Generative AI
Beyond Generative AI: World Models for Clinical Prediction, Counterfactuals, and Planning
Qazi, Mohammad Areeb, Nadeem, Maryam, Yaqub, Mohammad
Healthcare requires AI that is predictive, reliable, and data-efficient. However, recent generative models lack physical foundation and temporal reasoning required for clinical decision support. As scaling language models show diminishing returns for grounded clinical reasoning, world models are gaining traction because they learn multimodal, temporally coherent, and action-conditioned representations that reflect the physical and causal structure of care. This paper reviews World Models for healthcare systems that learn predictive dynamics to enable multistep rollouts, counterfactual evaluation and planning. We survey recent work across three domains: (i) medical imaging and diagnostics (e.g., longitudinal tumor simulation, projection-transition modeling, and Joint Embedding Predictive Architecture i.e., JEPA-style predictive representation learning), (ii) disease progression modeling from electronic health records (generative event forecasting at scale), and (iii) robotic surgery and surgical planning (action-conditioned guidance and control). We also introduce a capability rubric: L1 temporal prediction, L2 action-conditioned prediction, L3 counterfactual rollouts for decision support, and L4 planning/control. Most reviewed systems achieve L1--L2, with fewer instances of L3 and rare L4. We identify cross-cutting gaps that limit clinical reliability; under-specified action spaces and safety constraints, weak interventional validation, incomplete multimodal state construction, and limited trajectory-level uncertainty calibration. This review outlines a research agenda for clinically robust prediction-first world models that integrate generative backbones (transformers, diffusion, VAE) with causal/mechanical foundation for safe decision support in healthcare.
Towards Overcoming Data Scarcity in Nuclear Energy: A Study on Critical Heat Flux with Physics-consistent Conditional Diffusion Model
Alsafadi, Farah, Akins, Alexandra, Wu, Xu
Deep generative modeling provides a powerful pathway to overcome data scarcity in energy-related applications where experimental data are often limited, costly, or difficult to obtain. By learning the underlying probability distribution of the training dataset, deep generative models, such as the diffusion model (DM), can generate high-fidelity synthetic samples that statistically resemble the training data. Such synthetic data generation can significantly enrich the size and diversity of the available training data, and more importantly, improve the robustness of downstream machine learning models in predictive tasks. The objective of this paper is to investigate the effectiveness of DM for overcoming data scarcity in nuclear energy applications. By leveraging a public dataset on critical heat flux (CHF) that cover a wide range of commercial nuclear reactor operational conditions, we developed a DM that can generate an arbitrary amount of synthetic samples for augmenting of the CHF dataset. Since a vanilla DM can only generate samples randomly, we also developed a conditional DM capable of generating targeted CHF data under user-specified thermal-hydraulic conditions. The performance of the DM was evaluated based on their ability to capture empirical feature distributions and pair-wise correlations, as well as to maintain physical consistency. The results showed that both the DM and conditional DM can successfully generate realistic and physics-consistent CHF data. Furthermore, uncertainty quantification was performed to establish confidence in the generated data. The results demonstrated that the conditional DM is highly effective in augmenting CHF data while maintaining acceptable levels of uncertainty.
Artificial Intelligence and Accounting Research: A Framework and Agenda
Stratopoulos, Theophanis C., Wang, Victor Xiaoqi
Recent advances in artificial intelligence, particularly generative AI (GenAI) and large language models (LLMs), are fundamentally transforming accounting research, creating both opportunities and competitive threats for scholars. This paper proposes a framework that classifies AI-accounting research along two dimensions: research focus (accounting-centric versus AI-centric) and methodological approach (AI-based versus traditional methods). We apply this framework to papers from the IJAIS special issue and recent AI-accounting research published in leading accounting journals to map existing studies and identify research opportunities. Using this same framework, we analyze how accounting researchers can leverage their expertise through strategic positioning and collaboration, revealing where accounting scholars' strengths create the most value. We further examine how GenAI and LLMs transform the research process itself, comparing the capabilities of human researchers and AI agents across the entire research workflow. This analysis reveals that while GenAI democratizes certain research capabilities, it simultaneously intensifies competition by raising expectations for higher-order contributions where human judgment, creativity, and theoretical depth remain valuable. These shifts call for reforming doctoral education to cultivate comparative advantages while building AI fluency.
