The need for new methods to deal with big data is a common theme in most scientific fields, although its definition tends to vary with the context. Statistical ideas are an essential part of this, and as a partial response, a thematic program on statistical inference, learning, and models in big data was held in 2015 in Canada, under the general direction of the Canadian Statistical Sciences Institute, with major funding from, and most activities located at, the Fields Institute for Research in Mathematical Sciences. This paper gives an overview of the topics covered, describing challenges and strategies that seem common to many different areas of application, and including some examples of applications to make these challenges and strategies more concrete.

Continuous time Bayesian networks are investigated with a special focus on their ability to express causality. A framework is presented for doing inference in these networks. The central contributions are a representation of the intensity matrices for the networks and the introduction of a causality measure. A new model for high-frequency financial data is presented. It is calibrated to market data and by the new causality measure it performs better than older models.

The bipartite record linkage task consists of merging two disparate datafiles containing information on two overlapping sets of entities. This is non-trivial in the absence of unique identifiers and it is important for a wide variety of applications given that it needs to be solved whenever we have to combine information from different sources. Most statistical techniques currently used for record linkage are derived from a seminal paper by Fellegi and Sunter (1969). These techniques usually assume independence in the matching statuses of record pairs to derive estimation procedures and optimal point estimators. We argue that this independence assumption is unreasonable and instead target a bipartite matching between the two datafiles as our parameter of interest. Bayesian implementations allow us to quantify uncertainty on the matching decisions and derive a variety of point estimators using different loss functions. We propose partial Bayes estimates that allow uncertain parts of the bipartite matching to be left unresolved. We evaluate our approach to record linkage using a variety of challenging scenarios and show that it outperforms the traditional methodology. We illustrate the advantages of our methods merging two datafiles on casualties from the civil war of El Salvador.

We consider the sequential Bayesian optimization problem with bandit feedback, adopting a formulation that allows for the reward function to vary with time. We model the reward function using a Gaussian process whose evolution obeys a simple Markov model. We introduce two natural extensions of the classical Gaussian process upper confidence bound (GP-UCB) algorithm. The first, R-GP-UCB, resets GP-UCB at regular intervals. The second, TV-GP-UCB, instead forgets about old data in a smooth fashion. Our main contribution comprises of novel regret bounds for these algorithms, providing an explicit characterization of the trade-off between the time horizon and the rate at which the function varies. We illustrate the performance of the algorithms on both synthetic and real data, and we find the gradual forgetting of TV-GP-UCB to perform favorably compared to the sharp resetting of R-GP-UCB. Moreover, both algorithms significantly outperform classical GP-UCB, since it treats stale and fresh data equally.

We study the problem of recovering a hidden community of cardinality $K$ from an $n \times n$ symmetric data matrix $A$, where for distinct indices $i,j$, $A_{ij} \sim P$ if $i, j$ both belong to the community and $A_{ij} \sim Q$ otherwise, for two known probability distributions $P$ and $Q$ depending on $n$. If $P={\rm Bern}(p)$ and $Q={\rm Bern}(q)$ with $p>q$, it reduces to the problem of finding a densely-connected $K$-subgraph planted in a large Erd\"os-R\'enyi graph; if $P=\mathcal{N}(\mu,1)$ and $Q=\mathcal{N}(0,1)$ with $\mu>0$, it corresponds to the problem of locating a $K \times K$ principal submatrix of elevated means in a large Gaussian random matrix. We focus on two types of asymptotic recovery guarantees as $n \to \infty$: (1) weak recovery: expected number of classification errors is $o(K)$; (2) exact recovery: probability of classifying all indices correctly converges to one. Under mild assumptions on $P$ and $Q$, and allowing the community size to scale sublinearly with $n$, we derive a set of sufficient conditions and a set of necessary conditions for recovery, which are asymptotically tight with sharp constants. The results hold in particular for the Gaussian case, and for the case of bounded log likelihood ratio, including the Bernoulli case whenever $\frac{p}{q}$ and $\frac{1-p}{1-q}$ are bounded away from zero and infinity. An important algorithmic implication is that, whenever exact recovery is information theoretically possible, any algorithm that provides weak recovery when the community size is concentrated near $K$ can be upgraded to achieve exact recovery in linear additional time by a simple voting procedure.

