Chain-of-thought (CoT) rationales, which provide step-by-step reasoning to derive final answers, benefit LLMs in both inference and training. Incorporating rationales, either by generating them before answering during inference, or by placing them before or after the original answers during training - significantly improves model performance on mathematical, symbolic and commonsense reasoning tasks. However, most work focuses on the role of rationales in these reasoning tasks, overlooking their potential impact on other important tasks like natural language understanding (NLU) tasks. In this work, we raise the question: Can rationales similarly benefit NLU tasks? To conduct a systematic exploration, we construct NLURC, a comprehensive and high-quality NLU dataset collection with rationales, and develop various rationale-augmented methods. Through exploring the applicability of these methods on NLU tasks using the dataset, we uncover several potentially surprising findings: (1) CoT inference shifts from hindering NLU performance to surpassing direct label prediction as model size grows, indicating a positive correlation. (2) Most rationale-augmented training methods perform worse than label-only training, with one specially designed method consistently achieving improvements. (3) LLMs trained with rationales achieve significant performance gains on unseen NLU tasks, rivaling models ten times their size, while delivering interpretability on par with commercial LLMs.

We present a compact, strictly causal benchmark for streaming clinical time series on the MIT--BIH Arrhythmia Database using per-second heart rate. Two tasks are studied under record-level, non-overlapping splits: near-term tachycardia risk (next ten seconds) and one-step heart rate forecasting. We compare a GRU-D (RNN) and a Transformer under matched training budgets against strong non-learned baselines. Evaluation is calibration-aware for classification and proper for forecasting, with temperature scaling and grouped bootstrap confidence intervals. On MIT-BIH, GRU-D slightly surpasses the Transformer for tachycardia risk, while the Transformer clearly lowers forecasting error relative to GRU-D and persistence. Our results show that, in longitudinal monitoring, model choice is task-dependent: compact RNNs remain competitive for short-horizon risk scoring, whereas compact Transformers deliver clearer gains for point forecasting.

Protein-protein docking tools help in studying interactions between proteins, and are essential for drug, vaccine, and therapeutic development. However, the accuracy of a docking tool depends on a robust scoring function that can reliably differentiate between native and non-native complexes. PIsToN is a state-of-the-art deep learning-based scoring function that uses Vision Transformers in its architecture. Recently, the Mamba architecture has demonstrated exceptional performance in both natural language processing and computer vision, often outperforming Transformer-based models in their domains. In this study, we introduce PUMBA (Protein-protein interface evaluation with Vision Mamba), which improves PIsToN by replacing its Vision Transformer backbone with Vision Mamba. This change allows us to leverage Mamba's efficient long-range sequence modeling for sequences of image patches. As a result, the model's ability to capture both global and local patterns in protein-protein interface features is significantly improved. Evaluation on several widely-used, large-scale public datasets demonstrates that PUMBA consistently outperforms its original Transformer-based predecessor, PIsToN.

Prompt-based learning has emerged as a parameter-efficient finetuning (PEFT) approach to facilitate Large Language Model (LLM) adaptation to downstream tasks by conditioning generation with task-aware guidance. Despite its successes, current prompt-based learning methods heavily rely on laborious grid searching for optimal prompt length and typically require considerable number of prompts, introducing additional computational burden. Worse yet, our pioneer findings indicate that the task-aware prompt design is inherently limited by its absence of instance-aware information, leading to a subtle attention interplay with the input sequence. In contrast, simply incorporating instance-aware information as a part of the guidance can enhance the prompt-tuned model performance without additional fine-tuning. Moreover, we find an interesting phenomenon, namely "attention anchor", that incorporating instance-aware tokens at the earliest position of the sequence can successfully preserve strong attention to critical structural information and exhibit more active attention interaction with all input tokens. In light of our observation, we introduce Capsule Prompt-Tuning (CaPT), an efficient and effective solution that leverages off-the-shelf, informative instance semantics into prompt-based learning. Our approach innovatively integrates both instance-aware and task-aware information in a nearly parameter-free manner (i.e., one single capsule prompt). Empirical results demonstrate that our method can exhibit superior performance across various language tasks (e.g., 84.03\% average accuracy on T5-Large), serving as an "attention anchor," while enjoying high parameter efficiency (e.g., 0.003\% of model parameters on Llama3.2-1B).

We introduce Universal and Transferable Adversarial Perturbations (UTAP) for pathology foundation models that reveal critical vulnerabilities in their capabilities. Optimized using deep learning, UTAP comprises a fixed and weak noise pattern that, when added to a pathology image, systematically disrupts the feature representation capabilities of multiple pathology foundation models. Therefore, UTAP induces performance drops in downstream tasks that utilize foundation models, including misclassification across a wide range of unseen data distributions. In addition to compromising the model performance, we demonstrate two key features of UTAP: (1) universality: its perturbation can be applied across diverse field-of-views independent of the dataset that UTAP was developed on, and (2) transferability: its perturbation can successfully degrade the performance of various external, black-box pathology foundation models - never seen before. These two features indicate that UTAP is not a dedicated attack associated with a specific foundation model or image dataset, but rather constitutes a broad threat to various emerging pathology foundation models and their applications. We systematically evaluated UTAP across various state-of-the-art pathology foundation models on multiple datasets, causing a significant drop in their performance with visually imperceptible modifications to the input images using a fixed noise pattern. The development of these potent attacks establishes a critical, high-standard benchmark for model robustness evaluation, highlighting a need for advancing defense mechanisms and potentially providing the necessary assets for adversarial training to ensure the safe and reliable deployment of AI in pathology.

