Optical Coherence Tomography (OCT) is essential for diagnosing conditions such as glaucoma, diabetic retinopathy, and age-related macular degeneration. Accurate retinal layer segmentation enables quantitative biomarkers critical for clinical decision-making, but manual segmentation is time-consuming and variable, while conventional deep learning models often lack interpretability. This work proposes an improved SegNet-based deep learning framework for automated and interpretable retinal layer segmentation. Architectural innovations, including modified pooling strategies, enhance feature extraction from noisy OCT images, while a hybrid loss function combining categorical cross-entropy and Dice loss improves performance for thin and imbalanced retinal layers. Gradient-weighted Class Activation Mapping (Grad-CAM) is integrated to provide visual explanations, allowing clinical validation of model decisions. Trained and validated on the Duke OCT dataset, the framework achieved 95.77% validation accuracy, a Dice coefficient of 0.9446, and a Jaccard Index (IoU) of 0.8951. Class-wise results confirmed robust performance across most layers, with challenges remaining for thinner boundaries. Grad-CAM visualizations highlighted anatomically relevant regions, aligning segmentation with clinical biomarkers and improving transparency. By combining architectural improvements, a customized hybrid loss, and explainable AI, this study delivers a high-performing SegNet-based framework that bridges the gap between accuracy and interpretability. The approach offers strong potential for standardizing OCT analysis, enhancing diagnostic efficiency, and fostering clinical trust in AI-driven ophthalmic tools.

Stroke is the second most frequent cause of death world wide with an annual mortality of around 5.5 million. Recurrence rates of stroke are between 5 and 25% in the first year. As mortality rates for relapses are extraordinarily high (40%) it is of utmost importance to reduce the recurrence rates. We address this issue by detecting patients at risk of stroke recurrence at an early stage in order to enable appropriate therapy planning. To this end we collected 3D intracranial CTA image data and recorded concomitant heart diseases, the age and the gender of stroke patients between 2010 and 2024. We trained single- and multimodal deep learning based neural networks for binary relapse detection (Task 1) and for relapse free survival (RFS) time prediction together with a subsequent classification (Task 2). The separation of relapse from non-relapse patients (Task 1) could be solved with tabular data (AUC on test dataset: 0.84). However, for the main task, the regression (Task 2), our multimodal XSRD-net processed the modalities vision:tabular with 0.68:0.32 according to modality contribution measures. The c-index with respect to relapses for the multimodal model reached 0.68, and the AUC is 0.71 for the test dataset. Final, deeper interpretability analysis results could highlight a link between both heart diseases (tabular) and carotid arteries (vision) for the detection of relapses and the prediction of the RFS time. This is a central outcome that we strive to strengthen with ongoing data collection and model retraining.

Large Language Models (LLMs) have achieved remarkable performance across diverse tasks, yet their susceptibility to generating incorrect content during inference remains a critical unsolved challenge. While self-correction methods offer potential solutions, their effectiveness is hindered by two inherent limitations: (1) the absence of reliable guidance signals for error localization, and (2) the restricted reasoning depth imposed by conventional next-token decoding paradigms. To address these issues, we propose Feedback-Triggered Regeneration (FTR), a novel framework that synergizes user feedback with enhanced decoding dynamics. Specifically, FTR activates response regeneration only upon receiving negative user feedback, thereby circumventing error propagation from faulty self-assessment while preserving originally correct outputs. Furthermore, we introduce Long-Term Multipath (LTM) decoding, which enables systematic exploration of multiple reasoning trajectories through delayed sequence evaluation, effectively overcoming the myopic decision-making characteristic of standard next-token prediction. Extensive experiments on mathematical reasoning and code generation benchmarks demonstrate that our framework achieves consistent and significant improvements over state-of-the-art prompt-based self-correction methods.

