, 0.837 for the whole tumor, tumor core, and enhancing tumor on BraTS-2020.

Obesity is a critical healthcare issue affecting the United States. The least risky treatments available for obesity are behavioral interventions meant to promote diet and exercise. Often these interventions contain a mobile component that allows interventionists to collect participants level data and provide participants with incentives and goals to promote long term behavioral change. Recently, there has been interest in using direct financial incentives to promote behavior change. However, adherence is challenging in these interventions, as each participant will react differently to different incentive structure and amounts, leading researchers to consider personalized interventions. The key challenge for personalization, is that the clinicians do not know a priori how best to administer incentives to participants, and given finite intervention budgets how to disburse costly resources efficiently. In this paper, we consider this challenge of designing personalized weight loss interventions that use direct financial incentives to motivate weight loss while remaining within a budget. We create a machine learning approach that is able to predict how individuals may react to different incentive schedules within the context of a behavioral intervention. We use this predictive model in an adaptive framework that over the course of the intervention computes what incentives to disburse to participants and remain within the study budget. We provide both theoretical guarantees for our modeling and optimization approaches as well as demonstrate their performance in a simulated weight loss study. Our results highlight the cost efficiency and effectiveness of our personalized intervention design for weight loss.

Nanobodies (Nb) are monomeric heavy-chain fragments derived from heavy-chain only antibodies naturally found in Camelids and Sharks. Their considerably small size ( 3-4 nm; 13 kDa) and favorable biophysical properties make them attractive targets for recombinant production. Furthermore, their unique ability to bind selectively to specific antigens, such as toxins, chemicals, bacteria, and viruses, makes them powerful tools in cell biology, structural biology, medical diagnostics, and future therapeutic agents in treating cancer and other serious illnesses. However, a critical challenge in nanobodies production is the unavailability of nanobodies for a majority of antigens. Although some computational methods have been proposed to screen potential nanobodies for given target antigens, their practical application is highly restricted due to their reliance on 3D structures. Moreover, predicting nanobodyantigen interactions (binding) is a time-consuming and labor-intensive task. This study aims to develop a machine-learning method to predict Nanobody-Antigen binding solely based on the sequence data. We curated a comprehensive dataset of Nanobody-Antigen binding and nonbinding data and devised an embedding method based on gapped k-mers to predict binding based only on sequences of nanobody and antigen. Our approach achieves up to 90% accuracy in binding prediction and is significantly more efficient compared to the widely-used computational docking technique.

Our research investigates the potential of Large-scale Language Models (LLMs), specifically OpenAI's GPT, in credit risk assessment--a binary classification task. Our findings suggest that LLMs, when directed by judiciously designed prompts and supplemented with domainspecific knowledge, can parallel the performance of traditional Machine Learning (ML) models. Intriguingly, they achieve this with significantly less data--40 times less, utilizing merely 20 data points compared to the ML's 800. LLMs particularly excel in minimizing false positives and enhancing fairness, both being vital aspects of risk analysis. While our results did not surpass those of classical ML models, they underscore the potential of LLMs in analogous tasks, laying a groundwork for future explorations into harnessing the capabilities of LLMs in diverse ML tasks.

Discriminatory language and biases are often present in hate speech during conversations, which usually lead to negative impacts on targeted groups such as those based on race, gender, and religion. To tackle this issue, we propose an approach that involves a two-step process: first, detecting hate speech using a classifier, and then utilizing a debiasing component that generates less biased or unbiased alternatives through prompts. We evaluated our approach on a benchmark dataset and observed reduction in negativity due to hate speech comments. The proposed method contributes to the ongoing efforts to reduce biases in online discourse and promote a more inclusive and fair environment for communication.