Writing With Machines and Peers: Designing for Critical Engagement with Generative AI
Zhu, Xinran, Wang, Cong, Searsmith, Duane
The growing integration of generative AI in higher education is transforming how students write, learn, and engage with knowledge. As AI tools become more integrated into classrooms, there is an urgent need for pedagogical approaches that help students use them critically and reflectively. This study proposes a pedagogical design that integrates AI and peer feedback in a graduate-level academic writing activity. Over eight weeks, students developed literature review projects through multiple writing and revision stages, receiving feedback from both a custom-built AI reviewer and human peers. We examine two questions: (1) How did students interact with and incorporate AI and peer feedback during the writing process? and (2) How did they reflect on and build relationships with both human and AI reviewers? Data sources include student writing artifacts, AI and peer feedback, AI chat logs, and student reflections. Findings show that students engaged differently with each feedback source-relying on AI for rubric alignment and surface-level edits, and on peer feedback for conceptual development and disciplinary relevance. Reflections revealed evolving relationships with AI, characterized by increasing confidence, strategic use, and critical awareness of its limitations. The pedagogical design supported writing development, AI literacy, and disciplinary understanding. This study offers a scalable pedagogical model for integrating AI into writing instruction and contributes insights for system-level approaches to fostering meaningful human-AI collaboration in higher education.
Just Asking Questions: Doing Our Own Research on Conspiratorial Ideation by Generative AI Chatbots
FitzGerald, Katherine M., Riedlinger, Michelle, Bruns, Axel, Harrington, Stephen, Graham, Timothy, Angus, Daniel
Interactive chat systems that build on artificial intelligence frameworks are increasingly ubiquitous and embedded into search engines, Web browsers, and operating systems, or are available on websites and apps. Researcher efforts have sought to understand the limitations and potential for harm of generative AI, which we contribute to here. Conducting a systematic review of six AI-powered chat systems (ChatGPT 3.5; ChatGPT 4 Mini; Microsoft Copilot in Bing; Google Search AI; Perplexity; and Grok in Twitter/X), this study examines how these leading products respond to questions related to conspiracy theories. This follows the platform policy implementation audit approach established by Glazunova et al. (2023). We select five well-known and comprehensively debunked conspiracy theories and four emerging conspiracy theories that relate to breaking news events at the time of data collection. Our findings demonstrate that the extent of safety guardrails against conspiratorial ideation in generative AI chatbots differs markedly, depending on chatbot model and conspiracy theory. Our observations indicate that safety guardrails in AI chatbots are often very selectively designed: generative AI companies appear to focus especially on ensuring that their products are not seen to be racist; they also appear to pay particular attention to conspiracy theories that address topics of substantial national trauma such as 9/11 or relate to well-established political issues. Future work should include an ongoing effort extended to further platforms, multiple languages, and a range of conspiracy theories extending well beyond the United States.
