The use of high-fidelity computational simulations promises to enable high-throughput hypothesis testing and optimisation of cancer therapies. However, increasing realism comes at the cost of increasing computational requirements. This article explores the use of surrogate-assisted evolutionary algorithms to optimise the targeted delivery of a therapeutic compound to cancerous tumour cells with the multicellular simulator, PhysiCell. The use of both Gaussian process models and multi-layer perceptron neural network surrogate models are investigated. We find that evolutionary algorithms are able to effectively explore the parameter space of biophysical properties within the agent-based simulations, minimising the resulting number of cancerous cells after a period of simulated treatment. Both model-assisted algorithms are found to outperform a standard evolutionary algorithm, demonstrating their ability to perform a more effective search within the very small evaluation budget. This represents the first use of efficient evolutionary algorithms within a high-throughput multicellular computing approach to find therapeutic design optima that maximise tumour regression.

The paper represents an algorithm for planning safe and optimal routes for transport facilities with unrestricted movement direction that travel within areas with obstacles. Paper explains the algorithm using a ship as an example of such a transport facility. This paper also provides a survey of several existing solutions for the problem. The method employs an evolutionary algorithm to plan several locally optimal routes and a parallel genetic algorithm to create the final route by optimising the abovementioned set of routes. The routes are optimized against the arrival time, assuming that the optimal route is the route with the lowermost arrival time. It is also possible to apply additional restriction to the routes.

The computational effort for the evaluation of numerical simulations based on e.g. the finite-element method is high. Metamodels can be utilized to create a low-cost alternative. However the number of required samples for the creation of a sufficient metamodel should be kept low, which can be achieved by using adaptive sampling techniques. In this Master thesis adaptive sampling techniques are investigated for their use in creating metamodels with the Kriging technique, which interpolates values by a Gaussian process governed by prior covariances. The Kriging framework with extension to multifidelity problems is presented and utilized to compare adaptive sampling techniques found in the literature for benchmark problems as well as applications for contact mechanics. This thesis offers the first comprehensive comparison of a large spectrum of adaptive techniques for the Kriging framework. Furthermore a multitude of adaptive techniques is introduced to multifidelity Kriging as well as well as to a Kriging model with reduced hyperparameter dimension called partial least squares Kriging. In addition, an innovative adaptive scheme for binary classification is presented and tested for identifying chaotic motion of a Duffing's type oscillator.

The game of Tetris is an important benchmark for research in artificial intelligence and machine learning. This paper provides a historical account of the algorithmic developments in Tetris and discusses open challenges. Handcrafted controllers, genetic algorithms, and reinforcement learning have all contributed to good solutions. However, existing solutions fall far short of what can be achieved by expert players playing without time pressure. Further study of the game has the potential to contribute to important areas of research, including feature discovery, autonomous learning of action hierarchies, and sample-efficient reinforcement learning.

In this article we are going to discuss training neural networks using particle swarm optimization (PSO). Training a neural network is an optimization problem so the optimization algorithm is of primary importance. When training MLPs we are adjusting weights between neurons using an error function as our optimization objective. PNNs and GRNNs use a smoothing factor, σ to define the network. The objective is to find sigmas that minimize error.

Artificial Intelligence (AI) has the opportunity to revolutionize the way the United States Department of Defense (DoD) and Intelligence Community (IC) address the challenges of evolving threats, data deluge, and rapid courses of action. Developing an end-to-end artificial intelligence system involves parallel development of different pieces that must work together in order to provide capabilities that can be used by decision makers, warfighters and analysts. These pieces include data collection, data conditioning, algorithms, computing, robust artificial intelligence, and human-machine teaming. While much of the popular press today surrounds advances in algorithms and computing, most modern AI systems leverage advances across numerous different fields. Further, while certain components may not be as visible to end-users as others, our experience has shown that each of these interrelated components play a major role in the success or failure of an AI system. This article is meant to highlight many of these technologies that are involved in an end-to-end AI system. The goal of this article is to provide readers with an overview of terminology, technical details and recent highlights from academia, industry and government. Where possible, we indicate relevant resources that can be used for further reading and understanding.

Evolution and learning are two of the fundamental mechanisms by which life adapts in order to survive and to transcend limitations. These biological phenomena inspired successful computational methods such as evolutionary algorithms and deep learning. Evolution relies on random mutations and on random genetic recombination. Here we show that learning to evolve, i.e. learning to mutate and recombine better than at random, improves the result of evolution in terms of fitness increase per generation and even in terms of attainable fitness. We use deep reinforcement learning to learn to dynamically adjust the strategy of evolutionary algorithms to varying circumstances. Our methods outperform classical evolutionary algorithms on combinatorial and continuous optimization problems.

Pattern analysis often requires a pre-processing stage for extracting or selecting features in order to help the classification, prediction, or clustering stage discriminate or represent the data in a better way. The reason for this requirement is that the raw data are complex and difficult to process without extracting or selecting appropriate features beforehand. This paper reviews theory and motivation of different common methods of feature selection and extraction and introduces some of their applications. Some numerical implementations are also shown for these methods. Finally, the methods in feature selection and extraction are compared.

In this paper, a biologically-inspired adaptive intelligent secondary controller is developed for microgrids to tackle system dynamics uncertainties, faults, and/or disturbances. The developed adaptive biologically-inspired controller adopts a novel computational model of emotional learning in mammalian limbic system. The learning capability of the proposed biologically-inspired intelligent controller makes it a promising approach to deal with the power system non-linear and volatile dynamics without increasing the controller complexity, and maintain the voltage and frequency stabilities by using an efficient reference tracking mechanism. The performance of the proposed intelligent secondary controller is validated in terms of the voltage and frequency absolute errors in the simulated microgrid. Simulation results highlight the efficiency and robustness of the proposed intelligent controller under the fault conditions and different system uncertainties compared to other benchmark controllers.

Recent advances on Artificial Intelligence (AI) techniques have popularized their usage on a large number of applications. Specially on design and creative processes AI has emerged to support human design and creativity [1] [2] [3]. As stated on [4], the next step in this field is machine creativity in order to augment human capabilities on problem solving. Specially, in the design process, [5] proposed a computational and cognitive model assuming two parallel search spaces: the problem space and the solution space. Then an iterative process of search and evaluation within both spaces can allow to continually explore design possibilities.