In order to provide a robot with the ability to understand and react to a user's natural language inputs, the natural language must be connected to the robot's underlying representations of the world. Recently, large language models (LLMs) and 3D scene graphs (3DSGs) have become a popular choice for grounding natural language and representing the world. In this work, we address the challenge of using LLMs with 3DSGs to ground natural language. Existing methods encode the scene graph as serialized text within the LLM's context window, but this encoding does not scale to large or rich 3DSGs. Instead, we propose to use a form of Retrieval Augmented Generation to select a subset of the 3DSG relevant to the task. We encode a 3DSG in a graph database and provide a query language interface (Cypher) as a tool to the LLM with which it can retrieve relevant data for language grounding. We evaluate our approach on instruction following and scene question-answering tasks and compare against baseline context window and code generation methods. Our results show that using Cypher as an interface to 3D scene graphs scales significantly better to large, rich graphs on both local and cloud-based models. This leads to large performance improvements in grounded language tasks while also substantially reducing the token count of the scene graph content. A video supplement is available at https://www.youtube.com/watch?v=zY_YI9giZSA.

Existing adversarial attacks often neglect perturbation sparsity, limiting their ability to model structural changes and to explain how deep neural networks (DNNs) process meaningful input patterns. We propose ATOS (Attack Through Overlapping Sparsity), a differentiable optimization framework that generates structured, sparse adversarial perturbations in element-wise, pixel-wise, and group-wise forms. For white-box attacks on image classifiers, we introduce the Overlapping Smoothed L0 (OSL0) function, which promotes convergence to a stationary point while encouraging sparse, structured perturbations. By grouping channels and adjacent pixels, ATOS improves interpretability and helps identify robust versus non-robust features. We approximate the L-infinity gradient using the logarithm of the sum of exponential absolute values to tightly control perturbation magnitude. On CIFAR-10 and ImageNet, ATOS achieves a 100% attack success rate while producing significantly sparser and more structurally coherent perturbations than prior methods. The structured group-wise attack highlights critical regions from the network's perspective, providing counterfactual explanations by replacing class-defining regions with robust features from the target class.

This study presents a three-step machine learning framework to predict bubbles in the S&P 500 stock market by combining financial news sentiment with macroeconomic indicators. Building on traditional econometric approaches, the proposed approach predicts bubble formation by integrating textual and quantitative data sources. In the first step, bubble periods in the S&P 500 index are identified using a right-tailed unit root test, a widely recognized real-time bubble detection method. The second step extracts sentiment features from large-scale financial news articles using natural language processing (NLP) techniques, which capture investor's expectations and behavioral patterns. In the final step, ensemble learning methods are applied to predict bubble occurrences based on both sentiment-based and macroeconomic predictors. Model performance is evaluated through k-fold cross-validation and compared against benchmark machine learning algorithms. Empirical results indicate that the proposed three-step ensemble approach significantly improves predictive accuracy and robustness, providing valuable early warning insights for investors, regulators, and policymakers in mitigating systemic financial risks.

Prompt optimization has emerged as an effective alternative to retraining for improving the performance of Large Language Models (LLMs). However, most existing approaches treat evaluation as a black box, relying solely on numerical scores while offering limited insight into why a prompt succeeds or fails. They also depend heavily on trial-and-error refinements, which are difficult to interpret and control. In this paper, we introduce MA-SAPO, a Multi-Agent framework for Score-Aware Prompt Optimization. Compared to prior methods, MA-SAPO explicitly couples evaluation outcomes with structured reasoning to guide systematic edits. The framework specifically consists of two stages: during the Reasoning Phase, agents collaboratively explain metric scores, diagnose weaknesses, and synthesize targeted refinements that are stored as reusable reasoning assets; during the Test Phase, agents retrieve these assets to analyze optimized prompts and apply only evidence-grounded edits. By turning evaluation signals into interpretable reasoning chains, MA-SAPO produces prompt refinements that are more transparent, auditable, and controllable. Experiments on the HelpSteer1/2 benchmarks demonstrate consistent improvements over single-pass prompting, retrieval-augmented baselines, and prior multi-agent strategies, validating the effectiveness of our approach.

This paper presents a vision-only autonomous flight system for small UAVs operating in controlled indoor environments. The system combines semantic segmentation with monocular depth estimation to enable obstacle avoidance, scene exploration, and autonomous safe landing operations without requiring GPS or expensive sensors such as LiDAR. A key innovation is an adaptive scale factor algorithm that converts non-metric monocular depth predictions into accurate metric distance measurements by leveraging semantic ground plane detection and camera intrinsic parameters, achieving a mean distance error of 14.4 cm. The approach uses a knowledge distillation framework where a color-based Support Vector Machine (SVM) teacher generates training data for a lightweight U-Net student network (1.6M parameters) capable of real-time semantic segmentation. For more complex environments, the SVM teacher can be replaced with a state-of-the-art segmentation model. Testing was conducted in a controlled 5x4 meter laboratory environment with eight cardboard obstacles simulating urban structures. Extensive validation across 30 flight tests in a real-world environment and 100 flight tests in a digital-twin environment demonstrates that the combined segmentation and depth approach increases the distance traveled during surveillance and reduces mission time while maintaining 100% success rates. The system is further optimized through end-to-end learning, where a compact student neural network learns complete flight policies from demonstration data generated by our best-performing method, achieving an 87.5% autonomous mission success rate. This work advances practical vision-based drone navigation in structured environments, demonstrating solutions for metric depth estimation and computational efficiency challenges that enable deployment on resource-constrained platforms.