We propose to model the acoustic space of deep neural network (DNN) class-conditional posterior probabilities as a union of low-dimensional subspaces. To that end, the training posteriors are used for dictionary learning and sparse coding. Sparse representation of the test posteriors using this dictionary enables projection to the space of training data. Relying on the fact that the intrinsic dimensions of the posterior subspaces are indeed very small and the matrix of all posteriors belonging to a class has a very low rank, we demonstrate how low-dimensional structures enable further enhancement of the posteriors and rectify the spurious errors due to mismatch conditions. The enhanced acoustic modeling method leads to improvements in continuous speech recognition task using hybrid DNN-HMM (hidden Markov model) framework in both clean and noisy conditions, where upto 15.4% relative reduction in word error rate (WER) is achieved.

We present a system for online monitoring of maritime activity over streaming positions from numerous vessels sailing at sea. It employs an online tracking module for detecting important changes in the evolving trajectory of each vessel across time, and thus can incrementally retain concise, yet reliable summaries of its recent movement. In addition, thanks to its complex event recognition module, this system can also offer instant notification to marine authorities regarding emergency situations, such as risk of collisions, suspicious moves in protected zones, or package picking at open sea. Not only did our extensive tests validate the performance, efficiency, and robustness of the system against scalable volumes of real-world and synthetically enlarged datasets, but its deployment against online feeds from vessels has also confirmed its capabilities for effective, real-time maritime surveillance.

For many complex diseases, there is a wide variety of ways in which an individual can manifest the disease. The challenge of personalized medicine is to develop tools that can accurately predict the trajectory of an individual's disease, which can in turn enable clinicians to optimize treatments. We represent an individual's disease trajectory as a continuous-valued continuous-time function describing the severity of the disease over time. We propose a hierarchical latent variable model that individualizes predictions of disease trajectories. This model shares statistical strength across observations at different resolutions--the population, subpopulation and the individual level. We describe an algorithm for learning population and subpopulation parameters offline, and an online procedure for dynamically learning individual-specific parameters. Finally, we validate our model on the task of predicting the course of interstitial lung disease, a leading cause of death among patients with the autoimmune disease scleroderma. We compare our approach against state-of-the-art and demonstrate significant improvements in predictive accuracy.

In recent years there has been an increased interest in statistical analysis of data with multiple types of relations among a set of entities. Such multi-relational data can be represented as multi-layer graphs where the set of vertices represents the entities and multiple types of edges represent the different relations among them. For community detection in multi-layer graphs, we consider two random graph models, the multi-layer stochastic blockmodel (MLSBM) and a model with a restricted parameter space, the restricted multi-layer stochastic blockmodel (RMLSBM). We derive consistency results for community assignments of the maximum likelihood estimators (MLEs) in both models where MLSBM is assumed to be the true model, and either the number of nodes or the number of types of edges or both grow. We compare MLEs in the two models with other baseline approaches, such as separate modeling of layers, aggregating the layers and majority voting. RMLSBM is shown to have advantage over MLSBM when either the growth rate of the number of communities is high or the growth rate of the average degree of the component graphs in the multi-graph is low. We also derive minimax rates of error and sharp thresholds for achieving consistency of community detection in both models, which are then used to compare the multi-layer models with a baseline model, the aggregate stochastic block model. The simulation studies and real data applications confirm the superior performance of the multi-layer approaches in comparison to the baseline procedures.

Models for which the likelihood function can be evaluated only up to a parameter-dependent unknown normalising constant, such as Markov random field models, are used widely in computer science, statistical physics, spatial statistics, and network analysis. However, Bayesian analysis of these models using standard Monte Carlo methods is not possible due to the intractability of their likelihood functions. Several methods that permit exact, or close to exact, simulation from the posterior distribution have recently been developed. However, estimating the evidence and Bayes' factors (BFs) for these models remains challenging in general. This paper describes new random weight importance sampling and sequential Monte Carlo methods for estimating BFs that use simulation to circumvent the evaluation of the intractable likelihood, and compares them to existing methods. In some cases we observe an advantage in the use of biased weight estimates. An initial investigation into the theoretical and empirical properties of this class of methods is presented. Some support for the use of biased estimates is presented, but we advocate caution in the use of such estimates.