Computational Imaging Research Lab, Department of Biomedical Imaging and Image - guided Therapy, Medical University of Vienna, Austria . Abstract (2 50 words) Background We aimed to quantify hepatic vessel volumes across chronic liver disease stages and healthy controls using deep learning - based magnetic resonance imaging ( MRI) analysis, and assess correlations with biomarkers for liver (dys)function and fibrosis/portal hypertension. Methods We assessed retrospectively healthy controls, non - advanced and advanced chronic liver disease (ACLD) patients using a 3D U - Net model for hepatic vessel segmentation on portal venous phase gadoxetic acid - enhanced 3 - T MRI. Total (TVVR), hepatic (HVVR), and intrahepatic portal vein - to - volume ratios (PVVR) were compared between groups and c orrelat ed with: a lbumin - b ilirubin [ ALBI ] and "m odel for e nd - s tage l iver d isease - s odium " [ MELD - Na ] s core) and fibrosis/portal hypertension (Fibrosis - 4 [ FIB - 4 ] Score, liver stiffness measurement [ LSM ], hepatic venous pressure gradient [ HVPG ], platelet count [ PLT ], and spleen volume. Results We included 197 subjects, aged 54.9 13.8 years (mean standard deviation), 111 males ( 56 .3 TVVR and HVVR were highest in controls (3.9; 2.1), intermediate in non - ACLD (2.8; 1.7), and lowest in ACLD patients (2.3; 1.0) ( p 0. 001) . PVVR was reduced in both non - ACLD and ACLD patients (both 1.2) compared to controls (1.7) ( p 0. 001), but showed no difference between CLD groups ( p = 0.999) . TVVR and PVVR showed similar but weaker correlations. Conclusion s Deep learning - based hepatic vessel volumetry demonstrate d differences between healthy liver and chronic liver disease stages and shows correlations with established markers of disease severity. Relevance s tatement Hepatic vessel volumetry demonstrates differences between healthy liver and chronic liver disease stages, potentially serving as a non - invasive imaging biomarker.

Recently, Ainsworth et al. empirically demonstrated that, given two independently trained models, applying a parameter permutation that preserves the input-output behavior allows the two models to be connected by a low-loss linear path. When such a path exists, the models are said to achieve linear mode connectivity (LMC). Prior studies, including Ainsworth et al., have reported that achieving LMC requires not only an appropriate permutation search but also sufficiently wide models (e.g., a 32 $\times$ width multiplier for ResNet-20). This is broadly believed to be because increasing the model width ensures a large enough space of candidate permutations, increasing the chance of finding one that yields LMC. In this work, we empirically demonstrate that, even without any permutations, simply widening the models is sufficient for achieving LMC when using a suitable softmax temperature calibration. We further explain why this phenomenon arises by analyzing intermediate layer outputs. Specifically, we introduce layerwise exponentially weighted connectivity (LEWC), which states that the output of each layer of the merged model can be represented as an exponentially weighted sum of the outputs of the corresponding layers of the original models. Consequently the merged model's output matches that of an ensemble of the original models, which facilitates LMC. To the best of our knowledge, this work is the first to show that widening the model not only facilitates nonlinear mode connectivity, as suggested in prior research, but also significantly increases the possibility of achieving linear mode connectivity.

Model merging (MM) recently emerged as an effective method for combining large deep learning models. However, it poses significant security risks. Recent research shows that it is highly susceptible to backdoor attacks, which introduce a hidden trigger into a single fine-tuned model instance that allows the adversary to control the output of the final merged model at inference time. In this work, we propose a simple framework for understanding backdoor attacks by treating the attack itself as a task vector. $Backdoor\ Vector\ (BV)$ is calculated as the difference between the weights of a fine-tuned backdoored model and fine-tuned clean model. BVs reveal new insights into attacks understanding and a more effective framework to measure their similarity and transferability. Furthermore, we propose a novel method that enhances backdoor resilience through merging dubbed $Sparse\ Backdoor\ Vector\ (SBV)$ that combines multiple attacks into a single one. We identify the core vulnerability behind backdoor threats in MM: $inherent\ triggers$ that exploit adversarial weaknesses in the base model. To counter this, we propose $Injection\ BV\ Subtraction\ (IBVS)$ - an assumption-free defense against backdoors in MM. Our results show that SBVs surpass prior attacks and is the first method to leverage merging to improve backdoor effectiveness. At the same time, IBVS provides a lightweight, general defense that remains effective even when the backdoor threat is entirely unknown.

