The openness of social media enables the free exchange of opinions, but it also presents challenges in guiding opinion evolution towards global consensus. Existing methods often directly modify user views or enforce cross-group connections. These intrusive interventions undermine user autonomy, provoke psychological resistance, and reduce the efficiency of global consensus. Additionally, due to the lack of a long-term perspective, promoting local consensus often exacerbates divisions at the macro level. To address these issues, we propose the hierarchical, non-intrusive opinion guidance framework, H-NeiFi. It first establishes a two-layer dynamic model based on social roles, considering the behavioral characteristics of both experts and non-experts. Additionally, we introduce a non-intrusive neighbor filtering method that adaptively controls user communication channels. Using multi-agent reinforcement learning (MARL), we optimize information propagation paths through a long-term reward function, avoiding direct interference with user interactions. Experiments show that H-NeiFi increases consensus speed by 22.0% to 30.7% and maintains global convergence even in the absence of experts. This approach enables natural and efficient consensus guidance by protecting user interaction autonomy, offering a new paradigm for social network governance.

We propose UTS, a unit-based tissue segmentation framework for histopathology that classifies each fixed-size 32 32 tile, rather than each pixel, as the segmentation unit. This approach reduces annotation effort and improves computational efficiency without compromising accuracy. To implement this approach, we introduce a Multi-Level Vi sion Transformer (L-ViT), which benefits the multi-level feature representation to capture both fine-grained morphology and global tissue context. Trained to segment breast tissue into three categories ( infiltrating tumor, non-neoplastic stroma, and fat), UTS supports clinically relevant tasks such as tumor-stroma quantification and surgical margin assessment. Evaluated on 386,371 tiles from 459 H&E-stained regions, it outperforms U-Net variants and transformer-based baselines. Code and Dataset will be available at GitHub.

The rapid adoption of Large Language Model (LLM) agents and multi-agent systems enables remarkable capabilities in natural language processing and generation. However, these systems introduce security vulnerabilities that extend beyond traditional content generation to system-level compromises. This paper presents a comprehensive evaluation of the LLMs security used as reasoning engines within autonomous agents, highlighting how they can be exploited as attack vectors capable of achieving computer takeovers. We focus on how different attack surfaces and trust boundaries can be leveraged to orchestrate such takeovers. We demonstrate that adversaries can effectively coerce popular LLMs into autonomously installing and executing malware on victim machines. Our evaluation of 18 state-of-the-art LLMs reveals an alarming scenario: 94.4% of models succumb to Direct Prompt Injection, and 83.3% are vulnerable to the more stealthy and evasive RAG Backdoor Attack. Notably, we tested trust boundaries within multi-agent systems, where LLM agents interact and influence each other, and we revealed that LLMs which successfully resist direct injection or RAG backdoor attacks will execute identical payloads when requested by peer agents. We found that 100.0% of tested LLMs can be compromised through Inter-Agent Trust Exploitation attacks, and that every model exhibits context-dependent security behaviors that create exploitable blind spots.

Machine learning-assisted diagnosis shows promise, yet medical imaging datasets are often scarce, imbalanced, and constrained by privacy, making data augmentation essential. Classical generative models typically demand extensive computational and sample resources. Quantum computing offers a promising alternative, but existing quantum-based image generation methods remain limited in scale and often face barren plateaus. We present MediQ-GAN, a quantum-inspired GAN with prototype-guided skip connections and a dual-stream generator that fuses classical and quantum-inspired branches. Its variational quantum circuits inherently preserve full-rank mappings, avoid rank collapse, and are theory-guided to balance expressivity with trainability. Beyond generation quality, we provide the first latent-geometry and rank-based analysis of quantum-inspired GANs, offering theoretical insight into their performance. Across three medical imaging datasets, MediQ-GAN outperforms state-of-the-art GANs and diffusion models. While validated on IBM hardware for robustness, our contribution is hardware-agnostic, offering a scalable and data-efficient framework for medical image generation and augmentation.

Safe deployment of machine learning (ML) models in safety-critical domains such as medical imaging requires detecting inputs with characteristics not seen during training, known as out-of-distribution (OOD) detection, to prevent unreliable predictions. Effective OOD detection after deployment could benefit from access to the training data, enabling direct comparison between test samples and the training data distribution to identify differences. State-of-the-art OOD detection methods, however, either discard the training data after deployment or assume that test samples and training data are centrally stored together, an assumption that rarely holds in real-world settings. This is because shipping the training data with the deployed model is usually impossible due to the size of training databases, as well as proprietary or privacy constraints. We introduce the Isolation Network, an OOD detection framework that quantifies the difficulty of separating a target test sample from the training data by solving a binary classification task. We then propose Decentralized Isolation Networks (DIsoN), which enables the comparison of training and test data when data-sharing is impossible, by exchanging only model parameters between the remote computational nodes of training and deployment. We further extend DIsoN with class-conditioning, comparing a target sample solely with training data of its predicted class. We evaluate DIsoN on four medical imaging datasets (dermatology, chest X-ray, breast ultrasound, histopathology) across 12 OOD detection tasks. DIsoN performs favorably against existing methods while respecting data-privacy. This decentralized OOD detection framework opens the way for a new type of service that ML developers could provide along with their models: providing remote, secure utilization of their training data for OOD detection services. Code: https://github.com/FelixWag/DIsoN

