As educational systems evolve, ensuring that assessment items remain aligned with content standards is essential for maintaining fairness and instructional relevance. Traditional human alignment reviews are accurate but slow and labor-intensive, especially across large item banks. This study examines whether Large Language Models (LLMs) can accelerate this process without sacrificing accuracy. Using over 12,000 item-skill pairs in grades K-5, we tested three LLMs (GPT-3.5 Turbo, GPT-4o-mini, and GPT-4o) across three tasks that mirror real-world challenges: identifying misaligned items, selecting the correct skill from the full set of standards, and narrowing candidate lists prior to classification. In Study 1, GPT-4o-mini correctly identified alignment status in approximately 83-94% of cases, including subtle misalignments. In Study 2, performance remained strong in mathematics but was lower for reading, where standards are more semantically overlapping. Study 3 demonstrated that pre-filtering candidate skills substantially improved results, with the correct skill appearing among the top five suggestions more than 95% of the time. These findings suggest that LLMs, particularly when paired with candidate filtering strategies, can significantly reduce the manual burden of item review while preserving alignment accuracy. We recommend the development of hybrid pipelines that combine LLM-based screening with human review in ambiguous cases, offering a scalable solution for ongoing item validation and instructional alignment.

Transformers face scalability challenges due to the quadratic cost of attention, which involves dense similarity computations between queries and keys. We propose CAMformer, a novel accelerator that reinterprets attention as an associative memory operation and computes attention scores using a voltage-domain Binary Attention Content Addressable Memory (BA-CAM). This enables constant-time similarity search through analog charge sharing, replacing digital arithmetic with physical similarity sensing. CAMformer integrates hierarchical two-stage top-k filtering, pipelined execution, and high-precision contextualization to achieve both algorithmic accuracy and architectural efficiency. Evaluated on BERT and Vision Transformer workloads, CAMformer achieves over 10x energy efficiency, up to 4x higher throughput, and 6-8x lower area compared to state-of-the-art accelerators--while maintaining near-lossless accuracy.

Domain-specific text embeddings are critical for clinical natural language processing, yet systematic comparisons across model architectures remain limited. This study evaluates ten transformer-based embedding models adapted for cardiology through Low-Rank Adaptation (LoRA) fine-tuning on 106,535 cardiology text pairs derived from authoritative medical textbooks. Results demonstrate that encoder-only architectures, particularly BioLinkBERT, achieve superior domain-specific performance (separation score: 0.510) compared to larger decoder-based models, while requiring significantly fewer computational resources. The findings challenge the assumption that larger language models necessarily produce better domain-specific embeddings and provide practical guidance for clinical NLP system development. All models, training code, and evaluation datasets are publicly available to support reproducible research in medical informatics.

Randomized controlled trials (RCTs) have been the cornerstone of clinical evidence; however, their cost, duration, and restrictive eligibility criteria limit power and external validity. Studies using real-world data (RWD), historically considered less reliable for establishing causality, are now recognized to be important for generating real-world evidence (RWE). In parallel, artificial intelligence and machine learning (AI/ML) are being increasingly used throughout the drug development process, providing scalability and flexibility but also presenting challenges in interpretability and rigor that traditional statistics do not face. This Perspective argues that the future of evidence generation will not depend on RCTs versus RWD, or statistics versus AI/ML, but on their principled integration. To this end, a causal roadmap is needed to clarify inferential goals, make assumptions explicit, and ensure transparency about tradeoffs. We highlight key objectives of integrative evidence synthesis, including transporting RCT results to broader populations, embedding AI-assisted analyses within RCTs, designing hybrid controlled trials, and extending short-term RCTs with long-term RWD. We also outline future directions in privacy-preserving analytics, uncertainty quantification, and small-sample methods. By uniting statistical rigor with AI/ML innovation, integrative approaches can produce robust, transparent, and policy-relevant evidence, making them a key component of modern regulatory science.

Unmanned Aerial Vehicles (UAVs) are crucial in Search and Rescue (SAR) missions due to their ability to monitor vast maritime areas. However, small objects often remain difficult to detect from high altitudes due to low object-to-background pixel ratios. We propose an altitude-aware dynamic tiling method that scales and adaptively subdivides the image into tiles for enhanced small object detection. By integrating altitude-dependent scaling with an adaptive tiling factor, we reduce unnecessary computation while maintaining detection performance. Tested on the SeaDronesSee dataset [1] with YOLOv5 [2] and Slicing Aided Hyper Inference (SAHI) framework [3], our approach improves Mean Average Precision (mAP) for small objects by 38% compared to a baseline and achieves more than double the inference speed compared to static tiling. This approach enables more efficient and accurate UAV-based SAR operations under diverse conditions.

