Accurate and safe medication recommendations are critical for effective clinical decision-making, especially in multimorbidity cases. However, existing systems rely on point-wise prediction paradigms that overlook synergistic drug effects and potential adverse drug-drug interactions (DDIs). We propose FLAME, a finegrained list-wise alignment framework for large language models (LLMs), enabling drug-by-drug generation of drug lists. FLAME formulates recommendation as a sequential decision process, where each step adds or removes a single drug. To provide fine-grained learning signals, we devise step-wise Group Relative Policy Optimization (GRPO) with potential-based reward shaping, which explicitly models DDIs and optimizes the contribution of each drug to the overall prescription. Furthermore, FLAME enhances patient modeling by integrating structured clinical knowledge and collaborative information into the representation space of LLMs. Experiments on benchmark datasets demonstrate that FLAME achieves state-ofthe-art performance, delivering superior accuracy, controllable safety-accuracy trade-offs, and strong generalization across diverse clinical scenarios. Our code is available at https://github.com/cxfann/Flame.

We introduce Neural Green's Function, a neural solution operator for linear partial dif sitions.

The increasing capabilities of Large Language Models (LLMs) have raised concerns about their misuse in AI-generated plagiarism and social engineering. While various AI-generated text detectors have been proposed to mitigate these risks, many remain vulnerable to simple evasion techniques such as paraphrasing. However, recent detectors have shown greater robustness against such basic attacks. In this work, we introduce Adversarial Paraphrasing, a training-free attack framework that universally humanizes any AI-generated text to evade detection more effectively. Our approach leverages an off-the-shelf instruction-following LLM to paraphrase AI-generated content under the guidance of an AI text detector, producing adversarial examples that are specifically optimized to bypass detection. Extensive experiments show that our attack is both broadly effective and highly transferable across several detection systems. For instance, compared to simple paraphrasing attack--which, ironically, increases the true positive at 1% false positive (T@1%F) by 8.57% on RADAR and 15.03% on Fast-DetectGPT--adversarial paraphrasing, guided by OpenAI-RoBERTa-Large, reduces T@1%F by 64.49% on RADAR and a striking 98.96% on Fast-DetectGPT. Across a diverse set of detectors--including neural network-based, watermark-based, and zero-shot approaches--our attack achieves an average T@1%F reduction of 87.88% under the guidance of OpenAI-RoBERTa-Large. We also analyze the tradeoff between text quality and attack success to find that our method can significantly reduce detection rates, with mostly a slight degradation in text quality. Our adversarial setup highlights the need for more robust and resilient detection strategies in the light of increasingly sophisticated evasion techniques.

In domains such as molecular and protein generation, physical systems exhibit inherent symmetries that are critical to model. Two main strategies have emerged for learning invariant distributions: designing equivariant network architectures and using data augmentation to approximate equivariance. While equivariant architectures preserve symmetry by design, they often involve greater complexity and pose optimization challenges. Data augmentation, on the other hand, offers flexibility but may fall short in fully capturing symmetries. Our framework enhances both approaches by reducing training variance and providing a provably lower-variance gradient estimator.

AI agents today are mostly siloed -- they either retrieve and reason over vast amount of digital information and knowledge obtained online; or interact with the physical world through embodied perception, planning and action -- but rarely both. This separation limits their ability to solve tasks that require integrated physical and digital intelligence, such as cooking from online recipes, navigating with dynamic map data, or interpreting real-world landmarks using web knowledge. We introduce EMBODIEDWEBAGENTS, a novel paradigm for AI agents that fluidly bridge embodiment and web-scale reasoning.

This paper presents improved native unified multimodal models, i.e., Show-o2, that leverage autoregressive modeling and flow matching. Built upon a 3D causal variational autoencoder space, unified visual representations are constructed through a dual-path of spatial (-temporal) fusion, enabling scalability across image and video modalities while ensuring effective multimodal understanding and generation. Based on a language model, autoregressive modeling and flow matching are natively applied to the language head and flow head, respectively, to facilitate text token prediction and image/video generation. A two-stage training recipe is designed to effectively learn and scale to larger models. The resulting Show-o2 models demonstrate versatility in handling a wide range of multimodal understanding and generation tasks across diverse modalities, including text, images, and videos. Code and models are released at https://github.com/showlab/Show-o.

Recent advances in visual tokenizers have demonstrated their effectiveness for multimodal large language models and autoregressive generative models. However, most existing visual tokenizers rely on a fixed downsampling rate at a given visual resolution, and consequently produce a constant number of visual tokens, ignoring the fact that visual information of varying complexity warrant different token budgets. Motivated by this observation, we propose an adaptive video tokenizer "VaporTok" with two core contributions: Probabilistic Taildrop: We introduce a novel taildrop mechanism that learns a truncation index sampling distribution conditioned on visual complexity of the video.

Restoring images degraded by adverse weather remains a significant challenge due to the highly non-uniform and spatially heterogeneous nature of weather-induced artifacts, e.g., fine-grained rain streaks versus widespread haze. Accurately estimating the underlying degradation can intuitively provide restoration models with more targeted and effective guidance, enabling adaptive processing strategies. To this end, we propose a Morton-Order Degradation Estimation Mechanism (MODEM) for adverse weather image restoration. Central to MODEM is the Morton-Order 2D-Selective-Scan Module (MOS2D), which integrates Morton-coded spatial ordering with selective state-space models to capture long-range dependencies while preserving local structural coherence. Complementing MOS2D, we introduce a Dual Degradation Estimation Module (DDEM) that disentangles and estimates both global and local degradation priors.

We'll see how players react. Steam Next Fest has come around again, and this season, players may have some extra reason to look closely at the labels for whatever demos they test out. To do the math for you, that's 19.5 percent or just shy of a fifth of the games included in the showcase. The high prevalence is a bit surprising considering how many already released games have seen backlash from players when gen AI materials have been discovered. Many indie game leaders have also been particularly hawkish about when and how AI is used in development.

Variational quantum Eigensolver (VQE) is a leading candidate for harnessing quantum computers to advance quantum chemistry and materials simulations, yet its training efficiency deteriorates rapidly for large Hamiltonians. Two issues underlie this bottleneck: (i) the no-cloning theorem imposes a linear growth in circuit evaluations with the number of parameters per gradient step; and (ii) deeper circuits encounter barren plateaus (BPs), leading to exponentially increasing measurement overheads. To address these challenges, here we propose a deep learning framework, dubbed Titan, which identifies and freezes inactive parameters of a given ansätze at initialization for a specific class of Hamiltonians, reducing the optimization overhead without sacrificing accuracy. The motivation of Titan starts with our empirical findings that a subset of parameters consistently has negligible influence on training dynamics. Its design combines a theoretically grounded data construction strategy, ensuring each training example is informative and BP-resilient, with an adaptive neural architecture that generalizes across ansätze of varying sizes. Across benchmark transverse-field Ising models, Heisenberg models, and multiple molecule systems up to $30$ qubits, Titan achieves up to $3\times$ faster convergence and $40$-$60\%$ fewer circuit evaluations than state-of-the-art baselines, while matching or surpassing their estimation accuracy. By proactively trimming parameter space, Titan lowers hardware demands and offers a scalable path toward utilizing VQE to advance practical quantum chemistry and materials science.