In the last decade, due to high resolution cameras and accurate meta - phase analyzes, the accuracy of chromosome classification has improved substantially. However, current Karyotyping systems demand large number of high quality train data to have an adequa tely plausible Precision per each chromosome. Such provision of high quality train data with accurate devices are not yet accomplished in some out - reached pathological laboratories. To prevent false positive detections in low - cost systems and low - quality i mages settings, this paper improves the classification Precision of chromosomes using proposed reliability thresholding metrics and deliberately engineered features. The proposed method has been evaluated using a variation of deep Alex - Net neural network, SVM, K - Nearest - Neighbors, and their cascade pipelines to an automated filtering of semi - straight chromosome. The classification results have highly improved over 90% for the chromosomes with more common defections and translocations. Furthermore, a compara tive analysis over the proposed thresholding metrics has been conducted and the best metric is bolded with its salient characteristics. The high Precision results provided for a very low - quality G - banding database verifies suitability of the proposed metri cs and pruning method for Karyotyping facilities in poor countries and low - budget pathological laboratories. Keywords: G - banded Karyotyping, Precision, Reliability metrics, Pattern Recognition, Medical Imaging 1 Introduction One of the ways to study and dia gnose birth - defects and biological disorders is through using Cytogenetics. This branch of science endeavors to analyze chromosome shapes and patterns to find out common defects. The methods used for such analyzes includes G - Banding, Fluorescent In - Situ Hy bridization (FISH), Comparative Genomic Hybridization (CGH) and Chromosome - specific unique - sequence probes [27] . While Molecular Cytogenetics methods are effective in biological disorders, they do not necessarily manifest specific chromosome defects. FISH methods, though having higher accuracy results in stains, are costly and unable to identify all chromosome abnorm alities. Being temporary in sustaining fluorescence detector, they demand higher provision effort and substance supply that might not be affordable for some countries . Furthermore, detecting some abnormalities implies having G - banding technique involved an d not merely using stains.

Deep Learning (DL) holds enormous potential for improving medical imaging diagnostics, yet the lack of interpretability in most models hampers clinical trust and adoption. This paper presents an explainable deep learning framework for detecting brain tumors in MRI scans and pneumonia in chest X-ray images using two leading Convolutional Neural Networks, ResNet50 and DenseNet121. These models were trained on publicly available Kaggle datasets comprising 7,023 brain MRI images and 5,863 chest X-ray images, achieving high classification performance. DenseNet121 consistently outperformed ResNet50 with 94.3 percent vs. 92.5 percent accuracy for brain tumors and 89.1 percent vs. 84.4 percent accuracy for pneumonia. For better explainability, Gradient-weighted Class Activation Mapping (Grad-CAM) was integrated to create heatmap visualizations superimposed on the test images, indicating the most influential image regions in the decision-making process. Interestingly, while both models produced accurate results, Grad-CAM showed that DenseNet121 consistently focused on core pathological regions, whereas ResNet50 sometimes scattered attention to peripheral or non-pathological areas. Combining deep learning and explainable AI offers a promising path toward reliable, interpretable, and clinically useful diagnostic tools.

Identifying images generated by Generative Adversarial Networks (GANs) has become a significant challenge in digital image forensics. This research presents a wavelet-based detection method that uses discrete wavelet transform (DWT) preprocessing and a ResNet50 classification layer to differentiate the StyleGAN-generated images from real ones. Haar and Daubechies wavelet filters are applied to convert the input images into multi-resolution representations, which will then be fed to a ResNet50 network for classification, capitalizing on subtle artifacts left by the generative process. Moreover, the wavelet-based models are compared to an identical ResNet50 model trained on spatial data. The Haar and Daubechies preprocessed models achieved a greater accuracy of 93.8 percent and 95.1 percent, much higher than the model developed in the spatial domain (accuracy rate of 81.5 percent). The Daubechies-based model outperforms Haar, showing that adding layers of descriptive frequency patterns can lead to even greater distinguishing power. These results indicate that the GAN-generated images have unique wavelet-domain artifacts or "fingerprints." The method proposed illustrates the effectiveness of wavelet-domain analysis to detect GAN images and emphasizes the potential of further developing the capabilities of future deepfake detection systems.

This study examines the prompt fidelity of ChatGPT4o / DALL - E3 text - to - image visualisations by analysing whether anullributes explicitly specified in autogenously generated prompts are correctly rendered in the resulting images. Using two public - domain datasets comprising 200 visualisations of women working in the cultural and creative industries and 230 visualisations of museum curators, the study assessed accuracy across personal anullributes (age, hair), appearance (anullire, glasses), and paraphernalia (name tags, clipboards). While correctly rendered in most cases, DALL - E3 deviated from prompt specifications in 15.6% of all anullributes (n=710). Errors were lowest for paraphernalia, moderate for personal appearance, and highest for depictions of the person themselves, particularly age. These findings demonstrate measurable prompt - to - image fidelity gaps with implications for bias detection and model evaluation.

The proliferation of high-dimensional datasets in fields such as genomics, healthcare, and finance has created an urgent need for machine learning models that are both highly accurate and inherently interpretable. While traditional deep learning approaches deliver strong predictive performance, their lack of transparency often impedes their deployment in critical, decision-sensitive applications. In this work, we introduce the Hierarchical Attention-based Interpretable Network (HAIN), a novel architecture that unifies multi-level attention mechanisms, dimensionality reduction, and explanation-driven loss functions to deliver interpretable and robust analysis of complex biomedical data. HAIN provides feature-level interpretability via gradientweighted attention and offers global model explanations through prototype-based representations. Comprehensive evaluation on The Cancer Genome Atlas (TCGA) dataset demonstrates that HAIN achieves a classification accuracy of 94.3%, surpassing conventional post-hoc interpretability approaches such as SHAP and LIME in both transparency and explanatory power. Furthermore, HAIN effectively identifies biologically relevant cancer biomarkers, supporting its utility for clinical and research applications. By harmonizing predictive accuracy with interpretability, HAIN advances the development of transparent AI solutions for precision medicine and regulatory compliance.