Recent research has extensively studied how large language models manipulate integers in specific arithmetic tasks, and on a more fundamental level, how they represent numeric values. These previous works have found that language model embeddings can be used to reconstruct the original values, however, they do not evaluate whether language models actually model continuous values as continuous. Using expected properties of the embedding space, including linear reconstruction and principal component analysis, we show that language models not only represent numeric spaces as non-continuous but also introduce significant noise. Using models from three major providers (OpenAI, Google Gemini and Voyage AI), we show that while reconstruction is possible with high fidelity ($R^2 \geq 0.95$), principal components only explain a minor share of variation within the embedding space. This indicates that many components within the embedding space are orthogonal to the simple numeric input space. Further, both linear reconstruction and explained variance suffer with increasing decimal precision, despite the ordinal nature of the input space being fundamentally unchanged. The findings of this work therefore have implications for the many areas where embedding models are used, in-particular where high numerical precision, large magnitudes or mixed-sign values are common.

Numerous computational costs have been invested in existing well-trained checkpoints, but many of them remain underuti-lized due to engineering constraints or limited model capacity. To efficiently reuse this "sunk" cost, we propose to recycle pretrained checkpoints by expanding their parameter counts and continuing training. We propose orthogonal growth method well-suited for converged Mixture-of-Experts model: interpositional layer copying for depth growth and expert duplication with injected noise for width growth. To determine the optimal timing for such growth across checkpoints sequences, we perform comprehensive scaling experiments revealing that the final accuracy has a strong positive correlation with the amount of sunk cost, indicating that greater prior investment leads to better performance. We scale our approach to models with 70B parameters and over 1T training tokens, achieving 10.66% accuracy gain over training from scratch under the same additional compute budget. Our checkpoint recycling approach establishes a foundation for economically efficient large language model pretraining. The unprecedented success of large language models (LLMs) has been largely attributed to scaling laws (Kaplan et al., 2020; Hoffmann et al., 2022), which suggest that increasing model size However, training these models from scratch demands enormous computational resources, and the exponential growth of this cost poses a fundamental barrier to further progress. Consequently, developing methods to scale models efficiently under constrained computational budgets has become a critical research challenge. Modern LLM development pipelines routinely produce smaller pre-trained model checkpoints and numerous intermediate artifacts from processes like hyperparameter tuning or preliminary evaluations. These models are often discarded once training concludes, leaving much of their potential unrealized due to inherent size constraints.

Large Language Models have demonstrated remarkable capabilities across diverse domains, yet significant challenges persist when deploying them as AI agents for real-world long-horizon tasks. Existing LLM agents suffer from a critical limitation: they are test-time static and cannot learn from experience, lacking the ability to accumulate knowledge and continuously improve on the job. To address this challenge, we propose MUSE, a novel agent framework that introduces an experience-driven, self-evolving system centered around a hierarchical Memory Module. MUSE organizes diverse levels of experience and leverages them to plan and execute long-horizon tasks across multiple applications. After each sub-task execution, the agent autonomously reflects on its trajectory, converting the raw trajectory into structured experience and integrating it back into the Memory Module. This mechanism enables the agent to evolve beyond its static pretrained parameters, fostering continuous learning and self-evolution. We evaluate MUSE on the long-horizon productivity benchmark TAC. It achieves new SOTA performance by a significant margin using only a lightweight Gemini-2.5 Flash model. Sufficient Experiments demonstrate that as the agent autonomously accumulates experience, it exhibits increasingly superior task completion capabilities, as well as robust continuous learning and self-evolution capabilities. Moreover, the accumulated experience from MUSE exhibits strong generalization properties, enabling zero-shot improvement on new tasks. MUSE establishes a new paradigm for AI agents capable of real-world productivity task automation.

