Coronary angiography remains the gold standard for diagnosing Acute Coronary Syndrome (ACS). However, its resource-intensive and invasive nature can expose patients to procedural risks and diagnostic delays, leading to postponed treatment initiation. In this work, we introduce TREAT-Net, a multimodal deep learning framework for ACS treatment prediction that leverages non-invasive modalities, including echocardiography videos and structured clinical records. TREAT-Net integrates tabular-guided cross-attention to enhance video interpretation, along with a late fusion mechanism to align predictions across modalities. Trained on a dataset of over 9,000 ACS cases, the model outperforms unimodal and non-fused baselines, achieving a balanced accuracy of 67.6% and an AUROC of 71.1%. Cross-modality agreement analysis demonstrates 88.6% accuracy for intervention prediction.

Learning to learn is becoming a science, driven by the convergence of knowledge tracing, signal processing, and generative AI to model student learning states and optimize education. We propose CoTutor, an AI-driven model that enhances Bayesian Knowledge Tracing with signal processing techniques to improve student progress modeling and deliver adaptive feedback and strategies. Deployed as an AI copilot, CoTutor combines generative AI with adaptive learning technology. In university trials, it has demonstrated measurable improvements in learning outcomes while outperforming conventional educational tools. Our results highlight its potential for AI-driven personalization, scalability, and future opportunities for advancing privacy and ethical considerations in educational technology. Inspired by Richard Hamming's vision of computer-aided 'learning to learn,' CoTutor applies convex optimization and signal processing to automate and scale up learning analytics, while reserving pedagogical judgment for humans, ensuring AI facilitates the process of knowledge tracing while enabling learners to uncover new insights.

Scalable and realistic simulation of multi-agent traffic behavior is critical for advancing autonomous driving technologies. Although existing data-driven simulators have made significant strides in this domain, they predominantly rely on supervised learning to align simulated distributions with real-world driving scenarios. A persistent challenge, however, lies in the distributional shift that arises between training and testing, which often undermines model generalization in unseen environments. To address this limitation, we propose SMART -R1, a novel R1-style reinforcement fine-tuning paradigm tailored for next-token prediction models to better align agent behavior with human preferences and evaluation metrics. Our approach introduces a metric-oriented policy optimization algorithm to improve distribution alignment and an iterative "SFT -RFT -SFT" training strategy that alternates between Supervised Fine-Tuning (SFT) and Reinforcement Fine-Tuning (RFT) to maximize performance gains. The results on the Waymo Open Sim Agents Challenge (WOSAC) showcase that SMART -R1 achieves state-of-the-art performance with an overall realism meta score of 0.7858, ranking first on the leaderboard at the time of submission. Simulating multi-agent traffic behaviors plays a pivotal role in ensuring the safety and reliability of autonomous driving systems. However, modeling realistic and scalable traffic behaviors remains highly challenging due to the inherent uncertainty and multi-modality of human driving. Traditional simulators that simply replay logged data lack reactive capability, while rule-based methods, such as the Intelligent Driver Model (IDM) (Treiber et al., 2000), depend on handcrafted heuristics and fail to capture the diversity and realism of human behavior.

Scientific discovery is often slowed by the manual development of computational tools needed to analyze complex experimental data. Building such tools is costly and time-consuming because scientists must iteratively review literature, test modeling and scientific assumptions against empirical data, and implement these insights into efficient software. Large language models (LLMs) have demonstrated strong capabilities in synthesizing literature, reasoning with empirical data, and generating domain-specific code, offering new opportunities to accelerate computational method development. Existing LLM-based systems either focus on performing scientific analyses using existing computational methods or on developing computational methods or models for general machine learning without effectively integrating the often unstructured knowledge specific to scientific domains. Here, we introduce TusoAI , an agentic AI system that takes a scientific task description with an evaluation function and autonomously develops and optimizes computational methods for the application. TusoAI integrates domain knowledge into a knowledge tree representation and performs iterative, domain-specific optimization and model diagnosis, improving performance over a pool of candidate solutions. We conducted comprehensive benchmark evaluations demonstrating that TusoAI outperforms state-of-the-art expert methods, MLE agents, and scientific AI agents across diverse tasks, such as single-cell RNA-seq data denoising and satellite-based earth monitoring. Applying TusoAI to two key open problems in genetics improved existing computational methods and uncovered novel biology, including 9 new associations between autoimmune diseases and T cell subtypes and 7 previously unreported links between disease variants linked to their target genes. Our code is publicly available at https://github.com/Alistair-Turcan/TusoAI.