The relentless growth of large-scale artificial intelligence (AI) has created unprecedented demand for computational power, straining the energy, bandwidth, and scaling limits of conventional electronic platforms. Electronic-photonic integrated circuits (EPICs) have emerged as a compelling platform for next-generation AI systems, offering inherent advantages in ultra-high bandwidth, low latency, and energy efficiency for computing and interconnection. Beyond performance, EPICs also hold unique promises for sustainability. Fabricated in relaxed process nodes with fewer metal layers and lower defect densities, photonic devices naturally reduce embodied carbon footprint (CFP) compared to advanced digital electronic integrated circuits, while delivering orders-of-magnitude higher computing performance and interconnect bandwidth. To further advance the sustainability of photonic AI systems, we explore how electronic-photonic design automation (EPDA) and cross-layer co-design methodologies can amplify these inherent benefits. We present how advanced EPDA tools enable more compact layout generation, reducing both chip area and metal layer usage. We will also demonstrate how cross-layer device-circuit-architecture co-design unlocks new sustainability gains for photonic hardware: ultra-compact photonic circuit designs that minimize chip area cost, reconfigurable hardware topology that adapts to evolving AI workloads, and intelligent resilience mechanisms that prolong lifetime by tolerating variations and faults. By uniting intrinsic photonic efficiency with EPDA- and co-design-driven gains in area efficiency, reconfigurability, and robustness, we outline a vision for lifelong-sustainable electronic-photonic AI systems. This perspective highlights how EPIC AI systems can simultaneously meet the performance demands of modern AI and the urgent imperative for sustainable computing.

Spiking neural networks offer a promising path toward energy-efficient, brain-like associative memory. This paper introduces Word2Spike, a novel rate coding mechanism that combines continuous word embeddings and neuromorphic architectures. We develop a one-to-one mapping that converts multi-dimensional word vectors into spike-based attractor states using Poisson processes. Using BitNet b1.58 quantization, we maintain 97% semantic similarity of continuous embed-dings on SimLex-999 while achieving 100% reconstruction accuracy on 10,000 words from OpenAI's text-embedding-3-large. We preserve analogy performance (100% of original embedding performance) even under intentionally introduced noise, indicating a resilient mechanism for semantic encoding in neuromorphic systems.

Neurosymbolic (NeSy) frameworks combine neural representations and learning with symbolic representations and reasoning. Combining the reasoning capacities, explainability, and interpretability of symbolic processing with the flexibility and power of neural computing allows us to solve complex problems with more reliability while being data-efficient. However, this recently growing topic poses a challenge to developers with its learning curve, lack of user-friendly tools, libraries, and unifying frameworks. In this paper, we characterize the technical facets of existing NeSy frameworks, such as the symbolic representation language, integration with neural models, and the underlying algorithms. A majority of the NeSy research focuses on algorithms instead of providing generic frameworks for declarative problem specification to leverage problem solving. To highlight the key aspects of Neurosymbolic modeling, we showcase three generic NeSy frameworks - \textit{DeepProbLog}, \textit{Scallop}, and \textit{DomiKnowS}. We identify the challenges within each facet that lay the foundation for identifying the expressivity of each framework in solving a variety of problems. Building on this foundation, we aim to spark transformative action and encourage the community to rethink this problem in novel ways.

Large multimodal models (LMMs) have revolutionized text-to-image generation, but they risk perpetuating the harmful social biases in their training data. Prior work has identified gender bias in these models, but methodological limitations prevented large-scale, comparable, cross-model analysis. To address this gap, we introduce the Aymara Image Fairness Evaluation, a benchmark for assessing social bias in AI-generated images. We test 13 commercially available LMMs using 75 procedurally-generated, gender-neutral prompts to generate people in stereotypically-male, stereotypically-female, and non-stereotypical professions. We then use a validated LLM-as-a-judge system to score the 965 resulting images for gender representation. Our results reveal (p < .001 for all): 1) LMMs systematically not only reproduce but actually amplify occupational gender stereotypes relative to real-world labor data, generating men in 93.0% of images for male-stereotyped professions but only 22.5% for female-stereotyped professions; 2) Models exhibit a strong default-male bias, generating men in 68.3% of the time for non-stereotyped professions; and 3) The extent of bias varies dramatically across models, with overall male representation ranging from 46.7% to 73.3%. Notably, the top-performing model de-amplified gender stereotypes and approached gender parity, achieving the highest fairness scores. This variation suggests high bias is not an inevitable outcome but a consequence of design choices. Our work provides the most comprehensive cross-model benchmark of gender bias to date and underscores the necessity of standardized, automated evaluation tools for promoting accountability and fairness in AI development.

