Developing effective prompts demands significant cognitive investment to generate reliable, high-quality responses from Large Language Models (LLMs). By deploying case-specific prompt engineering techniques that streamline frequently performed life sciences workflows, researchers could achieve substantial efficiency gains that far exceed the initial time investment required to master these techniques. The Prompt Report published in 2025 outlined 58 different text-based prompt engineering techniques, highlighting the numerous ways prompts could be constructed. To provide actionable guidelines and reduce the friction of navigating these various approaches, we distil this report to focus on 6 core techniques: zero-shot, few-shot approaches, thought generation, ensembling, self-criticism, and decomposition. We breakdown the significance of each approach and ground it in use cases relevant to life sciences, from literature summarization and data extraction to editorial tasks. We provide detailed recommendations for how prompts should and shouldn't be structured, addressing common pitfalls including multi-turn conversation degradation, hallucinations, and distinctions between reasoning and non-reasoning models. We examine context window limitations, agentic tools like Claude Code, while analyzing the effectiveness of Deep Research tools across OpenAI, Google, Anthropic and Perplexity platforms, discussing current limitations. We demonstrate how prompt engineering can augment rather than replace existing established individual practices around data processing and document editing. Our aim is to provide actionable guidance on core prompt engineering principles, and to facilitate the transition from opportunistic prompting to an effective, low-friction systematic practice that contributes to higher quality research.

Artificial Intelligence Generated Content (AIGC) has rapidly emerged with the capability to generate different forms of content, including text, images, videos, and other modalities, which can achieve a quality similar to content created by humans. As a result, AIGC is now widely applied across various domains such as digital marketing, education, and public health, and has shown promising results by enhancing content creation efficiency and improving information delivery. However, there are few studies that explore the latest progress and emerging challenges of AIGC across different domains. To bridge this gap, this paper brings together 16 scholars from multiple disciplines to provide a cross-domain perspective on the trends and challenges of AIGC. Specifically, the contributions of this paper are threefold: (1) It first provides a broader overview of AIGC, spanning the training techniques of Generative AI, detection methods, and both the spread and use of AI-generated content across digital platforms. (2) It then introduces the societal impacts of AIGC across diverse domains, along with a review of existing methods employed in these contexts. (3) Finally, it discusses the key technical challenges and presents research propositions to guide future work. Through these contributions, this vision paper seeks to offer readers a cross-domain perspective on AIGC, providing insights into its current research trends, ongoing challenges, and future directions.

Neural Cellular Automata (NCA) represent a powerful framework for modeling biological self-organization, extending classical rule-based systems with trainable, differentiable (or evolvable) update rules that capture the adaptive self-regulatory dynamics of living matter. By embedding Artificial Neural Networks (ANNs) as local decision-making centers and interaction rules between localized agents, NCA can simulate processes across molecular, cellular, tissue, and system-level scales, offering a multiscale competency architecture perspective on evolution, development, regeneration, aging, morphogenesis, and robotic control. These models not only reproduce biologically inspired target patterns but also generalize to novel conditions, demonstrating robustness to perturbations and the capacity for open-ended adaptation and reasoning. Given their immense success in recent developments, we here review current literature of NCAs that are relevant primarily for biological or bioengineering applications. Moreover, we emphasize that beyond biology, NCAs display robust and generalizing goal-directed dynamics without centralized control, e.g., in controlling or regenerating composite robotic morphologies or even on cutting-edge reasoning tasks such as ARC-AGI-1. In addition, the same principles of iterative state-refinement is reminiscent to modern generative Artificial Intelligence (AI), such as probabilistic diffusion models. Their governing self-regulatory behavior is constraint to fully localized interactions, yet their collective behavior scales into coordinated system-level outcomes. We thus argue that NCAs constitute a unifying computationally lean paradigm that not only bridges fundamental insights from multiscale biology with modern generative AI, but have the potential to design truly bio-inspired collective intelligence capable of hierarchical reasoning and control.

Generative AI (GenAI) is rapidly entering K-12 classrooms, offering teachers new ways for teaching practices. Yet GenAI models are often trained on culturally uneven datasets, embedding a "default culture" that often misaligns with local classrooms. To understand how teachers navigate this gap, we defined the new concept Cultural Distance (the gap between GenAI's default cultural repertoire and the situated demands of teaching practice) and conducted in-depth interviews with 30 K-12 teachers, 10 each from South Africa, Taiwan, and the United States, who had integrated AI into their teaching practice. These teachers' experiences informed the development of our three-level cultural distance framework. This work contributes the concept and framework of cultural distance, six illustrative instances spanning in low, mid, high distance levels with teachers' experiences and strategies for addressing them. Empirically, we offer implications to help AI designers, policymakers, and educators create more equitable and culturally responsive GenAI tools for education.

The success and wide adoption of generative AI (GenAI), particularly large language models (LLMs), has attracted the attention of cybercriminals seeking to abuse models, steal sensitive data, or disrupt services. Moreover, providing security to LLM-based systems is a great challenge, as both traditional threats to software applications and threats targeting LLMs and their integration must be mitigated. In this survey, we shed light on security and privacy concerns of such LLM-based systems by performing a systematic review and comprehensive categorization of threats and defensive strategies considering the entire software and LLM life cycles. We analyze real-world scenarios with distinct characteristics of LLM usage, spanning from development to operation. In addition, threats are classified according to their severity level and to which scenarios they pertain, facilitating the identification of the most relevant threats. Recommended defense strategies are systematically categorized and mapped to the corresponding life cycle phase and possible attack strategies they attenuate. This work paves the way for consumers and vendors to understand and efficiently mitigate risks during integration of LLMs in their respective solutions or organizations. It also enables the research community to benefit from the discussion of open challenges and edge cases that may hinder the secure and privacy-preserving adoption of LLM-based systems.

