The World Health Organisation (WHO) revealed approximately 280 million people in the world suffer from depression. Yet, existing studies on early-stage depression detection using machine learning (ML) techniques are limited. Prior studies have applied a single stand-alone algorithm, which is unable to deal with data complexities, prone to overfitting, and limited in generalization. To this end, our paper examined the performance of several ML algorithms for early-stage depression detection using two benchmark social media datasets (D1 and D2). More specifically, we incorporated sentiment indicators to improve our model performance. Our experimental results showed that sentence bidirectional encoder representations from transformers (SBERT) numerical vectors fitted into the stacking ensemble model achieved comparable F1 scores of 69% in the dataset (D1) and 76% in the dataset (D2). Our findings suggest that utilizing sentiment indicators as an additional feature for depression detection yields an improved model performance, and thus, we recommend the development of a depressive term corpus for future work.

This research investigates the use of artificial intelligence and machine learning techniques to predict the toxicity of nanoparticles, a pressing concern due to their pervasive use in various industries and the inherent challenges in assessing their biological interactions. Employing models such as Decision Trees, Random Forests, and XGBoost, the study focuses on analyzing physicochemical properties like size, shape, surface charge, and chemical composition to determine their influence on toxicity. Our findings highlight the significant role of oxygen atoms, particle size, surface area, dosage, and exposure duration in affecting toxicity levels. The use of machine learning allows for a nuanced understanding of the intricate patterns these properties form in biological contexts, surpassing traditional analysis methods in efficiency and predictive power. These advancements aid in developing safer nanomaterials through computational chemistry, reducing reliance on costly and time-consuming experimental methods. This approach not only enhances our understanding of nanoparticle behavior in biological systems but also streamlines the safety assessment process, marking a significant stride towards integrating computational techniques in nanotoxicology.

Cryptocoins (i.e., Bitcoin, Ether, Litecoin) are tradable digital assets. Ownerships of cryptocoins are registered on distributed ledgers (i.e., blockchains). Secure encryption techniques guarantee the security of the transactions (transfers of coins among owners), registered into the ledger. Cryptocoins are exchanged for specific trading prices. The extreme volatility of such trading prices across all different sets of crypto-assets remains undisputed. However, the relations between the trading prices across different cryptocoins remains largely unexplored. Major coin exchanges indicate trend correlation to advise for sells or buys. However, price correlations remain largely unexplored. We shed some light on the trend correlations across a large variety of cryptocoins, by investigating their coin/price correlation trends over the past two years. We study the causality between the trends, and exploit the derived correlations to understand the accuracy of state-of-the-art forecasting techniques for time series modeling (e.g., GBMs, LSTM and GRU) of correlated cryptocoins. Our evaluation shows (i) strong correlation patterns between the most traded coins (e.g., Bitcoin and Ether) and other types of cryptocurrencies, and (ii) state-of-the-art time series forecasting algorithms can be used to forecast cryptocoins price trends. We released datasets and code to reproduce our analysis to the research community.

Deep neural network(DNN) based classifiers do extremely well in discriminating between observations, resulting in higher ROC AUC and accuracy metrics, but their outputs are often miscalibrated with respect to true event likelihoods. Post-hoc calibration algorithms are often used to calibrate the outputs of these classifiers. Methods like Isotonic regression, Platt scaling, and Temperature scaling have been shown to be effective in some cases but are limited by their parametric assumptions and/or their inability to capture complex non-linear relationships. We propose ForeCal - a novel post-hoc calibration algorithm based on Random forests. ForeCal exploits two unique properties of Random forests: the ability to enforce weak monotonicity and range-preservation. It is more powerful in achieving calibration than current state-of-the-art methods, is non-parametric, and can incorporate exogenous information as features to learn a better calibration function. Through experiments on 43 diverse datasets from the UCI ML repository, we show that ForeCal outperforms existing methods in terms of Expected Calibration Error(ECE) with minimal impact on the discriminative power of the base DNN as measured by AUC.

Heart failure affects millions of people worldwide, significantly reducing quality of life and leading to high mortality rates. Despite extensive research, the relationship between heart failure and mortality rates among ICU patients is not fully understood, indicating the need for more accurate prediction models. This study analyzed data from 1,177 patients over 18 years old from the MIMIC-III database, identified using ICD-9 codes. Preprocessing steps included handling missing data, removing duplicates, treating skewness, and using oversampling techniques to address data imbalances. Through rigorous feature selection using Variance Inflation Factor (VIF), expert clinical input, and ablation studies, 46 key features were identified to enhance model performance. Our analysis compared several machine learning models, including Logistic Regression, Support Vector Machine (SVM), Random Forest, LightGBM, and XGBoost. XGBoost emerged as the superior model, achieving a test AUC-ROC of 0.9228 (95\% CI 0.8748 - 0.9613), significantly outperforming our previous work (AUC-ROC of 0.8766) and the best results reported in existing literature (AUC-ROC of 0.824). The improved model's success is attributed to advanced feature selection methods, robust preprocessing techniques, and comprehensive hyperparameter optimization through Grid-Search. SHAP analysis and feature importance evaluations based on XGBoost highlighted key variables like leucocyte count and RDW, providing valuable insights into the clinical factors influencing mortality risk. This framework offers significant support for clinicians, enabling them to identify high-risk ICU heart failure patients and improve patient outcomes through timely and informed interventions.