Large Language Models (LLMs) remain vulnerable to prompt injection attacks, representing the most significant security threat in production deployments. We present Prompt Fencing, a novel architectural approach that applies cryptographic authentication and data architecture principles to establish explicit security boundaries within LLM prompts. Our approach decorates prompt segments with cryptographically signed metadata including trust ratings and content types, enabling LLMs to distinguish between trusted instructions and untrusted content. While current LLMs lack native fence awareness, we demonstrate that simulated awareness through prompt instructions achieved complete prevention of injection attacks in our experiments, reducing success rates from 86.7% (260/300 successful attacks) to 0% (0/300 successful attacks) across 300 test cases with two leading LLM providers. We implement a proof-of-concept fence generation and verification pipeline with a total overhead of 0.224 seconds (0.130s for fence generation, 0.094s for validation) across 100 samples. Our approach is platform-agnostic and can be incrementally deployed as a security layer above existing LLM infrastructure, with the expectation that future models will be trained with native fence awareness for optimal security. Keywords: Large Language Models, Prompt Injection, Cryptographic Security, Trust Boundaries, LLM Security Note: The experiments described in this paper were conducted in October 2025. This paper was written and submitted in November 2025.

Large language models (LLMs) are increasingly used to generate self-explanations alongside their predictions, a practice that raises concerns about the faithfulness of these explanations, especially in low-resource languages. This study evaluates the faithfulness of LLM-generated explanations in the context of emotion classification in Persian, a low-resource language, by comparing the influential words identified by the model against those identified by human annotators. We assess faithfulness using confidence scores derived from token-level log-probabilities. Two prompting strategies, differing in the order of explanation and prediction (Predict-then-Explain and Explain-then-Predict), are tested for their impact on explanation faithfulness. Our results reveal that while LLMs achieve strong classification performance, their generated explanations often diverge from faithful reasoning, showing greater agreement with each other than with human judgments. These results highlight the limitations of current explanation methods and metrics, emphasizing the need for more robust approaches to ensure LLM reliability in multilingual and low-resource contexts.

Community detection, or network clustering, is used to identify latent community structure in networks. Due to the scarcity of labeled ground truth in real-world networks, evaluating these algorithms poses significant challenges. To address this, researchers use synthetic network generators that produce networks with ground-truth community labels. RECCS is one such algorithm that takes a network and its clustering as input and generates a synthetic network through a modular pipeline. Each generated ground truth cluster preserves key characteristics of the corresponding input cluster, including connectivity, minimum degree, and degree sequence distribution. The output consists of a synthetically generated network, and disjoint ground truth cluster labels for all nodes. In this paper, we present two enhanced versions: RECCS+ and RECCS++. RECCS+ maintains algorithmic fidelity to the original RECCS while introducing parallelization through an orchestrator that coordinates algorithmic components across multiple processes and employs multithreading. RECCS++ builds upon this foundation with additional algorithmic optimizations to achieve further speedup. Our experimental results demonstrate that RECCS+ and RECCS++ achieve speedups of up to 49x and 139x respectively on our benchmark datasets, with RECCS++'s additional performance gains involving a modest accuracy tradeoff. With this newfound performance, RECCS++ can now scale to networks with over 100 million nodes and nearly 2 billion edges.

Stochastic Gradient Descent (SGD) often slows in the late stage of training due to anisotropic curvature and gradient noise. We analyze preconditioned SGD in the geometry induced by a symmetric positive definite matrix $\mathbf{M}$, deriving bounds in which both the convergence rate and the stochastic noise floor are governed by $\mathbf{M}$-dependent quantities: the rate through an effective condition number in the $\mathbf{M}$-metric, and the floor through the product of that condition number and the preconditioned noise level. For nonconvex objectives, we establish a preconditioner-dependent basin-stability guarantee: when smoothness and basin size are measured in the $\mathbf{M}$-norm, the probability that the iterates remain in a well-behaved local region admits an explicit lower bound. This perspective is particularly relevant in Scientific Machine Learning (SciML), where achieving small training loss under stochastic updates is closely tied to physical fidelity, numerical stability, and constraint satisfaction. The framework applies to both diagonal/adaptive and curvature-aware preconditioners and yields a simple design principle: choose $\mathbf{M}$ to improve local conditioning while attenuating noise. Experiments on a quadratic diagnostic and three SciML benchmarks validate the predicted rate-floor behavior.

Post-training quantization is an effective method for reducing the serving cost of large language models, where the standard approach is to use a round-to-nearest quantization level scheme. However, this often introduces large errors due to outliers in the weights. Proposed mitigation mechanisms include applying adaptive rounding, random rotation transformations or committing to a post-training target using calibration data. Unfortunately, this reliance on calibration data can be severely limiting in some real-world scenarios as such data may be unavailable or subject to privacy regulations. In this paper, we propose algorithms to optimize transformations and adaptive rounding without access to any calibration data. The optimization is achieved by designing a suitable proxy function for the quantization loss without calibration data. To maintain inference efficiency, we perform structured matrix transformations for single matrices. For paired weights that interact directly in the computation graph, we use dual matrix transformations and adaptive rounding methods. We conduct experiments on Gemma 2 models, and observe consistent improvement over the baselines. For Gemma 2 9B quantization, our method improves the average benchmark score from 61.9 to 62.4 for 4-bit quantization and from 52.0 to 60.6 for 3-bit quantization, while adding less than 3% of computation overhead. Furthermore, our method achieves performance comparable to the commonly used GPTQ method, which requires calibration data.