The integration of vision-language models (VLMs) is driving a new generation of embodied agents capable of operating in human-centered environments. However, as deployment expands, these systems face growing safety risks, particularly when executing hazardous instructions. Current safety evaluation benchmarks remain limited: they cover only narrow scopes of hazards and focus primarily on final outcomes, neglecting the agent's full perception-planning-execution process and thereby obscuring critical failure modes. Therefore, we present SAFE, a benchmark for systematically assessing the safety of embodied VLM agents on hazardous instructions. SAFE comprises three components: SAFE-THOR, an extensible adversarial simulation sandbox with a universal adapter that maps high-level VLM outputs to low-level embodied controls, supporting diverse agent workflow integration; SAFE-VERSE, a risk-aware task suite inspired by Asimov's Three Laws of Robotics, comprising 45 adversarial scenarios, 1,350 hazardous tasks, and 9,900 instructions that span risks to humans, environments, and agents; and SAFE-DIAGNOSE, a multi-level and fine-grained evaluation protocol measuring agent performance across perception, planning, and execution. Applying SAFE to nine state-of-the-art VLMs and two embodied agent workflows, we uncover systematic failures in translating hazard recognition into safe planning and execution. Our findings reveal fundamental limitations in current safety alignment and demonstrate the necessity of a comprehensive, multi-stage evaluation for developing safer embodied intelligence.

N-agent ad hoc teamwork (NAHT) is a newly introduced challenge in multi-agent reinforcement learning, where controlled subteams of varying sizes must dynamically collaborate with varying numbers and types of unknown teammates without pre-coordination. The existing learning algorithm (POAM) considers only independent learning for its flexibility in dealing with a changing number of agents. However, independent learning fails to fully capture the inter-agent dynamics essential for effective collaboration. Based on our observation that transformers deal effectively with sequences with varying lengths and have been shown to be highly effective for a variety of machine learning problems, this work introduces a centralized, transformer-based method for N-agent ad hoc teamwork. Our proposed approach incorporates historical observations and actions of all controlled agents, enabling optimal responses to diverse and unseen teammates in partially observable environments. Empirical evaluation on a StarCraft II task demonstrates that MAT-NAHT outperforms POAM, achieving superior sample efficiency and generalization, without auxiliary agent-modeling objectives. Keywords: multi-agent reinforcement learning, ad hoc teamwork, transformers, agent modeling Acknowledgements This work has taken place in the Learning Agents Research Group (LARG) at UT Austin.

Graphical User Interface (GUI) agents show promising capabilities for automating computer-use tasks and facilitating accessibility, but existing interactive benchmarks are mostly English-only, covering web-use or Windows, Linux, and Android environments, but not macOS. macOS is a major OS with distinctive GUI patterns and exclusive applications. To bridge the gaps, we present macOSWorld, the first comprehensive benchmark for evaluating GUI agents on macOS. macOSWorld features 202 multilingual interactive tasks across 30 applications (28 macOS-exclusive), with task instructions and OS interfaces offered in 5 languages (English, Chinese, Arabic, Japanese, and Russian). As GUI agents are shown to be vulnerable to deception attacks, macOSWorld also includes a dedicated safety benchmarking subset. Our evaluation on six GUI agents reveals a dramatic gap: proprietary computer-use agents lead at above 30% success rate, while open-source lightweight research models lag at below 5\%, highlighting the need for macOS domain adaptation. Multilingual benchmarks also expose common weaknesses, especially in Arabic, with a 28.8% average degradation compared to English. Results from safety benchmarking also highlight that deception attacks are more general and demand immediate attention. Project page: https://macos-world.github.io.

Time-inhomogeneous finite-horizon Markov decision processes (MDP) are frequently employed to model decision-making in dynamic treatment regimes and other statistical reinforcement learning (RL) scenarios. These fields, especially healthcare and business, often face challenges such as high-dimensional state spaces and time-inhomogeneity of the MDP process, compounded by insufficient sample availability which complicates informed decision-making. To overcome these challenges, we investigate knowledge transfer within time-inhomogeneous finite-horizon MDP by leveraging data from both a target RL task and several related source tasks. We have developed transfer learning (TL) algorithms that are adaptable for both batch and online $Q$-learning, integrating valuable insights from offline source studies. The proposed transfer $Q$-learning algorithm contains a novel {\em re-targeting} step that enables {\em cross-stage transfer} along multiple stages in an RL task, besides the usual {\em cross-task transfer} for supervised learning. We establish the first theoretical justifications of TL in RL tasks by showing a faster rate of convergence of the $Q^*$-function estimation in the offline RL transfer, and a lower regret bound in the offline-to-online RL transfer under stage-wise reward similarity and mild design similarity across tasks. Empirical evidence from both synthetic and real datasets is presented to evaluate the proposed algorithm and support our theoretical results.

