Neurodegeneration, characterized by the progressive loss of neuronal structure or function, is commonly assessed in clinical practice through reductions in cortical thickness or brain volume, as visualized by structural MRI. While informative, these conventional approaches lack the statistical sophistication required to fully capture the spatially correlated and heterogeneous nature of neurodegeneration, which manifests both in healthy aging and in neurological disorders. To address these limitations, brain age gap has emerged as a promising data-driven biomarker of brain health. The brain age gap prediction (BAGP) models estimate the difference between a person's predicted brain age from neuroimaging data and their chronological age. The resulting brain age gap serves as a compact biomarker of brain health, with recent studies demonstrating its predictive utility for disease progression and severity. However, practical adoption of BAGP models is hindered by their methodological obscurities and limited generalizability across diverse clinical populations. This tutorial article provides an overview of BAGP and introduces a principled framework for this application based on recent advancements in graph signal processing (GSP). In particular, we focus on graph neural networks (GNNs) and introduce the coVariance neural network (VNN), which leverages the anatomical covariance matrices derived from structural MRI. VNNs offer strong theoretical grounding and operational interpretability, enabling robust estimation of brain age gap predictions. By integrating perspectives from GSP, machine learning, and network neuroscience, this work clarifies the path forward for reliable and interpretable BAGP models and outlines future research directions in personalized medicine.

Deep neural networks are highly susceptible to adversarial attacks, which pose significant risks to security- and safety-critical applications. We present KoALA (KL-L0 Adversarial detection via Label Agreement), a novel, semantics-free adversarial detector that requires no architectural changes or adversarial retraining. KoALA operates on a simple principle: it detects an adversarial attack when class predictions from two complementary similarity metrics disagree. These metrics-KL divergence and an L0-based similarity-are specifically chosen to detect different types of perturbations. The KL divergence metric is sensitive to dense, low-amplitude shifts, while the L0-based similarity is designed for sparse, high-impact changes. We provide a formal proof of correctness for our approach. The only training required is a simple fine-tuning step on a pre-trained image encoder using clean images to ensure the embeddings align well with both metrics. This makes KOALA a lightweight, plug-and-play solution for existing models and various data modalities. Our extensive experiments on ResNet/CIFAR-10 and CLIP/Tiny-ImageNet confirm our theoretical claims. When the theorem's conditions are met, KoALA consistently and effectively detects adversarial examples. On the full test sets, KoALA achieves a precision of 0.94 and a recall of 0.81 on ResNet/CIFAR-10, and a precision of 0.66 and a recall of 0.85 on CLIP/Tiny-ImageNet.

Multimodal Large Language Models (MLLMs) have demonstrated significant capabilities in joint visual and linguistic tasks. However, existing Visual Question Answering (VQA) benchmarks often fail to evaluate deep semantic understanding, particularly in complex domains like visual art analysis. Confined to simple syntactic structures and surface-level attributes, these questions fail to capture the diversity and depth of human visual inquiry. This limitation incentivizes models to exploit statistical shortcuts rather than engage in visual reasoning. To address this gap, we introduce VQArt-Bench, a new, large-scale VQA benchmark for the cultural heritage domain. This benchmark is constructed using a novel multi-agent pipeline where specialized agents collaborate to generate nuanced, validated, and linguistically diverse questions. The resulting benchmark is structured along relevant visual understanding dimensions that probe a model's ability to interpret symbolic meaning, narratives, and complex visual relationships. Our evaluation of 14 state-of-the-art MLLMs on this benchmark reveals significant limitations in current models, including a surprising weakness in simple counting tasks and a clear performance gap between proprietary and open-source models.

A long-standing challenge in machine learning has been the rigid separation between data work and model refinement, enforced by slow fine-tuning cycles. The rise of Large Language Models (LLMs) overcomes this historical barrier, allowing applications developers to instantly govern model behavior by editing prompt instructions. This shift enables a new paradigm: data-model co-evolution, where a living test set and a model's instructions evolve in tandem. We operationalize this paradigm in an interactive system designed to address the critical challenge of encoding subtle, domain-specific policies into prompt instructions. The system's structured workflow guides people to discover edge cases, articulate rationales for desired behavior, and iteratively evaluate instruction revisions against a growing test set. A user study shows our workflow helps participants refine instructions systematically and specify ambiguous policies more concretely. This work points toward more robust and responsible LLM applications through human-in-the-loop development aligned with local preferences and policies.

In this paper, we presents a novel hierarchical federated learning architecture specifically designed for smart agricultural production systems and crop yield prediction. Our approach introduces a seasonal subscription mechanism where farms join crop-specific clusters at the beginning of each agricultural season. The proposed three-layer architecture consists of individual smart farms at the client level, crop-specific aggregators at the middle layer, and a global model aggregator at the top level. Within each crop cluster, clients collaboratively train specialized models tailored to specific crop types, which are then aggregated to produce a higher-level global model that integrates knowledge across multiple crops. This hierarchical design enables both local specialization for individual crop types and global generalization across diverse agricultural contexts while preserving data privacy and reducing communication overhead. Experiments demonstrate the effectiveness of the proposed system, showing that local and crop-layer models closely follow actual yield patterns with consistent alignment, significantly outperforming standard machine learning models. The results validate the advantages of hierarchical federated learning in the agricultural context, particularly for scenarios involving heterogeneous farming environments and privacy-sensitive agricultural data.

