For many real-world applications, we often need to select correlated variables---such as genetic variations and imaging features associated with Alzheimer's disease---in a high dimensional space. The correlation between variables presents a challenge to classical variable selection methods. To address this challenge, the elastic net has been developed and successfully applied to many applications. Despite its great success, the elastic net does not exploit the correlation information embedded in the data to select correlated variables. To overcome this limitation, we present a novel hybrid model, EigenNet, that uses the eigenstructures of data to guide variable selection. Specifically, it integrates a sparse conditional classification model with a generative model capturing variable correlations in a principled Bayesian framework. We develop an efficient active-set algorithm to estimate the model via evidence maximization. Experiments on synthetic data and imaging genetics data demonstrated the superior predictive performance of the EigenNet over the lasso, the elastic net, and the automatic relevance determination.

In many experiments, the data points collected live in high-dimensional observation spaces, yet can be assigned a set of labels or parameters. In electrophysiological recordings, for instance, the responses of populations of neurons generally depend on mixtures of experimentally controlled parameters. The heterogeneity and diversity of these parameter dependencies can make visualization and interpretation of such data extremely difficult. Standard dimensionality reduction techniques such as principal component analysis (PCA) can provide a succinct and complete description of the data, but the description is constructed independent of the relevant task variables and is often hard to interpret. Here, we start with the assumption that a particularly informative description is one that reveals the dependency of the high-dimensional data on the individual parameters. We show how to modify the loss function of PCA so that the principal components seek to capture both the maximum amount of variance about the data, while also depending on a minimum number of parameters. We call this method demixed principal component analysis (dPCA) as the principal components here segregate the parameter dependencies. We phrase the problem as a probabilistic graphical model, and present a fast Expectation-Maximization (EM) algorithm. We demonstrate the use of this algorithm for electrophysiological data and show that it serves to demix the parameter-dependence of a neural population response.

We show that for a general class of convex online learning problems, Mirror Descent can always achieve a (nearly) optimal regret guarantee.

Applications such as robot control and wireless communication require planning under uncertainty. Partially observable Markov decision processes (POMDPs) plan policies for single agents under uncertainty and their decentralized versions (DEC-POMDPs) find a policy for multiple agents. The policy in infinite-horizon POMDP and DEC-POMDP problems has been represented as finite state controllers (FSCs). We introduce a novel class of periodic FSCs, composed of layers connected only to the previous and next layer. Our periodic FSC method finds a deterministic finite-horizon policy and converts it to an initial periodic infinite-horizon policy. This policy is optimized by a new infinite-horizon algorithm to yield deterministic periodic policies, and by a new expectation maximization algorithm to yield stochastic periodic policies. Our method yields better results than earlier planning methods and can compute larger solutions than with regular FSCs.

The problem of selecting the right state-representation in a reinforcement learning problem is considered. Several models (functions mapping past observations to a finite set) of the observations are given, and it is known that for at least one of these models the resulting state dynamics are indeed Markovian. Without knowing neither which of the models is the correct one, nor what are the probabilistic characteristics of the resulting MDP, it is required to obtain as much reward as the optimal policy for the correct model (or for the best of the correct models, if there are several). We propose an algorithm that achieves that, with a regret of order T^{2/3} where T is the horizon time.

We introduce hierarchically supervised latent Dirichlet allocation (HSLDA), a model for hierarchically and multiply labeled bag-of-word data. Examples of such data include web pages and their placement in directories, product descriptions and associated categories from product hierarchies, and free-text clinical records and their assigned diagnosis codes. Out-of-sample label prediction is the primary goal of this work, but improved lower-dimensional representations of the bag-of-word data are also of interest. We demonstrate HSLDA on large-scale data from clinical document labeling and retail product categorization tasks. We show that leveraging the structure from hierarchical labels improves out-of-sample label prediction substantially when compared to models that do not.

Synaptic plasticity underlies learning and is thus central for development, memory, and recovery from injury. However, it is often difficult to detect changes in synaptic strength in vivo, since intracellular recordings are experimentally challenging. Here we present two methods aimed at inferring changes in the coupling between pairs of neurons from extracellularly recorded spike trains. First, using a generalized bilinear model with Poisson output we estimate time-varying coupling assuming that all changes are spike-timing-dependent. This approach allows model-based estimation of STDP modification functions from pairs of spike trains. Then, using recursive point-process adaptive filtering methods we estimate more general variation in coupling strength over time. Using simulations of neurons undergoing spike-timing dependent modification, we show that the true modification function can be recovered. Using multi-electrode data from motor cortex we then illustrate the use of this technique on in vivo data.

A majority of approximate dynamic programming approaches to the reinforcement learning problem can be categorized into greedy value function methods and value-based policy gradient methods. The former approach, although fast, is well known to be susceptible to the policy oscillation phenomenon. We take a fresh view to this phenomenon by casting a considerable subset of the former approach as a limiting special case of the latter. We explain the phenomenon in terms of this view and illustrate the underlying mechanism with artificial examples. We also use it to derive the constrained natural actor-critic algorithm that can interpolate between the aforementioned approaches. In addition, it has been suggested in the literature that the oscillation phenomenon might be subtly connected to the grossly suboptimal performance in the Tetris benchmark problem of all attempted approximate dynamic programming methods. We report empirical evidence against such a connection and in favor of an alternative explanation. Finally, we report scores in the Tetris problem that improve on existing dynamic programming based results.

Many functional descriptions of spiking neurons assume a cascade structure where inputs are passed through an initial linear filtering stage that produces a low-dimensional signal that drives subsequent nonlinear stages. This paper presents a novel and systematic parameter estimation procedure for such models and applies the method to two neural estimation problems: (i) compressed-sensing based neural mapping from multi-neuron excitation, and (ii) estimation of neural receptive yields in sensory neurons. The proposed estimation algorithm models the neurons via a graphical model and then estimates the parameters in the model using a recently-developed generalized approximate message passing (GAMP) method. The GAMP method is based on Gaussian approximations of loopy belief propagation. In the neural connectivity problem, the GAMP-based method is shown to be computational efficient, provides a more exact modeling of the sparsity, can incorporate nonlinearities in the output and significantly outperforms previous compressed-sensing methods. For the receptive field estimation, the GAMP method can also exploit inherent structured sparsity in the linear weights. The method is validated on estimation of linear nonlinear Poisson (LNP) cascade models for receptive fields of salamander retinal ganglion cells.

Several recent advances to the state of the art in image classification benchmarks have come from better configurations of existing techniques rather than novel approaches to feature learning. Traditionally, hyper-parameter optimization has been the job of humans because they can be very efficient in regimes where only a few trials are possible. Presently, computer clusters and GPU processors make it possible to run more trials and we show that algorithmic approaches can find better results. We present hyper-parameter optimization results on tasks of training neural networks and deep belief networks (DBNs). We optimize hyper-parameters using random search and two new greedy sequential methods based on the expected improvement criterion. Random search has been shown to be sufficiently efficient for learning neural networks for several datasets, but we show it is unreliable for training DBNs. The sequential algorithms are applied to the most difficult DBN learning problems from [Larochelle et al., 2007] and find significantly better results than the best previously reported. This work contributes novel techniques for making response surface models P (y|x) in which many elements of hyper-parameter assignment (x) are known to be irrelevant given particular values of other elements.