With advanced imaging, sequencing, and profiling technologies, multiple omics data become increasingly available and hold promises for many healthcare applications such as cancer diagnosis and treatment. Multimodal learning for integrative multi-omics analysis can help researchers and practitioners gain deep insights into human diseases and improve clinical decisions. However, several challenges are hindering the development in this area, including the availability of easily accessible open-source tools. This survey aims to provide an up-to-date overview of the data challenges, fusion approaches, datasets, and software tools from several new perspectives. We identify and investigate various omics data challenges that can help us understand the field better. We categorize fusion approaches comprehensively to cover existing methods in this area. We collect existing open-source tools to facilitate their broader utilization and development. We explore a broad range of omics data modalities and a list of accessible datasets. Finally, we summarize future directions that can potentially address existing gaps and answer the pressing need to advance multimodal learning for multi-omics data analysis.

A well-performing prediction model is vital for a recommendation system suggesting actions for energy-efficient consumer behavior. However, reliable and accurate predictions depend on informative features and a suitable model design to perform well and robustly across different households and appliances. Moreover, customers' unjustifiably high expectations of accurate predictions may discourage them from using the system in the long term. In this paper, we design a three-step forecasting framework to assess predictability, engineering features, and deep learning architectures to forecast 24 hourly load values. First, our predictability analysis provides a tool for expectation management to cushion customers' anticipations. Second, we design several new weather-, time- and appliance-related parameters for the modeling procedure and test their contribution to the model's prediction performance. Third, we examine six deep learning techniques and compare them to tree- and support vector regression benchmarks. We develop a robust and accurate model for the appliance-level load prediction based on four datasets from four different regions (US, UK, Austria, and Canada) with an equal set of appliances. The empirical results show that cyclical encoding of time features and weather indicators alongside a long-short term memory (LSTM) model offer the optimal performance.

End-to-end (E2E) task-oriented dialogue (ToD) systems are prone to fall into the so-called "likelihood trap", resulting in generated responses which are dull, repetitive, and often inconsistent with dialogue history. Comparing ranked lists of multiple generated responses against the "gold response" (from evaluation data) reveals a wide diversity in response quality, with many good responses placed lower in the ranked list. The main challenge, addressed in this work, is then how to reach beyond greedily generated system responses, that is, how to obtain and select such high-quality responses from the list of overgenerated responses at inference without availability of the gold response. To this end, we propose a simple yet effective reranking method which aims to select high-quality items from the lists of responses initially overgenerated by the system. The idea is to use any sequence-level (similarity) scoring function to divide the semantic space of responses into high-scoring versus low-scoring partitions. At training, the high-scoring partition comprises all generated responses whose similarity to the gold response is higher than the similarity of the greedy response to the gold response. At inference, the aim is to estimate the probability that each overgenerated response belongs to the high-scoring partition, given only previous dialogue history. We validate the robustness and versatility of our proposed method on the standard MultiWOZ dataset: our methods improve a state-of-the-art E2E ToD system by 2.0 BLEU, 1.6 ROUGE, and 1.3 METEOR scores, achieving new peak results. Additional experiments on the BiTOD dataset and human evaluation further ascertain the generalisability and effectiveness of the proposed framework.

In recent years several learning approaches to point goal navigation in previously unseen environments have been proposed. They vary in the representations of the environments, problem decomposition, and experimental evaluation. In this work, we compare the state-of-the-art Deep Reinforcement Learning based approaches with Partially Observable Markov Decision Process (POMDP) formulation of the point goal navigation problem. We adapt the (POMDP) sub-goal framework proposed by [1] and modify the component that estimates frontier properties by using partial semantic maps of indoor scenes built from images' semantic segmentation. In addition to the well-known completeness of the model-based approach, we demonstrate that it is robust and efficient in that it leverages informative, learned properties of the frontiers compared to an optimistic frontier-based planner. We also demonstrate its data efficiency compared to the end-to-end deep reinforcement learning approaches. We compare our results against an optimistic planner, ANS and DD-PPO on Matterport3D dataset using the Habitat Simulator. We show comparable, though slightly worse performance than the SOTA DD-PPO approach, yet with far fewer data.

