Electrophysiological (ExG) signals offer valuable insights into human physiology, yet building foundation models that generalize across everyday tasks remains challenging due to two key limitations: (i) insufficient data diversity, as most ExG recordings are collected in controlled labs with bulky, expensive devices; and (ii) task-specific model designs that require tailored processing (i.e., targeted frequency filters) and architectures, which limit generalization across tasks. To address these challenges, we introduce an approach for scalable, task-agnostic ExG monitoring in the wild. We collected 50 hours of unobtrusive free-living ExG data with an earphone-based hardware prototype to narrow the data diversity gap. At the core of our approach is Physiology-informed Multi-band Tokenization (PiMT), which decomposes ExG signals into 12 physiology-informed tokens, followed by a reconstruction task to learn robust representations. This enables adaptive feature recognition across the full frequency spectrum while capturing task-relevant information. Experiments on our new DailySense dataset-the first to enable ExG-based analysis across five human senses-together with four public ExG benchmarks, demonstrate that PiMT consistently outperforms state-of-the-art methods across diverse tasks.

Child speech differs from adult speech in acoustics, prosody, and language development, and disfluencies (repetitions, prolongations, blocks) further challenge Automatic Speech Recognition (ASR) and downstream Natural Language Processing (NLP). Recent large audio-language models (LALMs) demonstrate strong cross-modal audio understanding; however, their behavior in disfluent child speech remains underexplored. We evaluate several state-of-the-art LALMs in two settings: an interview (mixed speakers) and a reading task (single child). The tasks are (i) single-channel source separation to isolate the child and (ii) child-only summarization that preserves clinically relevant disfluencies and avoids adult-speech leakage. Evaluation combines Large Language Model (LLM) as a judge, human expert ratings, and BERTScore (F1), and we report agreement between models and between models and humans to assess reliability. Our findings delineate the conditions under which LALMs produce faithful child-only summaries from mixed audio and where they fail, offering practical guidance for clinical and educational deployments. We provide prompts and evaluation scripts to support replication.

The extent to which different neural or artificial neural networks (models) rely on equivalent representations to support similar tasks remains a central question in neuroscience and machine learning. Prior work has typically compared systems using a single representational similarity metric, yet each captures only one facet of representational structure. To address this, we leverage a suite of representational similarity metrics-each capturing a distinct facet of representational correspondence, such as geometry, unit-level tuning, or linear decodability-and assess brain region or model separability using multiple complementary measures. Metrics that preserve geometric or tuning structure (e.g., RSA, Soft Matching) yield stronger region-based discrimination, whereas more flexible mappings such as Linear Predictivity show weaker separation. These findings suggest that geometry and tuning encode brain-region- or model-family-specific signatures, while linearly decodable information tends to be more globally shared across regions or models. To integrate these complementary representational facets, we adapt Similarity Network Fusion (SNF), a framework originally developed for multi-omics data integration. SNF produces substantially sharper regional and model family-level separation than any single metric and yields robust composite similarity profiles. Moreover, clustering cortical regions using SNF-derived similarity scores reveals a clearer hierarchical organization that aligns closely with established anatomical and functional hierarchies of the visual cortex-surpassing the correspondence achieved by individual metrics.

The presence of interictal epileptiform discharges (IEDs) in electroencephalogram (EEG) recordings is a critical biomarker of epilepsy. Even trained neurologists find detecting IEDs difficult, leading many practitioners to turn to machine learning for help. While existing machine learning algorithms can achieve strong accuracy on this task, most models are uninterpretable and cannot justify their conclusions. Absent the ability to understand model reasoning, doctors cannot leverage their expertise to identify incorrect model predictions and intervene accordingly. To improve the human-model interaction, we introduce ProtoEEG-kNN, an inherently interpretable model that follows a simple case-based reasoning process. ProtoEEG-kNN reasons by comparing an EEG to similar EEGs from the training set and visually demonstrates its reasoning both in terms of IED morphology (shape) and spatial distribution (location). We show that ProtoEEG-kNN can achieve state-of-the-art accuracy in IED detection while providing explanations that experts prefer over existing approaches.

Precisely defining consciousness and identifying the mechanisms that effect it is a long-standing question, particularly relevant with advances in artificial intelligence. The scientific community is divided between physicalism and natural dualism. Physicalism posits consciousness is a physical process that can be modeled computationally; natural dualism rejects this hypothesis. Finding a computational model has proven elusive, particularly because of conflation of consciousness with other cognitive capabilities exhibited by humans, such as intelligence and physiological sensations. Here we show such a computational model that precisely models consciousness, natural or artificial, identifying the structural and functional mechanisms that effect it, confirming the physicalism hypothesis. We found such a model is obtainable when including the underlying (biological or digital) substrate and accounting for reactive behavior in substrate sub-systems (e.g., autonomous physiological responses). Results show that, unlike all other computational processes, consciousness is not independent of its substrate and possessing it is an evolutionary advantage for intelligent entities. Our result shows there is no impediment to the realization of fully artificial consciousness but, surprisingly, that it is also possible to realize artificial intelligence of arbitrary level without consciousness whatsoever, and that there is no advantage in imbuing artificial systems with consciousness.

