Accurate medication dosing holds an important position in the overall patient therapeutic process. Therefore, much research has been conducted to develop optimal administration strategy based on Reinforcement learning (RL). However, Relying solely on a few explicitly defined reward functions makes it difficult to learn a treatment strategy that encompasses the diverse characteristics of various patients. Moreover, the multitude of drugs utilized in clinical practice makes it infeasible to construct a dedicated reward function for each medication. Here, we tried to develop a reward network that captures clinicians' therapeutic intentions, departing from explicit rewards, and to derive an optimal heparin dosing policy. In this study, we introduce Offline Model-based Guided Reward Learning (OMG-RL), which performs offline inverse RL (IRL). Through OMG-RL, we learn a parameterized reward function that captures the expert's intentions from limited data, thereby enhancing the agent's policy. We validate the proposed approach on the heparin dosing task. We show that OMG-RL policy is positively reinforced not only in terms of the learned reward network but also in activated partial thromboplastin time (aPTT), a key indicator for monitoring the effects of heparin. This means that the OMG-RL policy adequately reflects clinician's intentions. This approach can be widely utilized not only for the heparin dosing problem but also for RL-based medication dosing tasks in general.

This article considers the impact of different thresholding methods to the Nearest Shrunken Centroid algorithm, which is popularly referred as the Prediction Analysis of Microarrays (PAM) for high-dimensional classification. PAM uses soft thresholding to achieve high computational efficiency and high classification accuracy but in the price of retaining too many features. When applied to microarray human cancers, PAM selected 2611 features on average from 10 multi-class datasets. Such a large number of features make it difficult to perform follow up study. One reason behind this problem is the soft thresholding, which is known to produce biased parameter estimate in regression analysis. In this article, we extend the PAM algorithm with two other thresholding methods, hard and order thresholding, and a deep search algorithm to achieve better thresholding parameter estimate. The modified algorithms are extensively tested and compared to the original one based on real data and Monte Carlo studies. In general, the modification not only gave better cancer status prediction accuracy, but also resulted in more parsimonious models with significantly smaller number of features.

An adaptive multiexpert mixture of feedback causal models can approximate missing or phantom nodes in large-scale causal models. The result gives a scalable form of \emph{big knowledge}. The mixed model approximates a sampled dynamical system by approximating its main limit-cycle equilibria. Each expert first draws a fuzzy cognitive map (FCM) with at least one missing causal node or variable. FCMs are directed signed partial-causality cyclic graphs. They mix naturally through convex combination to produce a new causal feedback FCM. Supervised learning helps each expert FCM estimate its phantom node by comparing the FCM's partial equilibrium with the complete multi-node equilibrium. Such phantom-node estimation allows partial control over these causal hallucinations and helps approximate the future trajectory of the dynamical system. But the approximation can be computationally heavy. Mixing the tuned expert FCMs gives a practical way to find several phantom nodes and thereby better approximate the feedback system's true equilibrium behavior.

Text Classification (TC) stands as a cornerstone within the realm of Natural Language Processing (NLP), particularly when viewed through the lens of computer science and engineering. The past decade has seen deep learning revolutionize TC, propelling advancements in text retrieval, categorization, information extraction, and summarization. The scholarly literature is rich with datasets, models, and evaluation criteria, with English being the predominant language of focus, despite studies involving Arabic, Chinese, Hindi, and others. The efficacy of TC models relies heavily on their ability to capture intricate textual relationships and nonlinear correlations, necessitating a comprehensive examination of the entire TC pipeline. This monograph provides an in-depth exploration of the TC pipeline, with a particular emphasis on evaluating the impact of each component on the overall performance of TC models. The pipeline includes state-of-the-art datasets, text preprocessing techniques, text representation methods, classification models, evaluation metrics, current results and future trends. Each chapter meticulously examines these stages, presenting technical innovations and significant recent findings. The work critically assesses various classification strategies, offering comparative analyses, examples, case studies, and experimental evaluations. These contributions extend beyond a typical survey, providing a detailed and insightful exploration of TC.

We introduce new \emph{soft diamond} regularizers that both improve synaptic sparsity and maintain classification accuracy in deep neural networks. These parametrized regularizers outperform the state-of-the-art hard-diamond Laplacian regularizer of Lasso regression and classification. They use thick-tailed symmetric alpha-stable ($\mathcal{S \alpha S}$) bell-curve synaptic weight priors that are not Gaussian and so have thicker tails. The geometry of the diamond-shaped constraint set varies from a circle to a star depending on the tail thickness and dispersion of the prior probability density function. Training directly with these priors is computationally intensive because almost all $\mathcal{S \alpha S}$ probability densities lack a closed form. A precomputed look-up table removed this computational bottleneck. We tested the new soft diamond regularizers with deep neural classifiers on the three datasets CIFAR-10, CIFAR-100, and Caltech-256. The regularizers improved the accuracy of the classifiers. The improvements included $4.57\%$ on CIFAR-10, $4.27\%$ on CIFAR-100, and $6.69\%$ on Caltech-256. They also outperformed $L_2$ regularizers on all the test cases. Soft diamond regularizers also outperformed $L_1$ lasso or Laplace regularizers because they better increased sparsity while improving classification accuracy. Soft-diamond priors substantially improved accuracy on CIFAR-10 when combined with dropout, batch, or data-augmentation regularization.