Sim2Real aims at training policies in high-fidelity simulation environments and effectively transferring them to the real world. Despite the developments of accurate simulators and Sim2Real RL approaches, the policies trained purely in simulation often suffer significant performance drops when deployed in real environments. This drop is referred to as the Sim2Real performance gap. Current Sim2Real RL methods optimize the simulator accuracy and variability as proxies for real-world performance. However, these metrics do not necessarily correlate with the real-world performance of the policy as established theoretically and empirically in the literature. We propose a novel framework to address this issue by directly adapting the simulator parameters based on real-world performance. We frame this problem as a bi-level RL framework: the inner-level RL trains a policy purely in simulation, and the outer-level RL adapts the simulation model and in-sim reward parameters to maximize real-world performance of the in-sim policy. We derive and validate in simple examples the mathematical tools needed to develop bi-level RL algorithms that close the Sim2Real performance gap.

This dissertation makes three main contributions. First, We identify a new connection between policy gradient and dynamic programming in MMDPs and propose the Coordinate Ascent Dynamic Programming (CADP) algorithm to compute a Markov policy that maximizes the discounted return averaged over the uncertain models. CADP adjusts model weights iteratively to guarantee monotone policy improvements to a local maximum. Second, We establish sufficient and necessary conditions for the exponential ERM Bellman operator to be a contraction and prove the existence of stationary deterministic optimal policies for ERM-TRC and EVaR-TRC. We also propose exponential value iteration, policy iteration, and linear programming algorithms for computing optimal stationary policies for ERM-TRC and EVaR-TRC. Third, We propose model-free Q-learning algorithms for computing policies with risk-averse objectives: ERM-TRC and EVaR-TRC. The challenge is that Q-learning ERM Bellman may not be a contraction. Instead, we use the monotonicity of Q-learning ERM Bellman operators to derive a rigorous proof that the ERM-TRC and the EVaR-TRC Q-learning algorithms converge to the optimal risk-averse value functions. The proposed Q-learning algorithms compute the optimal stationary policy for ERM-TRC and EVaR-TRC.

Disease progression modeling aims to characterize and predict how a patient's disease complications worsen over time based on longitudinal electronic health records (EHRs). Accurate modeling of disease progression, such as type 2 diabetes, can enhance patient sub-phenotyping and inform effective and timely interventions. However, the problem is challenging due to the need to learn continuous-time dynamics of progression patterns based on irregular-time event samples and patient heterogeneity (\eg different progression rates and pathways). Existing mechanistic and data-driven methods either lack adaptability to learn from real-world data or fail to capture complex continuous-time dynamics on progression trajectories. To address these limitations, we propose Temporally Detailed Hypergraph Neural Ordinary Differential Equation (TD-HNODE), which represents disease progression on clinically recognized trajectories as a temporally detailed hypergraph and learns the continuous-time progression dynamics via a neural ODE framework. TD-HNODE contains a learnable TD-Hypergraph Laplacian that captures the interdependency of disease complication markers within both intra- and inter-progression trajectories. Experiments on two real-world clinical datasets demonstrate that TD-HNODE outperforms multiple baselines in modeling the progression of type 2 diabetes and related cardiovascular diseases.

Unsupervised anomaly detection (UAD) plays a crucial role in neuroimaging for identifying deviations from healthy subject data and thus facilitating the diagnosis of neurological disorders. In this work, we focus on Bayesian flow networks (BFNs), a novel class of generative models, which have not yet been applied to medical imaging or anomaly detection. BFNs combine the strength of diffusion frameworks and Bayesian inference. We introduce AnoBFN, an extension of BFNs for UAD, designed to: i) perform conditional image generation under high levels of spatially correlated noise, and ii) preserve subject specificity by incorporating a recursive feedback from the input image throughout the generative process. We evaluate AnoBFN on the challenging task of Alzheimer's disease-related anomaly detection in FDG PET images. Our approach outperforms other state-of-the-art methods based on V AEs ( β -VAE), GANs (f-AnoGAN), and diffusion models (AnoDDPM), demonstrating its effectiveness at detecting anomalies while reducing false positive rates.

Persistent monitoring of dynamic targets is essential in real-world applications such as disaster response, environmental sensing, and wildlife conservation, where mobile agents must continuously gather information under uncertainty. We propose COMPASS, a multi-agent reinforcement learning (MARL) framework that enables decentralized agents to persistently monitor multiple moving targets efficiently. We model the environment as a graph, where nodes represent spatial locations and edges capture topological proximity, allowing agents to reason over structured layouts and revisit informative regions as needed. Each agent independently selects actions based on a shared spatio-temporal attention network that we design to integrate historical observations and spatial context. We model target dynamics using Gaussian Processes (GPs), which support principled belief updates and enable uncertainty-aware planning. We train COMPASS using centralized value estimation and decentralized policy execution under an adaptive reward setting. Our extensive experiments demonstrate that COMPASS consistently outperforms strong baselines in uncertainty reduction, target coverage, and coordination efficiency across dynamic multi-target scenarios.

Epilepsy is typically diagnosed through electroencephalography (EEG) and long-term video-EEG (vEEG) monitoring. The manual analysis of vEEG recordings is time-consuming, necessitating automated tools for seizure detection. Recent advancements in machine learning have shown promise in real-time seizure detection and prediction using EEG and video data. However, diversity of seizure symptoms, markup ambiguities, and limited availability of multimodal datasets hinder progress. This paper reviews the latest developments in automated video-EEG analysis and discusses the integration of multimodal data. We also propose a novel pipeline for treatment effect estimation from vEEG data using concept-based learning, offering a pathway for future research in this domain.