Hidden Markov Models (HMMs) can be applied to several important problems in molecular biology. We introduce a new convergent learning algorithm for HMMs that, unlike the classical Baum-Welch algorithm is smooth and can be applied online or in batch mode, with or without the usual Viterbi most likely path approximation. Left-right HMMs with insertion and deletion states are then trained to represent several protein families including immunoglobulins and kinases. In all cases, the models derived capture all the important statistical properties of the families and can be used efficiently in a number of important tasks such as multiple alignment, motif detection, and classification.

We propose in this paper a statistical model (planar hidden Markov model - PHMM) describing statistical properties of images. The model generalizes the single-dimensional HMM, used for speech processing, to the planar case. For this model to be useful an efficient segmentation algorithm, similar to the Viterbi algorithm for HMM, must exist We present conditions in terms of the PHMM parameters that are sufficient to guarantee that the planar segmentation problem can be solved in polynomial time, and describe an algorithm for that. This algorithm aligns optimally the image with the model, and therefore is insensitive to elastic distortions of images. Using this algorithm a joint optima1 segmentation and recognition of the image can be performed, thus overcoming the weakness of traditional OCR systems where segmentation is performed independently before the recognition leading to unrecoverable recognition errors. Tbe PHMM approach was evaluated using a set of isolated band-written digits. An overall digit recognition accuracy of 95% was acbieved. An analysis of the results showed that even in the simple case of recognition of isolated characters, the elimination of elastic distortions enhances the performance Significantly. We expect that the advantage of this approach will be even more significant for tasks such as connected writing recognition/spotting, for whicb there is no known high accuracy method of recognition.

Untill recently, state-of-the-art, large-vocabulary, continuous speech recognition (CSR) has employed Hidden Markov Modeling (HMM) to model speech sounds. In an attempt to improve over HMM we developed a hybrid system that integrates HMM technology with neural networks. We present the concept of a "Segmental Neural Net" (SNN) for phonetic modeling in CSR. By taking into account all the frames of a phonetic segment simultaneously, the SNN overcomes the well-known conditional-independence limitation of HMMs. In several speaker-independent experiments with the DARPA Resource Management corpus, the hybrid system showed a consistent improvement in performance over the baseline HMM system. 1 INTRODUCTION The current state of the art in continuous speech recognition (CSR) is based on the use of hidden Markov models (HMM) to model phonemes in context.

Matched filtering has been one of the most powerful techniques employed for transient detection. Here we will show that a dynamic neural network outperforms the conventional approach. When the artificial neural network (ANN) is trained with supervised learning schemes there is a need to supply the desired signal for all time, although we are only interested in detecting the transient. In this paper we also show the effects on the detection agreement of different strategies to construct the desired signal. The extension of the Bayes decision rule (011 desired signal), optimal in static classification, performs worse than desired signals constructed by random noise or prediction during the background.

We would like to incorporate speaker-dependent consistencies, such as gender, in an otherwise speaker-independent speech recognition system. In this paper we discuss a Gender Dependent Neural Network (GDNN) which can be tuned for each gender, while sharing most of the speaker independent parameters. We use a classification network to help generate gender-dependent phonetic probabilities for a statistical (HMM) recognition system. The gender classification net predicts the gender with high accuracy, 98.3% on a Resource Management test set. However, the integration of the GDNN into our hybrid HMM-neural network recognizer provided an improvement in the recognition score that is not statistically significant on a Resource Management test set.

Channel equalization problem is an important problem in high-speed communications. The sequences of symbols transmitted are distorted by neighboring symbols. Traditionally, the channel equalization problem is considered as a channel-inversion operation. One problem of this approach is that there is no direct correspondence between error probability and residual error produced by the channel inversion operation. In this paper, the optimal equalizer design is formulated as a classification problem. The optimal classifier can be constructed by Bayes decision rule. In general it is nonlinear. An efficient hybrid linear/nonlinear equalizer approach has been proposed to train the equalizer. The error probability of new linear/nonlinear equalizer has been shown to be better than a linear equalizer in an experimental channel. 1 INTRODUCTION

A number of hybrid multilayer perceptron (MLP)/hidden Markov model (HMM:) speech recognition systems have been developed in recent years (Morgan and Bourlard.

We present a methodological framework enabling a detailed description of the performance of Hopfield-like attractor neural networks (ANN) in the first two iterations. Using the Bayesian approach, we find that performance is improved when a history-based term is included in the neuron's dynamics. A further enhancement of the network's performance is achieved by judiciously choosing the censored neurons (those which become active in a given iteration) on the basis of the magnitude of their post-synaptic potentials. The contribution of biologically plausible, censored, historydependent dynamics is especially marked in conditions of low firing activity and sparse connectivity, two important characteristics of the mammalian cortex. In such networks, the performance attained is higher than the performance of two'independent' iterations, which represents an upper bound on the performance of history-independent networks.

The Bayesian "evidence" approximation has recently been employed to determine the noise and weight-penalty terms used in back-propagation. This paper shows that for neural nets it is far easier to use the exact result than it is to use the evidence approximation. Moreover, unlike the evidence approximation, the exact result neither has to be re-calculated for every new data set, nor requires the running of computer code (the exact result is closed form). In addition, it turns out that the evidence procedure's MAP estimate for neural nets is, in toto, approximation error. Another advantage of the exact analysis is that it does not lead one to incorrect intuition, like the claim that using evidence one can "evaluate different priors in light of the data". This paper also discusses sufficiency conditions for the evidence approximation to hold, why it can sometimes give "reasonable" results, etc.

We analyze the "query by committee" algorithm, a method for filtering informative queries from a random stream of inputs. We show that if the two-member committee algorithm achieves information gain with positive lower bound, then the prediction error decreases exponentially with the number of queries. We show that, in particular, this exponential decrease holds for query learning of thresholded smooth functions.