Preterm birth is a major cause of mortality and lifelong morbidity in childhood. Its complex and multifactorial origins limit the effectiveness of current clinical predictors and impede optimal care. In this study, a dual-branch deep learning architecture (PUUMA) was developed to predict gestational age (GA) at birth using T2* fetal MRI data from 295 pregnancies, encompassing a heterogeneous and imbalanced population. The model integrates both global whole-uterus and local placental features. Its performance was benchmarked against linear regression using cervical length measurements obtained by experienced clinicians from anatomical MRI and other Deep Learning architectures. The GA at birth predictions were assessed using mean absolute error. Accuracy, sensitivity, and specificity were used to assess preterm classification. Both the fully automated MRI-based pipeline and the cervical length regression achieved comparable mean absolute errors (3 weeks) and good sensitivity (0.67) for detecting preterm birth, despite pronounced class imbalance in the dataset. These results provide a proof of concept for automated prediction of GA at birth from functional MRI, and underscore the value of whole-uterus functional imaging in identifying at-risk pregnancies. Additionally, we demonstrate that manual, high-definition cervical length measurements derived from MRI, not currently routine in clinical practice, offer valuable predictive information. Future work will focus on expanding the cohort size and incorporating additional organ-specific imaging to improve generalisability and predictive performance.

The increasing size of large neural network models, specifically language models and foundational image models, poses deployment challenges, prompting efforts to reduce memory requirements and enhance computational efficiency. These efforts are critical to ensure practical deployment and effective utilization of these models across various applications. In this work, a novel type of neural network layers and models is developed that uses only single-bit parameters. In this novel type of models all parameters of all layers, including kernel weights and biases, only have values equal to zero or one. This novel type of models uses layers named as binary normalized layer. These binary normalized layers can be of any type, such as fully connected, convolutional, attention, etc., and they consist of slight variations of the corresponding conventional layers. To show the effectiveness of the binary normalized layers, two different models are configured to solve a multiclass image classification problem and a language decoder to predict the next token of a sequence. The model to solve the image classification has convolutional and fully connected layers, and the language model is composed of transformer blocks with multi-head attention. The results show that models with binary normalized layers present almost the same results obtained by equivalent models with real 32-bit parameters. The binary normalized layers allow to develop models that use 32 times less memory than current models and have equivalent performance. Besides, the binary normalized layers can be easily implemented on current computers using 1-bit arrays, and do not require the development of dedicated electronic hardware. This novel type of layers opens a new era for large neural network models with reduced memory requirements that can be deployed using simple and cheap hardware, such as mobile devices or only cpus.

Equipping large language models (LLMs) with complex, interleaved reasoning and tool-use capabilities has become a key focus in agentic AI research, especially with recent advances in reasoning-oriented (``thinking'') models. Such capabilities are key to unlocking a number of important applications. One such application is Deep Research (DR), which requires extensive search and reasoning over many sources. Our work in this paper focuses on the development of native Autonomous Single-Agent models for DR featuring minimal web crawling and Python tool integration. Unlike multi-agent systems, where agents take up pre-defined roles and are told what to do at each step in a static workflow, an autonomous single-agent determines its next action dynamically based on context, without manual directive. While prior work has proposed training recipes for base or instruction-tuned LLMs, we focus on continual reinforcement learning (RL) of reasoning-optimized models to further enhance agentic skills while preserving reasoning ability. Towards this end, we propose a simple RL recipe with entirely synthetic data, which we apply to various open-source LLMs. Our best variant SFR-DR-20B achieves up to 28.7% on Humanity's Last Exam benchmark. In addition, we conduct key analysis experiments to provide more insights into our methodologies.