The accelerated development, deployment and adoption of artificial intelligence systems has been fuelled by the increasing involvement of big tech. This has been accompanied by increasing ethical concerns and intensified societal and environmental impacts. In this article, we review and discuss how these phenomena are deeply entangled. First, we examine the growing and disproportionate influence of big tech in AI research and argue that its drive for scaling and general-purpose systems is fundamentally at odds with the responsible, ethical, and sustainable development of AI. Second, we review key current environmental and societal negative impacts of AI and trace their connections to big tech and its underlying economic incentives. Finally, we argue that while it is important to develop technical and regulatory approaches to these challenges, these alone are insufficient to counter the distortion introduced by big tech's influence. We thus review and propose alternative strategies that build on the responsibility of implicated actors and collective action.

The growing influence of Artificial Intelligence (AI) systems on decision-making in critical domains has exposed their potential to cause significant harms, often rooted in biases embedded across the AI lifecycle. While existing frameworks and taxonomies document bias or harms in isolation, they rarely establish systematic links between specific bias types and the harms they cause, particularly within real-world sociotechnical contexts. Technical fixes proposed to address AI biases are ill-equipped to address them and are typically applied after a system has been developed or deployed, offering limited preventive value. We propose ECHO, a novel framework for proactive AI harm anticipation through the systematic mapping of AI bias types to harm outcomes across diverse stakeholder and domain contexts. ECHO follows a modular workflow encompassing stakeholder identification, vignette-based presentation of biased AI systems, and dual (human-LLM) harm annotation, integrated within ethical matrices for structured interpretation. This human-centered approach enables early-stage detection of bias-to-harm pathways, guiding AI design and governance decisions from the outset. We validate ECHO in two high-stakes domains (disease diagnosis and hiring), revealing domain-specific, bias-to-harm patterns and demonstrating ECHO's potential to support anticipatory governance of AI systems

Heterogeneous Treatment Effect (HTE) and Conditional Average Treatment Effect (CATE) models relax the assumption that treatment effects are the same for every user. We present a large scale industrial framework for estimating HTE using experimental data from hundreds of millions of Snapchat users. By combining results across many experiments, the framework uncovers latent user characteristics that were previously unmeasurable and produces stable treatment effect estimates at scale. We describe the core components that enabled this system, including experiment selection, base learner design, and incremental training. We also highlight two applications: user influenceability to ads and user sensitivity to ads. An online A/B test using influenceability scores for targeting showed an improvement on key business metrics that is more than six times larger than what is typically considered significant.

This paper investigates the dynamical properties of tokens in pre-trained Transformer models and explores their application to improving Transformers. To this end, we analyze the dynamical system governing the continuous-time limit of the pre-trained model and characterize the asymptotic behavior of its solutions. Specifically, we characterize when tokens move closer to or farther from one another over time, depending on the model parameters. We provide sufficient conditions, based on these parameters, to identify scenarios where tokens either converge to zero or diverge to infinity. Unlike prior works, our conditions are broader in scope and more applicable to real-world models. Furthermore, we investigate how different forms of positional encoding -- specifically absolute and rotary -- affect these dynamical regimes. Empirical evidence reveals that the convergence scenario adversely impacts model performance. Motivated by these insights, we propose simple refinements to Transformer architectures that mitigate convergence behavior in models with absolute or rotary positional encoding. These findings support theoretical foundations and design principles for improving Transformer models.

Diffusion models like Stable Diffusion (SD) drive a vibrant open-source ecosystem including fully fine-tuned checkpoints and parameter-efficient adapters such as LoRA, LyCORIS, and ControlNet. However, these adaptation components are tightly coupled to a specific base model, making them difficult to reuse when the base model is upgraded (e.g., from SD 1.x to 2.x) due to substantial changes in model parameters and architecture. In this work, we propose Delta Sampling (DS), a novel method that enables knowledge transfer across base models with different architectures, without requiring access to the original training data. DS operates entirely at inference time by leveraging the delta: the difference in model predictions before and after the adaptation of a base model. This delta is then used to guide the denoising process of a new base model. We evaluate DS across various SD versions, demonstrating that DS achieves consistent improvements in creating desired effects (e.g., visual styles, semantic concepts, and structures) under different sampling strategies. These results highlight DS as an effective, plug-and-play mechanism for knowledge transfer in diffusion-based image synthesis. Code:~ https://github.com/Zhidong-Gao/DeltaSampling

Cardiovascular disease is the leading global cause of mortality, with coronary artery disease (CAD) as its most prevalent form, necessitating early risk prediction. While 3D coronary artery digital twins reconstructed from imaging offer detailed anatomy for personalized assessment, their analysis relies on computationally intensive computational fluid dynamics (CFD), limiting scalability. Data-driven approaches are hindered by scarce labeled data and lack of physiological priors. To address this, we present PINS-CAD, a physics-informed self-supervised learning framework. It pre-trains graph neural networks on 200,000 synthetic coronary digital twins to predict pressure and flow, guided by 1D Navier-Stokes equations and pressure-drop laws, eliminating the need for CFD or labeled data. When fine-tuned on clinical data from 635 patients in the multicenter FAME2 study, PINS-CAD predicts future cardiovascular events with an AUC of 0.73, outperforming clinical risk scores and data-driven baselines. This demonstrates that physics-informed pretraining boosts sample efficiency and yields physiologically meaningful representations. Furthermore, PINS-CAD generates spatially resolved pressure and fractional flow reserve curves, providing interpretable biomarkers. By embedding physical priors into geometric deep learning, PINS-CAD transforms routine angiography into a simulation-free, physiology-aware framework for scalable, preventive cardiology.

