Radiomics-based machine learning models show promise for clinical decision support but are vulnerable to distribution shifts caused by variations in imaging protocols, positioning, and segmentation. This study systematically investigates the robustness of radiomics-based machine learning models under distribution shifts across five MRI sequences. We evaluated how different acquisition protocols and segmentation strategies affect model reliability in terms of predictive power and uncertainty-awareness. Using a phantom of 16 fruits, we evaluated distribution shifts through: (1) protocol variations across T2-HASTE, T2-TSE, T2-MAP, T1-TSE, and T2-FLAIR sequences; (2) segmentation variations (full, partial, rotated); and (3) inter-observer variability. We trained XGBoost classifiers on 8 consistent robust features versus sequence-specific features, testing model performance under in-domain and out-of-domain conditions. Results demonstrate that models trained on protocol-invariant features maintain F1-scores >0.85 across distribution shifts, while models using all features showed 40% performance degradation under protocol changes. Dataset augmentation substantially improved the quality of uncertainty estimates and reduced the expected calibration error (ECE) by 35% without sacrificing accuracy. Temperature scaling provided minimal calibration benefits, confirming XGBoost's inherent reliability. Our findings reveal that protocol-aware feature selection and controlled phantom studies effectively predict model behavior under distribution shifts, providing a framework for developing robust radiomics models resilient to real-world protocol variations.

Disentangling shared network-level dynamics from region-specific activity is a central challenge in modeling multi-region neural data. We introduce SPIRE (Shared-Private Inter-Regional Encoder), a deep multi-encoder autoencoder that factorizes recordings into shared and private latent subspaces with novel alignment and disentanglement losses. Trained solely on baseline data, SPIRE robustly recovers cross-regional structure and reveals how external perturbations reorganize it. On synthetic benchmarks with ground-truth latents, SPIRE outperforms classical probabilistic models under nonlinear distortions and temporal misalignments. Applied to intracranial deep brain stimulation (DBS) recordings, SPIRE shows that shared latents reliably encode stimulation-specific signatures that generalize across sites and frequencies. These results establish SPIRE as a practical, reproducible tool for analyzing multi-region neural dynamics under stimulation. Understanding how distributed brain regions coordinate--and how this coordination is reorganized by interventions such as deep brain stimulation (DBS)--remains a major challenge. Disorders like dystonia and Parkinson's involve dysfunction in basal ganglia-thalamo-cortical circuits (Galvan et al., 2015; Jinnah & Hess, 2006; Obeso et al., 2008; Zhuang et al., 2004), and while DBS of targets such as globus pallidus internus (GPi) and subthalamic nucleus (STN) is clinically effective (Ben-abid, 2003; Lozano et al., 2019; Larsh et al., 2021) its network-level mechanisms remain poorly understood. Latent variable models can capture such effects by reducing neural activity to low-dimensional subspaces, but existing methods have key limitations. Classical models such as Gaussian Process Factor Analysis (GPFA) (Y u et al., 2008) and Canonical Correlation Analysis (CCA) (Bach & Jordan, 2005) assume linearity. DLAG (Delayed Latents Across Groups) (Gokcen et al., 2022) disentangles shared vs. private dynamics but is restricted to linear-Gaussian structure and spiking data. Multimodal models (SharedAE (Yi et al.), MMV AE (Shi et al., 2019)) align shared spaces but are not designed for intracranial recordings under stimulation. Critically, none of these frameworks provide a nonlinear, disentangling model that can separate shared versus private dynamics in human local field potential (LFP) data under external perturbation. Addressing this gap is essential: understanding how stimulation reorganizes intrinsic cross-regional coordination could reveal circuit-level mechanisms of DBS that remain invisible to local analyses.

The future of Requirements Engineering (RE) is increasingly driven by artificial intelligence (AI), reshaping how we elicit, analyze, and validate requirements. Traditional RE is based on labor-intensive manual processes prone to errors and complexity. AI-powered approaches, specifically large language models (LLMs), natural language processing (NLP), and generative AI, offer transformative solutions and reduce inefficiencies. However, the use of AI in RE also brings challenges like algorithmic bias, lack of explainability, and ethical concerns related to automation. To address these issues, this study introduces the Human-AI RE Synergy Model (HARE-SM), a conceptual framework that integrates AI-driven analysis with human oversight to improve requirements elicitation, analysis, and validation. The model emphasizes ethical AI use through transparency, explainability, and bias mitigation. We outline a multi-phase research methodology focused on preparing RE datasets, fine-tuning AI models, and designing collaborative human-AI workflows. This preliminary study presents the conceptual framework and early-stage prototype implementation, establishing a research agenda and practical design direction for applying intelligent data science techniques to semi-structured and unstructured RE data in collaborative environments.

