Image segmentation is a critical task in microscopy, essential for accurately analyzing and interpreting complex visual data. This task can be performed using custom models trained on domain-specific datasets, transfer learning from pre-trained models, or foundational models that offer broad applicability. However, foundational models often present a considerable number of non-transparent tuning parameters that require extensive manual optimization, limiting their usability for real-time streaming data analysis. Here, we introduce a reward function-based optimization to fine-tune foundational models and illustrate this approach for SAM (Segment Anything Model) framework by Meta. The reward functions can be constructed to represent the physics of the imaged system, including particle size distributions, geometries, and other criteria. By integrating a reward-driven optimization framework, we enhance SAM's adaptability and performance, leading to an optimized variant, SAM$^{*}$, that better aligns with the requirements of diverse segmentation tasks and particularly allows for real-time streaming data segmentation. We demonstrate the effectiveness of this approach in microscopy imaging, where precise segmentation is crucial for analyzing cellular structures, material interfaces, and nanoscale features.

Artificial intelligence deployment for automated photovoltaic (PV) monitoring faces interpretability barriers that limit adoption in energy infrastructure applications. While deep learning achieves high accuracy in thermal fault detection, validation that model decisions align with thermal physics principles remains lacking, creating deployment hesitancy where understanding model reasoning is critical. This study provides a systematic comparison of convolutional neural networks (ResNet-18, EfficientNet-B0) and vision transformers (ViT-Tiny, Swin-Tiny) for thermal PV fault detection, using XRAI saliency analysis to assess alignment with thermal physics principles. This represents the first systematic comparison of CNNs and vision transformers for thermal PV fault detection with physics-validated interpretability. Evaluation on 20,000 infrared images spanning normal operation and 11 fault categories shows that Swin Transformer achieves the highest performance (94% binary accuracy; 73% multiclass accuracy) compared to CNN approaches. XRAI analysis reveals that models learn physically meaningful features, such as localized hotspots for cell defects, linear thermal paths for diode failures, and thermal boundaries for vegetation shading, consistent with expected thermal signatures. However, performance varies significantly across fault types: electrical faults achieve strong detection (F1-scores >0.90) while environmental factors like soiling remain challenging (F1-scores 0.20-0.33), indicating limitations imposed by thermal imaging resolution. The thermal physics-guided interpretability approach provides methodology for validating AI decision-making in energy monitoring applications, addressing deployment barriers in renewable energy infrastructure.

The introduction of Artificial Intelligence (AI) into the domains of traditional art (visual arts, performing arts, and crafts) has sparked a complicated discussion about whether this might be an agent of disruption or an enhancement of our traditional art forms. This paper looks at the duality of AI, exploring the ways that recent technologies like Generative Adversarial Networks and Diffusion Models, and text-to-image generators are changing the fields of painting, sculpture, calligraphy, dance, music, and the arts of craft. Using examples and data, we illustrate the ways that AI can democratize creative expression, improve productivity, and preserve cultural heritage, while also examining the negative aspects, including: the threats to authenticity within art, ethical concerns around data, and issues including socio-economic factors such as job losses. While we argue for the context-dependence of the impact of AI (the potential for creative homogenization and the devaluation of human agency in artmaking), we also illustrate the potential for hybrid practices featuring AI in cuisine, etc. We advocate for the development of ethical guidelines, collaborative approaches, and inclusive technology development. In sum, we are articulating a vision of AI in which it amplifies our innate creativity while resisting the displacement of the cultural, nuanced, and emotional aspects of traditional art. The future will be determined by human choices about how to govern AI so that it becomes a mechanism for artistic evolution and not a substitute for the artist's soul.