Sparse autoencoders (SAEs) have recently become central tools for interpretability, leveraging dictionary learning principles to extract sparse, interpretable features from neural representations whose underlying structure is typically unknown. This paper evaluates SAEs in a controlled setting using MNIST, which reveals that current shallow architectures implicitly rely on a quasi-orthogonality assumption that limits the ability to extract correlated features. To move beyond this, we compare them with an iterative SAE that unrolls Matching Pursuit (MP-SAE), enabling the residual-guided extraction of correlated features that arise in hierarchical settings such as handwritten digit generation while guaranteeing monotonic improvement of the reconstruction as more atoms are selected.

Identifying evolutionary correspondences between cell types across species is a fundamental challenge in comparative genomics and evolutionary biology. Existing approaches often rely on either reference-based matching, which imposes asymmetry by designating one species as the reference, or projection-based matching, which may increase computational complexity and obscure biological interpretability at the cell-type level. Here, we present OT-MESH, an unsupervised computational framework leveraging entropy-regularized optimal transport (OT) to systematically determine cross-species cell type homologies. Our method uniquely integrates the Minimize Entropy of Sinkhorn (MESH) technique to refine the OT plan, transforming diffuse transport matrices into sparse, interpretable correspondences. Through systematic evaluation on synthetic datasets, we demonstrate that OT-MESH achieves near-optimal matching accuracy with computational efficiency, while maintaining remarkable robustness to noise. Compared to other OT-based methods like RefCM, OT-MESH provides speedup while achieving comparable accuracy. Applied to retinal bipolar cells (BCs) and retinal ganglion cells (RGCs) from mouse and macaque, OT-MESH accurately recovers known evolutionary relationships and uncovers novel correspondences, one of which was independently validated experimentally. Thus, our framework offers a principled, scalable, and interpretable solution for evolutionary cell type mapping, facilitating deeper insights into cellular specialization and conservation across species.

Large Language Models (LLMs) have achieved impressive performance in diverse natural language processing tasks, but specialized domains such as Web3 present new challenges and require more tailored evaluation. Despite the significant user base and capital flows in Web3, encompassing smart contracts, decentralized finance (DeFi), non-fungible tokens (NFTs), decentralized autonomous organizations (DAOs), on-chain governance, and novel token-economics, no comprehensive benchmark has systematically assessed LLM performance in this domain. To address this gap, we introduce the DMind Benchmark, a holistic Web3-oriented evaluation suite covering nine critical subfields: fundamental blockchain concepts, blockchain infrastructure, smart contract, DeFi mechanisms, DAOs, NFTs, token economics, meme concept, and security vulnerabilities. Beyond multiple-choice questions, DMind Benchmark features domain-specific tasks such as contract debugging and on-chain numeric reasoning, mirroring real-world scenarios. We evaluated 26 models, including ChatGPT, Claude, DeepSeek, Gemini, Grok, and Qwen, uncovering notable performance gaps in specialized areas like token economics and security-critical contract analysis. While some models excel in blockchain infrastructure tasks, advanced subfields remain challenging. Our benchmark dataset and evaluation pipeline are open-sourced on https://huggingface.co/datasets/DMindAI/DMind_Benchmark, reaching number one in Hugging Face's trending dataset charts within a week of release.

Zeroth-order or derivative-free optimization (MeZO) is an attractive strategy for finetuning large language models (LLMs) because it eliminates the memory overhead of backpropagation. However, it converges slowly due to the inherent curse of dimensionality when searching for descent directions in the high-dimensional parameter space of billion-scale LLMs. We propose ConMeZO, a novel zeroth-order optimizer that accelerates convergence by adaptive directional sampling. Instead of drawing the direction uniformly at random, ConMeZO restricts the sampling to a cone centered around a momentum estimate. This concentrates the search in directions where the true gradient is more likely to lie and thus reduces the effect of high dimensions. We prove that ConMeZO achieves the same worst-case convergence rate as MeZO. Empirically, when finetuning LLMs on natural language tasks, ConMeZO is up to 2X faster than MeZO while retaining the low-memory footprint of zeroth-order methods.

The Lasso has been widely used as a method for variable selection, valued for its simplicity and empirical performance. However, Lasso's selection stability deteriorates in the presence of correlated predictors. Several approaches have been developed to mitigate this limitation. In this paper, we provide a brief review of existing approaches, highlighting their limitations. We then propose a simple technique to improve the selection stability of Lasso by integrating a weighting scheme into the Lasso penalty function, where the weights are defined as an increasing function of a correlation-adjusted ranking that reflects the predictive power of predictors. Empirical evaluations on both simulated and real-world datasets demonstrate the efficacy of the proposed method. Additional numerical results demonstrate the effectiveness of the proposed approach in stabilizing other regularization-based selection methods, indicating its potential as a general-purpose solution.