Preference alignment is a critical step in making Large Language Models (LLMs) useful and aligned with (human) preferences. Existing approaches such as Reinforcement Learning from Human Feedback or Direct Preference Optimization typically require curated data and expensive optimization over billions of parameters, and eventually lead to persistent task-specific models. In this work, we introduce Preference alignment of Large Language Models via Residual Steering (PaLRS), a training-free method that exploits preference signals encoded in the residual streams of LLMs. From as few as one hundred preference pairs, PaLRS extracts lightweight, plug-and-play steering vectors that can be applied at inference time to push models toward preferred behaviors. We evaluate PaLRS on various small-to-medium-scale open-source LLMs, showing that PaLRS-aligned models achieve consistent gains on mathematical reasoning and code generation benchmarks while preserving baseline general-purpose performance. Moreover, when compared to DPO-aligned models, they perform better with huge time savings. Our findings highlight that PaLRS offers an effective, much more efficient and flexible alternative to standard preference optimization pipelines, offering a training-free, plug-and-play mechanism for alignment with minimal data.

Hoffman et al (2022)'s Chinchilla paper introduced the principle of compute-optimal scaling, laying a foundation for future scaling of language models. In the years since, however, valid concerns about Chinchilla have been raised: wide confidence intervals, discrepancies between its three approaches, and incongruities with other scaling laws. This raises a critical question for the field: Can practitioners still rely on Chinchilla's prescriptions? Our work demonstrates the answer is yes. We begin by uncovering that the model parameters central to Chinchilla's analyses were ambiguous: three interpretations are possible, with relative differences between different interpretations of model parameters as high as 15.2%. We find that, perhaps surprisingly, which model parameters are used for the analyses do not meaningfully affect key results: the scaling law estimates and the compute-optimal tokens-to-parameter ratio. Indeed, under one interpretation, the tokens-to-parameter ratio becomes more constant with the target compute budget. We then ask how distorted the Chinchilla model parameters could have been without meaningfully affecting the key results. By deliberately perturbing model parameters in four structured ways, we find that key Chinchilla results are most sensitive to additive or systematic errors, which can alter the otherwise flat trend of the optimal tokens-to-parameter ratio, but overall, Chinchilla's key results withstand sizable perturbations. Altogether, our findings offer the field renewed confidence in Chinchilla as a durable guide for scaling language models.

Reinforcement Learning with Verifiable Rewards (RLVR) for large language models (LLMs) has achieved remarkable progress in enhancing LLMs' reasoning capabilities on tasks with clear correctness criteria, such as mathematical reasoning tasks. Several training metrics, such as entropy or response length, have been observed to correlate with different reasoning behaviors in reinforcement learning. Prior approaches incorporate such priors through reward or advantage shaping, which often relies on hand-crafted penalties and preferences (e.g., higher-is-better or lower-is-better). However, without careful hyperparameter tuning, these directional priors can be overly biased and may lead to failure. To this end, we introduce Conditional advANtage estimatiON (CANON), amplifying the impact of the target metric without presuming its direction. Specifically, CANON regroups the sampled responses into two groups based on the higher or lower value of a target metric, measures which metric trend contributes to better performance through inter-group comparison, and identifies the better response within the same group. In summary, CANON based on entropy consistently outperforms prior methods across three LLMs on both math reasoning and high-complexity logic tasks. When applied to response length, CANON further improves token efficiency, yielding a more favorable Pareto frontier in the performance-cost trade-off.

