A framework is introduced for assessing the encoding accuracy and the discriminational ability of a population of neurons upon simultaneous presentation of multiple stimuli. Minimal square estimation errors are obtained from a Fisher information analysis in an abstract compound space comprising the features of all stimuli. Even for the simplest case of linear superposition of responses and Gaussian tuning, the symmetries in the compound space are very different from those in the case of a single stimulus. The analysis allows for a quantitative description of attentional effects and can be extended to include neural nonlinearities such as nonclassical receptive fields.

Psychophysical data suggest that temporal modulations of stimulus amplitude envelopes play a prominent role in the perceptual segregation of concurrent sounds. In particular, the detection of an unmodulated signal can be significantly improved by adding amplitude modulation to the spectral envelope of a competing masking noise. This perceptual phenomenon is known as "Comodulation Masking Release" (CMR). Despite the obvious influence of temporal structure on the perception of complex auditory scenes, the physiological mechanisms that contribute to CMR and auditory streaming are not well known. A recent physiological study by Nelken and colleagues has demonstrated an enhanced cortical representation of auditory signals in modulated noise. Our study evaluates these CMR-like response patterns from the perspective of a hypothetical auditory edge-detection neuron. It is shown that this simple neural model for the detection of amplitude transients can reproduce not only the physiological data of Nelken et al., but also, in light of previous results, a variety of physiological and psychoacoustical phenomena that are related to the perceptual segregation of concurrent sounds.

The responses of cortical sensory neurons are notoriously variable, with the number of spikes evoked by identical stimuli varying significantly from trial to trial. This variability is most often interpreted as'noise', purely detrimental to the sensory system. In this paper, we propose an alternative view in which the variability is related to the uncertainty, about world parameters, which is inherent in the sensory stimulus. Specifically, the responses of a population of neurons are interpreted as stochastic samples from the posterior distribution in a latent variable model. In addition to giving theoretical arguments supporting such a representational scheme, we provide simulations suggesting how some aspects of response variability might be understood in this framework.

If the cortex uses spike timing to compute, the timing of the spikes must be robust to perturbations. Based on a recent framework that provides a simple criterion to determine whether a spike sequence produced by a generic network is sensitive to initial conditions, and numerical simulations of a variety of network architectures, we argue within the limits set by our model of the neuron, that it is unlikely that precise sequences of spike timings are used for computation under conditions typically found in the cortex. 1 Introduction

From olfaction to vision and audition, there is an increasing need, and a growing number of experiments [1]-[8] that study responses of sensory neurons to natural stimuli. Natural stimuli have specific statistical properties [9, 10], and therefore sample only a subspace of all possible spatial and temporal frequencies explored during stimulation with white noise. Observing the full dynamic range of neural responses may require using stimulus ensembles which approximate those occurring in nature, and it is an attractive hypothesis that the neural representation of these natural signals may be optimized in some way. Finally, some neuron responses are strongly nonlinear and adaptive, and may not be predicted from a combination of responses to simple stimuli. It has also been shown that the variability in neural response decreases substantially when dynamical, rather than static, stimuli are used [11, 12]. For all these reasons, it would be attractive to have a rigorous method of analyzing neural responses to complex, naturalistic inputs.

Cortical synaptic plasticity depends on the relative timing of pre-and postsynaptic spikes and also on the temporal pattern of presynaptic spikes and of postsynaptic spikes. We study the hypothesis that cortical synaptic plasticity does not associate individual spikes, but rather whole firing episodes, and depends only on when these episodes start and how long they last, but as little as possible on the timing of individual spikes. Here we present the mathematical background for such a study. Standard methods from hidden Markov models are used to define what "firing episodes" are. Estimating the probability of being in such an episode requires not only the knowledge of past spikes, but also of future spikes. We show how to construct a causal learning rule, which depends only on past spikes, but associates pre-and postsynaptic firing episodes as if it also knew future spikes. We also show that this learning rule agrees with some features of synaptic plasticity in superficial layers of rat visual cortex (Froemke and Dan, Nature 416:433, 2002).

Adaptation is a ubiquitous neural and psychological phenomenon, with a wealth of instantiations and implications. Although a basic form of plasticity, it has, bar some notable exceptions, attracted computational theory of only one main variety. In this paper, we study adaptation from the perspective of factor analysis, a paradigmatic technique of unsupervised learning. We use factor analysis to reinterpret a standard view of adaptation, and apply our new model to some recent data on adaptation in the domain of face discrimination.

We introduce the notion of Morton-style factorial coding and illustrate how it may help understand information integration and perceptual coding in the brain. We show that by focusing on average responses one may miss the existence of factorial coding mechanisms that become only apparent when analyzing spike count histograms. We show evidence suggesting that the classical/nonclassical receptive field organization in the cortex effectively enforces the development of Morton-style factorial codes. This may provide some cues to help understand perceptual coding in the brain and to develop new unsupervised learning algorithms. While methods like ICA (Bell & Sejnowski, 1997) develop independent codes, in Morton-style coding the goal is to make two or more external aspects of the world become independent when conditioning on internal representations.

A population of neurons typically exhibits a broad diversity of responses to sensory inputs. The intuitive notion of functional classification is that cells can be clustered so that most of the diversity is captured by the identity of the clusters rather than by individuals within clusters. We show how this intuition can be made precise using information theory, without any need to introduce a metric on the space of stimuli or responses. Applied to the retinal ganglion cells of the salamander, this approach recovers classical results, but also provides clear evidence for subclasses beyond those identified previously. Further, we find that each of the ganglion cells is functionally unique, and that even within the same subclass only a few spikes are needed to reliably distinguish between cells.

Here we derive optimal gain functions for minimum mean square reconstruction from neural rate responses subjected to Poisson noise. The shape of these functions strongly depends on the length T of the time window within which spikes are counted in order to estimate the underlying firing rate. A phase transition towards pure binary encoding occurs if the maximum mean spike count becomes smaller than approximately three provided the minimum firing rate is zero. For a particular function class, we were able to prove the existence of a second-order phase transition analytically. The critical decoding time window length obtained from the analytical derivation is in precise agreement with the numerical results.