Kandinsky 5.0: A Family of Foundation Models for Image and Video Generation
Arkhipkin, Vladimir, Korviakov, Vladimir, Gerasimenko, Nikolai, Parkhomenko, Denis, Vasilev, Viacheslav, Letunovskiy, Alexey, Vaulin, Nikolai, Kovaleva, Maria, Kirillov, Ivan, Novitskiy, Lev, Koposov, Denis, Kiselev, Nikita, Varlamov, Alexander, Mikhailov, Dmitrii, Polovnikov, Vladimir, Shutkin, Andrey, Agafonova, Julia, Vasiliev, Ilya, Kargapoltseva, Anastasiia, Dmitrienko, Anna, Maltseva, Anastasia, Averchenkova, Anna, Kim, Olga, Nikulina, Tatiana, Dimitrov, Denis
This report introduces Kandinsky 5.0, a family of state-of-the-art foundation models for high-resolution image and 10-second video synthesis. The framework comprises three core line-up of models: Kandinsky 5.0 Image Lite - a line-up of 6B parameter image generation models, Kandinsky 5.0 Video Lite - a fast and lightweight 2B parameter text-to-video and image-to-video models, and Kandinsky 5.0 Video Pro - 19B parameter models that achieves superior video generation quality. We provide a comprehensive review of the data curation lifecycle - including collection, processing, filtering and clustering - for the multi-stage training pipeline that involves extensive pre-training and incorporates quality-enhancement techniques such as self-supervised fine-tuning (SFT) and reinforcement learning (RL)-based post-training. We also present novel architectural, training, and inference optimizations that enable Kandinsky 5.0 to achieve high generation speeds and state-of-the-art performance across various tasks, as demonstrated by human evaluation. As a large-scale, publicly available generative framework, Kandinsky 5.0 leverages the full potential of its pre-training and subsequent stages to be adapted for a wide range of generative applications. We hope that this report, together with the release of our open-source code and training checkpoints, will substantially advance the development and accessibility of high-quality generative models for the research community.
Training-free Detection of AI-generated images via Cropping Robustness
Choi, Sungik, Lee, Hankook, Lee, Moontae
AI-generated image detection has become crucial with the rapid advancement of vision-generative models. Instead of training detectors tailored to specific datasets, we study a training-free approach leveraging self-supervised models without requiring prior data knowledge. These models, pre-trained with augmentations like RandomResizedCrop, learn to produce consistent representations across varying resolutions. Motivated by this, we propose WaRPAD, a training-free AI-generated image detection algorithm based on self-supervised models. Since neighborhood pixel differences in images are highly sensitive to resizing operations, WaRPAD first defines a base score function that quantifies the sensitivity of image embeddings to perturbations along high-frequency directions extracted via Haar wavelet decomposition. To simulate robustness against cropping augmentation, we rescale each image to a multiple of the models input size, divide it into smaller patches, and compute the base score for each patch. The final detection score is then obtained by averaging the scores across all patches. We validate WaRPAD on real datasets of diverse resolutions and domains, and images generated by 23 different generative models. Our method consistently achieves competitive performance and demonstrates strong robustness to test-time corruptions. Furthermore, as invariance to RandomResizedCrop is a common training scheme across self-supervised models, we show that WaRPAD is applicable across self-supervised models.
Can Artificial Intelligence Accelerate Technological Progress? Researchers' Perspectives on AI in Manufacturing and Materials Science
Nelson, John P., Olugbade, Olajide, Shapira, Philip, Biddle, Justin B.
Applications of artificial intelligence or machine learning in research Modes of use Surrogate modeling for physics - based models Modeling of poorly understood phenomena Data preprocessing Large language model use Applications AI/ML as research tool Production process design, monitoring, & output prediction Part design & properties prediction Materials design & properties prediction AI/ML as research product Generative AI design tool for consumers Generic research tasks Large language models for coding Large language models for literature review Benefits of artificial intelligence or machine learning in research Reduction in accuracy/cost/speed trade - off in research, especially computer modeling Reduced computation time Replacing experimentation Reducing need for computationally intensive, physics - based models Saving research labor Exploring larger design spaces Address of previously unsolvable problems Model poorly understood relationships between variables Identify human - unidentifiable patterns or phenomena Downsides of artificial intelligence or machine learning in research Accuracy weaknesses Predict poorly outside regions of dense, high - quality training data Interpretability weaknesses Bounds of accuracy can be unclear Accuracy assessment can be difficult Long - run scientific progress concerns AI/ML cannot develop novel scientific theory AI/ML may bypass opportunities to identify empirical or theoretical novelties Resource issues Data acquisition and cleaning is time - intensive AI/ML models are computation - and energy - intensive to develop Inappropriate use issues Easy to over - trust May be inappropriately used to address problems soluble with simpler methods 8 Second, AI/ML models can be trained on input and output data for phenomena (e.g., complex production processes) which lack robust theoretical models, developing novel predictive capabilities in the absence of explicit, human - designed theory. This is somet imes referred to as "phenomenological modeling," as it attempts to model phenomena in the absence of mechanistic, explanatory understanding: [T]he first reason we choose to use AI is because we don't have a good model of what our system is. . . I get a bunch of data coming in and I have a bunch of sensor readings, you know. . . And I use the AI to map the bunch of sensor readings to the process health or process status or machine status that I have.