These studies have been accelerated by 1) the increasing sophistication of information and communication technology, 2) large-scale data obtained through longitudinal studies, etc., and 3) the opening of program codes for building predictive models using machine learning. In particular, these studies have become even more active in recent years with the advent of automated machine learning framework [4-6]. As an example, published studies have applied MLA to data from the UK Biobank large longitudinal cohort study to develop models to diagnose and predict disease onset in advance [4, 7]. Such studies have been conducted previously, and in 1988, J. W. Smith et al. applied neural networks to data collected by the National Institute of Diabetes and Digestive and Kidney Diseases from a population of Pima Indians near Phoenix, Arizona, to predict the onset of diabetes [8-11]. This dataset, called the PID dataset, is still the primary dataset used to evaluate MLA in recent years, and in 2014, a method was proposed to combine multiple prediction models to predict onset of the disease, showing a very high prediction accuracy of 0.97 [12-17]. As mentioned above, a great deal of research has been published in recent years on predictive models of disease using machine learning. However, there are issues such as inadequate reporting of prediction models and lack of external validation [18].

Introduction: Laboratory value represents a cornerstone of medical diagnostics, but suffers from slow turnaround times, and high costs and only provides information about a single point in time. The continuous estimation of laboratory values from non-invasive data such as electrocardiogram (ECG) would therefore mark a significant frontier in healthcare monitoring. Despite its transformative potential, this domain remains relatively underexplored within the medical community. Methods: In this preliminary study, we used a publicly available dataset (MIMIC-IV-ECG) to investigate the feasibility of inferring laboratory values from ECG features and patient demographics using tree-based models (XGBoost). We define the prediction task as a binary prediction problem of predicting whether the lab value falls into low or high abnormalities. The model performance can then be assessed using AUROC. Results: Our findings demonstrate promising results in the estimation of laboratory values related to different organ systems based on a small yet comprehensive set of features. While further research and validation are warranted to fully assess the clinical utility and generalizability of ECG-based estimation in healthcare monitoring, our findings lay the groundwork for future investigations into approaches to laboratory value estimation using ECG data. Such advancements hold promise for revolutionizing predictive healthcare applications, offering faster, non-invasive, and more affordable means of patient monitoring.

Previously, using forward-flux sampling (FFS) and machine learning (ML), we developed multivariate alarm systems to counter rare un-postulated abnormal events. Our alarm systems utilized ML-based predictive models to quantify committer probabilities as functions of key process variables (e.g., temperature, concentrations, and the like), with these data obtained in FFS simulations. Herein, we introduce a novel and comprehensive benchmark framework for rare-event prediction, comparing ML algorithms of varying complexity, including Linear Support-Vector Regressor and k-Nearest Neighbors, to more sophisticated algorithms, such as Random Forests, XGBoost, LightGBM, CatBoost, Dense Neural Networks, and TabNet. This evaluation uses comprehensive performance metrics, such as: $\textit{RMSE}$, model training, testing, hyperparameter tuning and deployment times, and number and efficiency of alarms. These balance model accuracy, computational efficiency, and alarm-system efficiency, identifying optimal ML strategies for predicting abnormal rare events, enabling operators to obtain safer and more reliable plant operations.

Boosting is an extremely successful idea, allowing one to combine multiple low accuracy classifiers into a much more accurate voting classifier. In this work, we present a new and surprisingly simple Boosting algorithm that obtains a provably optimal sample complexity. Sample optimal Boosting algorithms have only recently been developed, and our new algorithm has the fastest runtime among all such algorithms and is the simplest to describe: Partition your training data into 5 disjoint pieces of equal size, run AdaBoost on each, and combine the resulting classifiers via a majority vote. In addition to this theoretical contribution, we also perform the first empirical comparison of the proposed sample optimal Boosting algorithms. Our pilot empirical study suggests that our new algorithm might outperform previous algorithms on large data sets.

Introduction: Ensuring timely and accurate diagnosis of medical conditions is paramount for effective patient care. Electrocardiogram (ECG) signals are fundamental for evaluating a patient's cardiac health and are readily available. Despite this, little attention has been given to the remarkable potential of ECG data in detecting non-cardiac conditions. Methods: In our study, we used publicly available datasets (MIMIC-IV-ECG-ICD and ECG-VIEW II) to investigate the feasibility of inferring general diagnostic conditions from ECG features. To this end, we trained a tree-based model (XGBoost) based on ECG features and basic demographic features to estimate a wide range of diagnoses, encompassing both cardiac and non-cardiac conditions. Results: Our results demonstrate the reliability of estimating 23 cardiac as well as 21 non-cardiac conditions above 0.7 AUROC in a statistically significant manner across a wide range of physiological categories. Our findings underscore the predictive potential of ECG data in identifying well-known cardiac conditions. However, even more striking, this research represents a pioneering effort in systematically expanding the scope of ECG-based diagnosis to conditions not traditionally associated with the cardiac system.