Federated Learning (FL) holds the potential to advance equality in health by enabling diverse institutions to collaboratively train deep learning (DL) models, even with limited data. However, the significant resource requirements of FL often exclude centres with limited computational infrastructure, further widening existing healthcare disparities. To address this issue, we propose a Green AI-oriented adaptive layer-freezing strategy designed to reduce energy consumption and computational load while maintaining model performance. We tested our approach using different federated architectures for Magnetic Resonance Imaging (MRI)-to-Computed Tomography (CT) conversion. The proposed adaptive strategy optimises the federated training by selectively freezing the encoder weights based on the monitored relative difference of the encoder weights from round to round. A patience-based mechanism ensures that freezing only occurs when updates remain consistently minimal. The energy consumption and CO2eq emissions of the federation were tracked using the CodeCarbon library. Compared to equivalent non-frozen counterparts, our approach reduced training time, total energy consumption and CO2eq emissions by up to 23%. At the same time, the MRI-to-CT conversion performance was maintained, with only small variations in the Mean Absolute Error (MAE). Notably, for three out of the five evaluated architectures, no statistically significant differences were observed, while two architectures exhibited statistically significant improvements. Our work aligns with a research paradigm that promotes DL-based frameworks meeting clinical requirements while ensuring climatic, social, and economic sustainability. It lays the groundwork for novel FL evaluation frameworks, advancing privacy, equity and, more broadly, justice in AI-driven healthcare.

We show for invertible problems that transform data from a source domain (for example, Logic Condition Tables (LCTs)) to a destination domain (for example, Hardware Description Language (HDL) code), an approach of using Large Language Models (LLMs) as a lossless encoder from source to destination followed by as a lossless decoder back to the source, comparable to lossless compression in information theory, can mitigate most of the LLM drawbacks of hallucinations and omissions. Specifically, using LCTs as inputs, we generate the full HDL for a two-dimensional network-on-chip router (13 units, 1500-2000 lines of code) using seven different LLMs, reconstruct the LCTs from the auto-generated HDL, and compare the original and reconstructed LCTs. This approach yields significant productivity improvements, not only confirming correctly generated LLM logic and detecting incorrectly generated LLM logic but also assisting developers in finding design specification errors.

Machine learning (ML) has emerged as a powerful tool for accelerating the computational design and production of materials. In materials science, ML has primarily supported large-scale discovery of novel compounds using first-principles data and digital twin applications for optimizing manufacturing processes. However, applying general-purpose ML frameworks to complex industrial materials such as steel remains a challenge. A key obstacle is accurately capturing the intricate relationship between chemical composition, processing parameters, and the resulting microstructure and properties. To address this, we introduce a computational framework that combines physical insights with ML to develop a physics-informed continuous cooling transformation (CCT) model for steels. Our model, trained on a dataset of 4,100 diagrams, is validated against literature and experimental data. It demonstrates high computational efficiency, generating complete CCT diagrams with 100 cooling curves in under 5 seconds. It also shows strong generalizability across alloy steels, achieving phase classification F1 scores above 88% for all phases. For phase transition temperature regression, it attains mean absolute errors (MAE) below 20 °C across all phases except bainite, which shows a slightly higher MAE of 27 °C. This framework can be extended with additional generic and customized ML models to establish a universal digital twin platform for heat treatment. Integration with complementary simulation tools and targeted experiments will further support accelerated materials design workflows.

Large language model safety is usually assessed with static benchmarks, but key failures are dynamic: value drift under distribution shift, jailbreak attacks, and slow degradation of alignment in deployment. Building on a recent Second Law of Intelligence that treats ethical entropy as a state variable which tends to increase unless countered by alignment work, we make this framework operational for large language models. We define a five-way behavioral taxonomy, train a classifier to estimate ethical entropy S(t) from model transcripts, and measure entropy dynamics for base and instruction-tuned variants of four frontier models across stress tests. Base models show sustained entropy growth, while tuned variants suppress drift and reduce ethical entropy by roughly eighty percent. From these trajectories we estimate an effective alignment work rate gamma_eff and embed S(t) and gamma_eff in a monitoring pipeline that raises alerts when entropy drift exceeds a stability threshold, enabling run-time oversight of value drift.