The classification of diabetes and prediabetes by static glucose thresholds obscures the pathophysiological dysglycemia heterogeneity, primarily driven by insulin resistance (IR), beta-cell dysfunction, and incretin deficiency. This review demonstrates that continuous glucose monitoring and wearable technologies enable a paradigm shift towards non-invasive, dynamic metabolic phenotyping. We show evidence that machine learning models can leverage high-resolution glucose data from at-home, CGM-enabled oral glucose tolerance tests to accurately predict gold-standard measures of muscle IR and beta-cell function. This personalized characterization extends to real-world nutrition, where an individual's unique postprandial glycemic response (PPGR) to standardized meals, such as the relative glucose spike to potatoes versus grapes, could serve as a biomarker for their metabolic subtype. Moreover, integrating wearable data reveals that habitual diet, sleep, and physical activity patterns, particularly their timing, are uniquely associated with specific metabolic dysfunctions, informing precision lifestyle interventions. The efficacy of dietary mitigators in attenuating PPGR is also shown to be phenotype-dependent. Collectively, this evidence demonstrates that CGM can deconstruct the complexity of early dysglycemia into distinct, actionable subphenotypes. This approach moves beyond simple glycemic control, paving the way for targeted nutritional, behavioral, and pharmacological strategies tailored to an individual's core metabolic defects, thereby paving the way for a new era of precision diabetes prevention.

Recent LLM-based agents have demonstrated strong capabilities in automated ML engineering. However, they heavily rely on repeated full training runs to evaluate candidate solutions, resulting in significant computational overhead, limited scalability to large search spaces, and slow iteration cycles. To address these challenges, we introduce ArchPilot, a multi-agent system that integrates architecture generation, proxy-based evaluation, and adaptive search into a unified framework. ArchPilot consists of three specialized agents: an orchestration agent that coordinates the search process using a Monte Carlo Tree Search (MCTS)-inspired novel algorithm with a restart mechanism and manages memory of previous candidates; a generation agent that iteratively generates, improves, and debugs candidate architectures; and an evaluation agent that executes proxy training runs, generates and optimizes proxy functions, and aggregates the proxy scores into a fidelity-aware performance metric. This multi-agent collaboration allows ArchPilot to prioritize high-potential candidates with minimal reliance on expensive full training runs, facilitating efficient ML engineering under limited budgets. Experiments on MLE-Bench demonstrate that ArchPilot outperforms SOTA baselines such as AIDE and ML-Master, validating the effectiveness of our multi-agent system.

We introduce TwIST, a distributed training framework for efficient large language model (LLM) sparsification. TwIST trains multiple subnetworks in parallel, periodically aggregates their parameters, and resamples new subnetworks during training. This process identifies high-quality subnetworks ("golden tickets") without requiring post-training procedures such as calibration or Hessian-based recovery. As a result, TwIST enables zero-cost pruning at deployment time while achieving perplexity competitive with state-of-the-art post-training sparsification methods. The benefits are most pronounced under aggressive sparsity (e.g., 50%+), where TwIST significantly outperforms baseline methods; for example, reaching 23.14 PPL compared to 31.64 for the closest prior approach. Unlike unstructured pruning, TwIST produces structured, dense matrices that offer practical inference speedups and memory reductions on commodity hardware (e.g., CPUs) that do not support efficient sparse computation. TwIST provides an efficient training-time path to deployable sparse LLMs without additional fine-tuning or recovery overhead.

The need to remove specific student data from cognitive diagnosis (CD) models has become a pressing requirement, driven by users' growing assertion of their "right to be forgotten". However, existing CD models are largely designed without privacy considerations and lack effective data unlearning mechanisms. Directly applying general-purpose unlearning algorithms is suboptimal, as they struggle to balance unlearning completeness, model utility, and efficiency when confronted with the unique heterogeneous structure of CD models. To address this, our paper presents the first systematic study of the data unlearning problem for CD models, proposing a novel and efficient algorithm: hierarchical importance-guided forgetting (HIF). Our key insight is that parameter importance in CD models exhibits distinct layer-wise characteristics. HIF leverages this via an innovative smoothing mechanism that combines individual and layer-level importance, enabling a more precise distinction of parameters associated with the data to be unlearned. Experiments on three real-world datasets show that HIF significantly outperforms baselines on key metrics, offering the first effective solution for CD models to respond to user data removal requests and for deploying high-performance, privacy-preserving AI systems.

Automatic question generation (AQG) for mathematics education remains an elusive goal for Intelligent Tutoring Systems and educators. While pre-trained transformer-based language models have significantly advanced natural language generation, they often struggle to precisely control problem complexity and cognitive demands. In this paper, we introduce a collaborative multi-agent framework as a novel method of incorporating inference-time computation into AQG. This approach leverages multiple agents that it-eratively refine generated question-answer pairs to better balance complexity and cognitive demand. We evaluate the generated questions on five meta-evaluation criteria: relevance, importance, clarity, difficulty matching, answerability, to assess the system's ability to control the required complexity and quality of the questions. Preliminary evaluations show that this collaborative multi-agent framework elevates the quality of generated educational content by fostering a more nuanced balance between cognitive challenge and clarity. These promising outcomes suggest that integrating collaborative multi-agent workflows can yield more controlled, pedagogically valuable content that can help advance automated educational content generation and adaptive learning environments.

