Understanding the key factors shaping environmental hazard exposures and their associated environmental injustice issues is vital for formulating equitable policy measures. Traditional perspectives on environmental injustice have primarily focused on the socioeconomic dimensions, often overlooking the influence of heterogeneous urban characteristics. This limited view may obstruct a comprehensive understanding of the complex nature of environmental justice and its relationship with urban design features. To address this gap, this study creates an interpretable machine learning model to examine the effects of various urban features and their non-linear interactions to the exposure disparities of three primary hazards: air pollution, urban heat, and flooding. The analysis trains and tests models with data from six metropolitan counties in the United States using Random Forest and XGBoost. The performance is used to measure the extent to which variations of urban features shape disparities in environmental hazard levels. In addition, the analysis of feature importance reveals features related to social-demographic characteristics as the most prominent urban features that shape hazard extent. Features related to infrastructure distribution and land cover are relatively important for urban heat and air pollution exposure respectively. Moreover, we evaluate the models' transferability across different regions and hazards. The results highlight limited transferability, underscoring the intricate differences among hazards and regions and the way in which urban features shape hazard exposures. The insights gleaned from this study offer fresh perspectives on the relationship among urban features and their interplay with environmental hazard exposure disparities, informing the development of more integrated urban design policies to enhance social equity and environmental injustice issues.

In recent years there has been a shift from heuristics-based malware detection towards machine learning, which proves to be more robust in the current heavily adversarial threat landscape. While we acknowledge machine learning to be better equipped to mine for patterns in the increasingly high amounts of similar-looking files, we also note a remarkable scarcity of the data available for similarity-targeted research. Moreover, we observe that the focus in the few related works falls on quantifying similarity in malware, often overlooking the clean data. This one-sided quantification is especially dangerous in the context of detection bypass. We propose to address the deficiencies in the space of similarity research on binary files, starting from EMBER - one of the largest malware classification data sets. We enhance EMBER with similarity information as well as malware class tags, to enable further research in the similarity space. Our contribution is threefold: (1) we publish EMBERSim, an augmented version of EMBER, that includes similarity-informed tags; (2) we enrich EMBERSim with automatically determined malware class tags using the open-source tool AVClass on VirusTotal data and (3) we describe and share the implementation for our class scoring technique and leaf similarity method.

Monkeypox is a zoonotic disease. About 87000 cases of monkeypox were confirmed by the World Health Organization until 10th June 2023. The most prevalent methods for identifying this disease are image-based recognition techniques. Still, they are not too fast and could only be available to a few individuals. This study presents an independent application named SyMPox, developed to diagnose Monkeypox cases based on symptoms. SyMPox utilizes the robust XGBoost algorithm to analyze symptom patterns and provide accurate assessments. Developed using the Gradio framework, SyMPox offers a user-friendly platform for individuals to assess their symptoms and obtain reliable Monkeypox diagnoses.

Due to the unavailability of routing information in design stages prior to detailed routing (DR), the tasks of timing prediction and optimization pose major challenges. Inaccurate timing prediction wastes design effort, hurts circuit performance, and may lead to design failure. This work focuses on timing prediction after clock tree synthesis and placement legalization, which is the earliest opportunity to time and optimize a "complete" netlist. The paper first documents that having "oracle knowledge" of the final post-DR parasitics enables post-global routing (GR) optimization to produce improved final timing outcomes. To bridge the gap between GR-based parasitic and timing estimation and post-DR results during post-GR optimization, machine learning (ML)-based models are proposed, including the use of features for macro blockages for accurate predictions for designs with macros. Based on a set of experimental evaluations, it is demonstrated that these models show higher accuracy than GR-based timing estimation. When used during post-GR optimization, the ML-based models show demonstrable improvements in post-DR circuit performance. The methodology is applied to two different tool flows - OpenROAD and a commercial tool flow - and results on 45nm bulk and 12nm FinFET enablements show improvements in post-DR slack metrics without increasing congestion. The models are demonstrated to be generalizable to designs generated under different clock period constraints and are robust to training data with small levels of noise.

Heart failure (HF) is a critical condition in which the accurate prediction of mortality plays a vital role in guiding patient management decisions. However, clinical datasets used for mortality prediction in HF often suffer from an imbalanced distribution of classes, posing significant challenges. In this paper, we explore preprocessing methods for enhancing one-month mortality prediction in HF patients. We present a comprehensive preprocessing framework including scaling, outliers processing and resampling as key techniques. We also employed an aware encoding approach to effectively handle missing values in clinical datasets. Our study utilizes a comprehensive dataset from the Persian Registry Of cardio Vascular disease (PROVE) with a significant class imbalance. By leveraging appropriate preprocessing techniques and Machine Learning (ML) algorithms, we aim to improve mortality prediction performance for HF patients. The results reveal an average enhancement of approximately 3.6% in F1 score and 2.7% in MCC for tree-based models, specifically Random Forest (RF) and XGBoost (XGB). This demonstrates the efficiency of our preprocessing approach in effectively handling Imbalanced Clinical Datasets (ICD). Our findings hold promise in guiding healthcare professionals to make informed decisions and improve patient outcomes in HF management.

