With the continuous advancement of image generation technology, advanced models such as GPT-Image-1 and Qwen-Image have achieved remarkable text-to-image consistency and world knowledge However, these models still fall short in photorealistic image generation. Even on simple T2I tasks, they tend to produce " fake" images with distinct AI artifacts, often characterized by "overly smooth skin" and "oily facial sheens". To recapture the original goal of "indistinguishable-from-reality" generation, we propose RealGen, a photorealistic text-to-image framework. RealGen integrates an LLM component for prompt optimization and a diffusion model for realistic image generation. Inspired by adversarial generation, RealGen introduces a "Detector Reward" mechanism, which quantifies artifacts and assesses realism using both semantic-level and feature-level synthetic image detectors. We leverage this reward signal with the GRPO algorithm to optimize the entire generation pipeline, significantly enhancing image realism and detail. Furthermore, we propose RealBench, an automated evaluation benchmark employing Detector-Scoring and Arena-Scoring. It enables human-free photorealism assessment, yielding results that are more accurate and aligned with real user experience. Experiments demonstrate that RealGen significantly outperforms general models like GPT-Image-1 and Qwen-Image, as well as specialized photorealistic models like FLUX-Krea, in terms of realism, detail, and aesthetics. The code is available at https://github.com/yejy53/RealGen.

Automated personality and soft skill assessment from multimodal behavioral data remains challenging due to limited datasets and methods that fail to capture geometric structure inherent in human traits. We introduce RecruitView, a dataset of 2,011 naturalistic video interview clips from 300+ participants with 27,000 pairwise comparative judgments across 12 dimensions: Big Five personality traits, overall personality score, and six interview performance metrics. To leverage this data, we propose Cross-Modal Regression with Manifold Fusion (CRMF), a geometric deep learning framework that explicitly models behavioral representations across hyperbolic, spherical, and Euclidean manifolds. CRMF employs geometry-specific expert networks to capture hierarchical trait structures, directional behavioral patterns, and continuous performance variations simultaneously. An adaptive routing mechanism dynamically weights expert contributions based on input characteristics. Through principled tangent space fusion, CRMF achieves superior performance while training 40-50% fewer trainable parameters than large multimodal models. Extensive experiments demonstrate that CRMF substantially outperforms the selected baselines, achieving up to 11.4% improvement in Spearman correlation and 6.0% in concordance index. Our RecruitView dataset is publicly available at https://huggingface.co/datasets/AI4A-lab/RecruitView

With the rapid advancement of intelligent education, Computerized Adaptive Testing (CAT) has attracted increasing attention by integrating educational psychology with deep learning technologies. Unlike traditional paper-and-pencil testing, CAT aims to efficiently and accurately assess examinee abilities by adaptively selecting the most suitable items during the assessment process. However, its real-time and sequential nature presents limitations in practical scenarios, particularly in large-scale assessments where interaction costs are high, or in sensitive domains such as psychological evaluations where minimizing noise and interference is essential. These challenges constrain the applicability of conventional CAT methods in time-sensitive or resourceconstrained environments. To this end, we first introduce a novel task called one-shot adaptive testing (OAT), which aims to select a fixed set of optimal items for each test-taker in a one-time selection. Meanwhile, we propose PEOAT, a Personalization-guided Evolutionary question assembly framework for One-shot Adaptive Testing from the perspective of combinatorial optimization. Specifically, we began by designing a personalization-aware initialization strategy that integrates differences between examinee ability and exercise difficulty, using multi-strategy sampling to construct a diverse and informative initial population. Building on this, we proposed a cognitive-enhanced evolutionary framework incorporating schema-preserving crossover and cognitively guided mutation to enable efficient exploration through informative signals. To maintain diversity without compromising fitness, we further introduced a diversity-aware environmental selection mechanism. The effectiveness of PEOAT is validated through extensive experiments on two datasets, complemented by case studies that uncovered valuable insights.

Epidemic outcomes have a complex interplay with human behavior and beliefs. Most of the forecasting literature has focused on the task of predicting epidemic signals using simple mechanistic models or black-box models, such as deep transformers, that ingest all available signals without offering interpretability. However, to better understand the mechanisms and predict the impact of interventions, we need the ability to forecast signals associated with beliefs and behaviors in an interpretable manner. In this work, we propose a graph-based forecasting framework that first constructs a graph of interrelated signals based on trend similarity, and then applies graph neural networks (GNNs) for prediction. This approach enables interpretable analysis by revealing which signals are more predictable and which relationships contribute most to forecasting accuracy. We believe our method provides early steps towards a framework for interpretable modeling in domains with multiple potentially interdependent signals, with implications for building future simulation models that integrate behavior, beliefs, and observations.

Traditional video codecs optimized for pixel fidelity collapse at ultra-low bitrates and produce severe artifacts. This failure arises from a fundamental misalignment between pixel accuracy and human perception. We propose a semantic video compression framework named DiSCo that transmits only the most meaningful information while relying on generative priors for detail synthesis. The source video is decomposed into three compact modalities: a textual description, a spatiotemporally degraded video, and optional sketches or poses that respectively capture semantic, appearance, and motion cues. A conditional video diffusion model then reconstructs high-quality, temporally coherent videos from these compact representations. Temporal forward filling, token interleaving, and modality-specific codecs are proposed to improve multimodal generation and modality compactness. Experiments show that our method outperforms baseline semantic and traditional codecs by 2-10X on perceptual metrics at low bitrates.

