In many natural settings, the analysis goal is not to characterize a single data set in isolation, but rather to understand the difference between one set of observations and another. For example, given a background corpus of news articles together with writings of a particular author, one may want a topic model that explains word patterns and themes specific to the author. Another example comes from genomics, in which biological signals may be collected from different regions of a genome, and one wants a model that captures the differential statistics observed in these regions. This paper formalizes this notion of contrastive learning for mixture models, and develops spectral algorithms for inferring mixture components specific to a foreground data set when contrasted with a background data set. The method builds on recent moment-based estimators and tensor decompositions for latent variable models, and has the intuitive feature of using background data statistics to appropriately modify moments estimated from foreground data. A key advantage of the method is that the background data need only be coarsely modeled, which is important when the background is too complex, noisy, or not of interest. The method is demonstrated on applications in contrastive topic modeling and genomic sequence analysis.

There are two major routes to address linear inverse problems. Whereas regularization-based approaches build estimators as solutions of penalized regression optimization problems, Bayesian estimators rely on the posterior distribution of the unknown, given some assumed family of priors. While these may seem radically different approaches, recent results have shown that, in the context of additive white Gaussian denoising, the Bayesian conditional mean estimator is always the solution of a penalized regression problem. The contribution of this paper is twofold. First, we extend the additive white Gaussian denoising results to general linear inverse problems with colored Gaussian noise. Second, we characterize conditions under which the penalty function associated to the conditional mean estimator can satisfy certain popular properties such as convexity, separability, and smoothness. This sheds light on some tradeoff between computational efficiency and estimation accuracy in sparse regularization, and draws some connections between Bayesian estimation and proximal optimization.

We introduce RNADE, a new model for joint density estimation of real-valued vectors. Our model calculates the density of a datapoint as the product of one-dimensional conditionals modeled using mixture density networks with shared parameters. RNADE learns a distributed representation of the data, while having a tractable expression for the calculation of densities. A tractable likelihood allows direct comparison with other methods and training by standard gradient-based optimizers. We compare the performance of RNADE on several datasets of heterogeneous and perceptual data, finding it outperforms mixture models in all but one case.

Numerous datasets ranging from group memberships within social networks to purchase histories on e-commerce sites are represented by binary matrices. While this data is often either proprietary or sensitive, aggregated data, notably row and column marginals, is often viewed as much less sensitive, and may be furnished for analysis. Here, we investigate how these data can be exploited to make inferences about the underlying matrix H. Instead of assuming a generative model for H, we view the input marginals as constraints on the dataspace of possible realizations of H and compute the probability density function of particular entries H(i,j) of interest. We do this, for all the cells of H simultaneously, without generating realizations but rather via implicitly sampling the datasets that satisfy the input marginals. The end result is an efficient algorithm with running time equal to the time required by standard sampling techniques to generate a single dataset from the same dataspace. Our experimental evaluation demonstrates the efficiency and the efficacy of our framework in multiple settings.

We demonstrate that there is significant redundancy in the parameterization of several deep learning models. Given only a few weight values for each feature it is possible to accurately predict the remaining values. Moreover, we show that not only can the parameter values be predicted, but many of them need not be learned at all. We train several different architectures by learning only a small number of weights and predicting the rest. In the best case we are able to predict more than 95% of the weights of a network without any drop in accuracy.

We consider how to transfer knowledge from previous tasks to a current task in long-lived and bounded agents that must solve a sequence of MDPs over a finite lifetime. A novel aspect of our transfer approach is that we reuse reward functions. While this may seem counterintuitive, we build on the insight of recent work on the optimal rewards problem that guiding an agent's behavior with reward functions other than the task-specifying reward function can help overcome computational bounds of the agent. Specifically, we use good guidance reward functions learned on previous tasks in the sequence to incrementally train a reward mapping function that maps task-specifying reward functions into good initial guidance reward functions for subsequent tasks. We demonstrate that our approach can substantially improve the agent's performance relative to other approaches, including an approach that transfers policies.

Entropy rate quantifies the amount of disorder in a stochastic process. For spiking neurons, the entropy rate places an upper bound on the rate at which the spike train can convey stimulus information, and a large literature has focused on the problem of estimating entropy rate from spike train data. Here we present Bayes Least Squares and Empirical Bayesian entropy rate estimators for binary spike trains using Hierarchical Dirichlet Process (HDP) priors. Our estimator leverages the fact that the entropy rate of an ergodic Markov Chain with known transition probabilities can be calculated analytically, and many stochastic processes that are non-Markovian can still be well approximated by Markov processes of sufficient depth. Choosing an appropriate depth of Markov model presents challenges due to possibly long time dependencies and short data sequences: a deeper model can better account for long time-dependencies, but is more difficult to infer from limited data. Our approach mitigates this difficulty by using a hierarchical prior to share statistical power across Markov chains of different depths. We present both a fully Bayesian and empirical Bayes entropy rate estimator based on this model, and demonstrate their performance on simulated and real neural spike train data.

Point processes are popular models of neural spiking behavior as they provide a statistical distribution over temporal sequences of spikes and help to reveal the complexities underlying a series of recorded action potentials. However, the most common neural point process models, the Poisson process and the gamma renewal process, do not capture interactions and correlations that are critical to modeling populations of neurons. We develop a novel model based on a determinantal point process over latent embeddings of neurons that effectively captures and helps visualize complex inhibitory and competitive interaction. We show that this model is a natural extension of the popular generalized linear model to sets of interacting neurons. The model is extended to incorporate gain control or divisive normalization, and the modulation of neural spiking based on periodic phenomena. Applied to neural spike recordings from the rat hippocampus, we see that the model captures inhibitory relationships, a dichotomy of classes of neurons, and a periodic modulation by the theta rhythm known to be present in the data.

What if there is a teacher who knows the learning goal and wants to design good training data for a machine learner? We propose an optimal teaching framework aimed at learners who employ Bayesian models. Our framework is expressed as an optimization problem over teaching examples that balance the future loss of the learner and the effort of the teacher. This optimization problem is in general hard. In the case where the learner employs conjugate exponential family models, we present an approximate algorithm for finding the optimal teaching set. Our algorithm optimizes the aggregate sufficient statistics, then unpacks them into actual teaching examples. We give several examples to illustrate our framework.

In this work we develop efficient methods for learning random MAP predictors for structured label problems. In particular, we construct posterior distributions over perturbations that can be adjusted via stochastic gradient methods. We show that every smooth posterior distribution would suffice to define a smooth PAC-Bayesian risk bound suitable for gradient methods. In addition, we relate the posterior distributions to computational properties of the MAP predictors. We suggest multiplicative posteriors to learn super-modular potential functions that accompany specialized MAP predictors such as graph-cuts. We also describe label-augmented posterior models that can use efficient MAP approximations, such as those arising from linear program relaxations.