Marine invasive species spread through global shipping and generate substantial ecological and economic impacts. Traditional risk assessments require detailed records of ballast water and traffic patterns, which are often incomplete, limiting global coverage. This work advances a theoretical framework that quantifies invasion risk by combining environmental similarity across ports with observed and forecasted maritime mobility. Climate-based feature representations characterize each port's marine conditions, while mobility networks derived from Automatic Identification System data capture vessel flows and potential transfer pathways. Clustering and metric learning reveal climate analogues and enable the estimation of species survival likelihood along shipping routes. A temporal link prediction model captures how traffic patterns may change under shifting environmental conditions. The resulting fusion of environmental similarity and predicted mobility provides exposure estimates at the port and voyage levels, supporting targeted monitoring, routing adjustments, and management interventions.

Critical appraisal of scientific literature is an essential skill in the biomedical field. While large language models (LLMs) can offer promising support in this task, their reliability remains limited, particularly for critical reasoning in specialized domains. We introduce CareMedEval, an original dataset designed to evaluate LLMs on biomedical critical appraisal and reasoning tasks. Derived from authentic exams taken by French medical students, the dataset contains 534 questions based on 37 scientific articles. Unlike existing benchmarks, CareMedEval explicitly evaluates critical reading and reasoning grounded in scientific papers. Benchmarking state-of-the-art generalist and biomedical-specialized LLMs under various context conditions reveals the difficulty of the task: open and commercial models fail to exceed an Exact Match Rate of 0.5 even though generating intermediate reasoning tokens considerably improves the results. Yet, models remain challenged especially on questions about study limitations and statistical analysis. CareMedEval provides a challenging benchmark for grounded reasoning, exposing current LLM limitations and paving the way for future development of automated support for critical appraisal.

In multi-agent deep reinforcement learning (MADRL), agents can communicate with one another to perform a task in a coordinated manner. When multiple tasks are involved, agents can also leverage knowledge from one task to improve learning in other tasks. In this paper, we propose Multi-task Communication Skills (MCS), a MADRL with communication method that learns and performs multiple tasks simultaneously, with agents interacting through learnable communication protocols. MCS employs a Transformer encoder to encode task-specific observations into a shared message space, capturing shared communication skills among agents. To enhance coordination among agents, we introduce a prediction network that correlates messages with the actions of sender agents in each task. We adapt three multi-agent benchmark environments to multi-task settings, where the number of agents as well as the observation and action spaces vary across tasks. Experimental results demonstrate that MCS achieves better performance than multi-task MADRL baselines without communication, as well as single-task MADRL baselines with and without communication.

Global digital platforms are software systems designed to serve entire populations, with some already serving billions of people. We propose atomic transactions-based multiagent transition systems and protocols as a formal framework to study them; introduce essential agents -- minimal sets of agents the removal of which makes communication impossible; and show that the cardinality of essential agents partitions all global platforms into four classes: 1. Centralised -- one (the server) 2. Decentralised -- finite $>1$ (bootstrap nodes) 3. Federated -- infinite but not universal (all servers) 4. Grassroots -- universal (all agents) Our illustrative formal example is a global social network, for which we provide centralised, decentralised, federated, and grassroots specifications via multiagent atomic transactions, and prove they all satisfy the same basic correctness properties. We discuss informally additional global platforms -- currencies, ``sharing economy'' apps, AI, and more. While this may be the first characterisation of centralised, decentralised, and federated global platforms, grassroots platforms have been formally defined previously, but using different notions. Here, we prove that their original definition implies that all agents are essential, placing grassroots platforms in a distinct class within the broader formal context that includes all global platforms. This work provides the first mathematical framework for classifying any global platform -- existing or imagined -- by providing a multiagent atomic-transactions specification of it and determining the cardinality of the minimal set of essential agents in the ensuing multiagent protocol. It thus provides a unifying mathematical approach for the study of global digital platforms, perhaps the most important class of computer systems today.

We present a node-based storytelling system for multimodal content generation. The system represents stories as graphs of nodes that can be expanded, edited, and iteratively refined through direct user edits and natural-language prompts. Each node can integrate text, images, audio, and video, allowing creators to compose multimodal narratives. A task selection agent routes between specialized generative tasks that handle story generation, node structure reasoning, node diagram formatting, and context generation. The interface supports targeted editing of individual nodes, automatic branching for parallel storylines, and node-based iterative refinement. Our results demonstrate that node-based editing supports control over narrative structure and iterative generation of text, images, audio, and video. We report quantitative outcomes on automatic story outline generation and qualitative observations of editing workflows. Finally, we discuss current limitations such as scalability to longer narratives and consistency across multiple nodes, and outline future work toward human-in-the-loop and user-centered creative AI tools.