Given genetic variations and various phenotypical traits, such as Magnetic Resonance Imaging (MRI) features, we consider two important and related tasks in biomedical research: i)to select genetic and phenotypical markers for disease diagnosis and ii) to identify associations between genetic and phenotypical data. These two tasks are tightly coupled because underlying associations between genetic variations and phenotypical features contain the biological basis for a disease. While a variety of sparse models have been applied for disease diagnosis and canonical correlation analysis and its extensions have bee widely used in association studies (e.g., eQTL analysis), these two tasks have been treated separately. To unify these two tasks, we present a new sparse Bayesian approach for joint association study and disease diagnosis. In this approach, common latent features are extracted from different data sources based on sparse projection matrices and used to predict multiple disease severity levels based on Gaussian process ordinal regression; in return, the disease status is used to guide the discovery of relationships between the data sources. The sparse projection matrices not only reveal interactions between data sources but also select groups of biomarkers related to the disease. To learn the model from data, we develop an efficient variational expectation maximization algorithm. Simulation results demonstrate that our approach achieves higher accuracy in both predicting ordinal labels and discovering associations between data sources than alternative methods. We apply our approach to an imaging genetics dataset for the study of Alzheimer's Disease (AD). Our method identifies biologically meaningful relationships between genetic variations, MRI features, and AD status, and achieves significantly higher accuracy for predicting ordinal AD stages than the competing methods.

Artificial Immune System (AIS-MACA) a novel computational intelligence technique is can be used for strengthening the automated protein prediction system with more adaptability and incorporating more parallelism to the system. Most of the existing approaches are sequential which will classify the input into four major classes and these are designed for similar sequences. AIS-MACA is designed to identify ten classes from the sequences that share twilight zone similarity and identity with the training sequences with mixed and hybrid variations. This method also predicts three states (helix, strand, and coil) for the secondary structure. Our comprehensive design considers 10 feature selection methods and 4 classifiers to develop MACA (Multiple Attractor Cellular Automata) based classifiers that are build for each of the ten classes. We have tested the proposed classifier with twilight-zone and 1-high-similarity benchmark datasets with over three dozens of modern competing predictors shows that AIS-MACA provides the best overall accuracy that ranges between 80% and 89.8% depending on the dataset.

Inquire Biology is a prototype of a new kind of intelligent textbook -- one that answers students' questions, engages their interest, and improves their understanding. Inquire Biology provides unique capabilities via a knowledge representation that captures conceptual knowledge from the textbook and uses inference procedures to answer students' questions. In an initial controlled experiment, community college students using the Inquire Biology prototype outperformed students using either a hardcopy or conventional E-book version of the same biology textbook. While additional research is needed to fully develop Inquire Biology, the initial prototype clearly demonstrates the promise of applying knowledge representation and question-answering technology to electronic textbooks.

The Association for the Advancement of Artificial Intelligence was pleased to present the AAAI 2013 Spring Symposium Series, held Monday through Wednesday, March 25-27, 2013. The titles of the eight symposia were Analyzing Microtext, Creativity and (Early) Cognitive Development, Data Driven Wellness: From Self-Tracking to Behavior Change, Designing Intelligent Robots: Reintegrating AI II, Lifelong Machine Learning, Shikakeology: Designing Triggers for Behavior Change, Trust and Autonomous Systems, and Weakly Supervised Learning from Multimedia. This report contains summaries of the symposia, written, in most cases, by the cochairs of the symposium.

We give a brief overview of the Mario AI Championship, a series of competitions based on an open source clone of the seminal platform game Super Mario Bros. The competition has four tracks. The gameplay and learning tracks resemble traditional reinforcement learning competitions, the Level generation track focuses on the generation of entertaining game levels, and the Turing Test track focuses on humanlike game-playing behavior. We also outline some lessons learned from the competition and its future.

The field of intelligent tutoring systems has successfully delivered techniques and applications to provide personalized coaching and feedback for problem solving in a variety of domains. The core of this personalized instruction is a student model; the ITS component in charge of assessing student traits and states relevant to tailor the tutorial interaction to specific student needs during problem solving. There are however, other educational activities that can help learners acquire the target skills and abilities at different stages of learning including, among others, exploring interactive simulations and playing educational games. This article describes research on creating student models that support personalization for these novel types of interactions, their unique challenges, and how AI and machine learning can help.

We report recent advances in intelligent tutoring systems with conversational dialogue. Macroadaptivity refers to a system's capability to select appropriate instructional tasks for the learner to work on. Microadaptivity refers to a system's capability to adapt its scaffolding while the learner is working on a particular task. Learning progressions and deeper dialogue and natural language processing techniques are key features of DeepTutor, the first intelligent tutoring system based on learning progressions.

Increasing widespread use of educational technologies is producing vast amounts of data. Such data can be used to help advance our understanding of student learning and enable more intelligent, interactive, engaging, and effective education. In this article, we discuss the status and prospects of this new and powerful opportunity for data-driven development and optimization of educational technologies, focusing on intelligent tutoring systems We provide examples of use of a variety of techniques to develop or optimize the select, evaluate, suggest, and update functions of intelligent tutors, including probabilistic grammar learning, rule induction, Markov decision process, classification, and integrations of symbolic search and statistical inference.

This special issue of AI Magazine presents articles on some of the most interesting projects at the intersection of AI and Education. Included are articles on integrated systems such as virtual humans, an intellgent textbook a game-based learning environment as well as technology focused components such as student models and data mining. The issue concludes with an article summarizing the contemporary and emerging challenges at the intersection of AI and education.

Traditionally focused on good old-fashioned AI and robotics, the Spanish AI community holds a vigorous computational intelligence substrate. Neuromorphic, evolutionary, or fuzzylike systems have been developed by many research groups in the Spanish computer sciences. It is no surprise, then, that these naturegrounded efforts start to emerge, enriching the AI catalogue of research projects and publications and, eventually, leading to new directions of basic or applied research. In this article, we review the contribution of Melomics in computational creativity.