High Dynamic Range (HDR) imaging aims to reproduce the wide range of brightness levels present in natural scenes, which the human visual system can perceive but conventional digital cameras often fail to capture due to their limited dynamic range. To address this limitation, we propose a deep learning-based multi-exposure fusion approach for HDR image generation. The method takes a set of differently exposed Low Dynamic Range (LDR) images, typically an underexposed and an overexposed image, and learns to fuse their complementary information using a convolutional neural network (CNN). The underexposed image preserves details in bright regions, while the overexposed image retains information in dark regions; the network effectively combines these to reconstruct a high-quality HDR output. The model is trained in an unsupervised manner, without relying on ground-truth HDR images, making it practical for real-world applications where such data is unavailable. We evaluate our results using the Multi-Exposure Fusion Structural Similarity Index Measure (MEF-SSIM) and demonstrate that our approach achieves superior visual quality compared to existing fusion methods. A customized loss function is further introduced to improve reconstruction fidelity and optimize model performance.

Earth Observation (EO) Foundation Modelling (FM) holds great promise for simplifying and improving the use of EO data for diverse real-world tasks. However, most existing models require additional adaptation before they can be used and are structured rigidly around particular data sources or training approaches. To address this, we take inspiration from large language models, where diverse tasks, both pre-training and downstream, are implicitly captured through next-token prediction over unified token sequences, leveraging the structure and diversity of the training data. We introduce SITS-DECO (Satellite Image Time Series-DECoder Only), a proof-of-concept generative model that applies this unified-sequence framing to EO data. Using a simple GPT-style decoder-only architecture, and demonstrate its ability to perform useful EO tasks (pixel-wise, multi-temporal, multi-modal crop-type classification) in a purely generative framework. Through symbolic prompting, we show that the model can perform multiple supervised and self-supervised tasks within a single unified architecture, without task- or modality-specific adaptation. Despite its simplicity and lack of spatial context, SITS-DECO outperforms much larger EO foundation models on crop-type classification (PASTIS-R) demonstrating that dense temporal sequence modelling is a critical missing ingredient in the current paradigm. This work exemplifies a data-centric modelling paradigm in which capability arises from the diversity and structure of the training data rather than from architectural complexity. SITS-DECO provides a lightweight, practical route to multi-modal, multi-task EO modelling, and a conceptual bridge toward future generative EO foundation models.

Diabetic Retinopathy (DR), a vision-threatening complication of Dia-betes Mellitus (DM), is a major global concern, particularly in India, which has one of the highest diabetic populations. Prolonged hyperglycemia damages reti-nal microvasculature, leading to DR symptoms like microaneurysms, hemor-rhages, and fluid leakage, which, if undetected, cause irreversible vision loss. Therefore, early screening is crucial as DR is asymptomatic in its initial stages. Fundus imaging aids precise diagnosis by detecting subtle retinal lesions. This paper introduces a hybrid diagnostic framework combining traditional feature extraction and deep learning (DL) to enhance DR detection. While handcrafted features capture key clinical markers, DL automates hierarchical pattern recog-nition, improving early diagnosis. The model synergizes interpretable clinical data with learned features, surpassing standalone DL approaches that demon-strate superior classification and reduce false negatives. This multimodal AI-driven approach enables scalable, accurate DR screening, crucial for diabetes-burdened regions.

With the rapid growth of video data, text-video retrieval technology has become increasingly important in numerous application scenarios such as recommendation and search. Early text-video retrieval methods suffer from two critical drawbacks: first, they heavily rely on large-scale annotated video-text pairs, leading to high data acquisition costs; second, there is a significant modal gap between video and text features, which limits cross-modal alignment accuracy. With the development of vision-language model, adapting CLIP to video tasks has attracted great attention. However, existing adaptation methods generally lack enhancement for dynamic video features and fail to effectively suppress static redundant features. To address this issue, this paper proposes FDA-CLIP (Frame Difference Alpha-CLIP), which is a concise CLIP-based training framework for text-video alignment. Specifically, the method uses frame differences to generate dynamic region masks, which are input into Alpha-CLIP as an additional Alpha channel. This proactively guides the model to focus on semantically critical dynamic regions while suppressing static background redundancy. Experiments demonstrate that frame difference-guided video semantic encoding can effectively balance retrieval efficiency and accuracy.

Knee osteoarthritis (KOA) diagnosis from radiographs remains challenging due to the subtle morphological details that standard deep learning models struggle to capture effectively. We propose a novel multimodal framework that combines anatomical structure with radiographic features by integrating a morphological graph representation - derived from Segment Anything Model (SAM) segmentations - with a vision encoder. Our approach enforces alignment between geometry-informed graph embeddings and radiographic features through mutual information maximization, significantly improving KOA classification accuracy. By constructing graphs from anatomical features, we introduce explicit morphological priors that mirror clinical assessment criteria, enriching the feature space and enhancing the model's inductive bias. Experiments on the Osteoarthritis Initiative dataset demonstrate that our approach surpasses single-modality baselines by up to 10\% in accuracy (reaching nearly 80\%), while outperforming existing state-of-the-art methods by 8\% in accuracy and 11\% in F1 score. These results underscore the critical importance of incorporating anatomical structure into radiographic analysis for accurate KOA severity grading.