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Using the Future to "Sort Out" the Present: Rankprop and Multitask Learning for Medical Risk Evaluation

Neural Information Processing Systems

This paper presents two methods that can improve generalization on a broad class of problems. This class includes identifying low risk pneumonia patients. The first method, rankprop, tries to learn simple models that support ranking future cases while simultaneously learning to rank the training set. The second, multitask learning, uses lab tests available only during training, as additional target values to bias learning towards a more predictive hidden layer. Experiments using a database of pneumonia patients indicate that together these methods outperform standard backpropagation by 10-50%. Rankprop and MTL are applicable to a large class of problems in which the goal is to learn a relative ranking over the instance space, and where the training data includes features that will not be available at run time. Such problems include identifying higher-risk medical patients as early as possible, identifying lower-risk financial investments, and visual analysis of scenes that become easier to analyze as they are approached in the future. Acknowledgements We thank Greg Cooper, Michael Fine, and other members of the Pitt/CMU Cost-Effective Health Care group for help with the Medis Database. This work was supported by ARPA grant F33615-93-1-1330, NSF grant BES-9315428, Agency for Health Care Policy and Research grant HS06468, and an NSF Graduate Student Fellowship (Baluja).


Neuron-MOS Temporal Winner Search Hardware for Fully-Parallel Data Processing

Neural Information Processing Systems

Search for the largest (or the smallest) among a number of input data, Le., the winner-take-all (WTA) action, is an essential part of intelligent data processing such as data retrieval in associative memories [3], vector quantization circuits [4], Kohonen's self-organizing maps [5] etc. In addition to the maximum or minimum search, data sorting also plays an essential role in a number of signal processing such as median filtering in image processing, evolutionary algorithms in optimizing problems [6] and so forth.


Using Pairs of Data-Points to Define Splits for Decision Trees

Neural Information Processing Systems

CART either split the data using axis-aligned hyperplanes or they perform a computationally expensivesearch in the continuous space of hyperplanes with unrestricted orientations. We show that the limitations of the former can be overcome without resorting to the latter. For every pair of training data-points, there is one hyperplane that is orthogonal tothe line joining the data-points and bisects this line. Such hyperplanes are plausible candidates for splits. In a comparison on a suite of 12 datasets we found that this method of generating candidate splits outperformed the standard methods, particularly when the training sets were small. 1 Introduction Binary decision trees come in many flavours, but they all rely on splitting the set of k-dimensional data-points at each internal node into two disjoint sets.


Improving Committee Diagnosis with Resampling Techniques

Neural Information Processing Systems

Central to the performance improvement of a committee relative to individual networks is the error correlation between networks in the committee. We investigated methods of achieving error independence betweenthe networks by training the networks with different resampling sets from the original training set. The methods were tested on the sinwave artificial task and the real-world problems of hepatoma (liver cancer) and breast cancer diagnoses.


How Perception Guides Production in Birdsong Learning

Neural Information Processing Systems

The passeriformes or songbirds make up more than half of all bird species and are divided into two groups: the os cines which learn their songs and sub-oscines which do not. Oscines raised in isolation sing degraded species typical songs similar to wild song. Deafened oscines sing completely degraded songs (Konishi, 1965), while deafened sub-oscines develop normal songs (Kroodsma and Konishi, 1991) indicating that auditory feedback is crucial in oscine song learning. Innate structures in the bird brain regulate song learning.


Factorial Hidden Markov Models

Neural Information Processing Systems

Due to the simplicity and efficiency of its parameter estimation algorithm, the hidden Markov model (HMM) has emerged as one of the basic statistical tools for modeling discrete time series, finding widespread application in the areas of speech recognition (Rabinerand Juang, 1986) and computational molecular biology (Baldi et al., 1994). An HMM is essentially a mixture model, encoding information about the history of a time series in the value of a single multinomial variable (the hidden state). This multinomial assumption allows an efficient parameter estimation algorithm tobe derived (the Baum-Welch algorithm). However, it also severely limits the representational capacity of HMMs.


EM Optimization of Latent-Variable Density Models

Neural Information Processing Systems

There is currently considerable interest in developing general nonlinear densitymodels based on latent, or hidden, variables. Such models have the ability to discover the presence of a relatively small number of underlying'causes' which, acting in combination, give rise to the apparent complexity of the observed data set. Unfortunately, totrain such models generally requires large computational effort. In this paper we introduce a novel latent variable algorithm which retains the general nonlinear capabilities of previous models but which uses a training procedure based on the EM algorithm. We demonstrate the performance of the model on a toy problem and on data from flow diagnostics for a multiphase oil pipeline.


Modeling Interactions of the Rat's Place and Head Direction Systems

Neural Information Processing Systems

We have developed a computational theory of rodent navigation that includes analogs of the place cell system, the head direction system, and path integration. In this paper we present simulation results showing how interactions between the place and head direction systems can account for recent observations about hippocampal place cell responses to doubling and/or rotation of cue cards in a cylindrical arena (Sharp et at.,


Classifying Facial Action

Neural Information Processing Systems

Measurement of facial expressions is important for research and assessment psychiatry, neurology,and experimental psychology (Ekman, Huang, Sejnowski, & Hager, 1992), and has technological applications in consumer-friendly user interfaces, interactive videoand entertainment rating. The Facial Action Coding System (FACS) is a method for measuring facial expressions in terms of activity in the underlying facial muscles (Ekman & Friesen, 1978). We are exploring ways to automate FACS.


Softassign versus Softmax: Benchmarks in Combinatorial Optimization

Neural Information Processing Systems

Steven Gold Department of Computer Science Yale University New Haven, CT 06520-8285 AnandRangarajan Dept. of Diagnostic Radiology Yale University New Haven, CT 06520-8042 Abstract A new technique, termed soft assign, is applied for the first time to two classic combinatorial optimization problems, the traveling salesmanproblem and graph partitioning. Softassign, which has emerged from the recurrent neural network/statistical physics framework, enforces two-way (assignment) constraints without the use of penalty terms in the energy functions. The softassign can also be generalized from two-way winner-take-all constraints to multiple membership constraints which are required for graph partitioning. Thesoftassign technique is compared to the softmax (Potts glass). Within the statistical physics framework, softmax and a penalty term has been a widely used method for enforcing the two-way constraints common within many combinatorial optimization problems.The benchmarks present evidence that softassign has clear advantages in accuracy, speed, parallelizabilityand algorithmic simplicityover softmax and a penalty term in optimization problems with two-way constraints. 1 Introduction In a series of papers in the early to mid 1980's, Hopfield and Tank introduced techniques which allowed one to solve combinatorial optimization problems with recurrent neural networks [Hopfield and Tank, 1985].