Language agents [1-4] are AI agents [5] that integrate LLMs [6-8] as core components. LLMs excel at zero-shot generalization [9, 10], providing a notable advantage over traditional AI agents, such as those based on handcrafted rules or reinforcement learning, which often struggle to generalize to new environments [11]. While LLMs can exhibit flawed reasoning and logic when used in isolation [12-14], constructing a language agent by grounding LLMs in an environment with observational feedback can mitigate these issues. Early work on language agents used LLMs to directly output actions in the external environment [15-17], while more recently, language agents have been augmented with internal reasoning [18, 19] and planning [20, 21] procedures, as well as long-term memory storage [22, 23]. An emergent research challenge is to pose a theoretical description of the learning problem solved by language agents [4, 24] and to develop efficient methods to optimize the components of a language agent [24-26]. Here, we define common language agent tasks as language decision processes (LDPs) and frame language agents as stochastic computation graphs [27] that may be trained to solve LDPs. We show that pre-existing agents [18, 19, 21] can be implemented within our stochastic computation graph framework and introduce a simple and extensible software package named LDP that enables modular interchange of environments, agents, and optimizers, simplifying experimentation across a variety of settings. These authors jointly supervise technical work at FutureHouse.

In Reinforcement Learning (RL) theory, we impose restrictive assumptions to design an algorithm with provably sublinear regret. Common assumptions, like linear or RKHS models, and Gaussian or log-concave posteriors over the models, do not explain practical success of RL across a wider range of distributions and models. Thus, we study how to design RL algorithms with sublinear regret for isoperimetric distributions, specifically the ones satisfying the Log-Sobolev Inequality (LSI). LSI distributions include the standard setups of RL and others, such as many non-log-concave and perturbed distributions. First, we show that the Posterior Sampling-based RL (PSRL) yields sublinear regret if the data distributions satisfy LSI under some mild additional assumptions. Also, when we cannot compute or sample from an exact posterior, we propose a Langevin sampling-based algorithm design: LaPSRL. We show that LaPSRL achieves order optimal regret and subquadratic complexity per episode. Finally, we deploy LaPSRL with a Langevin sampler -- SARAH-LD, and test it for different bandit and MDP environments. Experimental results validate the generality of LaPSRL across environments and its competitive performance with respect to the baselines.

In this work, we propose a first-order sampling method called the Metropolis-adjusted Preconditioned Langevin Algorithm for approximate sampling from a target distribution whose support is a proper convex subset of $\mathbb{R}^{d}$. Our proposed method is the result of applying a Metropolis-Hastings filter to the Markov chain formed by a single step of the preconditioned Langevin algorithm with a metric $\mathscr{G}$, and is motivated by the natural gradient descent algorithm for optimisation. We derive non-asymptotic upper bounds for the mixing time of this method for sampling from target distributions whose potentials are bounded relative to $\mathscr{G}$, and for exponential distributions restricted to the support. Our analysis suggests that if $\mathscr{G}$ satisfies stronger notions of self-concordance introduced in Kook and Vempala (2024), then these mixing time upper bounds have a strictly better dependence on the dimension than when is merely self-concordant. We also provide numerical experiments that demonstrates the practicality of our proposed method. Our method is a high-accuracy sampler due to the polylogarithmic dependence on the error tolerance in our mixing time upper bounds.

Trajectory prediction aims to estimate an entity's future path using its current position and historical movement data, benefiting fields like autonomous navigation, robotics, and human movement analytics. Deep learning approaches have become key in this area, utilizing large-scale trajectory datasets to model movement patterns, but face challenges in managing complex spatial dependencies and adapting to dynamic environments. To address these challenges, we introduce TrajLearn, a novel model for trajectory prediction that leverages generative modeling of higher-order mobility flows based on hexagonal spatial representation. TrajLearn predicts the next $k$ steps by integrating a customized beam search for exploring multiple potential paths while maintaining spatial continuity. We conducted a rigorous evaluation of TrajLearn, benchmarking it against leading state-of-the-art approaches and meaningful baselines. The results indicate that TrajLearn achieves significant performance gains, with improvements of up to ~40% across multiple real-world trajectory datasets. In addition, we evaluated different prediction horizons (i.e., various values of $k$), conducted resolution sensitivity analysis, and performed ablation studies to assess the impact of key model components. Furthermore, we developed a novel algorithm to generate mixed-resolution maps by hierarchically subdividing hexagonal regions into finer segments within a specified observation area. This approach supports selective detailing, applying finer resolution to areas of interest or high activity (e.g., urban centers) while using coarser resolution for less significant regions (e.g., rural areas), effectively reducing data storage requirements and computational overhead. We promote reproducibility and adaptability by offering complete code, data, and detailed documentation with flexible configuration options for various applications.

This study proposes a unifying theoretical framework called generative emergent communication (generative EmCom) that bridges emergent communication, world models, and large language models (LLMs) through the lens of collective predictive coding (CPC). The proposed framework formalizes the emergence of language and symbol systems through decentralized Bayesian inference across multiple agents, extending beyond conventional discriminative model-based approaches to emergent communication. This study makes the following two key contributions: First, we propose generative EmCom as a novel framework for understanding emergent communication, demonstrating how communication emergence in multi-agent reinforcement learning (MARL) can be derived from control as inference while clarifying its relationship to conventional discriminative approaches. Second, we propose a mathematical formulation showing the interpretation of LLMs as collective world models that integrate multiple agents' experiences through CPC. The framework provides a unified theoretical foundation for understanding how shared symbol systems emerge through collective predictive coding processes, bridging individual cognitive development and societal language evolution. Through mathematical formulations and discussion on prior works, we demonstrate how this framework explains fundamental aspects of language emergence and offers practical insights for understanding LLMs and developing sophisticated AI systems for improving human-AI interaction and multi-agent systems.