Current exploration algorithms can be classified in two broad categories: Heuristic, and PAC optimal. While numerous researchers have used heuristic approaches such as epsilon-greedy exploration successfully, such approaches lack formal, finite sample guarantees and may need a significant amount of fine-tuning to produce good results. PAC optimal exploration algorithms, on the other hand, offer strong theoretical guarantees but are inapplicable in domains of realistic size. The goal of this paper is to bridge the gap between theory and practice, by introducing C-PACE, an algorithm which offers strong theoretical guarantees and can be applied to interesting, continuous space problems.

One of the most difficult tasks in value function approximation for Markov Decision Processes is finding an approximation architecture that is expressive enough to capture the important structure in the value function, while at the same time not overfitting the training samples. Recent results in non-parametric approximate linear programming (NP-ALP), have demonstrated that this can be done effectively using nothing more than a smoothness assumption on the value function. In this paper we extend these results to the case where samples come from real world transitions instead of the full Bellman equation, adding robustness to noise. In addition, we provide the first max-norm, finite sample performance guarantees for any form of ALP. NP-ALP is amenable to problems with large (multidimensional) or even infinite (continuous) action spaces, and does not require a model to select actions using the resulting approximate solution.

Semi-qualitative probabilistic networks (SQPNs) merge two important graphical model formalisms: Bayesian networks and qualitative probabilistic networks. They provide a very general modeling framework by allowing the combination of numeric and qualitative assessments over a discrete domain, and can be compactly encoded by exploiting the same factorization of joint probability distributions that are behind the Bayesian networks.  This paper explores the computational complexity of semi-qualitative probabilistic networks, and takes the polytree-shaped networks as its main target. We show that the inference problem is coNP-Complete for binary polytrees with multiple observed nodes. We also show that inferences can be performed in time linear in the number of nodes if there is a single observed node. Because our proof is constructive, we obtain an efficient linear time algorithm for SQPNs under such assumptions. To the best of our knowledge, this is the first exact polynomial-time algorithm for SQPNs. Together these results provide a clear picture of the inferential complexity in polytree-shaped SQPNs.

While great strides have been made in multiagent teamwork, existing approaches typically assume extensive information exists about teammates and how to coordinate actions. This paper addresses how robust teamwork can still be created even if limited or no information exists about a specific group of teammates, as in the ad hoc teamwork scenario. The main contribution of this paper is the first empirical evaluation of an agent cooperating with teammates not created by the authors, where the agent is not provided expert knowledge of its teammates. For this purpose, we develop a general-purpose teammate modeling method and test the resulting ad hoc team agent's ability to collaborate with more than 40 unknown teams of agents to accomplish a benchmark task. These agents were designed by people other than the authors without these designers planning for the ad hoc teamwork setting. A secondary contribution of the paper is a new transfer learning algorithm, TwoStageTransfer, that can improve results when the ad hoc team agent does have some limited observations of its current teammates.

POMDP (Partially Observable Markov Decision Process) is a mathematical framework that models planning under uncertainty. Solving a POMDP is an intractable problem and even the state of the art POMDP solvers are too computationally expensive for large domains. This is a major bottleneck. In this paper, we propose a new heuristic, called the pairwise heuristic, that can be used in a one-step greedy strategy to find a near optimal solution for POMDP problems very quickly. This approach is a good candidate for large problems where real-time solution is a necessity but exact optimality of the solution is not vital. The pairwise heuristic uses the optimal solutions for pairs of states. For each pair of states in the POMDP, we find the optimal sequence of actions to resolve the uncertainty and to maximize the reward, given that the agent is uncertain about which state of the pair it is in. Then we use these sequences as a heuristic and find the optimal action in each step of the greedy strategy using this heuristic. We have tested our method on the available large classical test benchmarks in various domains. The resulting total reward is close to, if not greater than, the total reward obtained by other state of the art POMDP solvers, while the time required to find the solution is always much less.

The implication problem of probabilistic conditional independencies is investigated in the presence of missing data. Here, graph separation axioms fail to hold for saturated conditional independencies, unlike the known idealized case with no missing data. Several axiomatic, algorithmic, and logical characterizations of the implication problem for saturated conditional independencies are established. In particular, equivalences are shown to the implication problem of a propositional fragment under Levesque's situations, and that of Lien's class of multivalued database dependencies under null values.

Graphical models have gained a lot of attention recently as a tool for learning and representing dependencies among variables in multivariate data. Often, domain scientists are looking specifically for differences among the dependency networks of different conditions or populations (e.g. differences between regulatory networks of different species, or differences between dependency networks of diseased versus healthy populations). The standard method for finding these differences is to learn the dependency networks for each condition independently and compare them. We show that this approach is prone to high false discovery rates (low precision) that can render the analysis useless. We then show that by imposing a bias towards learning similar dependency networks for each condition the false discovery rates can be reduced to acceptable levels, at the cost of finding a reduced number of differences. Algorithms developed in the transfer learning literature can be used to vary the strength of the imposed similarity bias and provide a natural mechanism to smoothly adjust this differential precision-recall tradeoff to cater to the requirements of the analysis conducted. We present real case studies (oncological and neurological) where domain experts use the proposed technique to extract useful differential networks that shed light on the biological processes involved in cancer and brain function.

Network medicine is an emerging paradigm for studying the co-occurrence between diseases. While diseases are often interlinked through complex patterns, most of the existing work in this area has focused on studying pairwise relationships between diseases. In this paper, we use a state-of-the-art Markov network learning method to learn interactions between musculoskeletal disorders and cardiovascular diseases and compare this to pairwise approaches. Our experimental results confirm that the sophisticated structure learner produces more accurate models, which can help reveal interesting patterns in the co-occurrence of diseases.

Network medicine is an emerging paradigm for studying the co-occurrence between diseases. While diseases are often interlinked through complex patterns, most of the existing work in this area has focused on studying pairwise relationships between diseases. In this paper, we use a state-of-the-art Markov network learning method to learn interactions between musculoskeletal disorders and cardiovascular diseases and compare this to pairwise approaches. Our experimental results confirm that the sophisticated structure learner produces more accurate models, which can help reveal interesting patterns in the co-occurrence of diseases.

Network medicine is an emerging paradigm for studying the co-occurrence between diseases. While diseases are often interlinked through complex patterns, most of the existing work in this area has focused on studying pairwise relationships between diseases. In this paper, we use a state-of-the-art Markov network learning method to learn interactions between musculoskeletal disorders and cardiovascular diseases and compare this to pairwise approaches. Our experimental results confirm that the sophisticated structure learner produces more accurate models, which can help reveal interesting patterns in the co-occurrence of diseases.