ABSTRACT This work introduces SAM-LLM, a novel hybrid architecture that bridges the gap between the contextual reasoning of Large Language Models (LLMs) and the physical precision of kinematic lane change models for autonomous driving. The system is designed for interpretable lane change trajectory prediction by finetuning an LLM to output the core physical parameters of a trajectory model instead of raw coordinates. For lane-keeping scenarios, the model predicts discrete coordinates, but for lane change maneuvers, it generates the parameters for an enhanced Sinusoidal Acceleration Model (SAM), including lateral displacement, maneuver duration, initial lateral velocity, and longitudinal velocity change. This parametric approach yields a complete, continuous, and physically plausible trajectory model that is inherently interpretable and computationally efficient, achieving an 80% reduction in output size compared to coordinate-based methods. The SAM-LLM achieves a state-of-the-art overall intention prediction accuracy of 98.73%, demonstrating performance equivalent to traditional LLM predictors while offering significant advantages in explainability and resource efficiency.

The ability to track a user's arm pose could be valuable in a wide range of applications, including fitness, rehabilitation, augmented reality input, life logging, and context-aware assistants. Unfortunately, this capability is not readily available to consumers. Systems either require cameras, which carry privacy issues, or utilize multiple worn IMUs or markers. In this work, we describe how an off-the-shelf smartphone and smartwatch can work together to accurately estimate arm pose. Moving beyond prior work, we take advantage of more recent ultra-wideband (UWB) functionality on these devices to capture absolute distance between the two devices. This measurement is the perfect complement to inertial data, which is relative and suffers from drift. We quantify the performance of our software-only approach using off-the-shelf devices, showing it can estimate the wrist and elbow joints with a \hl{median positional error of 11.0~cm}, without the user having to provide training data.

The integration of vision-language-action (VLA) models into embodied AI (EAI) robots is rapidly advancing their ability to perform complex, long-horizon tasks in humancentric environments. However, EAI systems introduce critical security risks: a compromised VLA model can directly translate adversarial perturbations on sensory input into unsafe physical actions. Traditional safety definitions and methodologies from the machine learning community are no longer sufficient. EAI systems raise new questions, such as what constitutes safety, how to measure it, and how to design effective attack and defense mechanisms in physically grounded, interactive settings. In this work, we present the first systematic study of adversarial safety attacks on embodied AI systems, grounded in ISO standards for human-robot interactions. We (1) formalize a principled taxonomy of safety violations (critical, dangerous, risky) based on physical constraints such as separation distance, velocity, and collision boundaries; (2) introduce ANNIEBench, a benchmark of nine safety-critical scenarios with 2,400 video-action sequences for evaluating embodied safety; and (3) ANNIE-Attack, a task-aware adversarial framework with an attack leader model that decomposes long-horizon goals into frame-level perturbations. Our evaluation across representative EAI models shows attack success rates exceeding 50% across all safety categories. We further demonstrate sparse and adaptive attack strategies and validate the real-world impact through physical robot experiments. These results expose a previously underexplored but highly consequential attack surface in embodied AI systems, highlighting the urgent need for security-driven defenses in the physical AI era. Code is available at https://github.com/RLCLab/Annie.

Agentic LLM AI agents are often little more than autonomous chatbots: actors following scripts, often controlled by an unreliable director. This work introduces a bottom-up framework that situates AI agents in their environment, with all behaviors triggered by changes in their environments. It introduces the notion of aspects, similar to the idea of umwelt, where sets of agents perceive their environment differently to each other, enabling clearer control of information. We provide an illustrative implementation and show that compared to a typical architecture, which leaks up to 83% of the time, aspective agentic AI enables zero information leakage. We anticipate that this concept of specialist agents working efficiently in their own information niches can provide improvements to both security and efficiency.

Epitopes are short antigenic peptide sequences which are recognized by antibodies or immune cell receptors. These are central to the development of immunotherapies, vaccines, and diagnostics. However, the rational design of synthetic epitope libraries is challenging due to the large combinatorial sequence space, $20^n$ combinations for linear epitopes of n amino acids, making screening and testing unfeasible, even with high throughput experimental techniques. In this study, we present a large language model, epiGPTope, pre-trained on protein data and specifically fine-tuned on linear epitopes, which for the first time can directly generate novel epitope-like sequences, which are found to possess statistical properties analogous to the ones of known epitopes. This generative approach can be used to prepare libraries of epitope candidate sequences. We further train statistical classifiers to predict whether an epitope sequence is of bacterial or viral origin, thus narrowing the candidate library and increasing the likelihood of identifying specific epitopes. We propose that such combination of generative and predictive models can be of assistance in epitope discovery. The approach uses only primary amino acid sequences of linear epitopes, bypassing the need for a geometric framework or hand-crafted features of the sequences. By developing a method to create biologically feasible sequences, we anticipate faster and more cost-effective generation and screening of synthetic epitopes, with relevant applications in the development of new biotechnologies.

