Artificial intelligence (AI) has sparked immense interest in drug discovery, but most current approaches only digitize existing high-throughput experiments. They remain constrained by conventional pipelines. As a result, they do not address the fundamental challenges of predicting drug effects in humans. Similarly, biomedical digital twins, largely grounded in real-world data and mechanistic models, are tailored for late-phase drug development and lack the resolution to model molecular interactions or their systemic consequences, limiting their impact in early-stage discovery. This disconnect between early discovery and late development is one of the main drivers of high failure rates in drug discovery. The true promise of AI lies not in augmenting current experiments but in enabling virtual experiments that are impossible in the real world: testing novel compounds directly in silico in the human body. Recent advances in AI, high-throughput perturbation assays, and single-cell and spatial omics across species now make it possible to construct programmable virtual humans: dynamic, multiscale models that simulate drug actions from molecular to phenotypic levels. By bridging the translational gap, programmable virtual humans offer a transformative path to optimize therapeutic efficacy and safety earlier than ever before. This perspective introduces the concept of programmable virtual humans, explores their roles in a new paradigm of drug discovery centered on human physiology, and outlines key opportunities, challenges, and roadmaps for their realization.

Though humans seem to be remarkable learners, arguments in cognitive science and philosophy of mind have long maintained that learning something fundamentally new is impossible. Specifically, Jerry Fodor's arguments for radical concept nativism hold that most, if not all, concepts are innate and that what many call concept learning never actually leads to the acquisition of new concepts. These arguments have deeply affected cognitive science, and many believe that the counterarguments to radical concept nativism have been either unsuccessful or only apply to a narrow class of concepts. This paper first reviews the features and limitations of prior arguments. We then identify three critical points - related to issues of expressive power, conceptual structure, and concept possession - at which the arguments in favor of radical concept nativism diverge from describing actual human cognition. We use ideas from computer science and information theory to formalize the relevant ideas in ways that are arguably more scientifically productive. We conclude that, as a result, there is an important sense in which people do indeed learn new concepts.

Despite growing interest in Learning-by-Teaching (LbT), few studies have explored how this paradigm can be implemented with autonomous, peer-like social robots in real classrooms. Most prior work has relied on scripted or Wizard-of-Oz behaviors, limiting our understanding of how real-time, interactive learning can be supported by artificial agents. This study addresses this gap by introducing Interactive Reinforcement Learning (RL) as a cognitive model for teachable social robots. We conducted two between-subject experiments with 58 primary school children, who either taught a robot or practiced independently on a tablet while learning French vocabulary (memorization) and grammatical rules (inference). The robot, powered by Interactive RL, learned from the child's evaluative feedback. Children in the LbT condition achieved significantly higher retention gains compared to those in the self-practice condition, especially on the grammar task. Learners with lower prior knowledge benefited most from teaching the robot. Behavioural metrics revealed that children adapted their teaching strategies over time and engaged more deeply during inference tasks. This work makes two contributions: (1) it introduces Interactive RL as a pedagogically effective and scalable model for peer-robot learning, and (2) it demonstrates, for the first time, the feasibility of deploying multiple autonomous robots simultaneously in real classrooms. These findings extend theoretical understanding of LbT by showing that social robots can function not only as passive tutees but as adaptive partners that enhance meta-cognitive engagement and long-term learning outcomes.

Human planning is efficient -- it frugally deploys limited cognitive resources to accomplish difficult tasks -- and flexible -- adapting to novel problems and environments. Computational approaches suggest that people construct simplified mental representations of their environment, balancing the complexity of a task representation with its utility. These models imply a nested optimisation in which planning shapes perception, and perception shapes planning -- but the perceptual and attentional mechanisms governing how this interaction unfolds remain unknown. Here, we harness virtual maze navigation to characterise how spatial attention controls which aspects of a task representation enter subjective awareness and are available for planning. We find that spatial proximity governs which aspects of a maze are available for planning, and that when task-relevant information follows natural (lateralised) contours of attention, people can more easily construct simplified and useful maze representations. This influence of attention varies considerably across individuals, explaining differences in people's task representations and behaviour. Inspired by the 'spotlight of attention' analogy, we incorporate the effects of visuospatial attention into existing computational accounts of value-guided construal. Together, our work bridges computational perspectives on perception and decision-making to better understand how individuals represent their environments in aid of planning.