Context: Deep Neural Networks (DNNs) are increasingly deployed in critical applications, where resilience against adversarial inputs is paramount. However, whether coverage-based or confidence-based, existing test prioritization methods often fail to efficiently identify the most fault-revealing inputs, limiting their practical effectiveness. Aims: This project aims to enhance fault detection and model robustness in DNNs by integrating Learning-Based Testing (LBT) with hypothesis and mutation testing to efficiently prioritize adversarial test cases. Methods: Our method selects a subset of adversarial inputs with a high likelihood of exposing model faults, without relying on architecture-specific characteristics or formal verification, making it adaptable across diverse DNNs. Results: Our results demonstrate that the proposed LBT method consistently surpasses baseline approaches in prioritizing fault-revealing inputs and accelerating fault detection. By efficiently organizing test permutations, it uncovers all potential faults significantly faster across various datasets, model architectures, and adversarial attack techniques. Conclusion: Beyond improving fault detection, our method preserves input diversity and provides effective guidance for model retraining, further enhancing robustness. These advantages establish our approach as a powerful and practical solution for adversarial test prioritization in real-world DNN applications.

Mixture-of-Experts (MoE) architectures have emerged as a promising direction, offering efficiency and scalability by activating only a subset of parameters during inference. However, current research remains largely performance-centric, with limited understanding of its internal mechanisms, thereby constraining broader progress. In this work, we use an internal metric to investigate the mechanisms of MoE architecture by explicitly incorporating routing mechanisms and analyzing expert-level behaviors. Through systematic analyses of a wide range of publicly available MoE models, we uncover several findings: (1) neuron utilization decreases as models evolve, reflecting stronger generalization; (2) training exhibits a dynamic trajectory, where benchmark performance alone provides limited signal while MUI reveals deeper insights; (3) task completion emerges from collaborative contributions of multiple experts, with shared experts driving concentration; and (4) activation patterns at the neuron level provide a fine-grained proxy for data diversity. Together, these results demonstrate the potential of MUI as a complementary indicator to benchmark performance, offering new insights into the capacity, dynamics, and specialization of MoE models. Our project can be found at https://yingjiahao14.github.io/MoE-MUI/.

Masked diffusion language models (MDLMs) have recently emerged as a promising alternative to autoregressive (AR) language models, offering properties such as parallel decoding, flexible generation orders, and the potential for fewer inference steps. Despite these advantages, decoding strategies and reinforcement learning (RL) algorithms tailored for MDLMs remain underexplored. A naive approach is to directly transfer techniques well-established for AR models to MDLMs. However, this raises an immediate question: Is such a naive transfer truly optimal? For example, 1) Block-wise and semi-AR decoding strategies are not employed during the training of MDLMs, so why do they outperform full diffusion-style decoding during inference? 2) Applying RL algorithms designed for AR models directly to MDLMs exhibits a training-inference inconsistency, since MDLM decoding are non-causal (parallel). This results in inconsistencies between the rollout trajectory and the optimization trajectory. To address these challenges, we propose EOS Early Rejection (EOSER) and Ascending Step-Size (ASS) decoding scheduler, which unlock the potential of MDLMs to perform full diffusion-style decoding, achieving competitive performance with fewer decoding steps. Additionally, we introduce Consistency Trajectory Group Relative Policy Optimization (CJ-GRPO) for taming MDLMs, which emphasizes the consistency between rollout trajectory and optimization trajectory, and reduces the optimization errors caused by skip-step optimization. We conduct extensive experiments on reasoning tasks, such as mathematical and planning benchmarks, using LLaDA-8B-Instruct. The results demonstrate that the proposed EOSER and ASS mechanisms, together with CJ-GRPO, hold significant promise for effectively and efficiently taming MDLMs. Code: https://github.com/yjyddq/EOSER-ASS-RL.