The Weibull distribution is a commonly adopted choice for modeling the survival of systems subject to maintenance over time. When only proxy indicators and censored observations are available, it becomes necessary to express the distribution's parameters as functions of time-dependent covariates. Deep neural networks provide the flexibility needed to learn complex relationships between these covariates and operational lifetime, thereby extending the capabilities of traditional regression-based models. Motivated by the analysis of a fleet of military vehicles operating in highly variable and demanding environments, as well as by the limitations observed in existing methodologies, this paper introduces WTNN, a new neural network-based modeling framework specifically designed for Weibull survival studies. The proposed architecture is specifically designed to incorporate qualitative prior knowledge regarding the most influential covariates, in a manner consistent with the shape and structure of the Weibull distribution. Through numerical experiments, we show that this approach can be reliably trained on proxy and right-censored data, and is capable of producing robust and interpretable survival predictions that can improve existing approaches.

Accurate forecasting of urban air pollution is essential for protecting public health and guiding mitigation policies. While Deep Learning (DL) and hybrid pipelines dominate recent research, their complexity and limited interpretability hinder operational use. This study investigates whether lightweight additive models -- Facebook Prophet (FBP) and NeuralProphet (NP) -- can deliver competitive forecasts for particulate matter (PM$_{2.5}$, PM$_{10}$) in Beijing, China. Using multi-year pollutant and meteorological data, we applied systematic feature selection (correlation, mutual information, mRMR), leakage-safe scaling, and chronological data splits. Both models were trained with pollutant and precursor regressors, with NP additionally leveraging lagged dependencies. For context, two machine learning baselines (LSTM, LightGBM) and one traditional statistical model (SARIMAX) were also implemented. Performance was evaluated on a 7-day holdout using MAE, RMSE, and $R^2$. Results show that FBP consistently outperformed NP, SARIMAX, and the learning-based baselines, achieving test $R^2$ above 0.94 for both pollutants. These findings demonstrate that interpretable additive models remain competitive with both traditional and complex approaches, offering a practical balance of accuracy, transparency, and ease of deployment.

We study online statistical inference for the solutions of stochastic optimization problems with equality and inequality constraints. Such problems are prevalent in statistics and machine learning, encompassing constrained $M$-estimation, physics-informed models, safe reinforcement learning, and algorithmic fairness. We develop a stochastic sequential quadratic programming (SSQP) method to solve these problems, where the step direction is computed by sequentially performing a quadratic approximation of the objective and a linear approximation of the constraints. Despite having access to unbiased estimates of population gradients, a key challenge in constrained stochastic problems lies in dealing with the bias in the step direction. As such, we apply a momentum-style gradient moving-average technique within SSQP to debias the step. We show that our method achieves global almost-sure convergence and exhibits local asymptotic normality with an optimal primal-dual limiting covariance matrix in the sense of Hájek and Le Cam. In addition, we provide a plug-in covariance matrix estimator for practical inference. To our knowledge, the proposed SSQP method is the first fully online method that attains primal-dual asymptotic minimax optimality without relying on projection operators onto the constraint set, which are generally intractable for nonlinear problems. Through extensive experiments on benchmark nonlinear problems, as well as on constrained generalized linear models and portfolio allocation problems using both synthetic and real data, we demonstrate superior performance of our method, showing that the method and its asymptotic behavior not only solve constrained stochastic problems efficiently but also provide valid and practical online inference in real-world applications.

Multi-step time-series prediction is an essential supportive step for decision-makers in several industrial areas. Artificial intelligence techniques, which use a neural network component in various forms, have recently frequently been used to accomplish this step. However, the complexity of the neural network structure still stands up as a critical problem against prediction accuracy. In this paper, a method inspired by the proportional-integral-derivative (PID) control approach is investigated to enhance the performance of neural network models used for multi-step ahead prediction of periodic time-series information while maintaining a negligible impact on the complexity of the system. The PID-based method is applied to the predicted value at each time step to bring that value closer to the real value. The water demand forecasting problem is considered as a case study, where two deep neural network models from the literature are used to prove the effectiveness of the proposed boosting method. Furthermore, to prove the applicability of this PID-based booster to other types of periodic time-series prediction problems, it is applied to enhance the accuracy of a neural network model used for multi-step forecasting of hourly energy consumption. The comparison between the results of the original prediction models and the results after using the proposed technique demonstrates the superiority of the proposed method in terms of prediction accuracy and system complexity.

Radiotherapy planning is a highly complex process that often varies significantly across institutions and individual planners. Most existing deep learning approaches for 3D dose prediction rely on reference plans as ground truth during training, which can inadvertently bias models toward specific planning styles or institutional preferences. In this study, we introduce a novel generative model that predicts 3D dose distributions based solely on user-defined preference flavors. These customizable preferences enable planners to prioritize specific trade-offs between organs-at-risk (OARs) and planning target volumes (PTVs), offering greater flexibility and personalization. Designed for seamless integration with clinical treatment planning systems, our approach assists users in generating high-quality plans efficiently. Comparative evaluations demonstrate that our method can surpasses the Varian RapidPlan model in both adaptability and plan quality in some scenarios.