Learning generalizable policies that can adapt to unseen environments remains challenging in visual Reinforcement Learning (RL). Existing approaches try to acquire a robust representation via diversifying the appearances of in-domain observations for better generalization. Limited by the specific observations of the environment, these methods ignore the possibility of exploring diverse real-world image datasets. In this paper, we investigate how a visual RL agent would benefit from the off-the-shelf visual representations. Surprisingly, we find that the early layers in an ImageNet pre-trained ResNet model could provide rather generalizable representations for visual RL. Hence, we propose Pre-trained Image Encoder for Generalizable visual reinforcement learning (PIE-G), a simple yet effective framework that can generalize to the unseen visual scenarios in a zero-shot manner. Extensive experiments are conducted on DMControl Generalization Benchmark, DMControl Manipulation Tasks, Drawer World, and CARLA to verify the effectiveness of PIE-G. Empirical evidence suggests PIE-G improves sample efficiency and significantly outperforms previous state-of-the-art methods in terms of generalization performance. In particular, PIE-G boasts a 55% generalization performance gain on average in the challenging video background setting. Project Page: https://sites.google.com/view/pie-g/home.

Partial Observability -- where agents can only observe partial information about the true underlying state of the system -- is ubiquitous in real-world applications of Reinforcement Learning (RL). Theoretically, learning a near-optimal policy under partial observability is known to be hard in the worst case due to an exponential sample complexity lower bound. Recent work has identified several tractable subclasses that are learnable with polynomial samples, such as Partially Observable Markov Decision Processes (POMDPs) with certain revealing or decodability conditions. However, this line of research is still in its infancy, where (1) unified structural conditions enabling sample-efficient learning are lacking; (2) existing sample complexities for known tractable subclasses are far from sharp; and (3) fewer sample-efficient algorithms are available than in fully observable RL. This paper advances all three aspects above for Partially Observable RL in the general setting of Predictive State Representations (PSRs). First, we propose a natural and unified structural condition for PSRs called \emph{B-stability}. B-stable PSRs encompasses the vast majority of known tractable subclasses such as weakly revealing POMDPs, low-rank future-sufficient POMDPs, decodable POMDPs, and regular PSRs. Next, we show that any B-stable PSR can be learned with polynomial samples in relevant problem parameters. When instantiated in the aforementioned subclasses, our sample complexities improve substantially over the current best ones. Finally, our results are achieved by three algorithms simultaneously: Optimistic Maximum Likelihood Estimation, Estimation-to-Decisions, and Model-Based Optimistic Posterior Sampling. The latter two algorithms are new for sample-efficient learning of POMDPs/PSRs.

Structural Health Monitoring (SHM) describes a process for inferring quantifiable metrics of structural condition, which can serve as input to support decisions on the operation and maintenance of infrastructure assets. Given the long lifespan of critical structures, this problem can be cast as a sequential decision making problem over prescribed horizons. Partially Observable Markov Decision Processes (POMDPs) offer a formal framework to solve the underlying optimal planning task. However, two issues can undermine the POMDP solutions. Firstly, the need for a model that can adequately describe the evolution of the structural condition under deterioration or corrective actions and, secondly, the non-trivial task of recovery of the observation process parameters from available monitoring data. Despite these potential challenges, the adopted POMDP models do not typically account for uncertainty on model parameters, leading to solutions which can be unrealistically confident. In this work, we address both key issues. We present a framework to estimate POMDP transition and observation model parameters directly from available data, via Markov Chain Monte Carlo (MCMC) sampling of a Hidden Markov Model (HMM) conditioned on actions. The MCMC inference estimates distributions of the involved model parameters. We then form and solve the POMDP problem by exploiting the inferred distributions, to derive solutions that are robust to model uncertainty. We successfully apply our approach on maintenance planning for railway track assets on the basis of a "fractal value" indicator, which is computed from actual railway monitoring data.

