Celiac Disease (CD) and Environmental Enteropathy (EE) are common causes of malnutrition and adversely impact normal childhood development. Both conditions require a tissue biopsy for diagnosis and a major challenge of interpreting clinical biopsy images to differentiate between these gastrointestinal diseases is striking histopathologic overlap between them. In the current study, we propose four diagnosis techniques for these diseases and address their limitations and advantages. First, the diagnosis between CD, EE, and Normal biopsies is considered, but the main challenge with this diagnosis technique is the staining problem. The dataset used in this research is collected from different centers with different staining standards. To solve this problem, we use color balancing in order to train our model with a varying range of colors. Random Multimodel Deep Learning (RMDL) architecture has been used as another approach to mitigate the effects of the staining problem. RMDL combines different architectures and structures of deep learning and the final output of the model is based on the majority vote. CD is a chronic autoimmune disease that affects the small intestine genetically predisposed children and adults. Typically, CD rapidly progress from Marsh I to IIIa. Marsh III is sub-divided into IIIa (partial villus atrophy), Marsh IIIb (subtotal villous atrophy), and Marsh IIIc (total villus atrophy) to explain the spectrum of villus atrophy along with crypt hypertrophy and increased intraepithelial lymphocytes. In the second part of this study, we proposed two ways for diagnosing different stages of CD. Finally, in the third part of this study, these two steps are combined as Hierarchical Medical Image Classification (HMIC) to have a model to diagnose the disease data hierarchically.

Mixtures of experts have become an indispensable tool for flexible modelling in a supervised learning context, and sparse Gaussian processes (GP) have shown promise as a leading candidate for the experts in such models. In the present article, we propose to design the gating network for selecting the experts from such mixtures of sparse GPs using a deep neural network (DNN). This combination provides a flexible, robust, and efficient model which is able to significantly outperform competing models. We furthermore consider efficient approaches to computing maximum a posteriori (MAP) estimators of these models by iteratively maximizing the distribution of experts given allocations and allocations given experts. We also show that a recently introduced method called Cluster-Classify- Regress (CCR) is capable of providing a good approximation of the optimal solution extremely quickly. This approximation can then be further refined with the iterative algorithm.

Training neural networks with binary weights and activations is a challenging problem due to the lack of gradients and difficulty of optimization over discrete weights. Many successful experimental results have been recently achieved using the empirical straight-through estimation approach. This approach has generated a variety of ad-hoc rules for propagating gradients through non-differentiable activations and updating discrete weights. We put such methods on a solid basis by obtaining them as viable approximations in the stochastic binary network (SBN) model with Bernoulli weights. In this model gradients are well-defined and the weight probabilities can be optimized by continuous techniques. By choosing the activation noises in SBN appropriately and choosing mirror descent (MD) for optimization, we obtain methods that closely resemble several existing straight-through variants, but unlike them, all work reliably and produce equally good results. We further show that variational inference for Bayesian learning of Binary weights can be implemented using MD updates with the same simplicity.

Time series with long-term structure arise in a variety of contexts and capturing this temporal structure is a critical challenge in time series analysis for both inference and forecasting settings. Traditionally, state space models have been successful in providing uncertainty estimates of trajectories in the latent space. More recently, deep learning, attention-based approaches have achieved state of the art performance for sequence modeling, though often require large amounts of data and parameters to do so. We propose Stanza, a nonlinear, non-stationary state space model as an intermediate approach to fill the gap between traditional models and modern deep learning approaches for complex time series. Stanza strikes a balance between competitive forecasting accuracy and probabilistic, interpretable inference for highly structured time series. In particular, Stanza achieves forecasting accuracy competitive with deep LSTMs on real-world datasets, especially for multi-step ahead forecasting.

In this work we aimed at comparing our findings in depression detection task with methodologies applied in present literature. Previously we showed that when electrophysiological signal (in this case electroencephalogram, EEG) is characterized by nonlinear measures, any of seven most popular classifiers yields high accuracy on the task. Following every step we done in this process we compare it with other researchers' practice and comment on other findings mainly from analysis of electrical signals or nonlinear analysis showing what would be optimal for further research. We focused on discussing various mistakes and differences that could potentially lead to unwarranted optimism and other misinterpretation of results. In Conclusion we summarize recommendation for future research in order to be applicable in clinical practice. Introduction Current clinical psychiatry is lacking objective biochemical or electrophysiological tests used for diagnosis unlike other medical disciplines. To diagnose depression, clinician will typically rely on the self-report from the patient and his experience in applying DSM manual, which is standardized list of symptoms to be checked in every case (in order to be qualified as a certain disorder). It is perfectly possible that two persons diagnosed with the same disorder have not overlapping symptoms, and that one person can have two distinct diagnosis. If someone has more than three episodes of depression, that is considered to be recurrent depression (after every episode the probability of the next one is doubling). This is particularly heard to treat and manage therapy which is ongoing through person's whole life. Apart from obsolete diagnostic, all antidepressants have serious side-effects, the waiting lists are very long (in Nederland they are between 6 and 9 months long) and the therapy can last for years or even decades. It is reported than only 11 - 30% of patients are improving in the first year of therapy (Rush et al., 2008).