Large Language Models (LLMs) enable dynamic game interactions but fail to follow essential procedural flows in rule-governed trading systems, eroding player trust. This work resolves the core tension between the creative flexibility of LLMs and the procedural demands of in-game trading (browse-offer-review-confirm). To this end, Autoregressive State-Tracking Prompting (ASTP) is introduced, a methodology centered on a strategically orchestrated prompt that compels an LLM to make its state-tracking process explicit and verifiable. Instead of relying on implicit contextual understanding, ASTP tasks the LLM with identifying and reporting a predefined state label from the previous turn. To ensure transactional integrity, this is complemented by a state-specific placeholder post-processing method for accurate price calculations. Evaluation across 300 trading dialogues demonstrates >99% state compliance and 99.3% calculation precision. Notably, ASTP with placeholder post-processing on smaller models (Gemini-2.5-Flash) matches larger models' (Gemini-2.5-Pro) performance while reducing response time from 21.2s to 2.4s, establishing a practical foundation that satisfies both real-time requirements and resource constraints of commercial games.

Evaluation and Management (E/M) coding, under the Current Procedural Terminology (CPT) taxonomy, documents medical services provided to patients by physicians. Used primarily for billing purposes, it is in physicians' best interest to provide accurate CPT E/M codes. %While important, it is an auxiliary task that adds to physicians' documentation burden. Automating this coding task will help alleviate physicians' documentation burden, improve billing efficiency, and ultimately enable better patient care. However, a number of real-world complexities have made E/M encoding automation a challenging task. In this paper, we elaborate some of the key complexities and present ProFees, our LLM-based framework that tackles them, followed by a systematic evaluation. On an expert-curated real-world dataset, ProFees achieves an increase in coding accuracy of more than 36\% over a commercial CPT E/M coding system and almost 5\% over our strongest single-prompt baseline, demonstrating its effectiveness in addressing the real-world complexities.

Generative agents are rapidly advancing in sophistication, raising urgent questions about how they might coordinate when deployed in online ecosystems. This is particularly consequential in information operations (IOs), influence campaigns that aim to manipulate public opinion on social media. While traditional IOs have been orchestrated by human operators and relied on manually crafted tactics, agentic AI promises to make campaigns more automated, adaptive, and difficult to detect. This work presents the first systematic study of emergent coordination among generative agents in simulated IO campaigns. Using generative agent-based modeling, we instantiate IO and organic agents in a simulated environment and evaluate coordination across operational regimes, from simple goal alignment to team knowledge and collective decision-making. As operational regimes become more structured, IO networks become denser and more clustered, interactions more reciprocal and positive, narratives more homogeneous, amplification more synchronized, and hashtag adoption faster and more sustained. Remarkably, simply revealing to agents which other agents share their goals can produce coordination levels nearly equivalent to those achieved through explicit deliberation and collective voting. Overall, we show that generative agents, even without human guidance, can reproduce coordination strategies characteristic of real-world IOs, underscoring the societal risks posed by increasingly automated, self-organizing IOs.

Modeling complex, non-linear, and uncertain relationships between input and output variables remains a central challenge in modern statistical learning and artificial intelligence. Traditional neural networks, trained via point estimation, have demonstrated remarkable success in a variety of domains but inherently provide deterministic predictions - that is, single-valued outputs without accompanying measures of uncertainty. This limitation becomes critical in domains characterized by limited, noisy, or ambiguous data, such as medicine, climate science, or finance, where quantifying uncertainty is as important as producing accurate predictions (Gal & Ghahramani, 2016; Kendall & Gal, 2017; Abdar et al., 2021). Bayesian Neural Networks (BNNs) provide a probabilistic extension of standard neural networks by treating weights and biases as random variables endowed with prior distributions (MacKay, 1992; Neal, 2012). Through Bayes' theorem, BNNs infer a posterior distribution over weights, allowing predictions to reflect epistemic uncertainty - the uncertainty arising from limited data and model knowledge. However, the exact posterior is analytically intractable for deep models, motivating approximate inference methods such as variational inference (Graves, 2011; Blundell et al., 2015) and Monte Carlo dropout (Gal & Ghahramani, 2016). Despite their appeal, these approaches may yield biased or overconfident posteriors due to restrictive variational families (Hern andez-Lobato & Adams, 2015a; Osband et al., 2023), often resulting in over-smoothed predictive distributions. An alternative paradigm for probabilistic modeling is the Mixture Density Network (MDN), introduced by Bridle (1990) and developed further by Jacobs et al. (1991).