In this study we present AI Prediction of Equatorial Plasma Bubbles (APE), a machine learning model that can accurately predict the Ionospheric Bubble Index (IBI) on the Swarm spacecraft. IBI is a correlation ($R^2$) between perturbations in plasma density and the magnetic field, whose source can be Equatorial Plasma Bubbles (EPBs). EPBs have been studied for a number of years, but their day-to-day variability has made predicting them a considerable challenge. We build an ensemble machine learning model to predict IBI. We use data from 2014-22 at a resolution of 1sec, and transform it from a time-series into a 6-dimensional space with a corresponding EPB $R^2$ (0-1) acting as the label. APE performs well across all metrics, exhibiting a skill, association and root mean squared error score of 0.96, 0.98 and 0.08 respectively. The model performs best post-sunset, in the American/Atlantic sector, around the equinoxes, and when solar activity is high. This is promising because EPBs are most likely to occur during these periods. Shapley values reveal that F10.7 is the most important feature in driving the predictions, whereas latitude is the least. The analysis also examines the relationship between the features, which reveals new insights into EPB climatology. Finally, the selection of the features means that APE could be expanded to forecasting EPBs following additional investigations into their onset.

While investigating methods to predict small molecule potencies, we found random forests or support vector machines paired with extended-connectivity fingerprints (ECFP) consistently outperformed recently developed methods. A detailed investigation into regression algorithms and molecular fingerprints revealed gradient-boosted decision trees, particularly CatBoost, in conjunction with a combination of ECFP, Avalon, and ErG fingerprints, as well as 200 molecular properties, to be most effective. Incorporating a graph neural network fingerprint further enhanced performance. We successfully validated our model across 22 Therapeutics Data Commons ADMET benchmarks. Our findings underscore the significance of richer molecular representations for accurate property prediction.

Recent research has shown that artificial intelligence (AI) models can exhibit bias in performance when trained using data that are imbalanced by protected attribute(s). Most work to date has focused on deep learning models, but classical AI techniques that make use of hand-crafted features may also be susceptible to such bias. In this paper we investigate the potential for race bias in random forest (RF) models trained using radiomics features. Our application is prediction of tumour molecular subtype from dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of breast cancer patients. Our results show that radiomics features derived from DCE-MRI data do contain race-identifiable information, and that RF models can be trained to predict White and Black race from these data with 60-70% accuracy, depending on the subset of features used. Furthermore, RF models trained to predict tumour molecular subtype using race-imbalanced data seem to produce biased behaviour, exhibiting better performance on test data from the race on which they were trained.

Privacy-preserving learning of gradient boosting decision trees (GBDT) has the potential for strong utility-privacy tradeoffs for tabular data, such as census data or medical meta data: classical GBDT learners can extract non-linear patterns from small sized datasets. The state-of-the-art notion for provable privacy-properties is differential privacy, which requires that the impact of single data points is limited and deniable. We introduce a novel differentially private GBDT learner and utilize four main techniques to improve the utility-privacy tradeoff. (1) We use an improved noise scaling approach with tighter accounting of privacy leakage of a decision tree leaf compared to prior work, resulting in noise that in expectation scales with $O(1/n)$, for $n$ data points. (2) We integrate individual R\'enyi filters to our method to learn from data points that have been underutilized during an iterative training process, which -- potentially of independent interest -- results in a natural yet effective insight to learning streams of non-i.i.d. data. (3) We incorporate the concept of random decision tree splits to concentrate privacy budget on learning leaves. (4) We deploy subsampling for privacy amplification. Our evaluation shows for the Abalone dataset ($<4k$ training data points) a $R^2$-score of $0.39$ for $\varepsilon=0.15$, which the closest prior work only achieved for $\varepsilon=10.0$. On the Adult dataset ($50k$ training data points) we achieve test error of $18.7\,\%$ for $\varepsilon=0.07$ which the closest prior work only achieved for $\varepsilon=1.0$. For the Abalone dataset for $\varepsilon=0.54$ we achieve $R^2$-score of $0.47$ which is very close to the $R^2$-score of $0.54$ for the nonprivate version of GBDT. For the Adult dataset for $\varepsilon=0.54$ we achieve test error $17.1\,\%$ which is very close to the test error $13.7\,\%$ of the nonprivate version of GBDT.

Federated Learning (FL) [1] is a novel machine learning paradigm where multiple parties collaboratively build machine learning models without centralizing their data. The concept of FL was first proposed by Google in 2016 [2] to describe a cross-device scenario where millions of mobile devices are coordinated by a central server while local data are not transferred. This concept is soon extended to a cross-silo collaboration scenario among organizations [3], where a small number of reliable organizations join a federation to train a machine learning model. In [3], FL is, for the first time, categorized into three categories based on how data is partitioned in the sample and feature space: Horizontal Federated Learning (HFL), Vertical Federated Learning (VFL) and Federated Transfer Learning (FTL) (See Figure 1). HFL refers to the FL setting where participants share the same feature space while holding different samples. For example, Google uses HFL to allow mobile phone users to use their dataset to collaboratively train a next-word prediction model [2]. VFL refers to the FL setting where datasets share the same samples/users while holding different features. For example, Webank uses VFL to collaborate with an invoice agency to build financial risk models for their enterprise customers [4].