Understanding how patterns of interaction between neural populations reorganize with behavior is central to systems neuroscience and to applications that decode or modulate brain activity. These interactions are often framed under the umbrella of brain connectivity, distinguished as structural (anatomical pathways), functional (statistical dependencies), and effective (directed influence)--complementary lenses on how distributed circuits communicate and adapt to task demands [1, 2]. Reviews emphasize both the promise and the challenges of connectivity-centric approaches, particularly the need to capture short-timescale dynamics while maintaining interpretability [3, 4]. Graph-based formulations make this agenda concrete: representing brain regions as nodes and their relationships as edges enables quantitative analysis of modularity, hubs, and task-dependent reconfiguration [5, 6]. Such network perspectives motivate methods that go beyond static, correlation-only descriptions toward dynamic, directed estimates that better align with mechanistic questions. We focus on intracranial local field potentials (LFPs), a high-temporal-resolution measure of population activity recorded simultaneously from multiple deep-brain regions [7, 8, 9, 10]. Multi-region LFP imposes unique modeling requirements: (i) many micro-contacts per region must be consolidated into coherent region-level trajectories; (ii) neural activity reconfigures across well-defined behavioral phases; and (iii) the spatial layout of contacts is high-dimensional and non-Euclidean [11]. Existing pipelines often average across behavior with a single correlation-based graph [2] or impose hard-coded anatomical connectivity [12, 13], limiting their ability to capture phase-specific, directed interactions. Recent machine learning advances in graph learning from neural time series highlight the opportunity but do not yet fill this gap.

Drug combinations offer therapeutic benefits but also carry the risk of adverse drug-drug interactions (DDIs), especially under complex molecular structures. Accurate DDI event prediction requires capturing fine-grained inter-drug relationships, which are critical for modeling metabolic mechanisms such as enzyme-mediated competition. However, existing approaches typically rely on isolated drug representations and fail to explicitly model atom-level cross-molecular interactions, limiting their effectiveness across diverse molecular complexities and DDI type distributions. To address these limitations, we propose MolBridge, a novel atom-level joint graph refinement framework for robust DDI event prediction. MolBridge constructs a joint graph that integrates atomic structures of drug pairs, enabling direct modeling of inter-drug associations. A central challenge in such joint graph settings is the potential loss of information caused by over-smoothing when modeling long-range atomic dependencies. To overcome this, we introduce a structure consistency module that iteratively refines node features while preserving the global structural context. This joint design allows MolBridge to effectively learn both local and global interaction outperforms state-of-the-art baselines, achieving superior performance across long-tail and inductive scenarios. patterns, yielding robust representations across both frequent and rare DDI types. Extensive experiments on two benchmark datasets show that MolBridge consistently. These results demonstrate the advantages of fine-grained graph refinement in improving the accuracy, robustness, and mechanistic interpretability of DDI event prediction.This work contributes to Web Mining and Content Analysis by developing graph-based methods for mining and analyzing drug-drug interaction networks.

Marked Temporal Point Process (MTPP) has been well studied to model the event distribution in marked event streams, which can be used to predict the mark and arrival time of the next event. However, existing studies overlook that the distribution of event marks is highly imbalanced in many real-world applications, with some marks being frequent but others rare. The imbalance poses a significant challenge to the performance of the next event prediction, especially for events of rare marks. To address this issue, we propose a thresholding method, which learns thresholds to tune the mark probability normalized by the mark's prior probability to optimize mark prediction, rather than predicting the mark directly based on the mark probability as in existing studies. In conjunction with this method, we predict the mark first and then the time. In particular, we develop a novel neural MTPP model to support effective time sampling and estimation of mark probability without computationally expensive numerical improper integration. Extensive experiments on real-world datasets demonstrate the superior performance of our solution against various baselines for the next event mark and time prediction. The code is available at https://github.com/undes1red/IFNMTPP.

Since the advent of various pre-trained large language models, extracting structured knowledge from scientific text has experienced a revolutionary change compared with traditional machine learning or natural language processing techniques. Despite these advances, accessible automated tools that allow users to construct, validate, and visualise datasets from scientific literature extraction remain scarce. We therefore developed ComProScanner, an autonomous multi-agent platform that facilitates the extraction, validation, classification, and visualisation of machine-readable chemical compositions and properties, integrated with synthesis data from journal articles for comprehensive database creation. We evaluated our framework using 100 journal articles against 10 different LLMs, including both open-source and proprietary models, to extract highly complex compositions associated with ceramic piezoelectric materials and corresponding piezoelectric strain coefficients (d33), motivated by the lack of a large dataset for such materials. DeepSeek-V3-0324 outperformed all models with a significant overall accuracy of 0.82. This framework provides a simple, user-friendly, readily-usable package for extracting highly complex experimental data buried in the literature to build machine learning or deep learning datasets.

W.J.T. Mitchell's influential essay 'What do pictures want?' shifts the theoretical focus away from the interpretative act of understanding pictures and from the motivations of the humans who create them to the possibility that the picture itself is an entity with agency and wants. In this article, I reframe Mitchell's question in light of contemporary AI image generation tools to ask: what do AI-generated images want? Drawing from art historical discourse on the nature of abstraction, I argue that AI-generated images want specificity and concreteness because they are fundamentally abstract. Multimodal text-to-image models, which are the primary subject of this article, are based on the premise that text and image are interchangeable or exchangeable tokens and that there is a commensurability between them, at least as represented mathematically in data. The user pipeline that sees textual input become visual output, however, obscures this representational regress and makes it seem like one form transforms into the other -- as if by magic.