The Trapped Gyro-Landau Fluid (TGLF) model provides fast, accurate predictions of turbulent transport in tokamaks, but whole device simulations requiring thousands of evaluations remain computationally expensive. Neural network (NN) surrogates offer accelerated inference with fully differentiable approximations that enable gradient-based coupling but typically require large training datasets to capture transport flux variations across plasma conditions, creating significant training burden and limiting applicability to expensive gyrokinetic simulations. We propose \textbf{TGLF-SINN (Spectra-Informed Neural Network)} with three key innovations: (1) principled feature engineering that reduces target prediction range, simplifying the learning task; (2) physics-guided regularization of transport spectra to improve generalization under sparse data; and (3) Bayesian Active Learning (BAL) to strategically select training samples based on model uncertainty, reducing data requirements while maintaining accuracy. Our approach achieves superior performance with significantly less training data. In offline settings, TGLF-SINN reduces logarithmic root mean squared error (LRMSE) by 12. 4\% compared to the current baseline \base. Using only 25\% of the complete dataset with BAL, we achieve LRMSE only 0.0165 higher than \base~and 0.0248 higher than our offline model (0.0583). In downstream flux matching applications, our NN surrogate provides 45x speedup over TGLF while maintaining comparable accuracy, demonstrating potential for training efficient surrogates for higher-fidelity models where data acquisition is costly and sparse.

In 2023, the National Eating Disorders Association's (NEDA) chatbot Tessa was suspended after providing harmful weight-loss advice to vulnerable users--an avoidable failure that underscores the risks of unsafe AI in healthcare contexts. This paper examines Tessa as a case study in absent safety engineering and demonstrates how a lightweight, modular safeguard could have prevented the incident. We propose a hybrid safety middleware that combines deterministic lexical gates with an in-line large language model (LLM) policy filter, enforcing fail-closed verdicts and escalation pathways within a single model call. Using synthetic evaluations, we show that this design achieves perfect interception of unsafe prompts at baseline cost and latency, outperforming traditional multistage pipelines. Beyond technical remedies, we map Tessa's failure patterns to established frameworks (OW ASP LLM Top10; NIST SP 800-53), connecting practical safeguards to actionable governance controls. The results highlight that robust, auditable safety in health-adjacent AI does not require heavyweight infrastructure: explicit, testable checks at the last mile are sufficient to prevent "another Tessa," while governance and escalation ensure sustainability in real-world deployment.

The Flexible Job-shop Scheduling Problem (FJSP) is a classical combinatorial optimization problem that has a wide-range of applications in the real world. In order to generate fast and accurate scheduling solutions for FJSP, various deep reinforcement learning (DRL) scheduling methods have been developed. However, these methods are mainly focused on the design of DRL scheduling Agent, overlooking the modeling of DRL environment. This paper presents a simple chronological DRL environment for FJSP based on discrete event simulation and an end-to-end DRL scheduling model is proposed based on the proximal policy optimization (PPO). Furthermore, a short novel state representation of FJSP is proposed based on two state variables in the scheduling environment and a novel comprehensible reward function is designed based on the scheduling area of machines. Experimental results on public benchmark instances show that the performance of simple priority dispatching rules (PDR) is improved in our scheduling environment and our DRL scheduling model obtains competing performance compared with OR-Tools, meta-heuristic, DRL and PDR scheduling methods.

We introduce Spectral NSR, a fully spectral neuro-symbolic reasoning framework that embeds logical rules as spectral templates and performs inference directly in the graph spectral domain. By leveraging graph signal processing (GSP) and frequency-selective filters grounded in the Laplacian eigenstructure of knowledge graphs, the architecture unifies the interpretability of symbolic reasoning with the scalability and adaptability of spectral learning. Beyond the core formulation, we incorporate a comprehensive set of extensions, including dynamic graph and basis learning, rational and diffusion filters for sharper spectral selectivity, mixture-of-spectral-experts for modular specialization, proof-guided training with spectral curricula, and uncertainty quantification for calibrated confidence. Additional enhancements such as large language model coupling, co-spectral transfer alignment, adversarial robustness, efficient GPU kernels, generalized Laplacians, and causal interventions further expand the versatility of the framework. Empirical evaluation on state-of-the-art reasoning benchmarks such as ProofWriter and CLUTRR demonstrates that Spectral NSR achieves superior accuracy, faster inference, improved robustness to adversarial perturbations, and higher interpretability compared to leading baselines including transformers, message-passing neural networks, and neuro-symbolic logic programming systems. Spectral attribution and proof-band agreement analyses confirm that model decisions align closely with symbolic proof structures, while transfer experiments validate effective domain adaptation through co-spectral alignment. These results establish Spectral NSR as a scalable and principled foundation for the next generation of reasoning systems, offering transparency, robustness, and generalization beyond conventional approaches.