The interpretation of Chest X-ray is an important diagnostic issue in clinical practice and especially in the resource-limited setting where the shortage of radiologists plays a role in delayed diagnosis and poor patient outcomes. Although the original CheXNet architecture has shown potential in automated analysis of chest radiographs, DenseNet-121 backbone is computationally inefficient and poorly single-label classifier. To eliminate such shortcomings, we suggest a better classification framework of chest disease that relies on EfficientNetV2-M and incorporates superior training approaches such as Automatic Mixed Precision training, AdamW, Cosine Annealing learning rate scheduling, and Exponential Moving Average regularization. We prepared a dataset of 18,080 chest X-ray images of three source materials of high authority and representing five key clinically significant disease categories which included Cardiomegaly, COVID-19, Normal, Pneumonia, and Tuberculosis. To achieve statistical reliability and reproducibility, nine independent experimental runs were run. The suggested architecture showed significant gains with mean test accuracy of 96.45 percent compared to 95.30 percent at baseline (p less than 0.001) and macro-averaged F1-score increased to 91.08 percent (p less than 0.001). Critical infectious diseases showed near-perfect classification performance with COVID-19 detection having 99.95 percent accuracy and Tuberculosis detection having 99.97 percent accuracy. Although 6.8 times more parameters are included, the training time was reduced by 11.4 percent and performance stability was increased by 22.7 percent. This framework presents itself as a decision-support tool that can be used to respond to a pandemic, screen tuberculosis, and assess thoracic disease regularly in various healthcare facilities.

Understanding how humans and AI systems interpret ambiguous visual stimuli offers critical insight into the nature of perception, reasoning, and decision-making. This paper examines image labeling performance across human participants and deep neural networks, focusing on low-resolution, perceptually degraded stimuli. Drawing from computational cognitive science, cognitive architectures, and connectionist-symbolic hybrid models, we contrast human strategies such as analogical reasoning, shape-based recognition, and confidence modulation with AI's feature-based processing. Grounded in Marr's tri-level hypothesis, Simon's bounded rationality, and Thagard's frameworks of representation and emotion, we analyze participant responses in relation to Grad-CAM visualizations of model attention. Human behavior is further interpreted through cognitive principles modeled in ACT-R and Soar, revealing layered and heuristic decision strategies under uncertainty. Our findings highlight key parallels and divergences between biological and artificial systems in representation, inference, and confidence calibration. The analysis motivates future neuro-symbolic architectures that unify structured symbolic reasoning with connectionist representations. Such architectures, informed by principles of embodiment, explainability, and cognitive alignment, offer a path toward AI systems that are not only performant but also interpretable and cognitively grounded.

Polysomnography (PSG), the gold standard test for sleep analysis, generates vast amounts of multimodal clinical data, presenting an opportunity to leverage self-supervised representation learning (SSRL) for pre-training foundation models to enhance sleep analysis. However, progress in sleep foundation models is hindered by two key limitations: (1) the lack of a shared dataset and benchmark with diverse tasks for training and evaluation, and (2) the absence of a systematic evaluation of SSRL approaches across sleep-related tasks. To address these gaps, we introduce Stanford Sleep Bench, a large-scale PSG dataset comprising 17,467 recordings totaling over 163,000 hours from a major sleep clinic, including 13 clinical disease prediction tasks alongside canonical sleep-related tasks such as sleep staging, apnea diagnosis, and age estimation. We systematically evaluate SSRL pre-training methods on Stanford Sleep Bench, assessing downstream performance across four tasks: sleep staging, apnea diagnosis, age estimation, and disease and mortality prediction. Our results show that multiple pretraining methods achieve comparable performance for sleep staging, apnea diagnosis, and age estimation. However, for mortality and disease prediction, contrastive learning significantly outperforms other approaches while also converging faster during pretraining. To facilitate reproducibility and advance sleep research, we will release Stanford Sleep Bench along with pretrained model weights, training pipelines, and evaluation code.

Convolutional Neural Networks (CNNs) for computer vision sometimes struggle with understanding images in a global context, as they mainly focus on local patterns. On the other hand, Vision Transformers (ViTs), inspired by models originally created for language processing, use self-attention mechanisms, which allow them to understand relationships across the entire image. In this paper, we compare different types of ViTs (pure, hierarchical, and hybrid) against traditional CNN models across various tasks, including object recognition, detection, and medical image classification. We conduct thorough tests on standard datasets like ImageNet for image classification and COCO for object detection. Additionally, we apply these models to medical imaging using the ChestX-ray14 dataset. We find that hybrid and hierarchical transformers, especially Swin and CvT, offer a strong balance between accuracy and computational resources. Furthermore, by experimenting with data augmentation techniques on medical images, we discover significant performance improvements, particularly with the Swin Transformer model. Overall, our results indicate that Vision Transformers are competitive and, in many cases, outperform traditional CNNs, especially in scenarios requiring the understanding of global visual contexts like medical imaging.

Continual learning in Neural Machine Translation (NMT) faces the dual challenges of catastrophic forgetting and the high computational cost of retraining. This study establishes Low-Rank Adaptation (LoRA) as a parameter-efficient framework to address these challenges in dedicated NMT architectures. We first demonstrate that LoRA-based fine-tuning adapts NMT models to new languages and domains with performance on par with full-parameter techniques, while utilizing only a fraction of the parameter space. Second, we propose an interactive adaptation method using a calibrated linear combination of LoRA modules. This approach functions as a gate-free mixture of experts, enabling real-time, user-controllable adjustments to domain and style without retraining. Finally, to mitigate catastrophic forgetting, we introduce a novel gradient-based regularization strategy specifically designed for low-rank decomposition matrices. Unlike methods that regularize the full parameter set, our approach weights the penalty on the low-rank updates using historical gradient information. Experimental results indicate that this strategy efficiently preserves prior domain knowledge while facilitating the acquisition of new tasks, offering a scalable paradigm for interactive and continual NMT.