Repurposing approved drugs offers a time-efficient and cost-effective alternative to traditional drug development. However, in silico prediction of repurposing candidates is challenging and requires the effective collaboration of specialists in various fields, including pharmacology, medicine, biology, and bioinformatics. Fragmented, specialized algorithms and tools often address only narrow aspects of the overall problem, and heterogeneous, unstructured data landscapes require specialized users to be involved. Hence, these data services do not integrate smoothly across workflows. With ChatDRex, we present a conversation-based, multi-agent system that facilitates the execution of complex bioinformatic analyses aiming for network-based drug repurposing prediction. It builds on the integrated systems medicine knowledge graph NeDRex. ChatDRex provides natural language access to its extensive biomedical KG and integrates bioinformatics agents for network analysis and drug repurposing, complemented by agents for functional coherence evaluation for in silico validation, as well as agents for literature mining and for discussing the obtained results in a scientific context. Its flexible multi-agent design assigns specific tasks to specialized agents, including query routing, data retrieval, algorithm execution, and result visualization. A dedicated reasoning module keeps the user in the loop and allows for hallucination detection. By enabling physicians and researchers without computer science expertise to control complex analyses in natural language, ChatDRex democratizes access to bioinformatics as an important resource for drug repurposing. It enables clinical experts to generate hypotheses and explore drug repurposing opportunities, ultimately accelerating the discovery of novel therapies and advancing personalized medicine and translational research.

Model merging combines multiple fine-tuned checkpoints into a single model without additional training, offering an attractive approach to reusing models and efficiently improving performance. However, it remains unclear whether the advantages reported for smaller models and classifiers generalize to LLMs. We present a large-scale, systematic evaluation of six state-of-the-art merging methods, including recent subspace methods, across four open-weight LLMs, twelve fine-tuned checkpoints per base model, and sixteen standard LLM benchmarks. Evaluating through standardized benchmarks, we measure both the probability that a merged model outperforms the base model and relative gains over the best individual checkpoint. Our results show that the oldest and simplest method, Task Arithmetic, is the only approach that reliably yields performance gains on LLMs. Other interference-aware and subspace merging methods typically result in significant performance drops. Our findings indicate that current merging techniques do not directly transfer to modern LLMs. This motivates the design of LLM-specific merging algorithms and merging-aware fine-tuning methods. Code will be released upon acceptance of this paper.

Remote sensing change captioning is an emerging and popular research task that aims to describe, in natural language, the content of interest that has changed between two remote sensing images captured at different times. Existing methods typically employ CNNs/Transformers to extract visual representations from the given images or incorporate auxiliary tasks to enhance the final results, with weak region awareness and limited temporal alignment. To address these issues, this paper explores the use of the SAM (Segment Anything Model) foundation model to extract region-level representations and inject region-of-interest knowledge into the captioning framework. Specifically, we employ a CNN/Transformer model to extract global-level vision features, leverage the SAM foundation model to delineate semantic- and motion-level change regions, and utilize a specially constructed knowledge graph to provide information about objects of interest. These heterogeneous sources of information are then fused via cross-attention, and a Transformer decoder is used to generate the final natural language description of the observed changes. Extensive experimental results demonstrate that our method achieves state-of-the-art performance across multiple widely used benchmark datasets. The source code of this paper will be released on https://github.com/Event-AHU/SAM_ChangeCaptioning

Deep neural networks (DNNs) and Kolmogorov-Arnold networks (KANs) are popular methods for function approximation due to their flexibility and expressivity. However, they typically require a large number of trainable parameters to produce a suitable approximation. Beyond making the resulting network less transparent, overparameterization creates a large optimization space, likely producing local minima in training that have quite different generalization errors. In this case, network initialization can have an outsize impact on the model's out-of-sample accuracy. For these reasons, we propose shallow universal polynomial networks (SUPNs). These networks replace all but the last hidden layer with a single layer of polynomials with learnable coefficients, leveraging the strengths of DNNs and polynomials to achieve sufficient expressivity with far fewer parameters. We prove that SUPNs converge at the same rate as the best polynomial approximation of the same degree, and we derive explicit formulas for quasi-optimal SUPN parameters. We complement theory with an extensive suite of numerical experiments involving SUPNs, DNNs, KANs, and polynomial projection in one, two, and ten dimensions, consisting of over 13,000 trained models. On the target functions we numerically studied, for a given number of trainable parameters, the approximation error and variability are often lower for SUPNs than for DNNs and KANs by an order of magnitude. In our examples, SUPNs even outperform polynomial projection on non-smooth functions.

Due to rising demands for Artificial Inteligence (AI) inference, especially in higher education, novel solutions utilising existing infrastructure are emerging. The utilisation of High-Performance Computing (HPC) has become a prevalent approach for the implementation of such solutions. However, the classical operating model of HPC does not adapt well to the requirements of synchronous, user-facing dynamic AI application workloads. In this paper, we propose our solution that serves LLMs by integrating vLLM, Slurm and Kubernetes on the supercomputer \textit{RAMSES}. The initial benchmark indicates that the proposed architecture scales efficiently for 100, 500 and 1000 concurrent requests, incurring only an overhead of approximately 500 ms in terms of end-to-end latency.