The quantification of social science remains a longstanding challenge, largely due to the philosophical nature of its foundational theories. Although quantum computing has advanced rapidly in recent years, its relevance to social theory remains underexplored. Most existing research focuses on micro-cognitive models or philosophical analogies, leaving a gap in system-level applications of quantum principles to the analysis of social systems. This study addresses that gap by proposing a theoretical and computational framework that combines quantum mechanics with Generative AI to simulate the emergence and evolution of social norms. Drawing on core quantum concepts--such as superposition, entanglement, and probabilistic measurement--this research models society as a dynamic, uncertain system and sets up five ideal-type experiments. These scenarios are simulated using 25 generative agents, each assigned evolving roles as compliers, resistors, or enforcers. Within a simulated environment monitored by a central observer (the Watcher), agents interact, respond to surveillance, and adapt to periodic normative disruptions. These interactions allow the system to self-organize under external stress and reveal emergent patterns. Key findings show that quantum principles, when integrated with generative AI, enable the modeling of uncertainty, emergence, and interdependence in complex social systems. Simulations reveal patterns including convergence toward normative order, the spread of resistance, and the spontaneous emergence of new equilibria in social rules. In conclusion, this study introduces a novel computational lens that lays the groundwork for a quantum-informed social theory. It offers interdisciplinary insights into how society can be understood not just as a structure to observe but as a dynamic system to simulate and redesign through quantum technologies.

Student cognitive modeling (SCM) is a fundamental task in intelligent education, with applications ranging from personalized learning to educational resource allocation. By exploiting students' response logs, SCM aims to predict their exercise performance as well as estimate knowledge proficiency in a subject. Data mining approaches such as matrix factorization can obtain high accuracy in predicting student performance on exercises, but the knowledge proficiency is unknown or poorly estimated. The situation is further exacerbated if only sparse interactions exist between exercises and students (or knowledge concepts). To solve this dilemma, we root monotonicity (a fundamental psychometric theory on educational assessments) in a co-factorization framework and present an autoencoder-like nonnegative matrix co-factorization (AE-NMCF), which improves the accuracy of estimating the student's knowledge proficiency via an encoder-decoder learning pipeline.

Humans learn from visual inputs at multiple timescales, both rapidly and flexibly acquiring visual knowledge over short periods, and robustly accumulating online learning progress over longer periods. Modeling these powerful learning capabilities is an important problem for computational visual cognitive science, and models that could replicate them would be of substantial utility in real-world computer vision settings. In this work, we establish benchmarks for both real-time and life-long continual visual learning. Our real-time learning benchmark measures a model's ability to match the rapid visual behavior changes of real humans over the course of minutes and hours, given a stream of visual inputs. Our life-long learning benchmark evaluates the performance of models in a purely online learning curriculum obtained directly from child visual experience over the course of years of development.

We introduce automated scientific minimization of regret (ASMR) -- a framework for automated computational cognitive science. Building on the principles of scientific regret minimization, ASMR leverages Centaur -- a recently proposed foundation model of human cognition -- to identify gaps in an interpretable cognitive model. These gaps are then addressed through automated revisions generated by a language-based reasoning model. We demonstrate the utility of this approach in a multi-attribute decision-making task, showing that ASMR discovers cognitive models that predict human behavior at noise ceiling while retaining interpretability. Taken together, our results highlight the potential of ASMR to automate core components of the cognitive modeling pipeline.

A central goal of cognitive modeling is to develop models that not only predict human behavior but also provide insight into the underlying cognitive mechanisms. While neural network models trained on large-scale behavioral data often achieve strong predictive performance, they typically fall short in offering interpretable explanations of the cognitive processes they capture. In this work, we explore the potential of pretrained large language models (LLMs) to serve as dual-purpose cognitive models--capable of both accurate prediction and interpretable explanation in natural language. Specifically, we employ reinforcement learning with outcome-based rewards to guide LLMs toward generating explicit reasoning traces for explaining human risky choices. Our findings demonstrate that this approach produces high-quality explanations alongside strong quantitative predictions of human decisions.

Autonomous AI is no longer a hard-to-reach concept, it enables the agents to move beyond executing tasks to independently addressing complex problems, adapting to change while handling the uncertainty of the environment. However, what makes the agents truly autonomous? It is agentic reasoning, that is crucial for foundation models to develop symbolic logic, statistical correlations, or large-scale pattern recognition to process information, draw inferences, and make decisions. However, it remains unclear why and how existing agentic reasoning approaches work, in comparison to biological reasoning, which instead is deeply rooted in neural mechanisms involving hierarchical cognition, multimodal integration, and dynamic interactions. In this work, we propose a novel neuroscience-inspired framework for agentic reasoning. Grounded in three neuroscience-based definitions and supported by mathematical and biological foundations, we propose a unified framework modeling reasoning from perception to action, encompassing four core types, perceptual, dimensional, logical, and interactive, inspired by distinct functional roles observed in the human brain. We apply this framework to systematically classify and analyze existing AI reasoning methods, evaluating their theoretical foundations, computational designs, and practical limitations. We also explore its implications for building more generalizable, cognitively aligned agents in physical and virtual environments. Finally, building on our framework, we outline future directions and propose new neural-inspired reasoning methods, analogous to chain-of-thought prompting. By bridging cognitive neuroscience and AI, this work offers a theoretical foundation and practical roadmap for advancing agentic reasoning in intelligent systems. The associated project can be found at: https://github.com/BioRAILab/Awesome-Neuroscience-Agent-Reasoning .