Generative AI is reshaping UX design practices through "vibe coding," where UX professionals express intent in natural language and AI translates it into functional prototypes and code. Despite rapid adoption, little research has examined how vibe coding reconfigures UX workflows and collaboration. Drawing on interviews with 20 UX professionals across enterprises, startups, and academia, we show how vibe coding follows a four-stage workflow of ideation, AI generation, debugging, and review. This accelerates iteration, supports creativity, and lowers barriers to participation. However, professionals reported challenges of code unreliability, integration, and AI over-reliance. We find tensions between efficiency-driven prototyping ("intending the right design") and reflection ("designing the right intention"), introducing new asymmetries in trust, responsibility, and social stigma within teams. Through the lens of responsible human-AI collaboration for AI-assisted UX design and development, we contribute a deeper understanding of deskilling, ownership and disclosure, and creativity safeguarding in the age of vibe coding.

Exploratory learning environments (ELEs), such as simulation-based platforms and open-ended science curricula, promote hands-on exploration and problem-solving but make it difficult for teachers to gain timely insights into students' conceptual understanding. This paper presents LearnLens, a generative AI (GenAI)-enhanced teacher-facing dashboard designed to support problem-based instruction in middle school science. LearnLens processes students' open-ended responses from digital assessments to provide various insights, including sample responses, word clouds, bar charts, and AI-generated summaries. These features elucidate students' thinking, enabling teachers to adjust their instruction based on emerging patterns of understanding. The dashboard was informed by teacher input during professional development sessions and implemented within a middle school Earth science curriculum. We report insights from teacher interviews that highlight the dashboard's usability and potential to guide teachers' instruction in the classroom.

This study investigates the aesthetic experience and educational value of collaborative artmaking with generative artificial intelligence (AI) among young learners and art students. Based on a survey of 112 participants, we examine how human creators renegotiate their roles, how conventional notions of originality are challenged, how the creative process is transformed, and how aesthetic judgment is formed in human-AI co-creation. Empirically, participants generally view AI as a partner that stimulates ideation and expands creative boundaries rather than a passive tool, while simultaneously voicing concerns about stylistic homogenization and the erosion of traditional authorship. Theoretically, we synthesize Dewey's aesthetics of experience, Ihde's postphenomenology, and actor-network theory (ANT) into a single analytical framework to unpack the dynamics between human creators and AI as a non-human actant. Findings indicate (i) a fluid subjectivity in which creators shift across multiple stances (director, dialogic partner, discoverer); (ii) an iterative, dialogic workflow (intent-generate-select-refine) that centers critical interpretation; and (iii) an educational value shift from technical skill training toward higher-order competencies such as critical judgment, cross-modal ideation, and reflexivity. We argue that arts education should cultivate a critical co-creation stance toward technology, guiding learners to collaborate with AI while preserving human distinctiveness in concept formation, judgment, and meaning-making.

Large Language Models (LLMs) are increasingly integrated into financial applications, yet existing red-teaming research primarily targets harmful content, largely neglecting regulatory risks. In this work, we aim to investigate the vulnerability of financial LLMs through red-teaming approaches. We introduce Risk-Concealment Attacks (RCA), a novel multi-turn framework that iteratively conceals regulatory risks to provoke seemingly compliant yet regulatory-violating responses from LLMs. To enable systematic evaluation, we construct FIN-Bench, a domain-specific benchmark for assessing LLM safety in financial contexts. Extensive experiments on FIN-Bench demonstrate that RCA effectively bypasses nine mainstream LLMs, achieving an average attack success rate (ASR) of 93.18%, including 98.28% on GPT-4.1 and 97.56% on OpenAI o1. These findings reveal a critical gap in current alignment techniques and underscore the urgent need for stronger moderation mechanisms in financial domains. We hope this work offers practical insights for advancing robust and domain-aware LLM alignment.

Continual learning -- the ability to acquire knowledge incrementally without forgetting previous skills -- is fundamental to natural intelligence. While the human brain excels at this, artificial neural networks struggle with "catastrophic forgetting," where learning new tasks erases previously acquired knowledge. This challenge is particularly severe for text-to-image diffusion models, which generate images from textual prompts. Additionally, these models face "mode collapse," where their outputs become increasingly repetitive over time. To address these challenges, we apply Latent Replay, a neuroscience-inspired approach, to diffusion models. Traditional replay methods mitigate forgetting by storing and revisiting past examples, typically requiring large collections of images. Latent Replay instead retains only compact, high-level feature representations extracted from the model's internal architecture. This mirrors the hippocampal process of storing neural activity patterns rather than raw sensory inputs, reducing memory usage while preserving critical information. Through experiments with five sequentially learned visual concepts, we demonstrate that Latent Replay significantly outperforms existing methods in maintaining model versatility. After learning all concepts, our approach retained 77.59% Image Alignment (IA) on the earliest concept, 14% higher than baseline methods, while maintaining diverse outputs. Surprisingly, random selection of stored latent examples outperforms similarity-based strategies. Our findings suggest that Latent Replay enables efficient continual learning for generative AI models, paving the way for personalized text-to-image models that evolve with user needs without excessive computational costs.