Even under perfect fixation the human eye is under steady motion (tremor, microsaccades, slow drift). The "dynamic" theory of vision [1,2] states that eye-movements can improve hyperacuity. According to this theory, eye movements are thought to create variable spatial excitation patterns on the photoreceptor grid, which will allow for better spatiotemporal summation at later stages.

Recent work has examined the estimation of models of stimulus-driven neural activity in which some linear filtering process is followed by a nonlinear, probabilistic spiking stage. We analyze the estimation of one such model for which this nonlinear step is implemented by a noisy, leaky, integrate-and-fire mechanism with a spike-dependent aftercurrent. Thismodel is a biophysically plausible alternative to models with Poisson (memory-less) spiking, and has been shown to effectively reproduce various spiking statistics of neurons in vivo. However, the problem of estimating the model from extracellular spike train data has not been examined in depth. We formulate the problem in terms of maximum likelihoodestimation, and show that the computational problem of maximizing the likelihood is tractable.

Significant plasticity in sensory cortical representations can be driven in mature animals either by behavioural tasks that pair sensory stimuli with reinforcement, or by electrophysiological experiments that pair sensory input with direct stimulation of neuromodulatory nuclei, but usually not by sensory stimuli presented alone. Biologically motivated theories of representational learning, however, have tended to focus on unsupervised mechanisms, which may play a significant role on evolutionary or developmental timescales,but which neglect this essential role of reinforcement in adult plasticity. By contrast, theoretical reinforcement learning has generally dealt with the acquisition of optimal policies for action in an uncertain world, rather than with the concurrent shaping of sensory representations. This paper develops a framework for representational learning which builds on the relative success of unsupervised generativemodelling accountsof cortical encodings to incorporate the effects of reinforcement in a biologically plausible way.

We present a unified view for online classification, regression, and uniclass problems.This view leads to a single algorithmic framework for the three problems. We prove worst case loss bounds for various algorithms for both the realizable case and the non-realizable case. A conversion of our main online algorithm to the setting of batch learning is also discussed. Theend result is new algorithms and accompanying loss bounds for the hinge-loss.

We describe a pattern acquisition algorithm that learns, in an unsupervised fashion,a streamlined representation of linguistic structures from a plain natural-language corpus. This paper addresses the issues of learning structuredknowledge from a large-scale natural language data set, and of generalization to unseen text. The implemented algorithm represents sentencesas paths on a graph whose vertices are words (or parts of words). Significant patterns, determined by recursive context-sensitive statistical inference, form new vertices. Linguistic constructions are represented bytrees composed of significant patterns and their associated equivalence classes. An input module allows the algorithm to be subjected toa standard test of English as a Second Language (ESL) proficiency. Theresults are encouraging: the model attains a level of performance consideredto be "intermediate" for 9th-grade students, despite having been trained on a corpus (CHILDES) containing transcribed speech of parents directed to small children.

In this article, we present a novel approach to solving the localization problem in cellular networks. The goal is to estimate a mobile user's position, based on measurements of the signal strengths received from network base stations. Our solution works by building Gaussian process models for the distribution of signal strengths, as obtained in a series of calibration measurements. In the localization stage, the user's position canbe estimated by maximizing the likelihood of received signal strengths with respect to the position. We investigate the accuracy of the proposed approach on data obtained within a large indoor cellular network.

We propose a novel method of dimensionality reduction for supervised learning. Given a regression or classification problem in which we wish to predict a variable Y from an explanatory vector X, we treat the problem ofdimensionality reduction as that of finding a low-dimensional "effective subspace"of X which retains the statistical relationship between X and Y . We show that this problem can be formulated in terms of conditional independence. To turn this formulation into an optimization problem, we characterize the notion of conditional independence using covariance operators on reproducing kernel Hilbert spaces; this allows us to derive a contrast function for estimation of the effective subspace. Unlike manyconventional methods, the proposed method requires neither assumptions on the marginal distribution of X, nor a parametric model of the conditional distribution of Y .

This paper proposes neural mechanisms of transcranial magnetic stimulation (TMS).TMS can stimulate the brain non-invasively through a brief magnetic pulse delivered by a coil placed on the scalp, interfering with specific cortical functions with a high temporal resolution. Due to these advantages, TMS has been a popular experimental tool in various neuroscience fields. However, the neural mechanisms underlying TMSinduced interferenceare still unknown; a theoretical basis for TMS has not been developed. This paper provides computational evidence that inhibitory interactionsin a neural population, not an isolated single neuron, play a critical role in yielding the neural interference induced by TMS.

A key issue in supervised protein classification is the representation of input sequencesof amino acids. Recent work using string kernels for protein datahas achieved state-of-the-art classification performance. However, suchrepresentations are based only on labeled data -- examples with known 3D structures, organized into structural classes -- while in practice, unlabeled data is far more plentiful. In this work, we develop simpleand scalable cluster kernel techniques for incorporating unlabeled datainto the representation of protein sequences. We show that our methods greatly improve the classification performance of string kernels andoutperform standard approaches for using unlabeled data, such as adding close homologs of the positive examples to the training data. We achieve equal or superior performance to previously presented cluster kernel methods while achieving far greater computational efficiency.

We describe a new approximation algorithm for solving partially observable MDPs. Our bounded policy iteration approach searches through the space of bounded-size, stochastic finite state controllers, combining several advantages of gradient ascent (efficiency, search through restricted controller space) and policy iteration (less vulnerability to local optima).