Whether language models (LMs) have inductive biases that favor typologically frequent grammatical properties over rare, implausible ones has been investigated, typically using artificial languages (ALs) (White and Cotterell, 2021; Kuribayashi et al., 2024). In this paper, we extend these works from two perspectives. First, we extend their context-free AL formalization by adopting Generalized Categorial Grammar (GCG) (Wood, 2014), which allows ALs to cover attested but previously overlooked constructions, such as unbounded dependency and mildly context-sensitive structures. Second, our evaluation focuses more on the generalization ability of LMs to process unseen longer test sentences. Thus, our ALs better capture features of natural languages and our experimental paradigm leads to clearer conclusions -- typologically plausible word orders tend to be easier for LMs to productively generalize.

Large Language Models (LLMs) typically rely on a large number of parameters for token embedding, leading to substantial storage requirements and memory footprints. In particular, LLMs deployed on edge devices are memory-bound, and reducing the memory footprint by compressing the embedding layer not only frees up the memory bandwidth but also speeds up inference. To address this, we introduce CARVQ, a post-training novel Corrective Adaptor combined with group Residual Vector Quantization. CARVQ relies on the composition of both linear and non-linear maps and mimics the original model embedding to compress to approximately 1.6 bits without requiring specialized hardware to support lower-bit storage. We test our method on pre-trained LLMs such as LLaMA-3.2-1B, LLaMA-3.2-3B, LLaMA-3.2-3B-Instruct, LLaMA-3.1-8B, Qwen2.5-7B, Qwen2.5-Math-7B and Phi-4, evaluating on common generative, discriminative, math and reasoning tasks. We show that in most cases, CARVQ can achieve lower average bitwidth-per-parameter while maintaining reasonable perplexity and accuracy compared to scalar quantization. Our contributions include a novel compression technique that is compatible with state-of-the-art transformer quantization methods and can be seamlessly integrated into any hardware supporting 4-bit memory to reduce the model's memory footprint in memory-constrained devices. This work demonstrates a crucial step toward the efficient deployment of LLMs on edge devices.

Fine-grained perception of multimodal information is critical for advancing human-AI interaction. With recent progress in audio-visual technologies, Omni Language Models (OLMs), capable of processing audio and video signals in parallel, have emerged as a promising paradigm for achieving richer understanding and reasoning. However, their capacity to capture and describe fine-grained details remains limited explored. In this work, we present a systematic and comprehensive investigation of omni detailed perception from the perspectives of the data pipeline, models, and benchmark. We first identify an inherent "co-growth" between detail and hallucination in current OLMs. To address this, we propose Omni-Detective, an agentic data generation pipeline integrating tool-calling, to autonomously produce highly detailed yet minimally hallucinatory multimodal data. Based on the data generated with Omni-Detective, we train two captioning models: Audio-Captioner for audio-only detailed perception, and Omni-Captioner for audio-visual detailed perception. Under the cascade evaluation protocol, Audio-Captioner achieves the best performance on MMAU and MMAR among all open-source models, surpassing Gemini 2.5 Flash and delivering performance comparable to Gemini 2.5 Pro. On existing detailed captioning benchmarks, Omni-Captioner sets a new state-of-the-art on VDC and achieves the best trade-off between detail and hallucination on the video-SALMONN 2 testset. Given the absence of a dedicated benchmark for omni detailed perception, we design Omni-Cloze, a novel cloze-style evaluation for detailed audio, visual, and audio-visual captioning that ensures stable, efficient, and reliable assessment. Experimental results and analysis demonstrate the effectiveness of Omni-Detective in generating high-quality detailed captions, as well as the superiority of Omni-Cloze in evaluating such detailed captions.

Chemical pretrained models, sometimes referred to as foundation models, are receiving considerable interest for drug discovery applications. The general chemical knowledge extracted from self-supervised training has the potential to improve predictions for critical drug discovery endpoints, including on-target potency and ADMET properties. Multi-task learning has previously been successfully leveraged to improve predictive models. Here, we show that enabling multitasking in finetuning of chemical pretrained graph neural network models such as Kinetic GROVER Multi-Task (KERMT), an enhanced version of the GROVER model, and Knowledge-guided Pre-training of Graph Transformer (KGPT) significantly improves performance over non-pretrained graph neural network models. Surprisingly, we find that the performance improvement from finetuning KERMT in a multitask manner is most significant at larger data sizes. Additionally, we publish two multitask ADMET data splits to enable more accurate benchmarking of multitask deep learning methods for drug property prediction. Finally, we provide an accelerated implementation of the KERMT model on GitHub, unlocking large-scale pretraining, finetuning, and inference in industrial drug discovery workflows.

KEY WORDS: Artificial Intelligence (AI), Theranostics, Dosimetry, Radiopharmaceutical Therapy (RPT), Patient-friendly dosimetry KEY POINTS - The rapid evolution of radiopharmaceutical therapy (RPT) highlights the growing need for personalized and patient-centered dosimetry. - Artificial Intelligence (AI) offers solutions to the key limitations in current dosimetry calculations. - The main advances on AI for simplified dosimetry toward patient-friendly RPT are reviewed. - Future directions on the role of AI in RPT dosimetry are discussed.