So far there has been no general method for relating extracellular electrophysiological measured activity of neurons in the associative cortex to underlying network or "cognitive" states. We propose to model such data using a multivariate Poisson Hidden Markov Model. We demonstrate the application of this approach for temporal segmentation of the firing patterns, and for characterization of the cortical responses to external stimuli. Using such a statistical model we can significantly discriminate two behavioral modes of the monkey, and characterize them by the different firing patterns, as well as by the level of coherency of their multi-unit firing activity. Our study utilized measurements carried out on behaving Rhesus monkeys by M. Abeles, E. Vaadia, and H. Bergman, of the Hadassa Medical School of the Hebrew University. 1 Introduction Hebb hypothesized in 1949 that the basic information processing unit in the cortex is a cell-assembly which may include thousands of cells in a highly interconnected network[l].

Hidden Markov Models (HMMs) can be applied to several important problems in molecular biology. We introduce a new convergent learning algorithm for HMMs that, unlike the classical Baum-Welch algorithm is smooth and can be applied online or in batch mode, with or without the usual Viterbi most likely path approximation. Left-right HMMs with insertion and deletion states are then trained to represent several protein families including immunoglobulins and kinases. In all cases, the models derived capture all the important statistical properties of the families and can be used efficiently in a number of important tasks such as multiple alignment, motif detection, and classification.

Hidden Markov Models (HMMs) can be applied to several important problems in molecular biology. We introduce a new convergent learning algorithm for HMMs that, unlike the classical Baum-Welch algorithm is smooth and can be applied online or in batch mode, with or without the usual Viterbi most likely path approximation. Left-right HMMs with insertion and deletion states are then trained to represent several protein families including immunoglobulins and kinases. In all cases, the models derived capture all the important statistical properties of the families and can be used efficiently in a number of important tasks such as multiple alignment, motif detection, and classification.

A number of hybrid multilayer perceptron (MLP)/hidden Markov model (HMM:) speech recognition systems have been developed in recent years (Morgan and Bourlard.

University of Toronto University of Toronto University of Colorado Toronto, ONT M5S lA4 Toronto, ONT M5S lA4 Boulder, CO 80309-0430 Abstract We present a general formulation for a network of stochastic directional units. This formulation is an extension of the Boltzmann machine in which the units are not binary, but take on values in a cyclic range, between 0 and 271' radians. The conditional distribution of a unit's stochastic state is a circular version of the Gaussian probability distribution, known as the von Mises distribution. This combination of a value and a certainty provides additional representational power in a unit. Many kinds of information can naturally be represented in terms of angular, or directional, variables.

This paper describes a technique for learning both the number of states and the topology of Hidden Markov Models from examples. The induction process starts with the most specific model consistent with the training data and generalizes by successively merging states. Both the choice of states to merge and the stopping criterion are guided by the Bayesian posterior probability. We compare our algorithm with the Baum-Welch method of estimating fixed-size models, and find that it can induce minimal HMMs from data in cases where fixed estimation does not converge or requires redundant parameters to converge. 1 INTRODUCTION AND OVERVIEW Hidden Markov Models (HMMs) are a well-studied approach to the modelling of sequence data. HMMs can be viewed as a stochastic generalization of finite-state automata, where both the transitions between states and the generation of output symbols are governed by probability distributions. HMMs have been important in speech recognition (Rabiner & Juang, 1986), cryptography, and more recently in other areas such as protein classification and alignment (Haussler, Krogh, Mian & SjOlander, 1992; Baldi, Chauvin, Hunkapiller & McClure, 1993). Practitioners have typically chosen the HMM topology by hand, so that learning the HMM from sample data means estimating only a fixed number of model parameters. The standard approach is to find a maximum likelihood (ML) or maximum a posteriori probability (MAP) estimate of the HMM parameters.

So far there has been no general method for relating extracellular electrophysiological measured activity of neurons in the associative cortex to underlying network or "cognitive" states. We propose to model such data using a multivariate Poisson Hidden Markov Model. We demonstrate the application of this approach for temporal segmentation of the firing patterns, and for characterization of the cortical responses to external stimuli. Using such a statistical model we can significantly discriminate two behavioral modes of the monkey, and characterize them by the different firing patterns, as well as by the level of coherency of their multi-unit firing activity. Our study utilized measurements carried out on behaving Rhesus monkeys by M. Abeles, E. Vaadia, and H. Bergman, of the Hadassa Medical School of the Hebrew University. 1 Introduction Hebb hypothesized in 1949 that the basic information processing unit in the cortex is a cell-assembly which may include thousands of cells in a highly interconnected network[l].

We proposed a model of Time Warping Invariant Neural Networks (TWINN) to handle the time warped continuous signals. Although TWINN is a simple modification of well known recurrent neural network, analysis has shown that TWINN completely removes time warping and is able to handle difficult classification problem. It is also shown that TWINN has certain advantages over the current available sequential processing schemes: Dynamic Programming(DP)[I], Hidden Markov Model( HMM)[2], Time Delayed Neural Networks(TDNN) [3] and Neural Network Finite Automata(NNFA)[4]. We also analyzed the time continuity employed in TWINN and pointed out that this kind of structure can memorize longer input history compared with Neural Network Finite Automata (NNFA). This may help to understand the well accepted fact that for learning grammatical reference with NNF A one had to start with very short strings in training set. The numerical example we used is a trajectory classification problem. This problem, making a feature of variable sampling rates, having internal states, continuous dynamics, heavily time-warped data and deformed phase space trajectories, is shown to be difficult to other schemes. With TWINN this problem has been learned in 100 iterations. For benchmark we also trained the exact same problem with TDNN and completely failed as expected.

Untill recently, state-of-the-art, large-vocabulary, continuous speech recognition (CSR) has employed Hidden Markov Modeling (HMM) to model speech sounds. In an attempt to improve over HMM we developed a hybrid system that integrates HMM technology with neural networks. We present the concept of a "Segmental Neural Net" (SNN) for phonetic modeling in CSR. By taking into account all the frames of a phonetic segment simultaneously, the SNN overcomes the well-known conditional-independence limitation of HMMs. In several speaker-independent experiments with the DARPA Resource Management corpus, the hybrid system showed a consistent improvement in performance over the baseline HMM system. 1 INTRODUCTION The current state of the art in continuous speech recognition (CSR) is based on the use of hidden Markov models (HMM) to model phonemes in context.

We propose in this paper a statistical model (planar hidden Markov model - PHMM) describing statistical properties of images. The model generalizes the single-dimensional HMM, used for speech processing, to the planar case. For this model to be useful an efficient segmentation algorithm, similar to the Viterbi algorithm for HMM, must exist We present conditions in terms of the PHMM parameters that are sufficient to guarantee that the planar segmentation problem can be solved in polynomial time, and describe an algorithm for that. This algorithm aligns optimally the image with the model, and therefore is insensitive to elastic distortions of images. Using this algorithm a joint optima1 segmentation and recognition of the image can be performed, thus overcoming the weakness of traditional OCR systems where segmentation is performed independently before the recognition leading to unrecoverable recognition errors. Tbe PHMM approach was evaluated using a set of isolated band-written digits. An overall digit recognition accuracy of 95% was acbieved. An analysis of the results showed that even in the simple case of recognition of isolated characters, the elimination of elastic distortions enhances the performance Significantly. We expect that the advantage of this approach will be even more significant for tasks such as connected writing recognition/spotting, for whicb there is no known high accuracy method of recognition.