Query-product relevance analysis is a foundational technology in e-commerce search engines and has become increasingly important in AI-driven e-commerce. The recent emergence of large language models (LLMs), particularly their chain-of-thought (CoT) reasoning capabilities, offers promising opportunities for developing relevance systems that are both more interpretable and more robust. However, existing training paradigms have notable limitations: SFT and DPO suffer from poor generalization on long-tail queries and from a lack of fine-grained, stepwise supervision to enforce rule-aligned reasoning. In contrast, reinforcement learning with verification rewards (RLVR) suffers from sparse feedback, which provides insufficient signal to correct erroneous intermediate steps, thereby undermining logical consistency and limiting performance in complex inference scenarios. To address these challenges, we introduce the Stepwise Hybrid Examination Reinforcement Learning framework for Taobao Search Relevance (TaoSR-SHE). At its core is Stepwise Reward Policy Optimization (SRPO), a reinforcement learning algorithm that leverages step-level rewards generated by a hybrid of a high-quality generative stepwise reward model and a human-annotated offline verifier, prioritizing learning from critical correct and incorrect reasoning steps. TaoSR-SHE further incorporates two key techniques: diversified data filtering to encourage exploration across varied reasoning paths and mitigate policy entropy collapse, and multi-stage curriculum learning to foster progressive capability growth. Extensive experiments on real-world search benchmarks show that TaoSR-SHE improves both reasoning quality and relevance-prediction accuracy in large-scale e-commerce settings, outperforming SFT, DPO, GRPO, and other baselines, while also enhancing interpretability and robustness.

Climate policy studies require models that capture the combined effects of multiple greenhouse gases on global temperature, but these models are computationally expensive and difficult to embed in reinforcement learning. We present a multi-agent reinforcement learning (MARL) framework that integrates a high-fidelity, highly efficient climate surrogate directly in the environment loop, enabling regional agents to learn climate policies under multi-gas dynamics. As a proof of concept, we introduce a recurrent neural network architecture pretrained on ($20{,}000$) multi-gas emission pathways to surrogate the climate model CICERO-SCM. The surrogate model attains near-simulator accuracy with global-mean temperature RMSE $\approx 0.0004 \mathrm{K}$ and approximately $1000\times$ faster one-step inference. When substituted for the original simulator in a climate-policy MARL setting, it accelerates end-to-end training by $>\!100\times$. We show that the surrogate and simulator converge to the same optimal policies and propose a methodology to assess this property in cases where using the simulator is intractable. Our work allows to bypass the core computational bottleneck without sacrificing policy fidelity, enabling large-scale multi-agent experiments across alternative climate-policy regimes with multi-gas dynamics and high-fidelity climate response.

In single-cell perturbation prediction, a central task is to forecast the effects of perturbing a gene unseen in the training data. The efficacy of such predictions depends on two factors: (1) the similarity of the target gene to those covered in the training data, which informs model (epistemic) uncertainty, and (2) the quality of the corresponding training data, which reflects data (aleatoric) uncertainty. Both factors are critical for determining the reliability of a prediction, particularly as gene perturbation is an inherently stochastic biochemical process. In this paper, we propose PRESCRIBE (PREdicting Single-Cell Response wIth Bayesian Estimation), a multivariate deep evidential regression framework designed to measure both sources of uncertainty jointly. Our analysis demonstrates that PRESCRIBE effectively estimates a confidence score for each prediction, which strongly correlates with its empirical accuracy. This capability enables the filtering of untrustworthy results, and in our experiments, it achieves steady accuracy improvements of over 3% compared to comparable baselines.

Large language models (LLMs) have demonstrated remarkable progress in reasoning, often through supervised fine-tuning (SFT). However, SFT is resource-intensive, relying on large curated datasets, rejection-sampled demonstrations, and uniform optimization across all tokens, even though only a fraction carry meaningful learning value. In this work, we explore a counterintuitive idea: can smaller language models (SLMs) teach larger language models (LLMs) by revealing high-value reasoning moments that reflect the latter's unique strength? We propose LightReasoner, a novel framework that leverages the behavioral divergence between a stronger expert model (LLM) and a weaker amateur model (SLM). LightReasoner operates in two stages: (1) a sampling stage that pinpoints critical reasoning moments and constructs supervision examples capturing the expert's advantage through expert-amateur contrast, and (2) a fine-tuning stage that aligns the expert model with these distilled examples, amplifying its reasoning strengths. Across seven mathematical benchmarks, LightReasoner improves accuracy by up to 28.1%, while reducing time consumption by 90%, sampled problems by 80%, and tuned token usage by 99%, all without relying on ground-truth labels. By turning weaker SLMs into effective teaching signals, LightReasoner offers a scalable and resource-efficient approach for advancing LLM reasoning. Code is available at: https://github.com/HKUDS/LightReasoner