Deep candidate generation (DCG) that narrows down the collection of relevant items from billions to hundreds via representation learning is essential to large-scale recommender systems. Standard approaches approximate maximum likelihood estimation (MLE) through sampling for better scalability and address the problem of DCG in a way similar to language modeling. However, live recommender systems face severe unfairness of exposure with a vocabulary several orders of magnitude larger than that of natural language, implying that (1) MLE will preserve and even exacerbate the exposure bias in the long run in order to faithfully fit the observed samples, and (2) suboptimal sampling and inadequate use of item features can lead to inferior representations for the unfairly ignored items. In this paper, we introduce CLRec, a Contrastive Learning paradigm that has been successfully deployed in a real-world massive recommender system, to alleviate exposure bias in DCG. We theoretically prove that a popular choice of contrastive loss is equivalently reducing the exposure bias via inverse propensity scoring, which provides a new perspective on the effectiveness of contrastive learning. We further employ a fixed-size queue to store the items' representations computed in previously processed batches, and use the queue to serve as an effective sampler of negative examples. This queue-based design provides great efficiency in incorporating rich features of the thousand negative items per batch thanks to computation reuse. Extensive offline analyses and four-month online A/B tests in Mobile Taobao demonstrate substantial improvement, including a dramatic reduction in the Matthew effect.

Learning from demonstrations (LfD) improves the exploration efficiency of a learning agent by incorporating demonstrations from experts. However, demonstration data can often come from multiple experts with conflicting goals, making it difficult to incorporate safely and effectively in online settings. We address this problem in the static and dynamic optimization settings by modelling the uncertainty in source and target task functions using normal-inverse-gamma priors, whose corresponding posteriors are, respectively, learned from demonstrations and target data using Bayesian neural networks with shared features. We use this learned belief to derive a quadratic programming problem whose solution yields a probability distribution over the expert models. Finally, we propose Bayesian Experience Reuse (BERS) to sample demonstrations in accordance with this distribution and reuse them directly in new tasks. We demonstrate the effectiveness of this approach for static optimization of smooth functions, and transfer learning in a high-dimensional supply chain problem with cost uncertainty.

Imitation learning is an approach for generating intelligent behavior when the cost function is unknown or difficult to specify. Building upon work in inverse reinforcement learning (IRL), Generative Adversarial Imitation Learning (GAIL) aims to provide effective imitation even for problems with large or continuous state and action spaces. Driver modeling is one example of a problem where the state and action spaces are continuous. Human driving behavior is characterized by non-linearity and stochasticity, and the underlying cost function is unknown. As a result, learning from human driving demonstrations is a promising approach for generating human-like driving behavior. This article describes the use of GAIL for learning-based driver modeling. Because driver modeling is inherently a multi-agent problem, where the interaction between agents needs to be modeled, this paper describes a parameter-sharing extension of GAIL called PS-GAIL to tackle multi-agent driver modeling. In addition, GAIL is domain agnostic, making it difficult to encode specific knowledge relevant to driving in the learning process. This paper describes Reward Augmented Imitation Learning (RAIL), which modifies the reward signal to provide domain-specific knowledge to the agent. Finally, human demonstrations are dependent upon latent factors that may not be captured by GAIL. This paper describes Burn-InfoGAIL, which allows for disentanglement of latent variability in demonstrations. Imitation learning experiments are performed using NGSIM, a real-world highway driving dataset. Experiments show that these modifications to GAIL can successfully model highway driving behavior, accurately replicating human demonstrations and generating realistic, emergent behavior in the traffic flow arising from the interaction between driving agents.

We consider shared workspace scenarios with humans and robots acting to achieve independent goals, termed as parallel play. We model these as general-sum games and construct a framework that utilizes the Nash equilibrium solution concept to consider the interactive effect of both agents while planning. We find multiple Pareto-optimal equilibria in these tasks. We hypothesize that people act by choosing an equilibrium based on social norms and their personalities. To enable coordination, we infer the equilibrium online using a probabilistic model that includes these two factors and use it to select the robot's action. We apply our approach to a close-proximity pick-and-place task involving a robot and a simulated human with three potential behaviors - defensive, selfish, and norm-following. We showed that using a Bayesian approach to infer the equilibrium enables the robot to complete the task with less than half the number of collisions while also reducing the task execution time as compared to the best baseline. We also performed a study with human participants interacting either with other humans or with different robot agents and observed that our proposed approach performs similar to human-human parallel play interactions. The code is available at https://github.com/shray/bayes-nash

Sound modelling is the process of developing algorithms that generate sound under parametric control. There are a few distinct approaches that have been developed historically including modelling the physics of sound production and propagation, assembling signal generating and processing elements to capture acoustic features, and manipulating collections of recorded audio samples. While each of these approaches has been able to achieve high-quality synthesis and interaction for specific applications, they are all labour-intensive and each comes with its own challenges for designing arbitrary control strategies. Recent generative deep learning systems for audio synthesis are able to learn models that can traverse arbitrary spaces of sound defined by the data they train on. Furthermore, machine learning systems are providing new techniques for designing control and navigation strategies for these models. This paper is a review of developments in deep learning that are changing the practice of sound modelling.