Reinforcement learning (RL) gained considerable attention by creating decision-making agents that maximize rewards received from fully observable environments. However, many real-world problems are partially or noisily observable by nature, where agents do not receive the true and complete state of the environment. Such problems are formulated as partially observable Markov decision processes (POMDPs). Some studies applied RL to POMDPs by recalling previous decisions and observations or inferring the true state of the environment from received observations. Nevertheless, aggregating observations and decisions over time is impractical for environments with high-dimensional continuous state and action spaces. Moreover, so-called inference-based RL approaches require large number of samples to perform well since agents eschew uncertainty in the inferred state for the decision-making. Active inference is a framework that is naturally formulated in POMDPs and directs agents to select decisions by minimising expected free energy (EFE). This supplies reward-maximising (exploitative) behaviour in RL, with an information-seeking (exploratory) behaviour. Despite this exploratory behaviour of active inference, its usage is limited to discrete state and action spaces due to the computational difficulty of the EFE. We propose a unified principle for joint information-seeking and reward maximization that clarifies a theoretical connection between active inference and RL, unifies active inference and RL, and overcomes their aforementioned limitations. Our findings are supported by strong theoretical analysis. The proposed framework's superior exploration property is also validated by experimental results on partial observable tasks with high-dimensional continuous state and action spaces. Moreover, the results show that our model solves reward-free problems, making task reward design optional.

In heterogeneous networks (HetNets), the overlap of small cells and the macro cell causes severe cross-tier interference. Although there exist some approaches to address this problem, they usually require global channel state information, which is hard to obtain in practice, and get the sub-optimal power allocation policy with high computational complexity. To overcome these limitations, we propose a multi-agent deep reinforcement learning (MADRL) based power control scheme for the HetNet, where each access point makes power control decisions independently based on local information. To promote cooperation among agents, we develop a penalty-based Q learning (PQL) algorithm for MADRL systems. By introducing regularization terms in the loss function, each agent tends to choose an experienced action with high reward when revisiting a state, and thus the policy updating speed slows down. In this way, an agent's policy can be learned by other agents more easily, resulting in a more efficient collaboration process. Simulation results show that our proposed PQL can learn the desired power control policy from a dynamic environment where the locations of users change episodically and outperform existing DTE MADRL algorithms. The authors are with the Department of Electrical and Electronic Engineering, Imperial College London, London SW7 2AZ, U.K. (e-mail: k.xu21@imperial.ac.uk; huynh.nguyen@imperial.ac.uk; geoffrey.li@imperial.ac.uk) In conventional cellular networks, a macro base station (BS) needs to provide access to the core network for all user devices (UDs) in the cell.

We consider a multi-agent episodic MDP setup where an agent (leader) takes action at each step of the episode followed by another agent (follower). The state evolution and rewards depend on the joint action pair of the leader and the follower. Such type of interactions can find applications in many domains such as smart grids, mechanism design, security, and policymaking. We are interested in how to learn policies for both the players with provable performance guarantee under a bandit feedback setting. We focus on a setup where both the leader and followers are {\em non-myopic}, i.e., they both seek to maximize their rewards over the entire episode and consider a linear MDP which can model continuous state-space which is very common in many RL applications. We propose a {\em model-free} RL algorithm and show that $\tilde{\mathcal{O}}(\sqrt{d^3H^3T})$ regret bounds can be achieved for both the leader and the follower, where $d$ is the dimension of the feature mapping, $H$ is the length of the episode, and $T$ is the total number of steps under the bandit feedback information setup. Thus, our result holds even when the number of states becomes infinite. The algorithm relies on {\em novel} adaptation of the LSVI-UCB algorithm. Specifically, we replace the standard greedy policy (as the best response) with the soft-max policy for both the leader and the follower. This turns out to be key in establishing uniform concentration bound for the value functions. To the best of our knowledge, this is the first sub-linear regret bound guarantee for the Markov games with non-myopic followers with function approximation.