Calibrating agent-based epidemic models is computationally demanding. We present a supervised machine learning calibrator that learns the inverse mapping from epidemic time series to SIR parameters. A three-layer bidirectional LSTM ingests 60-day incidence together with population size and recovery rate, and outputs transmission probability, contact rate, and R0. Training uses a composite loss with an epidemiology-motivated consistency penalty that encourages R0 \* recovery rate to equal transmission probability \* contact rate. In a 1000-scenario simulation study, we compare the calibrator with Approximate Bayesian Computation (likelihood-free MCMC). The method achieves lower error across all targets (MAE: R0 0.0616 vs 0.275; transmission 0.0715 vs 0.128; contact 1.02 vs 4.24), produces tighter predictive intervals with near nominal coverage, and reduces wall clock time from 77.4 s to 2.35 s per calibration. Although contact rate and transmission probability are partially nonidentifiable, the approach reproduces epidemic curves more faithfully than ABC, enabling fast and practical calibration. We evaluate it on SIR agent based epidemics generated with epiworldR and provide an implementation in R.

Large Language Models (LLMs) are increasingly capable of interpreting multimodal inputs to generate complex 3D shapes, yet robust methods to evaluate geometric and structural fidelity remain underdeveloped. This paper introduces a human-in-the-loop framework for the quantitative evaluation of LLM-generated 3D models, supporting applications such as democratization of CAD design, reverse engineering of legacy designs, and rapid prototyping. We propose a comprehensive suite of similarity and complexity metrics--including volumetric accuracy, surface alignment, dimensional fidelity, and topological intricacy--to benchmark generated models against ground-truth CAD references. Using an L-bracket component as a case study, we systematically compare LLM performance across four input modalities: 2D orthographic views, isometric sketches, geometric structure trees, and code-based correction prompts. Our findings demonstrate improved generation fidelity with increased semantic richness, with code-level prompts achieving perfect reconstruction across all metrics. A key contribution of this work is demonstrating that our proposed quantitative evaluation approach enables significantly faster convergence toward the ground truth, especially compared to traditional qualitative methods based solely on visual inspection and human intuition. This work not only advances the understanding of AI-assisted shape synthesis but also provides a scalable methodology to validate and refine generative models for diverse CAD applications.

This paper introduces ArGen (Auto-Regulation of Generative AI systems), a framework for aligning Large Language Models (LLMs) with complex sets of configurable, machine-readable rules spanning ethical principles, operational safety protocols, and regulatory compliance standards. Moving beyond just preference-based alignment, ArGen is designed to ensure LLMs adhere to these multifaceted policies through a novel synthesis of principle-based automated reward scoring, Group Relative Policy Optimisation (GRPO), and an Open Policy Agent (OPA) inspired governance layer. This approach provides the technical foundation for achieving and demonstrating compliance with diverse and nuanced governance requirements. To showcase the framework's capability to operationalize a deeply nuanced and culturally-specific value system, we present an in-depth case study: the development of a medical AI assistant guided by principles from Dharmic ethics (such as Ahimsa and Dharma), as derived from texts like the Bhagavad Gita. This challenging application demonstrates ArGen's adaptability, achieving a 70.9% improvement in domain-scope adherence over the baseline. Through our open-source repository, we show that ArGen's methodology offers a path to 'Governable Al' systems that are technically proficient, ethically robust, and verifiably compliant for safe deployment in diverse global contexts.