The rigid, uniform allocation of computation in standard Transformer (TF) architectures can limit their efficiency and scalability, particularly for large-scale models and long sequences. Addressing this, we introduce Subjective Depth Transformers (SDT) and Subjective Timescale Transformers (STT), two distinct architectures that leverage Bayesian surprise signals to dynamically route computation, learning where and when to compute within decoder-only TFs. SDT augments a decoder-only stack with alternating Decision and Dynamic layers: a Decision layer computes a full block 'posterior' and a lightweight 'prior,' while a Dynamic layer employs fixed-capacity Top-K routing based on Bayesian surprise (Expected and Unexpected Change), maintaining a static compute graph. STT extends this conditional computation to the temporal domain: a transition network predicts residual updates, forming a temporal 'change hypothesis' that informs a router to dynamically execute or bypass TF blocks for each token, managing KV-cache contributions. Both architectures exhibit the predicted shift from novelty to prediction driven gating over training, suggesting alignment with surprise based principles. While operating at reduced capacity, they offer preliminary insights into the compute-accuracy trade-offs of conditional computation. The proposed architectures establish a flexible framework for efficiency, reducing self-attention computation by 75% and KV-cache requirements by 50% within each compute skipping layer, setting a pathway for more efficient models.

Recent divide-and-conquer reasoning approaches, particularly those based on Chain-of-Thought (CoT), have substantially improved the Text-to-SQL capabilities of Large Language Models (LLMs). However, when applied to complex enterprise databases, such methods struggle to maintain coherent reasoning due to limited context capacity, unreliable schema linking, and weak grounding in database semantics. To overcome these issues, we introduce DSR-SQL, a \textbf{D}ual-\textbf{S}tate \textbf{R}easoning framework that models Text-to-SQL as an interaction between an adaptive context state and a progressive generation state. The first constructs a compact, semantically faithful environment by refining large schemas and selecting relevant structures, while the second formalizes SQL synthesis as feedback-guided state transitions, enabling the model to self-correct and align with user intent. Without any post-training or in-context examples, DSR-SQL achieves competitive performance, reaching 35.28\% execution accuracy on Spider 2.0-Snow and 68.32\% on BIRD development set. Our implementation will be open-sourced at: https://github.com/DMIRLAB-Group/DSR-SQL.

Misinformation frequently spreads in user comments under online news articles, highlighting the need for effective methods to detect factually incorrect information. To strongly support or refute claims extracted from such comments, it is necessary to identify relevant documents and pinpoint the exact text spans that justify or contradict each claim. This paper focuses on the latter task -- fine-grained evidence extraction for Czech and Slovak claims. We create new dataset, containing two-way annotated fine-grained evidence created by paid annotators. We evaluate large language models (LLMs) on this dataset to assess their alignment with human annotations. The results reveal that LLMs often fail to copy evidence verbatim from the source text, leading to invalid outputs. Error-rate analysis shows that the {llama3.1:8b model achieves a high proportion of correct outputs despite its relatively small size, while the gpt-oss-120b model underperforms despite having many more parameters. Furthermore, the models qwen3:14b, deepseek-r1:32b, and gpt-oss:20b demonstrate an effective balance between model size and alignment with human annotations.

How does irrelevant information (i.e., distractors) affect test-time scaling in vision-language models (VLMs)? Prior studies on language models have reported an inverse scaling effect, where textual distractors lead to longer but less effective reasoning. To investigate whether similar phenomena occur in multimodal settings, we introduce Idis (Images with distractors), a visual question-answering dataset that systematically varies distractors along semantic, numerical, and spatial dimensions. Our analyses reveal that visual distractors differ fundamentally from textual ones: although inverse scaling persists, adding visual distractors reduces accuracy without increasing reasoning length. We further show that tracking attribute counts within reasoning traces provides key insights into how distractors, reasoning length, and accuracy interact. Finally, we demonstrate that these trends extend to established visual bias benchmarks such as Waterbirds, and we propose a simple prompting strategy to mitigate bias-driven predictions in reasoning models.

Aspect-Based Sentiment Analysis (ABSA) has emerged as a critical tool for extracting fine-grained sentiment insights from user-generated content, particularly in e-commerce and social media domains. However, research on Bangla ABSA remains significantly underexplored due to the absence of comprehensive datasets and specialized frameworks for triplet extraction in this language. This paper introduces BanglaASTE, a novel framework for Aspect Sentiment Triplet Extraction (ASTE) that simultaneously identifies aspect terms, opinion expressions, and sentiment polarities from Bangla product reviews. Our contributions include: (1) creation of the first annotated Bangla ASTE dataset containing 3,345 product reviews collected from major e-commerce platforms including Daraz, Facebook, and Rokomari; (2) development of a hybrid classification framework that employs graph-based aspect-opinion matching with semantic similarity techniques; and (3) implementation of an ensemble model combining BanglaBERT contextual embeddings with XGBoost boosting algorithms for enhanced triplet extraction performance. Experimental results demonstrate that our ensemble approach achieves superior performance with 89.9% accuracy and 89.1% F1-score, significantly outperforming baseline models across all evaluation metrics. The framework effectively addresses key challenges in Bangla text processing including informal expressions, spelling variations, and data sparsity. This research advances the state-of-the-art in low-resource language sentiment analysis and provides a scalable solution for Bangla e-commerce analytics applications.