Recent work on autonomous scientific discovery has leveraged LLM-based agents to integrate problem specification, experiment planning, and execution into end-to-end systems. However, these frameworks are often confined to narrow application domains, offer limited real-time interaction with researchers, and lack principled mechanisms for determining when to halt exploration, resulting in inefficiencies, reproducibility challenges, and under-utilized human expertise. To address these gaps, we propose \textit{SelfAI}, a general multi-agent platform that combines a User Agent for translating high-level research objectives into standardized experimental configurations, a Cognitive Agent powered by LLMs with optimal stopping criteria to iteratively refine hyperparameter searches, and an Experiment Manager responsible for orchestrating parallel, fault-tolerant training workflows across heterogeneous hardware while maintaining a structured knowledge base for continuous feedback. We further introduce two novel evaluation metrics, Score and $\text{AUP}_D$, to quantify discovery efficiency and search diversity. Across regression, NLP, computer vision, scientific computing, medical imaging, and drug discovery benchmarks, SelfAI consistently achieves strong performance and reduces redundant trials compared to classical Bayesian optimization and LLM-based baselines, while enabling seamless interaction with human researchers.

Model merging has emerged as a practical paradigm for integrating multiple independently trained models into a single model without joint retraining. Previous studies have demonstrated the effectiveness of combining parameters through strategies such as parameter decomposition, coefficient optimization, and subspace learning, significantly reducing the need for expensive joint training and achieving strong empirical performance across diverse tasks. However, these approaches predominantly treat merging as a problem of parameter space decomposition or fusion coefficient optimization, while overlooking the critical role of directional information in both parameter and feature spaces. In practice, naïve merging introduces inconsistencies in dominant parameter directions and disrupts structural coherence across models, which can degrade performance. Moreover, coefficient-based optimization methods implicitly assume compatible feature-space directions across models. However, Neural Collapse indicates that class features follow structured directional patterns, which may differ across independently trained models, making coefficient optimization alone insufficient. In this work, we emphasize the importance of \emph{directional alignment} and introduce a unified geometric framework, \emph{Merging with Directional Alignment} (\method{}), which aligns directional structures consistently in both the parameter and feature spaces. Our analysis shows that directional alignment improves structural coherence, and extensive experiments across benchmarks, model scales, and task configurations further validate the effectiveness of our approach.

Recent research has explored LLMs as scalable tools for relevance labeling, but studies indicate they are susceptible to priming effects, where prior relevance judgments influence later ones. Although psychological theories link personality traits to such biases, it is unclear whether simulated personalities in LLMs exhibit similar effects. We investigate how Big Five personality profiles in LLMs influence priming in relevance labeling, using multiple LLMs on TREC 2021 and 2022 Deep Learning Track datasets. Our results show that certain profiles, such as High Openness and Low Neuroticism, consistently reduce priming susceptibility. Additionally, the most effective personality in mitigating priming may vary across models and task types. Based on these findings, we propose personality prompting as a method to mitigate threshold priming, connecting psychological evidence with LLM-based evaluation practices.

The constrained nature of synthesizable chemical space poses a significant challenge for sampling molecules that are both synthetically accessible and possess desired properties. In this work, we present PrexSyn, an efficient and programmable model for molecular discovery within synthesizable chemical space. PrexSyn is based on a decoder-only transformer trained on a billion-scale datastream of synthesizable pathways paired with molecular properties, enabled by a real-time, high-throughput C++-based data generation engine. The large-scale training data allows PrexSyn to reconstruct the synthesizable chemical space nearly perfectly at a high inference speed and learn the association between properties and synthesizable molecules. Based on its learned property-pathway mappings, PrexSyn can generate synthesizable molecules that satisfy not only single-property conditions but also composite property queries joined by logical operators, thereby allowing users to ``program'' generation objectives. Moreover, by exploiting this property-based querying capability, PrexSyn can efficiently optimize molecules against black-box oracle functions via iterative query refinement, achieving higher sampling efficiency than even synthesis-agnostic baselines, making PrexSyn a powerful general-purpose molecular optimization tool. Overall, PrexSyn pushes the frontier of synthesizable molecular design by setting a new state of the art in synthesizable chemical space coverage, molecular sampling efficiency, and inference speed.

Accurate prediction of enzyme kinetic parameters is crucial for drug discovery, metabolic engineering, and synthetic biology applications. Current computational approaches face limitations in capturing complex enzyme-substrate interactions and often focus on single parameters while neglecting the joint prediction of catalytic turnover numbers (Kcat) and Michaelis-Menten constants (Km). We present EnzyCLIP, a novel dual-encoder framework that leverages contrastive learning and cross-attention mechanisms to predict enzyme kinetic parameters from protein sequences and substrate molecular structures. Our approach integrates ESM-2 protein language model embeddings with ChemBERTa chemical representations through a CLIP-inspired architecture enhanced with bidirectional cross-attention for dynamic enzyme-substrate interaction modeling. EnzyCLIP combines InfoNCE contrastive loss with Huber regression loss to learn aligned multimodal representations while predicting log10-transformed kinetic parameters. The model is trained on the CatPred-DB database containing 23,151 Kcat and 41,174 Km experimentally validated measurements, and achieved competitive performance with R2 scores of 0.593 for Kcat and 0.607 for Km prediction. XGBoost ensemble methods applied to the learned embeddings further improved Km prediction (R2 = 0.61) while maintaining robust Kcat performance.