This paper proposes a data-efficient detection method for deep neural networks against backdoor attacks under a black-box scenario. The proposed approach is motivated by the intuition that features corresponding to triggers have a higher influence in determining the backdoored network output than any other benign features. To quantitatively measure the effects of triggers and benign features on determining the backdoored network output, we introduce five metrics. To calculate the five-metric values for a given input, we first generate several synthetic samples by injecting the input's partial contents into clean validation samples. Then, the five metrics are computed by using the output labels of the corresponding synthetic samples. One contribution of this work is the use of a tiny clean validation dataset. Having the computed five metrics, five novelty detectors are trained from the validation dataset. A meta novelty detector fuses the output of the five trained novelty detectors to generate a meta confidence score. During online testing, our method determines if online samples are poisoned or not via assessing their meta confidence scores output by the meta novelty detector. We show the efficacy of our methodology through a broad range of backdoor attacks, including ablation studies and comparison to existing approaches. Our methodology is promising since the proposed five metrics quantify the inherent differences between clean and poisoned samples. Additionally, our detection method can be incrementally improved by appending more metrics that may be proposed to address future advanced attacks.

The problem of change detection in images finds application in different domains like diagnosis of diseases in the medical field, detecting growth patterns of cities through remote sensing, and finding changes in legal documents and contracts. However, this paper presents a survey on core techniques and rules to detect changes in different versions of a document image. Our discussions on change detection focus on two categories -- content-based and layout-based. The content-based techniques intelligently extract and analyze the image contents (text or non-text) to show the possible differences, whereas the layout-based techniques use structural information to predict document changes. We also summarize the existing datasets and evaluation metrics used in change detection experiments. The shortcomings and challenges the existing methods face are reported, along with some pointers for future research work.

Fair graph partition of social networks is a crucial step toward ensuring fair and non-discriminatory treatments in unsupervised user analysis. Current fair partition methods typically consider node balance, a notion pursuing a proportionally balanced number of nodes from all demographic groups, but ignore the bias induced by imbalanced edges in each cluster. To address this gap, we propose a notion edge balance to measure the proportion of edges connecting different demographic groups in clusters. We analyze the relations between node balance and edge balance, then with line graph transformations, we propose a co-embedding framework to learn dual node and edge fairness-aware representations for graph partition. We validate our framework through several social network datasets and observe balanced partition in terms of both nodes and edges along with good utility. Moreover, we demonstrate our fair partition can be used as pseudo labels to facilitate graph neural networks to behave fairly in node classification and link prediction tasks.

As machine learning has been deployed ubiquitously across applications in modern data science, algorithmic fairness has become a great concern. Among them, imposing fairness constraints during learning, i.e. in-processing fair training, has been a popular type of training method because they don't require accessing sensitive attributes during test time in contrast to post-processing methods. While this has been extensively studied in classical machine learning models, their impact on deep neural networks remains unclear. Recent research has shown that adding fairness constraints to the objective function leads to severe over-fitting to fairness criteria in large models, and how to solve this challenge is an important open question. To tackle this, we leverage the wisdom and power of pre-training and fine-tuning and develop a simple but novel framework to train fair neural networks in an efficient and inexpensive way -- last-layer fine-tuning alone can effectively promote fairness in deep neural networks. This framework offers valuable insights into representation learning for training fair neural networks.

This paper presents a novel algorithm for crack localisation and detection based on visual and tactile analysis via fibre-optics. A finger-shaped sensor based on fibre-optics is employed for the data acquisition to collect data for the analysis and the experiments. To detect the possible locations of cracks a camera is used to scan an environment while running an object detection algorithm. Once the crack is detected, a fully-connected graph is created from a skeletonised version of the crack. A minimum spanning tree is then employed for calculating the shortest path to explore the crack which is then used to develop the motion planner for the robotic manipulator. The motion planner divides the crack into multiple nodes which are then explored individually. Then, the manipulator starts the exploration and performs the tactile data classification to confirm if there is indeed a crack in that location or just a false positive from the vision algorithm. If a crack is detected, also the length, width, orientation and number of branches are calculated. This is repeated until all the nodes of the crack are explored. In order to validate the complete algorithm, various experiments are performed: comparison of exploration of cracks through full scan and motion planning algorithm, implementation of frequency-based features for crack classification and geometry analysis using a combination of vision and tactile data. From the results of the experiments, it is shown that the proposed algorithm is able to detect cracks and improve the results obtained from vision to correctly classify cracks and their geometry with minimal cost thanks to the motion planning algorithm.