This paper presents an integrated robotic fused deposition modeling additive manufacturing system featuring closed-loop thermal control and intelligent in-situ defect correction using a 6-degree of freedom robotic arm and an Oak-D camera. The robot arm end effector was modified to mount an E3D hotend thermally regulated by an IoT microcontroller, enabling precise temperature control through real-time feedback. Filament extrusion system was synchronized with robotic motion, coordinated via ROS2, ensuring consistent deposition along complex trajectories. A vision system based on OpenCV detects layer-wise defects position, commanding autonomous re-extrusion at identified sites. Experimental validation demonstrated successful defect mitigation in printing operations. The integrated system effectively addresses challenges real-time quality assurance. Inverse kinematics were used for motion planning, while homography transformations corrected camera perspectives for accurate defect localization. The intelligent system successfully mitigated surface anomalies without interrupting the print process. By combining real-time thermal regulation, motion control, and intelligent defect detection & correction, this architecture establishes a scalable and adaptive robotic additive manufacturing framework suitable for aerospace, biomedical, and industrial applications.

In recent years, machine learning has become an increasingly powerful tool for supporting seizure detection and monitoring in epilepsy care. Traditional approaches focus on identifying seizures only after they begin, which limits the opportunity for early intervention and proactive treatment. In this study, we propose a novel approach that integrates both real-time seizure detection and prediction, aiming to capture subtle temporal patterns in EEG data that may indicate an upcoming seizure. Our approach was evaluated using the CHB-MIT Scalp EEG Database, which includes 969 hours of recordings and 173 seizures collected from 23 pediatric and young adult patients with drug-resistant epilepsy. To support seizure detection, we implemented a range of supervised machine learning algorithms, including K-Nearest Neighbors, Logistic Regression, Random Forest, and Support Vector Machine. The Logistic Regression achieved 90.9% detection accuracy with 89.6% recall, demonstrating balanced performance suitable for clinical screening. Random Forest and Support Vector Machine models achieved higher accuracy (94.0%) but with 0% recall, failing to detect any seizures, illustrating that accuracy alone is insufficient for evaluating medical ML models with class imbalance. For seizure prediction, we employed Long Short-Term Memory (LSTM) networks, which use deep learning to model temporal dependencies in EEG data. The LSTM model achieved 89.26% prediction accuracy. These results highlight the potential of developing accessible, real-time monitoring tools that not only detect seizures as traditionally done, but also predict them before they occur. This ability to predict seizures marks a significant shift from reactive seizure management to a more proactive approach, allowing patients to anticipate seizures and take precautionary measures to reduce the risk of injury or other complications.

Forget and Rewire (FaR) methodology has demonstrated strong resilience against Bit-Flip Attacks (BFAs) on Transformer-based models by obfuscating critical parameters through dynamic rewiring of linear layers. However, the application of FaR introduces non-negligible performance and memory overheads, primarily due to the runtime modification of activation pathways and the lack of hardware-level optimization. To overcome these limitations, we propose FaRAccel, a novel hardware accelerator architecture implemented on FPGA, specifically designed to offload and optimize FaR operations. FaRAccel integrates reconfigurable logic for dynamic activation rerouting, and lightweight storage of rewiring configurations, enabling low-latency inference with minimal energy overhead. We evaluate FaRAccel across a suite of Transformer models and demonstrate substantial reductions in FaR inference latency and improvement in energy efficiency, while maintaining the robustness gains of the original FaR methodology. To the best of our knowledge, this is the first hardware-accelerated defense against BFAs in Transformers, effectively bridging the gap between algorithmic resilience and efficient deployment on real-world AI platforms.