A First-Principles Based Risk Assessment Framework and the IEEE P3396 Standard
Tong, Richard J., Cortรชs, Marina, DeFalco, Jeanine A., Underwood, Mark, Zalewski, Janusz
Generative Artificial Intelligence (AI) is enabling unprecedented automation in content creation and decision support, but it also raises novel risks. This paper presents a first-principles risk assessment framework underlying the IEEE P3396 Recommended Practice for AI Risk, Safety, Trustworthiness, and Responsibility. We distinguish between process risks (risks arising from how AI systems are built or operated) and outcome risks (risks manifest in the AI system's outputs and their real-world effects), arguing that generative AI governance should prioritize outcome risks. Central to our approach is an information-centric ontology that classifies AI-generated outputs into four fundamental categories: (1) Perception-level information, (2) Knowledge-level information, (3) Decision/Action plan information, and (4) Control tokens (access or resource directives). This classification allows systematic identification of harms and more precise attribution of responsibility to stakeholders (developers, deployers, users, regulators) based on the nature of the information produced. We illustrate how each information type entails distinct outcome risks (e.g. deception, misinformation, unsafe recommendations, security breaches) and requires tailored risk metrics and mitigations. By grounding the framework in the essence of information, human agency, and cognition, we align risk evaluation with how AI outputs influence human understanding and action. The result is a principled approach to AI risk that supports clear accountability and targeted safeguards, in contrast to broad application-based risk categorizations. We include example tables mapping information types to risks and responsibilities. This work aims to inform the IEEE P3396 Recommended Practice and broader AI governance with a rigorous, first-principles foundation for assessing generative AI risks while enabling responsible innovation.
Toward Valid Generative Clinical Trial Data with Survival Endpoints
Chassat, Perrine, Nguyen, Van Tuan, Ducrot, Lucas, Lanoy, Emilie, Guilloux, Agathe
Clinical trials face mounting challenges: fragmented patient populations, slow enrollment, and unsustainable costs, particularly for late phase trials in oncology and rare diseases. While external control arms built from real-world data have been explored, a promising alternative is the generation of synthetic control arms using generative AI. A central challenge is the generation of time-to-event outcomes, which constitute primary endpoints in oncology and rare disease trials, but are difficult to model under censoring and small sample sizes. Existing generative approaches, largely GAN-based, are data-hungry, unstable, and rely on strong assumptions such as independent censoring. We introduce a variational autoencoder (VAE) that jointly generates mixed-type covariates and survival outcomes within a unified latent variable framework, without assuming independent censoring. Across synthetic and real trial datasets, we evaluate our model in two realistic scenarios: (i) data sharing under privacy constraints, where synthetic controls substitute for original data, and (ii) control-arm augmentation, where synthetic patients mitigate imbalances between treated and control groups. Our method outperforms GAN baselines on fidelity, utility, and privacy metrics, while revealing systematic miscalibration of type I error and power. We propose a post-generation selection procedure that improves calibration, highlighting both progress and open challenges for generative survival modeling.