Auto-bidding is central to computational advertising, achieving notable commercial success by optimizing advertisers' bids within economic constraints. Recently, large generative models show potential to revolutionize auto-bidding by generating bids that could flexibly adapt to complex, competitive environments. Among them, diffusers stand out for their ability to address sparse-reward challenges by focusing on trajectory-level accumulated rewards, as well as their explainable capability, i.e., planning a future trajectory of states and executing bids accordingly. However, diffusers struggle with generation uncertainty, particularly regarding dynamic legitimacy between adjacent states, which can lead to poor bids and further cause significant loss of ad impression opportunities when competing with other advertisers in a highly competitive auction environment. To address it, we propose a Causal auto-Bidding method based on a Diffusion completer-aligner framework, termed CBD. Firstly, we augment the diffusion training process with an extra random variable t, where the model observes t-length historical sequences with the goal of completing the remaining sequence, thereby enhancing the generated sequences' dynamic legitimacy. Then, we employ a trajectory-level return model to refine the generated trajectories, aligning more closely with advertisers' objectives. Experimental results across diverse settings demonstrate that our approach not only achieves superior performance on large-scale auto-bidding benchmarks, such as a 29.9% improvement in conversion value in the challenging sparse-reward auction setting, but also delivers significant improvements on the Kuaishou online advertising platform, including a 2.0% increase in target cost.

Astrocytes are critical glial cells whose altered morphology and density are hallmarks of many neurological disorders. However, their intricate branching and stain dependent variability make automated detection of histological images a highly challenging task. To address these challenges, we propose a hybrid CNN Transformer detector that combines local feature extraction with global contextual reasoning. A heatmap guided query mechanism generates spatially grounded anchors for small and faint astrocytes, while a lightweight Transformer module improves discrimination in dense clusters. Evaluated on ALDH1L1 and GFAP stained astrocyte datasets, the model consistently outperformed Faster R-CNN, YOLOv11 and DETR, achieving higher sensitivity with fewer false positives, as confirmed by FROC analysis. These results highlight the potential of hybrid CNN Transformer architectures for robust astrocyte detection and provide a foundation for advanced computational pathology tools.

Graph neural networks (GNNs) have emerged as a state-of-the-art data-driven tool for modeling connectivity data of graph-structured complex networks and integrating information of their nodes and edges in space and time. However, as of yet, the analysis of social networks using the time series of people's mobile connectivity data has not been extensively investigated. In the present study, we investigate four snapshot - based temporal GNNs in predicting the phone call and SMS activity between users of a mobile communication network. In addition, we develop a simple non - GNN baseline model using recently proposed EdgeBank method. Our analysis shows that the ROLAND temporal GNN outperforms the baseline model in most cases, whereas the other three GNNs perform on average worse than the baseline. The results show that GNN based approaches hold promise in the analysis of temporal social networks through mobile connectivity data. However, due to the relatively small performance margin between ROLAND and the baseline model, further research is required on specialized GNN architectures for temporal social network analysis.

--Missing data represents a fundamental challenge in machine learning applications, often reducing model performance and reliability. This problem is particularly acute in fields like bioinformatics and clinical machine learning, where datasets are frequently incomplete due to the nature of both data generation and data collection. While numerous imputation methods exist, from simple statistical techniques to advanced deep learning models, no single method consistently performs well across diverse datasets and missingness mechanisms. This paper proposes a novel Meta-Imputation approach that learns to combine the outputs of multiple base imputers to predict missing values more accurately. By training the proposed method called Meta-Imputation Balanced (MIB) on synthetically masked data with known ground truth, the system learns to predict the most suitable imputed value based on the behavior of each method. We evaluate our method on tabular data under the Missing Completely at Random (MCAR) assumption using both direct metrics, where Mean Absolute Error (MAE) and Root Mean Squared Error (RMSE) are computed between imputed values and their corresponding original ground truth values in the artificially masked positions, and indirect metrics, which measure the RMSE of a target variable predicted by machine learning models trained on the imputed datasets. Across three benchmark datasets, the model achieved the lowest or near-lowest RMSE and delivered stable downstream predictive performance, even when individual imputers varied in performance.

AI is transforming the healthcare domain and is increasingly helping practitioners to make health-related decisions. Therefore, accountability becomes a crucial concern for critical AI-driven decisions. Although regulatory bodies, such as the EU commission, provide guidelines, they are highlevel and focus on the ''what'' that should be done and less on the ''how'', creating a knowledge gap for actors. Through an extensive analysis, we found that the term accountability is perceived and dealt with in many different ways, depending on the actor's expertise and domain of work. With increasing concerns about AI accountability issues and the ambiguity around this term, this paper bridges the gap between the ''what'' and ''how'' of AI accountability, specifically for AI systems in healthcare. We do this by analysing the concept of accountability, formulating an accountability framework, and providing a three-tier structure for handling various accountability mechanisms. Our accountability framework positions the regulations of healthcare AI systems and the mechanisms adopted by the actors under a consistent accountability regime. Moreover, the three-tier structure guides the actors of the healthcare AI system to categorise the mechanisms based on their conduct. Through our framework, we advocate that decision-making in healthcare AI holds shared dependencies, where accountability should be dealt with jointly and should foster collaborations. We highlight the role of explainability in instigating communication and information sharing between the actors to further facilitate the collaborative process.